The Fukushima accident showed that the safety of multiple nuclear power plants (NPPs) at the same site could be jeopardized simultaneously. Since then, many studies have focused on developing strategies to prevent the spread of multi-unit accidents, with numerous countries establishing strategies to use mobile equipment. However, mobile equipment strategies are inherently accompanied by a high degree of uncertainty regarding operation success and duration because multiple organizations and personnel interact in various ways during multi-unit accident situations. Furthermore, supplementing current fixed equipment with additional mobile equipment requires extra resources. Therefore, cross-tie strategies that use currently installed fixed equipment can provide additional means to manage site risk with relatively few additional costs. This study proposes a multi-unit probabilistic safety assessment–based risk evaluation framework for utilizing cross-tie systems in NPPs and a modeling methodology to quantify the effectiveness of the cross-tie strategies. A case study was conducted to evaluate the risk reduction from using cross-tie strategies for emergency diesel generators and alternate AC diesel generators, which are power systems utilized in multi-unit loss of offsite power initiating events. It is expected that the developed framework and methodology can be utilized for other types of cross-tie strategies as well.