Paper II of this two-part paper investigated the effects of leading-edge (LE) manufacturing defects on the open-water cavitation performance of a full-scale propeller based on the geometry of David Taylor Model Basin propeller by using the three-dimensional (3D) steady Reynolds-Averaged Navier–Stokes solver. Various simulation parameters, including domain size, grid size, stretch ratio, first-grid spacing, y+, and turbulence model, were carefully examined for their effects on the solutions, leading to the development of the best modeling practices for the full-scale propeller with LE defects. Employing these recommended best-practice settings, simulations were conducted on the full-scale propellers with 0.10, 0.25, and 0.50 mm LE defects. Compared to the predictions from Paper I [Jin et al., “Numerical study on effects of leading-edge manufacturing defects on cavitation performance of a full-scale propeller—Paper I: Simulation for the model- and full-scale propellers without defect,” Phys. Fluids 36, 105179 (2024).], which did not account for LE defects, the results showed that the LE defects within International Standards Organization (ISO) 484 Class S tolerances narrow the cavitation buckets. As a consequence, such LE defects can result in more than 40% reduction in cavitation inception speed, which is similar to the conclusions drawn from earlier two-dimensional (2D) studies [Jin et al., “2D CFD studies on effects of leading-edge propeller manufacturing defects on cavitation performance,” in SNAME Maritime Convention (The Society of Naval Architects and Marine Engineers, 2020).]. Note that Paper I [Jin et al., “Numerical study on effects of leading-edge manufacturing defects on cavitation performance of a full-scale propeller—Paper I: Simulation for the model- and full-scale propellers without defect,” Phys. Fluids 36, 105179 (2024).] presents the simulations for the model- and full-scale propellers without LE defects.