Full-text Database Research Articles

Improving the system of scientific and methodological support of libraries of scientific institutions of the Ural Branch of the Russian Academy of Sciences

The purpose of the article is to identify ways to develop the system of scientific and methodological support for the work of structural divisions of scientific institutions of the Ural Branch of the Russian Academy of Sciences (UB RAS) (libraries, departments, sectors) that provide information and library support for their activities. The scientific and methodological center for libraries of scientific institutions of UB RAS is the Central Scientific Library of the Ural Branch of the Russian Academy of Sciences (CSL UB RAS). To determine the priority directions of development of CSL UB RAS in the fi of scientific and methodological support of the network libraries, the analysis of the main indicators of their activities in the period from 2017 to 2021 was carried out. It revealed a steady decline in the indicators of library visits in stationary conditions, a decrease in the receipt of literature on physical media, an increase in the issuance of documents (mainly electronic documents from remote full–text databases) and an increase in applications in the distant format. Based on the data obtained and taking into account current trends in the fi of information support for science, the priority directions of CSL UB RAS activities developing the scientific and methodological support system for network libraries have been formulated. The implementation of these directions will ensure the effective use of the aggregated collection of libraries’ printed publications, the joint development of electronic sources of foreign scientific information, the organization of effective information services using remote technologies, the development of scientific libraries’ personnel potential, taking into account current trends in the information infrastructure of science. Strengthening system links within the network of libraries of UB RAS scientific institutions will become one of the components for building an effective system of cooperation and coordination of libraries of the Russian Academy of Sciences.

Scientific Bibliography in the State Public Scientific Technological Library of the Siberian Branch of the Russian Academy of Sciences: Stages of Development, Modern Realities and Prospects

The article objective is to show the bibliographic activity development on information research support in the State Public Scientific Technological Library of the Siberian Branch of the Russian Academy of Sciences (SPSTL SB RAS). Namely, changes in the technology of creating information resources of own generation due to computers and software; to represent the product types created by employees during 1958–2021; to highlight topics of traditional bibliographic current and retrospective indexes, bibliographic and full-text databases. The paper presents quantitative characteristics of the generated electronic resources; shows the forms of bibliographic services: information selective dissemination, differentiated services for managers, electronic thematic exhibitions of literature based on the databases; gives a brief description of bibliometric research. The authors determine prospects to develop the number of SPSTL SB RAS information and bibliographic complex. They are growing the authoritative data files in bibliographic databases, expanding the repertoire of Open Access sources to select information for regional bibliographic resources, developing interactive forms of information services for scientists and specialists; participating the semantic web through linked data technology based on authoritative files as an object (predicate), improving the service capabilities of the information search system (access to full texts).

Correlation between Serum 25-Hydroxyvitamin D Levels and Gastric Cancer: A Systematic Review and Meta-Analysis.

The purpose of this meta-analysis was to evaluate the relationship between serum 25-hydroxyvitamin D[25(OH)D] levels and gastric cancer. PubMed, Embase, Cochrane Library, Web of Science, The China Academic Journals full-text database, Wanfang Database of Chinese Academic Journals, VIP Chinese Science and Technology Periodicals database, and Chinese Biomedical Literature database were systematically searched. Case-control studies on the correlation between serum 25-hydroxyvitamin D levels and gastric cancer were retrieved, and the data extracted were analyzed. The results of 9 case-control studies containing 671 patients showed that serum 25(OH)D levels in the gastric cancer group were lower than those in the control group (weighted mean difference (WMD) = -8.90, 95% confidence interval (CI): -11.5, -6.32, p < 0.01); the risk of vitamin D deficiency in the gastric cancer group was higher than that in the control group (Odds ratio = 3.09, 95% CI: 1.96, 4.87, p < 0.01). The serum 25(OH)D levels in patients with well and moderately differentiated gastric cancer were higher than those in patients with poorly differentiated gastric cancer (WMD = -3.58, 95% CI: -6.41, -0.74, p = 0.01). Thus, low levels of vitamin D may increase the risk of gastric cancer. Systematic review registration: PROSPERO CRD42022327942.

