Product Functionality Research Articles

Surface Quality as a Factor Affecting the Functionality of Products Manufactured with Metal and 3D Printing Technologies.

Surface engineering is one of the most extensive industries. Virtually all areas of the economy benefit from the achievements of surface engineering. Surface quality affects the quality of finished products as well as the quality of manufactured parts. It affects both functional qualities and esthetics. Surface quality affects the image and reputation of a brand. This is particularly true for cars and household appliances. Surface modification of products is also aimed at improving their functional and protective properties. This applies to surfaces for producing hydrophobic surfaces, anti-wear protection of friction pairs, corrosion protection, and others. Metal technologies and 3D printing benefit from surface technologies that improve their functionality and facilitate the operation of products. Surface engineering offers a range of different coating and layering methods from varnishing and painting to sophisticated nanometric coatings. This paper presents an overview of selected surface engineering issues pertaining to metal products, with a particular focus on surface modification of products manufactured by 3D printing technology. It evaluates the impact of the surface quality of products on their functional and performance qualities.

Neural stem cell-derived extracellular vesicles purified by monolith chromatography retain stimulatory effect on in vitro scratch assay.

BackgroundExtracellular vesicles (EVs) have gained traction as potential cell-free therapeutic candidates. Development of purification methods that are scalable and robust is a major focus of EV research. Yet, there is still little in the literature which evaluates purification methods against potency of the EV product. AimsIn the present study, we examine two monolith chromatography methods with a focus on assessing the ability of purified EVs to retain stimulatory effects on firbroblasts to connect scalable purification methods with product outputs. MethodsWe characterised EVs recovered from CTX0E03 (CTX) neural stem cell-conditioned medium in terms of biomarker distribution, functional capacity, and purity. We evaluated the ability of EVs to promote wound closure in an in vitro scratch assay prior to, and following two monolith chromatography steps (anion exchange, and hydrophobic interaction) to determine whether these options may better serve EV bioprocessing. ResultsEVs from CTX cells were successful in initiating wound repair on a fibroblast scratch assay over 72 hours with a single 20μg dose. EV preparations presented the markers CD9, CD81, CD63, but also contained culture albumin and DNA as process impurities. EVs recovered by tangential flow filtration could be successfully purified further by both monolith chromatography steps. Post-monolith EV stimulation was conserved. ConclusionThe results indicate that monolith chromatography is a viable purification method for EVs derived from cell culture that doesn't detract from the product's ability to stimulate fibroblasts, suggesting that product functionality is conserved. Further work is needed in developing suitable downstream processes and analytics to achieve clinically relevant purities for injectable biologics.

Development of kefir product with Bifidobacterium animalis subsp. lactis (BB-12) activated by Sanguisorba officinalis L. extract

This study addresses the challenge of enhancing the activation of Bifidobacterium animalis subsp. lactis (BB-12) to improve the quality and functionality of kefir-based products. The objective was to develop a kefir product enriched with Bifidobacterium animalis subsp. lactis, activated using an extract of Sanguisorba officinalis L., a natural antioxidant, to reduce activation time and boost probiotic efficacy. Two kefir samples were prepared: a control and an experimental product enriched with Bifidobacterium animalis subsp. lactis activated by Sanguisorba officinalis L. at 10⁻⁵ g/cm³ concentration. The experimental sample exhibited a significant increase in Bifidobacterium animalis subsp. lactis count, reaching 9.52 lg(CFU/cm3), within 30 minutes at 37±1 °C, outperforming the control. This rapid activation led to improved physicochemical properties, including enhanced flavor, consistency, and a slower increase in titratable acidity over 14 days, indicating prolonged shelf life. The amino acid profile was enriched, with higher levels of essential amino acids such as valine, leucine, methionine, as well as increased water-soluble vitamins including riboflavin, ascorbic acid, and pantothenic acid. The slower decline in Bifidobacterium animalis subsp. lactis population during storage further highlighted the probiotic stability of the enriched kefir. These findings demonstrate that activating Bifidobacterium animalis subsp. lactis with Sanguisorba officinalis L. extract enhances the nutritional and functional qualities of kefir. This product holds potential for commercial application in the functional food industry, offering consumers a probiotic-rich, nutritionally superior fermented dairy option

