Abstract
Background/aim Some of the patients suffering from cardiac arrest (CA) remain in a chronic unconscious state in intensive care units (ICUs). The primary aim of this study was to evaluate the efficacy of chest compression (CC) on cerebral oxygenation during cardiopulmonary resuscitation (CPR). As a secondary goal, we attempted to determine the effects of regional cerebral oxygen saturation (rSO2) values on consciousness and the survival rate using the Full Outline of Unresponsiveness (FOUR) scoring method.Materials and methodsThis observational preliminary study was carried out with 20 patients with CA who were hospitalized in ICUs. The rSO2 values measured by near-infrared spectroscopy were recorded during CA. FOUR scoring was used to determine the neurological status, severity of disease, and degree of organ dysfunction in survivors.Results Return of spontaneous circulation (ROSC) was gained in 8 (40%) of 20 patients. Maximum rSO2 values were higher in survivors than in nonsurvivors (P = 0.005). The mean FOUR score before CA was 11.50 ± 0.8 in survivors, whereas this value was 7.87 ± 0.7 for 1 week after ROSC (P < 0.0001). There was a significant positive correlation between the minimum and mean rSO2 values and the mean 1-week FOUR scores in survivors (r = 0.811, r = 0.771 and P = 0.015, P = 0.025, respectively).Conclusion Our results suggest that the maximum rSO2 values affect ROSC while the minimum and mean rSO2 values affect the post-cardiac arrest neurological outcome.
Highlights
When brain perfusion is impaired, an irreversible process begins for neurons within about 5–8 min [1]
Our results suggest that the maximum rSO2 values affect return of spontaneous circulation (ROSC) while the minimum and mean rSO2 values affect the postcardiac arrest neurological outcome
Cerebral oximetry achieved by near-infrared spectroscopy (NIRS) technology provides information about a level of brain oxygenation and cerebral perfusion [5]
Summary
When brain perfusion is impaired, an irreversible process begins for neurons within about 5–8 min [1]. Impairment of brain perfusion during cardiac arrest (CA) almost always causes reduction of cerebral oxygenation, resulting in neurological damage [2]. If the first intervention cannot be fast, or if adequate chest compression (CC) cannot be provided during cardiopulmonary resuscitation (CPR), sufficient cerebral oxygenation cannot be obtained. This is closely related to chronic unconsciousness or minimal consciousness state in cases of return of spontaneous circulation (ROSC). Cerebral oximetry achieved by near-infrared spectroscopy (NIRS) technology provides information about a level of brain oxygenation and cerebral perfusion [5]. Studies have shown that high regional cerebral oxygen saturation (rSO2)
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