The Handbook of Clinical Neuroepidemiology is a multi-author book offering an exhaustive survey of the epidemiology of neurological disorders. The first chapter provides an extensive and clear overview of fundamental concepts of statistics and epidemiology, and this key part of the book gives readers the essentials on how to interpret and do epidemiological research. The chapter includes a CD that shows how to download a statistical package R (a language and environment useful for data handling, statistical analysis, and preparation of graphics). By using part of data from the Fletcher Challenge Heart and Health Study, the CD provides numerous examples to drive the reader along the intricate paths of statistical techniques. The rest of the book consists of 17 chapters devoted to neurological disorders. These chapters give crucial up-to-date reviews of epidemiology, not only for major neurological diseases but also for disorders for which epidemiological literature is scanty (low back pain, toxic and metabolic disorders, neuromuscular disorders, and neuropsychiatric disorders). Neurological disorders are discussed from descriptive (prevalence, incidence, and mortality) and analytical (risk factors and comorbidities) epidemiological points of view, and the chapters on stroke, traumatic brain injury, neuromuscular disorders, CNS tumours, and Huntington's disease include paragraphs dedicated to clinical management or treatment. Migraine is deeply analysed, with special emphasis on its individual and social effects. Other neurological disorders are outlined, focusing on diagnostic criteria and classification (peripheral neuropathies) or nosographic aspects (dementia). The chapter on neurological aspects of ageing is unusual for a neuroepidemiology text because it looks at structural, biochemical, and molecular changes in the brain. Although unusual, this section gives interesting information on the relation between biological changes and cognition and on the interpretation of epidemiological associations. The last chapter reviews measurement scales. Interestingly, outcome measures for clinical trials in neurology are addressed with an original approach—the effect of illness on the patient's daily life. In this way, the change in quality of life caused by treatment can be recorded. In my opinion, this book would be helpful for specialists in neuroepidemiology, but more so for clinicians who work in neurology and for general health professionals who refer to epidemiology and to evidence-based medicine.