3D Printing with Self-Healing Materials and Applications

3D printing also called as the additive manufacturing. It is revolutionizing various industries by enabling the production of complex objects directly from digital models. This technology offers significant advantages over traditional manufacturing methods. Especially in reducing material waste and increased design flexibility. The range of 3D printing application contains healthcare to aerospace, reflecting its growing importance in modern society. Recently, 3D printing advancements have introduced in self-healing (SH) materials, it saved limitations related to the durability and repairability of printed objects. SH materials are categorized into external and internal systems. External SH materials use embedded healing agents that repair damage through chemical reactions, while internal systems rely on dynamic bonding within the material itself. This innovation not only extends the functional life of 3D printed items but also supports trends in mass customization and sustainability. This paper explores the mechanisms, types, and applications of SH materials in 3D printing, and mainly focus on their potential to enhance product longevity and functionality across medical, construction, and consumer goods sectors.

Evaluating women's jacket sleeves designs for sustainable fashion and textile waste reduction

Finding the most efficient marker planning method is crucial to reduce cut-and-sew waste. Small adjustments to the design and pattern can help reduce the amount of fabric waste, since marking loss happens during the cutting process because of spaces and unusable sections between pattern pieces and the curved pattern edges. Existing research mainly concentrates on optimising the consumption of textile material without taking into account the design, aesthetics and functionality of the final product. On the other hand, they are mainly focused on optimizing the sleeves’ construction and in search of new design solutions, with gaps in quantitative and comparative analysis to reduce waste while producing women's jackets. This article aims to propose and explore constructive changes in women's jacket designs with 5 different types of sleeves, to assess the possibility of reducing cut-and-sew waste levels in the cutting process. There have been created 4 different marker plans for each type of sleeve to achieve the high-efficiency markers. It was found that the semi-raglan sleeve showed the marker efficiency with the best results (76.04%), followed by the raglan sleeve with 72.03% and 72.34% for the drop shoulder sleeve. Interestingly, for the raglan and semi-raglan sleeve variants, the marker efficiency is not affected by the specific geometric characteristics. The Principal Component Analysis (PCA) method was used to determine which pattern arrangement variant was most appropriate for the different sleeve types.

Bacillus clausii: A Review into Story of Its Probiotic Success and Potential Food Applications

Probiotics are live microbiota that can confer their hereditary health benefits upon the host. They can positively alter the diversity of the host’s gut microbiota population. Bacillus clausii is a spore-producing potential probiotic. Its application in the food industry has been highly recommended. Clausii spores are greatly resistant to harsh food processing treatment (heat and industrial pressure) and they can maintain their physiological traits (acid, bile salt) inside the human gut. The utilization of spores can enhance the nutritional viability of livestock, as well as the functionality of on-shelf products. This contemporary review covers the great attributes of B. clausii, including physiological characteristics, modes of action, probiotics benefits, a safety assessment, and the bacteria food industry applications for the purposes of producing enhanced functional foods known as probiotic foods. To our knowledge, although B. clausii has been widely applied in food industry, the amount of the literature that is dedicated to its role in sustainable food production and addresses its potential sporogenous probiotic behavior is fewer as compared to non-sporogenous lactic acid bacteria (Lactobacillus spp. and Bifidobacterium spp.). In our review, we also discovered a lack of empirical evidence on the synbiotic and synergistic behavior of clausii in combination with other active nutrients. Therefore, our review suggests that more studies should be conducted on the potential probiotic contribution of B. clausii in sustainable food production and its synergistic and synbiotic behavior in conjunction with other active nutrients.

Novel Encapsulation Approaches in the Functional Food Industry: With a Focus on Probiotic Cells and Bioactive Compounds.

Bioactive substances can enhance host health by modulating biological reactions, but their absorption and utilization by the body are crucial for positive effects. Encapsulation of probiotics is rapidly advancing in food science, with new approaches such as 3D printing, spray-drying, microfluidics, and cryomilling. Co-encapsulation with bioactives presents a cost-effective and successful approach to delivering probiotic components to specific colon areas, improving viability and bioactivity. However, the exact method by which bioactive chemicals enhance probiotic survivability remains uncertain. Co-crystallization as an emerging encapsulation method improves the physical characteristics of active components. It transforms the structure of sucrose into uneven agglomerated crystals, creating a porous network to protect active ingredients. Likewise, electrohydrodynamic techniques are used to generate fibers with diverse properties, protecting bioactive compounds from harsh circumstances at ambient temperature. Electrohydrodynamic procedures are highly adaptable, uncomplicated, and easily expandable, resulting in enhanced product quality and functionality across various food domains. Furthermore, food byproducts offer nutritional benefits and technical potential, aligning with circular economy principles to minimize environmental impact and promote economic growth. Hence, industrialized nations can capitalize on the growing demand for functional foods by incorporating these developments into their traditional cuisine and partnering with businesses to enhance manufacturing and production processes.