Исторические аспекты нормативно-правового регулирования работы аптек как структурных подразделений медицинских организаций

Along with the development and improvement of the structure of medical organizations, much attention is paid to the drug provision of the therapeutic and diagnostic process in them, which contributes to improving the quality of medical care.&#x0D; Our theoretical research is based on a practical analysis of empirical data of regulatory and legal acts and documents regulating the issues of drug provision of medical organizations in Russia and abroad. Structural and functional analysis by the authors was used in the study of abstract and full-text databases published in digital online resources with materials of drug provision for medical and diagnostic work; infographics and scientific articles.&#x0D; The study has revealed that a number of requirements for pharmaceutical activities of pharmacy organizations and modern requirements for drug provision for the implementation of therapeutic and diagnostic activities do not correspond to the dynamic development of drug provision for patients of medical organizations.&#x0D; We came to the conclusion that, in modern conditions of the development of medical care to the population, in general, there are enough regulatory legal acts and documents for the organization of the work of pharmacy organizations as structural divisions of medical organizations. But, if we take into account the diversity of medical organizations, their profile, the possibility of changing the structure of medical departments, directions of medical care, then this may require changing the nomenclature of ready-made and manufactured medicines in specific conditions.&#x0D; As the results of the study have shown, joint efforts of all stakeholders in pharmacy and healthcare, as well as regulators of pharmaceutical and medical activities are needed to develop standard organizational and methodological recommendations for medical organizations carrying out medical and diagnostic activities based on the best traditions of Good Pharmacy Practice (GPP) and the International Pharmaceutical Federation (FIP). At the heart of this work, in our opinion, it is necessary to organize experimental studies using functional mathematical models of pharmacy activity in a number of therapeutic and preventive medical organizations to digitalize the organization of drug provision in them with expert evaluation of the results by specialists of all interested parties.

Analysis of Acupoints Combination for Cancer-Related Anorexia Based on Association Rule Mining.

We investigated the acupoint selection regulations and workable core acupoint combinations in cancer-related anorexia (CA) treatment. The Apriori algorithm, complemented by the FP-growth algorithm, was used to mine association rules based on retrieved randomized control trials (RCTs) and clinical control trials (CCTs). We searched the following databases for acupuncture treatment regimens for CA: PubMed, Embase, Cochrane Central, Web of Science, WanFang Data, VIP, China Journal Full-Text Database (CNKI), and SinoMed (CBM). We extracted acupoints prescriptions from the 27 enrolled RCTs and CCTs for analysis. There have been 38 acupoints refined from 27 prescriptions. The pinnacle three regularly chosen acupoints were Zusanli (ST36), Zhongwan (RN12), and Sanyinjiao (SP6). We investigated 10 association rules, and the consequences confirmed that {RN4} ≥ {RN12}, {PC6} ≥ {ST36}, {RN12, SP6} ≥ {RN4}, {HT7} ≥ {RN12}, and {DU20} ≥ {RN12} had been the most frequent associated rules in the adoption literature. Zusanli (ST36), Sanyinjiao (SP6), Guanyuan (RN4), Zhongwan (RN12), Neiguan (PC6), Shenmen (HT7), and Baihui (DU20) would be regarded as acupuncture prescriptions in the treatment of CA.

Study on molecular biological mechanism of Chinese herbal medicines for the treatment of gastric precancerous lesions based on data mining and network pharmacology.

To explore the molecular biological mechanisms of Chinese herbal medicines for the treatment of gastric precancerous lesions by data mining and network pharmacology. The keywords "gastric precancerous lesions""gastric precancerous disease""gastric mucosal intraepithelial neoplasia""gastric mucosal heterogeneous hyperplasia""gastric precancerous state""chronic gastritis, atrophic""combined Chinese and Western medicine""Chinese medicine therapy""efficacy evaluation" "randomized controlled trial"were searched in China Journal Full-text Database, Wanfang Data, VIP database, PubMed and Embase from 2001 to 2021. The information was extracted from the literature which met the inclusion and exclusion criteria, and the database was constructed to identify the high-frequency herbal medicines. The top six Chinese herbal medicines were analyzed by the network pharmacology methods, including the acquisition of herbs compounds and gastric precancerous lesions targets using Pharmacology Database and Analysis Platform and GeneCards databases, construction of protein-protein interaction network, and screening of core targets, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of core targets through Metascape platform, etc., to elucidate their active components, targets and pathways. A total of 482 compound prescriptions with 603 herbal medicines were included, and the top 6 herbal medicines with higher application frequency were Ume plum (63.35%), Curcuma longa (58.54%), Paeonia lactiflora (54.06%), Salvia miltiorrhiza (49.92%), Rhizoma alba (46.43%), and Astragalus membranaceus (45.44%). The results of the network pharmacological analysis showed that the active ingredients were 4 types from Ume plum, 3 from Curcuma longa, 9 from Paeonia lactiflora, 13 from Salvia miltiorrhiza, 7 from Astragalus alba, and 9 from Astragalus; 77 predicted targets were in Ume plum, 11 in Curcuma longa, 33 in Paeonia lactiflora, 58 in Salvia miltiorrhiza, 65 in Astragalus alba and 89 in Astragalus; and 98 crossover genes were obtained after these targets were compared with the disease genes, among which HSP90AA1, AKT1, TP53, STAT3, MAPK1 and TNF had higher relevance to the treatment of gastric precancerous lesions. The results of the GO enrichment analysis showed that the active ingredients of high frequency Chinese medicine mostly acted through biological processes such as response to inorganic substance, response to hormone, gland development, positive regulation of cell migration, positive regulation of cell motility, etc. The targets include cellular components such as vesicle lumen, secretory granule lumen, cytoplasmic vesicle lumen, transcription regulator complex, and with molecular functions such as kinase binding, protein kinase binding and DNA-binding transcription factor binding. The results of the KEGG pathway enrichment analysis showed that Paeonia lactiflora, Ulmus lucidus, Salvia miltiorrhiza and Astragalus mainly act through the cancer pathway and PI3K-AKT pathway; Curcuma longa and Rhizoma alba mainly act through the cancer pathway and proteoglycans in cancer, and all six herbs were involved in the cancer pathway and five herbs are involved in the PI3K-AKT pathway. In this study, we obtained the top 6 high-frequency Chinese herbal medicines in the treatment of gastric precancerous lesions by data mining method, and revealed that their mechanisms are involved in cell proliferation, differentiation, immunity, inflammation and other processes mainly through cancer pathway, PI3K-AKT signaling pathway, proteoglycans in cancer.

