The purpose of this research was to determine the effect of moderated heterogeneous subassemblies located in the core of a sodium-cooled fast reactor on minor actinide (MA) destruction rates over the lifecycle of the core. Additionally, particular emphasis was placed on the power peaking of the pins and the assemblies with the moderated targets as compared to standard unmoderated heterogeneous targets and a core without MA targets present. Power peaking analysis was performed on the target assemblies and on the fuel assemblies adjacent to the targets. The moderated subassemblies had a marked improvement in the overall destruction of heavy metals in the targets. The design with acceptable power peaking results had a 12.25% greater destruction of heavy metals than a similar ex-core unmoderated assembly. The increase in minor actinide destruction was most evident with americium where the moderated assemblies reduced the initial amount to less than 3% of the initial loading over a period of five years core residency. In order to take advantage of the high minor actinide destruction and minimize the power peaking effects, a hybrid scenario was devised where the targets resided ex-core in a moderated assembly for the first 506.9 effective full power days (EFPDs) and were moved to an in-core arrangement with the moderated targets removed for the remainder of the lifecycle. The hybrid model had an assembly and pin power peaking of less than 2.0 and a higher heavy metal and minor actinide destruction rate than the standard unmoderated heterogeneous targets either in-core or ex-core. The hybrid model has a 54.5% greater Am reduction over the standard ex-core model. It also had a 27.8% greater production of Cm and a 41.5% greater production of Pu than the standard ex-core model. The radiotoxicity of the targets in the hybrid design was 20% less than the discharged standard ex-core targets.