THE INFLUENCE OF THE CUTTING PARAMETERS ON THE SURFACE ROUGHNESS AND VIBRATION SIGNAL IN THE TURNING PROCESS

The performance of the final part of the turning process, a topic of practical importance, heavily depends on the cutting parameters. Surface quality, a crucial product attribute in manufacturing, often tops consumer demands during machining due to its significant influence on product functionality. This paper assesses the correlation between the detected vibration signal, statistical parameters (Crest, Kurtosis and I-kaz3D coefficient) and surface roughness and provides valuable insights for practical applications. When the tool experiences vibrations during material removal, these oscillations leave a ripple effect on the surface of the workpiece. We aim to determine the impact of cutting parameters on surface roughness while turning 42CrMo4 steel using a carbide tool insert. Cutting parameters, such as spindle speed, feed, and depth of cut, were used. Signal processing is carried out using different techniques to identify the effect of the cutting parameters on vibration signals. Finally, we delve into the interaction effects between the cutting parameters, vibration signals and surface roughness, offering a comprehensive understanding of real-world manufacturing scenarios. Higher I-kaz3D coefficients correspond to higher surface roughness values. The I-kaz3D coefficient decreases as the surface roughness measurements decrease, indicating that the I-kaz3D technique can accurately indicate an increase or decrease in surface roughness. On the other hand, the cutting force Fc was the component most strongly correlated with surface roughness (Ra), yielding the best results across all indices (adjusted R²adj = 95.1%, er=.8 ± 2.3%).

Prospects for increasing the functionality of milk-containing products through the use of non-traditional plant raw materials

It is an undeniable fact that nutrition is an important and integral part of human life. Unfortunately, nutrition is not always complete and balanced. It has been established that only rational nutrition is the lever by which it is possible to ensure normal growth and development of the body. Food industry enterprises are trying to create exactly such conditions for adequate human adaptation to the regalia of the surrounding world, namely, they develop and produce specialized products that contribute not only to disease prevention, but also to a stable increase in mental and physical performance. Moreover, these activities do not contradict the state policy in terms of improving the health of the population, through the introduction of healthy nutrition products into the retail network, through various assistance to manufacturing enterprises (subsidies, grant support). Regarding manufacturers of milk-containing food products, the importance of which is undeniable, they quite actively promote product lines for certain segments of the population, for example, children, pregnant and lactating women and the elderly. The main objective of the research is to develop a technology for a milk-containing product (drinking yoghurt) that includes several functions important for humans, namely, functional, diabetic, probiotic ones. The product is given the specified functions by including scientifically substantiated components in the recipe, including those from non-traditional raw materials. Standard and individual research methods have been used to confirm the quality indicators of the finished product. The main results of the research include determining the type of plant material that meets the specified requirements and characteristics and contributes to giving the finished product additional properties (prebiotic, functional, diabetic). The final result of the research is obtaining a product that helps increase the body resistance to the negative environmental effects. The use of secondary plant materials for food purposes, which contributes to the design of a food product with a certain quality composition and specified consumer properties, in comparison with existing analogues, can be considered the novelty of the research.

Evaluating Large Language Models for Material Selection

Abstract Material selection is a crucial step in conceptual design due to its significant impact on the functionality, aesthetics, manufacturability, and sustainability impact of the final product. This study investigates the use of Large Language Models (LLMs) for material selection in the product design process and compares the performance of LLMs against expert choices for various design scenarios. By collecting a dataset of expert material preferences, the study provides a basis for evaluating how well LLMs can align with expert recommendations through prompt engineering and hyperparameter tuning. The divergence between LLM and expert recommendations is measured across different model configurations, prompt strategies, and temperature settings. This approach allows for a detailed analysis of factors influencing the LLMs' effectiveness in recommending materials. The results from this study highlight two failure modes, and identify parallel prompting as a useful prompt-engineering method when using LLMs for material selection. The findings further suggest that, while LLMs can provide valuable assistance, their recommendations often vary significantly from those of human experts. This discrepancy underscores the need for further research into how LLMs can be better tailored to replicate expert decision-making in material selection. This work contributes to the growing body of knowledge on how LLMs can be integrated into the design process, offering insights into their current limitations and potential for future improvements.