Comparison on the prognosis of severe aortic stenosis patients treated with transcatheter aortic valve replacement versus surgical aortic valve replacement: a systematic review and meta-analysis

Objective: To systematically review the prognosis of transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis. Methods: A systematic search of PubMed, EMBASE, Scopus, Cochrane Library, China biomedical literature database, China journal full text database (CNKI), Wanfang database and VIP database from January 2012 to February 2022 was conducted for randomized controlled trial (RCT) that comparing TAVR and SAVR in the treatment of severe aortic stenosis. The primary outcomes were the incidence of all-cause mortality, stroke incidence, reoperation rate and complications (pacemaker implantation, atrial fibrillation) at 1 month and 1, 2, 5 years after operation. Jadad scale was used to evaluate the literature quality of RCTs. All statistical analyses were performed using the standard statistical procedures provided in RevMan 5.4.1. Results: A total of 17 studies including 11 712 patients were identified, including 6 007 patients treated with TAVR and 5 705 patients treated with SAVR. There were 4 high-quality studies and 13 medium-quality studies. The results of meta-analysis showed that the rate of new onset atrial fibrillation was lower in TAVR group than that in SAVR group (RR=0.28, 95%CI 0.21-0.38, P<0.001), and there was no significant difference in all-cause death, stroke, pacemaker implantation and reoperation rate (all P>0.05) at 30 days follow-up. At one year after TAVR and SAVR treatment, all-cause mortality (RR=0.85, 95%CI 0.74-0.97, P=0.01) and new onset atrial fibrillation (RR=0.28, 95%CI 0.20-0.39, P<0.001) were lower in TAVR group than SAVR group. However, the pacemaker implantation rate was higher in TAVR group than that of SAVR group (RR=1.79, 95%CI 1.11-2.89, P=0.02), while there was no significant difference in the incidence of stroke and reoperation between the two groups (P>0.05). At two years after TAVR and SAVR treatment, the pacemaker implantation rate was higher in TAVR group than that in SAVR group (RR=2.23, 95%CI 1.28-3.86, P=0.004), and the rate of new atrial fibrillation was lower in TAVR group than that in SAVR group (RR=0.46, 95%CI 0.38-0.56, P<0.001). There was no significant difference in all-cause death, stroke and reoperation rates between the two groups (P>0.05). At five years after TAVR and SAVR treatment, the pacemaker implantation rate (RR=1.89, 95%CI 1.13-3.17, P=0.02) and reoperation rate (RR=3.64, 95%CI 1.75-7.58, P=0.000 5) were higher in TAVR group than those in SAVR group, while the rate of new onset atrial fibrillation was lower in TAVR group than that in SAVR group (RR=0.45, 95%CI 0.37-0.55, P<0.001). There was no significant difference in all-cause death and stroke incidence between the two groups (all P>0.05). Conclusions: The all-cause mortality and the incidence of new onset atrial fibrillation after TAVR are lower than SAVR, and TAVR is a preferred therapy for patients with aortic stenosis.

