Function Of Separation Research Articles

Elastic wave demultiplexer with frequency dependent topological valley Hall edge states

Valley Hall topological insulators (VHTIs) hold great promise for enhancing the manipulation of elastic wave propagation by their intrinsic topologically protected mechanism. Different from most of VHTIs designed by the deterministic Dirac degeneracy, a more flexible design of VHTIs is proposed by the accidental Dirac degeneracy to steer elastic wave propagation. Based on the accidental Dirac degeneracy, a kind of hexagonal phononic crystal is designed to independently control the topological phase transitions at different frequency ranges. Consequently, a two-channel topological demultiplexer is designed with the function of frequency separation for flexural waves, and its effectivity is verified by numerical simulations and experimental testing. Comparing with traditional designs of demultiplexers, the VHTIs-based demultiplexer possesses a series of advantages in robust performance, easy fabrication and low energy leakage, and sheds light on developing new generation of elastic wave devices.

Формирование профессиональной судейской корпорации в России (XVIII–XXI вв.)

The article introduces a comprehensive analysis of professional judicial corporation in Russia in the XVIII–XXI centuries in its theoretical and historical aspects. The research objective was to clarify the concept and categories of judicial power, as well as to model the process of its development in Russia. The issue of professions and professional corporations as social phenomena is a matter of sociology. For lawyers, sociological studies are important in connection with the issue of judicial corporation development, i.e., its theoretical and historical development. The author relied on the structural and functional approach to the professionalization model developed by sociologist G. Vilensky, who interpreted the categories of judicial profession, judiciary, and judicial corporation. The authors revealed the directions in the development of the professional judicial corporation in Russia in the XVIII–XXI centuries and periodized this process. A separate and permanent judicial function determined the emergence of professional judiciary, organizationally represented by a professional judicial corporation. The profession of a judge is all these elements combined. The judicial corporation developed in Russia in three directions, i.e., normative, organizational, and symbolic, with a prominent regulatory influence of the state. The judicial profession and professional corporation started to develop in Russia during the judicial reforms in the XVIII century. This slow, nonlinear, and discrete process was completed as late as in the XXI century with all the necessary stages of professionalization: the professional corporation finally became the organization form of the Russian judiciary. The authors revealed five stages in the history of the professional judicial corporation in Russia: 1) XVIII century; 2) the first half of the XIX century; 3) 1864–1917; 4) 1917–1989; 5) 1989 – early XXI century.

Mathematical simulation of À LA Einstein loss of the non-separable character of a function for two particles at the quantum-classical boundary

In this article, we present mathematical simulations of non-separable functions (those that would “correspond” to two entangled quantum particles) that lose this character only as a result of approaching the quantum-classical frontier. No mathematical representation of the action of deteriorating agents of quantum entanglement was included in the simulation. Such loss manifests itself both from the point of view of position space and momentum space. For certain limits, compatible with the space considered, the non-separable functions defined here transform into separable functions or cancel each other out at this boundary, thus erasing the (mathematical representation of) the quantum characteristic with no equivalent in the classical world. These simulations do not concern the loss of a physical property or characteristic, but rather the loss of a mathematical characteristic of a function for two quantum particles. The “ghostly action at a distance”, colloquially expressed by Prof. A. Einstein, has a “spatially limited and non-instantaneous action” as it’s opposite, which mathematically takes place in simulations of non-separable quantum functions, as shown here.

Investigation of the Electrocatalytic Reduction of Peroxydisulfate Using Scanning Electrochemical Microscopy.