Advancements in Metal Processing Additive Technologies: Selective Laser Melting (SLM)

Nowadays, the use of metal processing additive technologies is a rapidly growing field in the manufacturing industry. These technologies, such as metal 3D printing (also known as additive manufacturing) and laser cladding, allow for the production of complex geometries and intricate designs that would be impossible with traditional manufacturing methods. They also offer the ability to create parts with customized properties, such as improved strength, wear resistance, and corrosion resistance. In other words, these technologies have the potential to revolutionize the way we design and produce products, reducing costs and increasing efficiency to improve product quality and functionality. One of the significant advantages of these metal processing additive technologies is a reduction in waste and environmental impact. However, there are also some challenges associated with these technologies. One of the main challenges is the cost of equipment and materials, which can be prohibitively expensive for small businesses and individuals. Additionally, the quality of parts produced with these technologies can be affected by factors such as printing speed, temperature, and post-processing methods. This review article aims to contribute to a deep understanding of the processing, properties, and applications of ferrous and non-ferrous alloys in the context of SLM to assist readers in obtaining high-quality AM components. Simultaneously, it emphasizes the importance of further research, optimization, and cost-effective approaches to promote the broader adoption of SLM technology in the industry.

A critical review of composite filaments for fused deposition modeling: Material properties, applications, and future directions

This review paper provides a comprehensive analysis of recent advancements in the development and application of composite filaments for fused deposition modeling (FDM) 3D printing technology. Focusing on the integration of various materials such as nano-fillers, fibers, and bio-based polymers into polylactic acid (PLA) and other thermoplastics, this study delves into how these composites enhance mechanical, thermal and functional properties of the printed objects. We critically assess studies that investigate the impact of raster orientation, filler content, and material composition on tensile, bending, and impact strength, as well as on the thermal stability and degradation behavior of composite filaments. The review highlights key findings from the literature, including the optimization of filament formulations to achieve superior mechanical performance, improved thermal resistance, and specific functional characteristics suitable for a wide range of applications from biomedical to structural components. Moreover, this paper discusses the challenges associated with composite filament production, including material compatibility, dispersion of nano-fillers, and the need for printer hardware adjustments. Future directions for research in the field are identified, emphasizing the potential for new material combinations, sustainability considerations, and the development of filaments designed for specific industrial applications. An effective way to better meet designers’ expectations for qualified materials is composite filaments. This review focuses on how these elements can be applied to improve both product design and functionality. A guide is presented in choosing composite filaments that can meet the features expected from the designed product.

Exploring digital art's role in cultural product innovation in northeast China’s industrial base

This research investigates the impact of digital art on the innovation of cultural and creative products, particularly in Northeast China's historical industrial regions. It explores how digital art enhances product design and functionality, ultimately improving market competitiveness. Data was collected via a questionnaire survey targeting employees in these regions, with SEM used to analyze the relationships between digital art, product innovation, and market competitiveness, focusing on the mediating role of product innovation. The results reveal that integrating digital art significantly enhances market competitiveness by advancing technology, enriching design aesthetics, and aligning products with market demands. Product innovation is identified as a key mediator in this process, underscoring digital art's essential role in the development of cultural and creative products. The study concludes that digital art not only boosts the artistic quality and market appeal of these products but also drives continuous innovation, positioning it as a vital force in the cultural industry's growth. As technology advances, digital art is expected to become increasingly influential in shaping the future of cultural and creative sectors.

Analysis and evaluation of adaptive remanufacturing strategies for mechanical products

Abstract Resource scarcity and unsustainable production of products are critical challenges in today’s manufacturing landscape. In this context, adaptive remanufacturing of products could play an important role. This concept prioritizes restoring product functionality over adhering strictly to original specifications, achieving a higher yield in a cost-effective manner. The objective of this work is to explore adaptive remanufacturing and provide methods to analyse the potential in production. For this purpose, four cases of adaptive remanufacturing are differentiated and an assessment matrix to evaluate product suitability for this process, considering various criteria, is presented. These two tools aid industries in assessing the viability and advantages of adaptive remanufacturing, promoting more sustainability across industries.