A Systematic Review and Meta-Analysis of the Efficacy of Uterine Artery Embolization in the Treatment of Endometriosis.

Objective To compare the efficacy of uterine artery embolization (UAE) with traditional methods for treating endometriosis. Methods The randomized controlled trials of uterine artery embolization and other medical treatments for endometriosis in PubMed, Embase, Web of Science, Cochrane Library, China Journal Full-Text Database, Wanfang Database, VIP Database, and China Biomedical Literature Database were retrieved by computer. The search time was up to June 2022. The quality of articles was evaluated by Cochrane ROB 2.0, and meta-analysis was performed by Stata15.1 software. Results 7 studies were finally included. Meta-analysis showed that the serum CA125 level after uterine artery embolization was significantly lower than that in the control group (SMD = −0.85, 95%CI (−1.12, −0.59)], and the postoperative visual analogue scale (VAS) of dysmenorrhea was significantly lower than that in the control group (SMD = −1.86, 95%CI (−2.21, −1.50)) There was no significant difference in the effective rate, FSH level, E2 level, and LH level between the two groups. Conclusion UAE can effectively reduce the VAS score of dysmenorrhea and serum CA125 level for treating endometriosis. However, due to the limitation of the quality of included articles, more large sample size and high quality RCTs are needed to provide stronger evidence-based medicine evidence for clinical practice.

Clinical efficacy and safety of removing blood stasis and resolving phlegm in the treatment of epilepsy with cognitive impairment: A systematic review and meta-analysis.

Backgrounds:Epilepsy is a chronic encephalopathy caused by abnormal discharge of neurons in the brain, resulting in brain dysfunction. Cognitive impairment is one of the most common complications of epilepsy. The current treatment of epilepsy in the control of symptoms at the same time cause a lot of side effects, especially the aggravation of cognitive impairment. Many literatures have stated that the efficacy and safety of integrated Traditional Chinese and western medicine in the treatment of epilepsy with cognitive impairment is superior to that of western medicine alone. In this systematic review and meta-analysis, we intend to evaluate the clinical efficacy and safety of removing stasis and resolving phlegm in the treatment of epilepsy with cognitive impairment.Objective:To systematically evaluate the clinical efficacy and safety of removing blood stasis and resolving phlegm in the treatment of epilepsy with cognitive impairment.Methods:The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to conduct this systematic review. The Chinese Journal Full Text Database (CNKI), Wanfang Database, CQVIP Database (CQVIP), Cochrane Library, EMbase, and Pubmed were searched by computer, and randomized controlled studies on the efficacy of removing blood stasis and resolving phlegm in the treatment of epilepsy with cognitive disorders were included. Retrieval was carried out until January 2022, and relevant data were extracted for meta-analysis using Rev Man5.3 software.Results:Fourteen randomized controlled studies with a total of 1198 patients were included, including 601 patients in the control group and 597 patients in the treatment group (experimental group).Results:Meta-analysis results showed that compared with the treatment of epilepsy with cognitive impairment in the western anti-epileptic drugs group alone, the treatment of epilepsy with cognitive impairment combined with the method of removing blood stasis and resolving phlegm could significantly improve the clinical efficacy of epilepsy (OR = 3.41, 95% CI 2.39–4.88, P < .001). Improved the TCM symptom score (OR = 3.99, 95% CI 1.72–9.26, P < .001). Increased the EEG improvement rate (RR = 1.39, 95% CI 1.05–1.84, P = .02). Improved MOCA score and cognitive function (MD = 3.54, 95% CI 1.68–5.40, P < .001). Improved QOLIE-31 cognitive function score. Improved cognitive function (MD = 7.22, 95% CI 3.35–11.08, P < .001). Improved the incidence of adverse reactions (RR = 0.50, 95% CI 0.33–0.76, P = .001).Conclusion:Compared with the treatment of epilepsy with cognitive impairment by western anti-epileptic drugs alone, the treatment of epilepsy with cognitive impairment combined with the method of removing blood stasis and resolving phlegm is superior to the treatment of epilepsy with cognitive impairment by western anti-epileptic drugs alone.

Advances in the differential diagnosis of transient hyperthyroidism in pregnancy and Graves' disease.

