Function In Primary Hyperparathyroidism Research Articles

Improvement in renal function in primary hyperparathyroidism following parathyroidectomy.

Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured pre- and post-parathyroidectomy in 9 patients with primary hyperparathyroidism. Radiological studies had shown no sign of renal calculi or nephrocalcinosis in these patients. Before operation, GFR ranged from 98.5 to 23.4 ml/min/1.7 m2 and ERPF ranged from 510 to 127 ml/min/1.7 m2. After operation, GFR rose to a range of 108.8 to 48.7 ml/min/1.7 m2, and ERPF ranged from 556 to 189 ml/min/1.7 m2. The results suggest that early diagnosis and surgery are important, both to prevent progressive renal damage and to improve the possibility of recovery where functional damage has occurred.

Renal function in primary hyperparathyroidism. A follow-up study two to eleven years after surgery comprising 139 patients.

Out of 160 consecutive patients operated upon for primary hyperparathyroidism, a follow-up study on renal function could be performed in 139. Clearances of inulin (CIN) and paraaminohippurate (CPAH) were determined before and after surgery in 75 of the patients. The average length of postoperative observation was 4.8 years (range 2-11 years) in this group. On average, CIN and CPAH were well maintained at the follow-up compared to the preoperative findings. This was true even for the group of patients with abnormal renal function before surgery. Only in two patients was an unequivocal decrease of CIN demonstrated. In two other subjects, however, serum creatinine showed an increase in the face of equivocal changes in CIN and CPAH.In 64 patients kidney function was evaluated only from the serum creatinine level. The average postoperative period of observation was 5.4 years (range 2-9 years). Renal function had deteriorated in two patients, one of whom suffered from chronic nephritis. Among 13 deceased patien...

Renal function in primary hyperparathyroidism and in non-hyperparathyroid hypercalcemia.

ABSTRACT. Renal function was studied in 18 patients with moderate hypercalcemia. Eight patients had primary hyperparathyroidism while 10 patients suffered from malignancies, vitamin D intoxication or sarcoidosis. Glomerular filtration rate was significantly higher (p>0.01) in patients with primary hyperparathyroidism (mean serum calcium concentration 3.00 mmol/l) than in patients with hypercalcemia of non‐hyperparathyroid origin (mean serum calcium concentration 3.02 mmol/l). Renal plasma flow was 45% higher in hyperparathyroid patients than in non‐hyperparathyroid patients, but the difference was not significant. Filtration fraction was higher (p>0.05) in patients with primary hyperparathyroidism than in other patients. In seven patients with primary hyperparathyroidism, renal function was studied before and after parathyroidectomy. In spite of a decrease in mean serum calcium concentration from 3.01 to 2.26 mmol/l, glomerular filtration rate and renal plasma flow remained unchanged. In six patients with non‐hyperparathyroid hypercalcemia, correction of the hypercalcemia (mean serum calcium concentration decreased from 2.99 to 2.34 mmol/l) was followed by significantly increased glomerular filtration rate (p>0.01) and renal plasma flow (p>0.05). Filtration fraction remained unchanged after correction of hypercalcemia in patients with primary hyperparathyroidism as well as in patients with non‐hyperparathyroid hypercalcemia. These results suggest a different effect of calcium on the glomerular filtration rate and renal plasma flow in patients with primary hyperparathyroidism and in patients suffering from hypercalcemia of non‐hyperparathyroid origin. These results also suggest that the presence of circulating parathyroid hormone in patients with primary hyperparathyroidism diminishes the depressive effect of calcium on the glomerular filtration rate.

Gastric function in primary hyperparathyroidism in man.

1. GASTRIC function was studied pre-operatively in 55 patients with primary hyperparathyroidism. In all patients the diagnosis of hyperparathyroidism was proved by the removal of an enlarged parathyroid gland or glands, following which the serum calcium fell to normal or below. 2. Twenty patients (38 per cent) gave a history of dyspepsia. All patients were given a barium meal and 12 (22 per cent) were found to have a duodenal ulcer. Male patients had dyspepsia and/or an ulcer more frequently than female patients. 3. Kay's augmented histamine test was carried out in all patients. Six patients (11 per cent) had achlorhydria, six had hyperchlorhydria (11 per cent), the remaining patients secreting normal amounts of acid. The acid secretion did not differ significantly from that of a group of euparathyroid patients studied under similar circumstances who did not have duodenal ulcer on barium meal. 4. Antigastric-parietal-cell antibodies and antithyroid antibodies were absent in all 20 patients, including five with achlorhydria, tested. 5. Serum gastrin was slightly elevated in three out of 10 patients preoperatively, and there was no consistent change following parathyroidectomy. 6. Although there is a high incidence of dyspepsia and of duodenal ulcer in patients with primary hyperparathyroidism they do not tend to have increased acid secretion.

An Approach to the Pre- and Post-Operative Assessment of Parathyroid Function in Primary Hyperparathyroidism (HPT).

Excerpt Three major clinical problems relating to primary hyperparathyroidism (HPT) have been under investigation in our institution for several years. [1] Which patient with borderline or definite...

Some Observations on Renal Function before and after Correction of Hypercalcemia.

s1 April 1963Some Observations on Renal Function before and after Correction of Hypercalcemia.H. Lovice, M.D., T. B. Connor, M.D.H. Lovice, M.D.Search for more papers by this author, T. B. Connor, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-744_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty patients with hypercalcemia had creatinine clearances (Ccr) and urine concentration tests performed before and after correction of this abnormality. These measurements were repeated at multiple intervals from 1 week to 5 years following correction of hypercalcemia. Fifteen patients had surgically proven hyperparathyroidism, and in 5 patients the hypercalcemia was corrected as follows: thyrotoxicosis (1), RAI therapy; lung cancer (1), supervoltage radiotherapy; myeloma (2) and sarcoidosis (1), prednisone therapy.Prior to correction of their hypercalcemia, 7 of 15 patients with hyperparathyroidism had reduced Ccr (mean Ccr 53 ml/minute) and mean serum calcium of 13.9 mg/100 ml. Mean serum calcium in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Md. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPre- and postoperative evaluation of renal function with five different tests in patients with primary hyperparathyroidismRenal Consequences of Immobilisation in Children with Fractured FemursDisorders of urinary concentration and dilutionRenal Function in Primary Hyperparathyroidism and in Non-Hyperparathyroid HypercalcemiaReversible Renal Failure Caused by Hypercalcemia 1 April 1963Volume 58, Issue 4Page: 744-745KeywordsAttentionCalciumCreatinineHypercalcemiaHyperparathyroidismLung and intrathoracic tumorsMyelomaSarcoidosisUrine Issue Published: 1 April 1963 PDF DownloadLoading ...