The elementary steps of the electrocatalytic reduction of S2O82- using the Ru(NH3)63+/2+ redox couple were investigated using scanning electrochemical microscopy (SECM) and steady-state voltammetry (SSV). SECM investigations were carried out in a 0.1 M KCl solution using a 3.5 μm radius carbon ultramicroelectrode (UME) as the SECM tip and a 25 μm radius platinum UME as the substrate electrode. Approach curves were recorded in the positive feedback mode of SECM by reducing Ru(NH3)63+ at the tip electrode and oxidizing Ru(NH3)62+ at the substrate electrode, as a function of the tip-substrate separation and S2O82- concentration. The one-electron reaction between electrogenerated Ru(NH3)62+ and S2O82- yields the unstable S2O83•-, which rapidly dissociates to produce highly oxidizing SO4•-. Because SO4•- is such a strongly oxidizing species, it can be further reduced at both the tip and the substrate, or it can react with Ru(NH3)62+ to regenerate Ru(NH3)63+. SECM approach curves display a complex dependence on the tip-substrate distance, d, due to redox mediation reactions at both the tip and the substrate. Finite element method (FEM) simulations of both SECM approach curves and SSV confirm a previously proposed mechanism for the mediated reduction of S2O82- using the Ru(NH3)63+/2+ redox couple. Our results provide a lower limit for dissociation rate constant of S2O83•- (∼1 × 106 s-1), as well as the rate constants for electron transfer between SO4•- and Ru(NH3)62+ (∼1 × 109 M-1 s-1) and between S2O82- and Ru(NH3)62+ (∼7 × 105 M-1 s-1).

Estimating major merger rates and spin parameters ab initio via the clustering of critical events

Abstract We build a model to predict from first principles the properties of major mergers. We predict these from the coalescence of peaks and saddle points in the vicinity of a given larger peak, as one increases the smoothing scale in the initial linear density field as a proxy for cosmic time. To refine our results, we also ensure, using a suite of ∼400 power-law Gaussian random fields smoothed at ∼30 different scales, that the relevant peaks and saddles are topologically connected: they should belong to a persistent pair before coalescence. Our model allows us to (a) compute the probability distribution function of the satellite-merger separation in Lagrangian space: they peak at three times the smoothing scale; (b) predict the distribution of the number of mergers as a function of peak rarity: haloes typically undergo two major mergers (>1:10) per decade of mass growth; (c) recover that the typical spin brought by mergers: it is of the order of a few tens of percent.

Trajectory Planning through Model Inversion of an Underactuated Spatial Gantry Crane Moving in Structured Cluttered Environments

Handling suspended loads in cluttered environments is critical due to the oscillations arising while the load is traveling. Exploiting active control algorithms is often unviable in industrial applications, due to the necessity of installing sensors on the load side, which is expensive and often impractical due to technological limitations. In this light, this paper proposes a trajectory planning method for underactuated, non-flat, non-minimum phase spatial gantry crane moving in structured cluttered environments. The method relies on model inversion. First, the system dynamics is partitioned into actuated and unactuated coordinates and then the load displacements are described as a non-linear separable function of these. The unactuated dynamic is unstable; hence, the displacement, velocity, and acceleration references are modified through the output redefinition technique. Finally, platform trajectory is computed, and the desired displacements of the load are obtained. The effectiveness of the proposed method is assessed through numerical and experimental tests performed on a laboratory testbed composed by an Adept Quattro robot moving a pendulum. The load is moved in a cluttered environment, and collisions are avoided while simultaneously tracking the prescribed trajectory effectively.

Extinction Values toward Embedded Planets in Protoplanetary Disks Estimated from Hydrodynamic Simulations

Upcoming new coronographs with deeper contrast limits, together with planned and current high-contrast imaging campaigns, will push the detectability limit of protoplanets. These planet-hunting campaigns present a new opportunity to characterize protoplanets and their surrounding environments. However, there are clear uncertainties as to what the extinction levels are at different regions of protoplanetary disks, which will impede our ability to characterize young planets. A correct understanding of the expected extinction, together with multiple photometric observations, will lead to constraints on the extinction levels, dust growth, disk evolution, and protoplanetary accretion rates. In this work, we used hydrodynamic simulations and protoplanetary disk observational constraints obtained from both dust and gas emission to explore the expected extinction maps for continuum filters associated with strong hydrogen lines as tracers of accretion and key broadband photometric filters. We provide a scaling relationship for the extinction as a function of planetary separation and disk mass for three different gas giant masses. We also report values for a subset of disks of interest targeted by multiple imaging campaigns. The described values will be useful for the optimal design of future planet-hunting surveys and for giving context to nondetections in protoplanetary disks and the observed fluxes of point sources along with the birth conditions of protoplanets.

