Objectives: After being a solid method of measuring consciousness for decades,the Glasgow Coma Scale (GCS) was offered to bereplaced with a better option: The Full Outline of Unresponsiveness (FOUR) score, which several studies later confirmed to besuperior due to its independence from verbal response and ability to consider brain stem reflexes. In this study, we decided to comparethe two scales in the prognosis of stroke, which has never been conducted before.Patients and Methods: We conducted both methods on 150 stroke patients during admission to the emergency service and assessedthem during a 3-month follow-up after discharge.Results: The type of stroke was 80% ischemic and 20% hemorrhagic. 55.3% survived after a 3-month follow-up. The FOUR score hada significant converse relation with hospitalization, a relation with the GCS lacked. The FOUR score also had a stronger correlationwith the outcome of stroke than the GCS. Additionally, the receiver operating characteristic (ROC) curve showed greater sensitivityand specificity in the FOUR score in the prognoses of stroke patients.Conclusion: We recommend using the FOUR score as the first priority.