The occurrence of thyrotoxicosis during pregnancy is mainly attributed to gestational transient thyrotoxicosis (GTT) and Graves' disease (GD). It is important to distinguish between GTT and Graves' disease because the two diseases are treated very differently. However, a gold standard for the differential diagnosis of the two diseases is currently lacking, and the most common method of differentiation is based on past medical history and clinical presentation combined with thyroid-related antibodies. A literature search of the electronic databases PubMed, Embase, Medline, Google Scholar, Cochrane Library, China Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journals Full Text Database and China Biomedical CD-ROM was performed. The search period ranged from journal inception until 2022. We used the following search terms in "All fields": {["thyroid" (common field) OR "thyroid" (subject line)] OR "hyperthyroidism" (common field)} AND {["pregnancy" (title) OR "pregnancy" (title)] AND "one over" (common field)} OR {["pregnancy" (common field) OR "pregnancy" (common field) OR "pregnancy" (subject line)] AND "Graves'" (common field)}. In recent years, some clinical studies at home and abroad have proposed other meaningful differential indicators, such as thyroid stimulating hormone, chorionic gonadotropin, thyroid hormone levels and thyroid ultrasound. The differential diagnostic significance of each of these indicators is summarised here with the goal of providing a better reference for the differential diagnosis of hyperthyroidism during pregnancy in clinical practice.

The Origin and Development of Piji Pills: An Ancient Prescription of Traditional Chinese Medicine.

Objective Ancient prescriptions of traditional Chinese medicine (TCM) are an important source for innovative drug research and development, which has garnered increasing attention in recent years. Piji Pills, an ancient TCM prescription, has a long history and remarkable clinical efficacy in the treatment of digestive disorders. Thus, the purpose of this study was to explore the origin and development of Piji Pills and to discuss the potential future direction of an ancient TCM prescription. Method We analyzed the origin and development of the Piji Pills by reviewing literature records and their evolution in ancient books. We used a full-text database covering 2,090 TCM ancient books and implemented the full-text retrieval function based on Ulysses software. A full-text search was conducted using the keyword “Piji Pills” (“脾积丸” in Chinese). The results generated 128 pieces of literature from 35 ancient TCM books. In order to identify pertinent sections from the generated results, the results were proofread by two independent authors (Fudong Liu and Xiaochen Jiang) who had sufficient experience concerning ancient books. The developmental process of the Piji Pills was divided into early, late, and modern times. With the approach of statistical methods and chronological description, we manually searched, indexed, and transformed 2,090 ancient TCM books. Result From the time Piji Pills were first proposed, the records in ancient books became increasingly detailed, providing an in-depth discussion of their composition, dosage, and action mechanisms. In modern times, the research on key drugs found in Piji Pills has made a great contribution to clinical practice. However, the compound research on Piji Pills is still relatively superficial and requires further in-depth study. Conclusions In this study, statistical methods were used to chronologically clarify the developmental process of Piji Pills. We found that the Piji Pills were widely used and had a significant advantage in the treatment of digestive system diseases. In-depth knowledge mining of ancient books could potentially promote the theoretical innovation of TCM and the research of new drugs.

Identification of influencing components on water scarcity management performance for sustainability in limited water resource area: a review

Water management by policy makers is based on multi-perspective information. In the case of water, scarcity causes public health, economic, and ecosystem problems because of the lack of safe water when the demand exceeds its availability. This study identified the influencing components of water scarcity management performance by systematic review methods based on two English full-text databases: Scopus and ScienceDirect from 2012 to 2022. A total of 22 studies were selected from 850 records by using the inclusion criteria and performance evaluation by the scoring rubric method. Moreover, the article quality was assessed using a critical appraisal tool by the Joanna Briggs Institute (JBI) critical appraisal checklist method. The result of this review revealed that the main influencing components of water scarcity management are related to the availability of water quantity and demand. Water availability is associated with the hydrological cycle which has uncertainty due to climate change. While the demand components depend on water use, population, industry and urbanization. Most of the studies in the literature review considered only water balance of water availability and demand. Such an approach is insufficient to achieve water security for sustainable development goals. Additional components including environmental components such as water quality degradation should be considered as these components can reduce the availability of freshwater resources. From an economic point of view, the benefit of water utilization should be prioritized in scarce water management in consideration of fairness in water rights. It is also essential to consider the contribution to socio-economic aspects from stakeholder meetings and participation.

A network meta-analysis of curative effect of different treatment methods on patients with brain metastasis of breast cancer.