Doubly heavy dibaryons as seen by string theory

We propose the stringy description of the system consisting of two heavy and four light quarks in the case of two light flavors of equal mass. As an application, we consider the three low-lying Born-Oppenheimer potentials as a function of the heavy quark separation. Our analysis shows that the ground state potential is described in terms of both hadroquarkonia and hadronic molecules. A connected string configuration makes the dominant contribution to the potential of an excited state at small separations, and for separations larger than 0.1 fm, it exhibits the diquark-diquark-diquark structure [Qq][Qq][qq]. For better understanding the quark organization inside the system, we introduce several critical separations related to the processes of string reconnection, breaking and junction annihilation. We also discuss the simplest string configurations including the five-string junctions and their implications for the system, in particular the emergence of composite quark objects different from diquarks and the process of junction fusion. Published by the American Physical Society 2024

Numerically Exact Simulation of Photodoped Mott Insulators.

A description of long-lived photodoped states in Mott insulators is challenging, as it needs to address exponentially separated timescales. We demonstrate how properties of such states can be computed using numerically exact steady state techniques, in particular, the quantum Monte Carlo algorithm, by using a time-local ansatz for the distribution function with separate Fermi functions for the electron and hole quasiparticles. The simulations show that the Mott gap remains robust to large photodoping, and the photodoped state has hole and electron quasiparticles with strongly renormalized properties.

Ubiquitin ligase TRIM15 promotes the progression of pancreatic cancer via the upregulation of the IGF2BP2-TLR4 axis

BackgroundThe tripartite motif family, predominantly characterized by its E3 ubiquitin ligase activities, is involved in various cellular processes including signal transduction, apoptosis and autophagy, protein quality control, immune regulation, and carcinogenesis. Tripartite Motif Containing 15 (TRIM15) plays an important role in melanoma progression through extracellular signal-regulated kinase activation; however, data on its role in pancreatic tumors remain lacking. We previously demonstrated that TRIM15 targeted lipid synthesis and metabolism in pancreatic cancer; however, other specific regulatory mechanisms remain elusive. MethodsWe used transcriptomics and proteomics, conducted a series of phenotypic experiments, and used a mouse orthotopic transplantation model to study the specific mechanism of TRIM15 in pancreatic cancer in vitro and in vivo. ResultsTRIM15 overexpression promoted the progression of pancreatic cancer by upregulating the toll-like receptor 4. The TRIM15 binding protein, IGF2BP2, could combine with TLR4 to inhibit its mRNA degradation. Furthermore, the ubiquitin level of IGF2BP2 was positively correlated with TRIM15. ConclusionsTRIM15 could ubiquitinate IGF2BP2 to enhance the function of phase separation and the maintenance of mRNA stability of TLR4. TRIM15 is a potential therapeutic target against pancreatic cancer.

Highly-accelerated CEST MRI using frequency-offset-dependent k-space sampling and deep-learning reconstruction.

To develop a highly accelerated CEST Z-spectral acquisition method using a specifically-designed k-space sampling pattern and corresponding deep-learning-based reconstruction. For k-space down-sampling, a customized pattern was proposed for CEST, with the randomized probability following a frequency-offset-dependent (FOD) function in the direction of saturation offset. For reconstruction, the convolution network (CNN) was enhanced with a Partially Separable (PS) function to optimize the spatial domain and frequency domain separately. Retrospective experiments on a self-acquired human brain dataset (13 healthy adults and 15 brain tumor patients) were conducted using k-space resampling. The prospective performance was also assessed on six healthy subjects. In retrospective experiments, the combination of FOD sampling and PS network (FOD + PSN) showed the best quantitative metrics for reconstruction, outperforming three other combinations of conventional sampling with varying density and a regular CNN (nMSE and SSIM, p < 0.001 for healthy subjects). Across all acceleration factors from 4 to 14, the FOD + PSN approach consistently outperformed the comparative methods in four contrast maps including MTRasym, MTRrex, as well as the Lorentzian Difference maps of amide and nuclear Overhauser effect (NOE). In the subspace replacement experiment, the error distribution demonstrated the denoising benefits achieved in the spatial subspace. Finally, our prospective results obtained from healthy adults and brain tumor patients (14×) exhibited the initial feasibility of our method, albeit with less accurate reconstruction than retrospective ones. The combination of FOD sampling and PSN reconstruction enabled highly accelerated CEST MRI acquisition, which may facilitate CEST metabolic MRI for brain tumor patients.

Proximity-Induced Exchange Interaction: A New Pathway for Quantum Sensing Using Spin Centers in Hexagonal Boron Nitride.

