<p indent="0mm">At various stages in their life cycle, plants encounter several pathogenic microbes that challenge their growth and development. The sophisticated innate plant immune system prevents the growth of harmful microbes via two interconnected defense strategies based on pathogen perception. These strategies involve microbe-associated molecular pattern-triggered immunity (PTI) and microbial effector-triggered immunity (ETI). It has been demonstrated that the actin cytoskeleton plays an essential role in plant innate immunity. Upon pathogen attack, host actin undergoes active rearrangement. Disrupting this actin remodeling leads to impaired plant resistance to bacterial pathogens. Here, we introduced the rearrangement of the actin cytoskeleton during plant-microbe interaction. We also reviewed the current understanding of how PTI-induced actin remodeling is regulated and determined the function of the host actin cytoskeleton in plant immunity. Further, we discussed the possible research directions to further explore the role of the host cytoskeleton during plant-microbial interactions.