Background:Breast cancer (BC) is a malignant tumor with the highest incidence rate worldwide, and its incidence of breast cancer brain metastases is increased in recent years. Although significant progress has been made in the systematic treatment of BC that of breast cancer brain metastases is still very difficult. Organically integrating local and systemic therapies remains an urgent problem to be solved. In this study, a network meta-analysis was performed to collect the treatment effects of different treatment measures on patients with BC brain metastasis in recent years, evaluate and screen the current best clinical treatment scheme, and assist doctors in formulating clinical treatment schemes.Methods:Keywords were used to search databases, such as the Chinese Journal Full-text Database, VIP Chinese Science and Technology Journal Full-text Database (VP-CSJFD), Wanfang Data Journal Paper Resources (Wangfang), PubMed, the Cochrane Library, and EMBASE. The retrieval period was from the establishment of each database to February 2022. Qualified randomized controlled studies were screened according to the inclusion and exclusion criteria, and Stata 16 software was adopted for mesh meta-analysis of binary variable data. Using R4 0.2 software, and calling GeMTC and JAGS packages in R software, the Bayesian network model analysis of survival data was completed.Conclusion:Combined with overall response rate, disease control rate, and overall survival, whole-brain radiation therapy + 3-dimensional conformal radiation therapy + Che may be the intervention measure with the highest objective remission rate for patients with brain metastasis of BC, besides, it may also be the intervention measure of the highest disease control rate in patients after treatment. In contrast, WBRT + Che may be the intervention with the lowest overall survival risk ratio after treatment.

Cyrkularne modele biznesowe w miastach szwedzkich i holenderskich

Contemporary problems related to the poor condition of our natural environment force changes in management models. The model that the economy has followed so far is a linear model - a highly consumption-based model that leads to an increased amount of waste and pollution, and consequently to not taking into account the interests of all stakeholders. As cities struggle with numerous problems (including a constantly growing population, pollution, demand for raw materials, etc.) they should change the way they are managed. The aim of the study is to identify which of them are most often used by these cities. The research questions asked in the article are: what is the role of the city as an authority in these models - is it an implementer or a recipient of circular models solutions? According to the current state of knowledge, is it possible to say that thanks to circular models used in cities the quality of life of residents is improving (from an environmental and social perspective)? The research method used was a review of professional literature (WoS and Scopus databases, as well as full-text databases), internet sources and reports. Three types of circular business models, in which Swedish and Dutch cities participate, were identified. The models that are used predominantly in cities in both Sweden and the Netherlands are models of sharing consumption. Cities as authorities assume different roles - they are both implementers and recipients of the models. It cannot be stated unequivocally that the introduction of circular business models in the current form has a positive effect on the quality of life in a city. Therefore, further research and experiments must be carried out, e.g. in the direction of expanding these models.

Effectiveness and Safety of Thyroid Hormone Therapy in Patients with Dilated Cardiomyopathy: A Systematic Review and Meta-analysis of RCTs.

Previous research demonstrated that short-term treatment of dilated cardiomyopathy with thyroid hormones exerted beneficial hemodynamic effects when added to standard anti-heart failure therapy, but it remains debatable whether thyroid hormones can be used to treat dilated cardiomyopathy. Therefore, we conducted a meta-analysis to evaluate the effectiveness and safety of thyroid hormone treatment in patients with dilated cardiomyopathy. The Cochrane Clinical Trials Registry database, PubMed, Embase, Chinese Biomedical Literature Database, China Academic Journals full-text database, Wanfang Database, China Science and Technology Journal Database, and Clinical Trials.gov were screened through 15 October, 2021. Randomized controlled clinical trials were selected based on study inclusion criteria. Two independent reviewers extracted the data and assessed study bias using the Cochrane risk of bias tool. For the data synthesis, the weighted mean difference was calculated using baseline and post-thyroid hormone treatment data. Random-effects models were used for the meta-analysis. The primary outcomes were left ventricular ejection fraction after a minimum follow-up of 1week and adverse events. Ten of the 1149 published reports met the inclusion criteria (N = 608 randomized individuals). After reasonable use of thyroid hormone therapy, left ventricular ejection fraction increased (weighted mean difference, 3.94; 95% confidence interval 3.06-4.81; I2 = 0.00%), cardiac output increased, and left ventricular end-diastolic diameter decreased, but left ventricular mass index and thyroid function were unaffected. Adverse events were reported in the intervention group of two studies. The ten studies demonstrated a low risk of bias. Adding thyroid hormones to conventional anti-heart failure treatment in patients with DCM appears to be an effectiveand well tolerated therapeutic option. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42021286043).

Effect of Ultrasonic Osteotome on Therapeutic Efficacy and Safety of Spinal Surgery: A System Review and Meta-Analysis.