Defects in hexagonal boron nitride (hBN), a two-dimensional van der Waals material, have attracted a great deal of interest because of its potential in various quantum applications. Due to hBN's two-dimensional nature, the spin center in hBN can be engineered in the proximity of the target material, providing advantages over its three-dimensional counterparts, such as the nitrogen-vacancy center in diamond. Here we propose a novel quantum sensing protocol driven by exchange interaction between the spin center in hBN and the underlying magnetic substrate induced by the magnetic proximity effect. By first-principles calculation, we demonstrate that the induced exchange interaction dominates over the dipole-dipole interaction by orders of magnitude when in the proximity. The interaction remains antiferromagnetic across all stacking configurations between the spin center in hBN and the target van der Waals magnets. Additionally, we explored the scaling behavior of the exchange field as a function of the spatial separation between the spin center and the targets.

Integrating inverse design and partially etched platform: an ultra-compact polarization splitter and rotator as an example

Silicon photonics devices benefit greatly from a partially etched platform and inverse design. Herein, we propose a bi-layer polarization splitter and rotator with a topology pattern and demonstrate it on a silicon-on-insulator platform. Our device exhibits a significantly reduced physical footprint of only 2µm×6µm, compared to traditional directional couplers and tapered waveguides. The device accomplishes the functions of polarization conversion and separation in such a compact design without redundant tapered or bending waveguides. The tested minimum insertion loss with the fabrication batch reaches 0.57 and 0.67 dB for TE and TM modes, respectively. The TE mode demonstrates a wider bandwidth and lower ILs than the TM modes, averaging around 1 dB from 1530 to 1565 nm. The M modes exhibit approximately 2 dB ILs at the same wavelength range, decreasing to about 1 dB between 1565 and 1580 nm. Improved designs and fabrication conditions strongly suggest the potential for further performance enhancement in the device. This successful initiative validates the exceptional performance resulting from the integration of the partially etched platform and inverse design, providing valuable insights for future photonic integrated device designs.

Non-compatible fully [formula omitted] symmetric Davey–Stewartson system: Localized excitation and folded solitary wave

This paper studies a non-compatible fully PT symmetric Davey–Stewartson system which models the evolution of optical wave packet in nonlinear optics. “Non-compatible” means the first two equations of the system are inconsistent that do not need to comply with extra constraint like the compatible case. We employ the multi-linear variable separation approach to derive variable separation solution for this system. The obtained solutions contain four separated free functions, render enough freedom for us to generate diverse solitons. Firstly, we construct two kinds of localized excitations: lump-lattice and periodic-lattice structure. Secondly, we obtain four typical folded solitary waves, i.e. worm-dromion shaped, fin shaped and octopus shaped waves, by introducing suitable multi-valued functions. Lastly, we systematically analyze the interaction between two and three foldons, and give the classification of it. To our knowledge, this is the first time variable separation solution been reported in PT symmetric system. The basic idea of separating variables that used in this paper can be extended to other symmetric systems.

Surface wettability control and electron transport regulation in zerovalent iron for enhanced removal of emerging polystyrene microplastics-heavy metal contaminants

Emerging microplastics-heavy metal (MPs-HM) contaminants in wastewaters pose an emerging health and environmental risk due to their persistence and increasing ecological risks (e.g., “Trojan horse” effect). Hence, removing MPs in solution and preventing secondary releases of HM has become a key challenge when tackling with MPs pollution. Leveraging the hydrophobic nature of MPs and the electron transfer efficiency from Fe0 to HM, we demonstrate an alkylated and sulfidated nanoscale zerovalent iron (AS-nZVI) featuring a delicate “core-shell-hydrophobic film” nanostructure. Exemplified by polystyrene (PS) MPs-Pb(II) removal, the three nanocomponents offer synergistic functions for the rapid separation of MPs, as well as the reduction and stabilization of Pb(II). The outmost hydrophobic film of AS-nZVI greatly improves the anticorrosion performance of nanoscale zerovalent iron and the enrichment abilities of hydrophobic MPs, achieving a maximum removal capacity of MPs to 2725.87 mgMPs·gFe−1. This MPs enrichment promotes the subsequent reductive removal of Pb(II) through the electron transfer from the iron core of AS-nZVI to Pb(II), a process further strengthened by the introduced sulfur. When considering the inevitable aging of MPs in wastewaters due to mechanical wear or microbial degradation, our study concurrently examines the efficiencies and behaviors of AS-nZVI in removing virgin-MPs-Pb(II) and aged-MPs-Pb(II). The batch results reveal that AS-nZVI has an exceptional ability to remove above 99.6 % Pb(II) for all reaction systems. Overall, this work marks a pioneering effort in highlighting the importance of MPs-toxin combinations in dealing with MPs contamination and in demonstrating the utility of nZVI techniques for MPs-contaminated water purification.