Gamma, electron beam and X-ray irradiation effects on polymers in an advanced bone cement mixer device

The medical device industry has been investigating ways to increase the use of alternatives to cobalt-60 gamma radiation and ethylene-oxide gas sterilization, such as electron beam (E-beam) and X-ray radiation, due to regulatory and market pressures. One impediment to switching to E-beam or X-ray technology for sterilization is the lack of data on the effects of these radiation sources on medical device polymers. To provide such data this work considers irradiation and testing of a common single-use medical bone cement mixing system, the Stryker Advanced Cement Mixer (ACM®), that is composed of seven polymer materials. The ACM® devices considered here were processed to sterilization-relevant doses (15, 25, 50, and 70 kGy) using three radiation technologies: gamma, E-beam, and X-ray. The system and its polymer components were tested for product functionality, as well as mechanical and visual properties to determine how exposure effects may be influenced by radiation technology and dose level. We found that although there were instances of statistically significant differences in effects between the gamma-irradiated products and those irradiated with E-beam and X-ray, those effects were negligible in terms of retained functionality of the product and retained mechanical properties of the polymer components. Overall, results of this study demonstrate that, for of the effects studied, E-beam and X-ray are viable alternatives to cobalt-60 gamma radiation for sterilization of the polymer-based device investigated.

Factors Influencing the Continued Use of Procreate Digital Painting Software by Fine Arts Students in Chongqing, China

Background and Aim: With the rise of digital technology, digital painting software has become a tool for artistic expression. The purpose of this paper is to explore the factors that influence the continued use of Procreate digital painting software by undergraduate art students in Chongqing, China, through three major theories: ECM, UTAUT 2, SCT, and other modeling frameworks. Materials and Methods: This study adopted a quantitative approach to data collection using a five-point Likert scale for the questionnaire. The sample of this study was undergraduate students of six fine arts programs in different regions of Chongqing, China, and the participants were selected through a Judgmental or purposive sampling technique. The instrument used to collect the data was a questionnaire and the data were analyzed on 487 valid questionnaires, CFA and SEM were executed to validate the fit, validity, and reliability of the model and to confirm the causality between the variables for hypothesis testing. Results: All hypotheses were supported, with perceived usefulness and satisfaction as direct influences. self-efficacy had the most significant effect on perceived usefulness. Conclusion: Key factors influencing Chongqing art students' continued use of Procreate digital drawing software include hedonic motivation, confirmation, self-efficacy, and knowledge application, which together contribute to students' continuance intention to use the software by enhancing satisfaction and perceived usefulness. This study provides new perspectives for understanding the use of digital drawing software in art education, offers insights for educational institutions to optimize digital strategies for art education, helps software developers to improve product functionality, and guides art students to make more effective use of digital tools for art creation, thus promoting the in-depth application and development of digital drawing technology in the art field.

Research On the Application of Augmented Reality Technology in Cultural and Creative Products: Taking the Imperial Palace Calendar as An Example

In the context of Internet +, many emerging technologies are widely used in the field of cultural and creative products. Because of its interactive experience, fun and entertainment, function extension and other technical characteristics, augmented reality technology has become a bridge linking virtual and real world, and has brought a new idea for the innovation and development of cultural and creative products. Its advantage lies in the realization of real-time interaction, three-way registration, virtual reality interaction and other functional characteristics, so that cultural and creative products have the advantages of multi-dimensional information, user selective transmission, virtual reality interaction, improve product experience, break time and space restrictions, and expand product functionality. It has met the diversified and personalized consumption needs of consumers, and has become an important way for the innovation and development of cultural and creative products, subverting the development mode of traditional cultural and creative products. This paper analyzes the advantages of augmented reality technology in the application of cultural and creative products by taking the cultural and creative products of Beijing Palace Museum - the Palace Museum calendar as an example. This paper discusses how to use augmented reality technology to enhance the experience of cultural and creative products, including thematic, interactive and cultural aspects. Through in-depth exploration of cultural connotation and creative expression, we can create unique and attractive cultural and creative products, meet the needs of modern consumers, and promote the protection and inheritance of traditional Chinese culture.

The role of business analysts in driving financial inclusion through product innovation