Background A meta-analysis was performed to evaluate the effectiveness and safety of ultrasonic osteotomes in spine surgery to standard spinal surgery procedures. Methods Using the search keywords “bone curette”, “cutter”, “scalpel”, “bone shaver”, “aspirator”, “osteotome”, “ultrasonic”, “piezosurgery”, and “dent ∗” in the databases of PubMed (1966-2021.12), Cochrane Library, Embase (1986-2018.12), Web of Science (1978-2021.12), and China Academic Journals Full-Text Database (CNKI, 1979-2021.12). Two researchers reviewed the literature, extracted and extensively assessed the data, and included information on the study quality. RevMan v5.3.5.0 was used for the meta-analysis. Results A total of 10 trials with a total of 911 patients were included. The meta-analysis findings revealed that, when compared to traditional methods, ultrasonic osteotomes could save operation time (OR = −18.83, 95 percent CI (-22.76, -14.99), P = 0.03) and reduce intraoperative bleeding (OR = −66.73, 95 percent CI (-75.70, -57.76), P = 0.04) and postoperative complications (OR = 0.38, 95 percent CI (0.21, 0.69), P = 0.001). There was, however, no significant difference in the hospital stay (OR = −1.34, 95 percent CI (-1.90, -0.77), P = 0.23) and symptom improvement rate (OR = 1.03, 95 percent CI (0.73, 1.45), P = 0.86). Conclusion There is evidence that using an ultrasonic osteotome in spine surgery is safe and effective and may minimize intraoperative bleeding and save time. However, there is no significant difference in symptom improvement rate, hospital stay length, or postoperative complications compared to standard surgical equipment. Therefore, more high-quality investigations are needed to corroborate the initial results.

Overview of the systematic reviews of premature ovarian insufficiency treated with acupuncture 针灸治疗早发性卵巢功能不全系统评价的再评价

ObjectiveTo assess the reliability of the methodological quality and outcome measures of systematic reviews (SR)/meta-analysis of premature ovarian insufficiency (POI) treated with acupuncture. MethodsSR/meta-analysis of POI treated with acupuncture were searched on POI from the databases including PubMed, Web of Science, EMBase, the Cochran Library, Chinese biomedical literature database (SinoMed), China journal full-text database (CNKI), Wanfang data knowledge service platform (Wanfang) and VIP information Chinese periodical service platform (VIP), from inception to 1st May 2021. Using A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2) scale and Grades of Recommendations Assessment, Development and Evaluation (GRADE) system, the methodological quality and outcome measures of the included studies were appraised. ResultsTen articles of SR/meta-analysis were included, published from 2015 to 2020. Using AMSTAR 2, 5 articles of SR/meta-analysis were rated as critical low quality in methods, 3 articles as low quality, and 2 articles as moderate quality. The results of GRADE showed that among the 50 outcomes the quality of evidence of 22 outcomes was very low, that of 25 outcomes was low and that of 3 outcomes was moderate. ConclusionThe methodological quality and the reliability of outcome measures were not high in existing SR/meta-analysis on POI treated with acupuncture, which may affect the translation of the SR/meta-analysis findings into clinical practice. It is necessary to further strengthen the methodological quality and reporting standard of SR/meta-analysis, as well as the robustness of design and implementation of randomized controlled trials(RCTs), in order to generate high quality evidences for clinical decision-making and practice.

Towards Digitisation of Kiswahili Programmes: Problems and Prospects for the University Libraries in Kenya - A Case Study of Tom Mboya University College

This paper explores the concept of digitisation. Basically, digitisation is no longer a new concept when it comes to the field of library and information science. But as a third world country like Kenya, with specific reference to Tom Mboya University College, to narrow down, to Kiswahili programmes, it is still a challenging issue. The paper mainly focused on the recent updates of the library digitisation activities and more particularly identified the digitisation process identically. The findings of this paper are quite shocking, this is so because, very few university libraries in Kenya have taken digitisation of Kiswahili programmes successfully. In essence, Tom Mboya University College library as a case study is still far behind any sort of digitisation of Kiswahili programmes. More so, Tom Mboya University College is still struggling to put in place the required infrastructural facilities to take up the digitisation project. It is assumed that the initiatives for coming up with a bibliographic database, full-text database, hosting indigenous information product and specifically the Kiswahili programmes by the Kiswahili lecturers in the department over the internet and technology-based information activities are at the elementary level at Tom Mboya University College in Kenya. This paper, therefore, hopes that the findings of this research will help Tom Mboya University College library to identify its problems regarding digitisation and hopefully be able to find out the most suitable solution

Effects of GLP-1 receptor agonists on arrhythmias and its subtypes in patients with type 2 diabetes: A systematic review and meta-analysis.