БИРОБИДЖАН: ИСТОРИЧЕСКИЕ ПРЕОБРАЗОВАНИЯ ТОРГОВЫХ ПРОСТРАНСТВ ГОРОДА-СПУТНИКА

A number of studies are devoted to the urban development of settlements in the Far East, but they do not consider trade spaces as structureforming spaces, whereas they often form the framework of the city. After studying the cadastral maps of Birobidzhan, topographic survey materials, online maps and other documents, we identified five historical periods of formation of outdoor trade spaces in Birobidzhan and their architectural and planning features. The first stage was 1928-1933: the period of free development of the territory, when the trade environment was an instrument of social adaptation of the developed space. The second was 1932-1937, when professional architects were invited to the planning and development of the city, and the market square received its official status. The third stage was 1937-1990: the period of planned development of the territory, when the planned trade environment was formed. The fourth was in the 1990s: it was the time of post-socialist transformation, the typical feature of which was self-organization of market space, the trade street reflected the crisis phenomena in the urban system. The fifth stage lasts from 2000 to the present and includes reorganization of trade spaces: demolition of old pavilions and stalls in the Central Market area, emergence of seasonal fairs as a new form of open trade in the city, concentration of small open trade spaces near the existing markets at the same time with separate functioning of large shopping centres that close the adjacent territories from street trade. The comprehensive programme for the implementation of the concept "Compact competitive city with jewish colour on the border with China" (master plan of Birobidzhan until 2030) envisages, among other things, the renovation of trade spaces. It should take into account trade as a social phenomenon.

Simultaneous assessment of renal function with hybrid SPECT/CT during whole-body bonescintigraphy (WbBS) in patients with prostate carcinoma (PC) and concomitant urological diseases with impaired renal drainage

Introduction: Whole-body bone scintigraphy (WbBS) is the „gold standard“ worldwide for early detection and evaluation of treatment of bone metastatic tumors, incl.PC.Due to the known renal excretion of the osteotropic RPh – 99mTc-methylene diphosphonate (99mTc-MDP), it is possible to perform an „early“ assessment of renal function, followed by a „late“ standard WbBS with SPECT/CT. Aim: The aim of the present study was to evaluate and indicate the diagnostic utility of a single administration of 99mTc-MDP with a dual protocol implemented in the CNM for sequential scintigraphic assessment of renal function and early detection, staging and evaluation of the treatment effect of bone metastases in patients with PCand concomitant urological diseases. Materials and methods: We present three patients with PC, referred for restaging of the oncological disease and performing WbBS in the CNM in USHATO, Sofia, Bulgaria. According to the indications and assessment of a nuclear medicine physician, a one-day protocol was carried out and introduced in the CNM, starting with dynamic renal scintigraphy (DRS) at the time of bo-lus i.v.injection of 99mTc-MDP and subsequent after the 2nd hour planar WbBS with hybrid target or wholebody SPECT/CT scan. Results: The first patient is with metastatic PC after complex treatment.Due to elevated levels of creatinine, „early“ DRS and „late“ restaging WbBS were performed, with reported full therapeutic effect of bone-metastatic disease and isosthenuric changes in right kidney, but with altered secretory-excretory phases and reduced total GFR.The second case is a patient with high-risk CP, who underwent hormonal and definitive radiation therapy, with episodes of renal colic. DRS revealed a hydronephrotic type nephrogram on the right, and a subsequent CT scan showed osteoporotic compression fractures of two vertebrae, without bon metastasis. An additional SPECT/CT finding is a calcium-dense calculus as a probable cause of the hydronephrotic changes. The third patient, is with high-risk CP and undergonetreatment. Initial DRSshowed secretory-excretory dysfunction of the right kidney with retention in the pyelocaliceal system. SubsequentWbBSand SPECT/CT revealed a complete therapeutic effect of a solitary bony lesion in the 6th right rib and malrotation of the right kidney with a staghorn calculus in the pyelon. All patients are referred for urological control. Conclusion: DRS performed with hybrid SPECT/ CT, in the course of routine WbBS, for re-staging of patients with CP, gives along with bone metastatic follow-up, valuable functional information about the separated renal function, drainage and morphological guidance for pathological changes from concomitant urological diseases.