Business analysts play a pivotal role in advancing financial inclusion by driving product innovation tailored to underserved and marginalized populations. Their involvement is crucial in identifying and addressing gaps in financial services, ensuring that products and solutions are designed to meet diverse needs effectively. This review explores the contributions of business analysts in promoting financial inclusion through innovative product development, emphasizing their impact on creating accessible, affordable, and user-centric financial solutions. In the context of financial inclusion, business analysts utilize data-driven insights and market research to identify barriers faced by underserved communities. By analyzing customer needs, behaviors, and preferences, they provide valuable input on designing products that cater to the specific requirements of these populations. Their expertise enables the development of financial products that are not only accessible but also affordable and inclusive, such as microloans, mobile banking solutions, and digital payment platforms. Business analysts also facilitate collaboration between various stakeholders, including financial institutions, technology providers, and regulatory bodies, to ensure that innovative solutions align with industry standards and regulations. They play a critical role in bridging the gap between technical teams and end-users, translating complex requirements into actionable product features and functionalities. Their work ensures that new financial products are user-friendly and capable of addressing the unique challenges faced by marginalized groups. Furthermore, business analysts contribute to ongoing product improvements by continuously gathering and analyzing user feedback. This iterative approach allows for the refinement of financial products, ensuring that they remain relevant and effective in promoting financial inclusion. By leveraging advanced analytics and emerging technologies, business analysts help in identifying new opportunities and optimizing existing solutions to enhance financial access and participation. In conclusion, business analysts are essential in driving financial inclusion through product innovation. Their role in understanding market needs, facilitating stakeholder collaboration, and ensuring continuous improvement is critical to developing financial products that are accessible, affordable, and inclusive. Their contributions help bridge financial gaps and promote equitable access to financial services. Keywords: Business Analysts, Financial Inclusion, Product Innovation, Market Research, Financial Products, Accessibility, User-Centric Solutions.

Comparison of Colorimetric Methods for Measuring the Solubility of Legume Proteins.

Increasing the use of plant proteins in foods requires improving their physical and chemical properties, such as emulsification, gelation capacity, and thermal stability. These properties determine the acceptability and functionality of food products. Higher protein solubility significantly impacts these properties by affecting denaturation and the stability of emulsifiers or gels. Therefore, developing plant-based protein ingredients requires accurately and conveniently measuring their solubility. Colorimetric solubility methods overcome many issues of more robust combustion and titration methods, but complicated chemical mechanisms limit their applicability for certain proteins. This study aims to compare the effectiveness of four common colorimetric solubility measurement methods for pulse and non-pulse legume proteins and hydrolysates. Pea, chickpea, lentil, and soy protein isolates were made from defatted flour and their solubility at a range of pHs was measured using the Bradford, Lowry, bicinchoninic acid (BCA), and biuret methods. Solubility was also measured for chickpea and soy protein hydrolysates made using Alcalase and Flavourzyme. A comparison of the methods for solubility quantification revealed that the Bradford and Lowry methods most closely match the expected results for the unhydrolyzed protein, with the BCA and biuret methods underestimating solubility by 30%. The Lowry method was the preferred method for hydrolysate solubility measurement, with the Bradford method measuring 0% solubility at the isoelectric point due to an inability to interact with peptides that are soluble at this pH. This study identifies reliable methods for measuring plant protein solubility that establish uniform outcomes and enable a better comparison across studies, giving a consensus for key functional properties in food applications.

Research Quality of Clinical Trials Reported for Foods with Function Claims in Japan, 2023-2024: Evaluation Based on a Revised Tool to Assess Risk of Bias in Randomized Trials.

The Foods with Function Claim was introduced in Japan in April 2015 to make more products available that are labeled with health functions. A product's functionality of function claims must be explained by the scientific evidence presented in clinical trials (CTs) or systematic reviews, but the quality of recent CTs is unclear. The purpose of this study was to evaluate the risk of bias (RoB) using "a revised tool to assess risk (RoB 2)" published in 2018 for notifications based on all recent CTs published on the Consumer Affairs Agency website. A total of 38 submitted papers based on CTs that were published on the Consumer Affairs Agency website during the period from 1 January 2023 to 30 June 2024 were eligible. The RoB 2 tool provides a framework for considering the risk of bias in the findings of any type of randomized trial. This tool with five domains was used to evaluate the quality of research methods. Eligible CTs were assessed as "low risk" (11%, n = 4), "medium risk" (13%, n = 5), and "high risk" (76%, n = 29). A number of highly biased papers were published. Bias occurred in all five domains, especially "bias in selection of the reported result (Domain 5)", which was the most serious ("high risk"; 75%). For elements correlated with RoB, there was no significant difference (p = 0.785) in the RoB 2 score between for-profit and academic research in the author's affiliated organization. There was no significant difference (p = 0.498) in the RoB score between the published year categories of 2000-2019 and 2020-2024, and no significant difference (p = 0.643) in the RoB score between English and Japanese language publications. Overall, the quality of the latest CTs submitted after 2023 was very low, occurring in all five domains, and was most serious for "bias in selection of the reported result (Domain 5)".