PurposeAn update of a systematic review and meta-analysis of the risk of arrhythmias and their subtypes in type 2 diabetic patients receiving glucagon-like peptide 1 receptor agonist (GLP-1RA) medication according to data from the Cardiovascular Outcome Trial(CVOT).MethodsRandomized controlled trials (RCT) on GLP-1RA therapy and cardiovascular outcomes in type 2 diabetes mellitus patients published in full-text journal databases such as MEDLINE (via PubMed), Embase, Clinical Trials.gov, and the Cochrane Library from establishment to March 1, 2022 were searched. We assessed the quality of individual studies by the Cochrane risk-of-bias algorithm. RevMan 5.4.1 software was use for calculating meta-analysis.ResultsA total of 60,081 randomized participants were included in the data of these 8 GLP-1RA cardiovascular outcomes trials. Pooled analysis reported no significant effect on total arrhythmia [RR=0.96, 95% CI (0.96, 1.05), p =0.36], and its subtypes such as atrial fibrillation [RR=0.96, 95% CI (0.86, 1.07), p =0.43], atrial flutter [RR= 0.82, 95% CI (0.57, 1.19), p =0.30], atrial tachycardia [RR=0.64, 95% CI (0.20, 2.01), p =0.44)], sinoatrial node dysfunction [RR=0.74, 95% CI (0.44, 1.25), p =0.26], ventricular preterm systole [RR=1.42, 95% CI (0.62, 3.26), p =0.41], second degree AV block [RR=0.96, 95% CI (0.53, 1.72), p =0.88], complete AV block [RR=0.75, 95% CI (0.49, 1.17), p =0.21], ventricular fibrillation [RR=1.00, 95% CI (0.50, 2.02), p =1.00], ventricular tachycardia [RR=1.37, 95% CI (0.91, 2.08), p =0.13] from treatment with GLP-1RA versus placebo. However, the risk of hypoglycemia was reduced by about 30% [RR=0.70, 95% CI (0.57, 0.87), p=0.001] and the risk of pneumonia by about 25% [RR=0.85, 95% CI (0.75, 0.97), p=0.01], both statistically significant differences.ConclusionIn type 2 diabetic patients, treatment with GLP-1RA has no significant effect on the risk of major arrhythmias but significantly reduces the risk of hypoglycemia and pneumonia.

Continuous Subcutaneous Insulin Infusion (CSII) Combined with Oral Glucose-Lowering Drugs in Type 2 Diabetes: A Systematic Review and Network Meta-Analysis of Randomized, Controlled Trials.

The clinical efficacy of continuous subcutaneous insulin infusion (CSII) therapy combined with six classes of oral glucose-lowering drugs (GLDs) (TZDs/metformin/acarbose/GLP-1 receptor agonist/SGLT-2 inhibitor/DPP-4 inhibitor) was evaluated by a network meta-analysis to provide an evidence-based reference in making a clinical decision on CSII combined with drugs in the treatment of type 2 diabetes. Data were retrieved from eight databases: the Chinese Journal Full-Text Database (CNKI), VIP Chinese Science and Technology Periodicals Full-Text Database (VP-CSFD), Wanfang Data Journal Paper Resource (WANFANG), China Biomedical Database (CBM), PubMed, Embase, Cochrane Library, and Web of Science. The retrieval period dated from the library’s construction to 27 June 2021. The search was for randomized, controlled trial studies (RCT) on insulin infusion (CSII) combined with oral hypoglycemic drugs (TZDs/metformin/acarbose/GLP-1 receptor agonist/SGLT-2 inhibitor/DPP-4 inhibitor) in the treatment of type 2 diabetes. Quality evaluation and data extraction were performed on the studies included, and network meta-analysis was performed with R4.0.1 software. A total of 56 publications was included in the final network meta-analysis, with a total sample size of 4395. Results based on the network meta-analysis were that CSII combined with a metformin works best on fasting blood glucose (FBG) and 2 h postprandial blood glucose (2hPG) and improves insulin resistance (lower HOMA-IR levels). CSII combined with a DPP-4 inhibitor had the best clinical effect in reducing glycosylated hemoglobin levels. Treatment with CSII combined with a DPP-4 inhibitor was the fastest way to achieve the blood glucose standard. In terms of insulin dosage, an insulin pump (CSII) combined with the GLP-1 receptor agonist can significantly reduce insulin dosage. Network meta-analysis evidence suggests that an insulin infusion (CSII) combined with oral hypoglycemic drugs can improve clinical efficacy in controlling blood sugar and improving insulin resistance, insulin dosage, and standard time. However, the most outstanding performance was that of insulin infusion (CSII) combined with metformin, which had the best clinical effect in controlling blood sugar and improving insulin resistance.