Integrated distance sampling models for simple point counts.

Point counts (PCs) are widely used in biodiversity surveys but, despite numerous advantages, simple PCs suffer from several problems: detectability, and therefore abundance, is unknown; systematic spatiotemporal variation in detectability yields biased inferences, and unknown survey area prevents formal density estimation and scaling-up to the landscape level. We introduce integrated distance sampling (IDS) models that combine distance sampling (DS) with simple PC or detection/nondetection (DND) data to capitalize on the strengths and mitigate the weaknesses of each data type. Key to IDS models is the view of simple PC and DND data as aggregations of latent DS surveys that observe the same underlying density process. This enables the estimation of separate detection functions, along with distinct covariate effects, for all data types. Additional information from repeat or time-removal surveys, or variable survey duration, enables the separate estimation of the availability and perceptibility components of detectability with DS and PC data. IDS models reconcile spatial and temporal mismatches among data sets and solve the above-mentioned problems of simple PC and DND data. To fit IDS models, we provide JAGS code and the new "IDS()" function in the R package unmarked. Extant citizen-science data generally lack the information necessary to adjust for detection biases, but IDS models address this shortcoming, thus greatly extending the utility and reach of these data. In addition, they enable formal density estimation in hybrid designs, which efficiently combine DS with distance-free, point-based PC or DND surveys. We believe that IDS models have considerable scope in ecology, management, and monitoring.

On Correlation Aversion and Insurance Demand

This is a study of decision problems under two-dimensional risk. We use an existing index of absolute correlation aversion to conveniently classify bivariate preferences, with respect to attitudes toward this risk. This classification seems to be more important than whether decision makers are correlation-averse or correlation-seeking for the study of insurance demand when a loss has a multidimensional impact. On this note, we also re-examine Mossin’s theorem under bivariate preferences, where full insurance is preferred with a fair premium, while less than full coverage is preferred with a proportional premium loading. Furthermore, based on the comparative statics of this two-dimensional insurance model for changes in correlation aversion, we derive testable implications about the classification of bivariate utility functions. For the particular case when the two-dimensional risk can be interpreted as risk on income and health, we identify the form of separable utility functions depending on health status and income that is consistent with household disability insurance decisions.

The rheology of interactions between leukocytes, platelets and the vessel wall in thrombo-inflammation.

Leukocytes and platelets must adhere to the wall of blood vessels to carry out their protective functions in inflammation and haemostasis. Recruitment is critically dependent on rheological variables (wall shear rate and stress, red cell aggregation and haematocrit) which affect delivery to the vessel wall as well as velocities and forces experienced there. Leukocyte recruitment is efficient only up to wall shear rates of about 300s-1 and usually restricted to low-shear post-capillary venules in inflammation. Being smaller, platelets experience lower velocities and shear forces adjacent to the wall and can adhere at much higher shear rates for haemostasis in arteries. In addition, we found quite different effects of variations in haematocrit or red cell aggregation on attachment of neutrophils or platelets, which also assist their separate recruitment in venules or arteries. However, it has become increasingly evident that inflammatory and thrombotic responses may occur together, with platelets promoting the adhesion and activation of neutrophils and monocytes. Indeed, it is 30 years since we demonstrated that platelets could cause neutrophils to aggregate in suspension and, when attached to a surface, could support selectin-mediated rolling of all leukocytes. Thrombin-activated platelets could further induce neutrophil activation and immobilisation. In some conditions, platelets could bind to intact endothelial monolayers and capture neutrophils or monocytes. Subsequently, we found that extracellular vesicles released by activated platelets (PEV) fulfilled similar functions when deposited on surfaces or bound to endothelial cells. In murine models, platelets or PEV could act as bridges for monocytes in inflamed vessels. Thus, leukocytes and platelets are rheologically adapted for their separate functions, while novel thrombo-inflammatory pathways using platelets or PEV may underlie pathogenic leukocyte recruitment.