The use of multirotor drones for industrial applications is accelerating, and fuel cell based propulsion systems are highlighted as a promising approach to improve endurance – one of the current main limitations. Due to multirotor drones’ unique requirements, careful system design is needed to maximize the performance advantage. In this work a sensitivity analysis that quantifies the impact of central system parameters for an X8 multirotor drone with a 2 kW fuel cell hybrid system is presented and discussed. Thrust stand measurements identified a 20–30% efficiency loss from the coaxial configuration, and a ‘single’ configuration can reduce power consumption by 700 W at 25 kg take-off mass. Thus, a smaller fuel cell system can be used, giving an additional 1 kg mass saving and 75–140 W power reduction. Peak endurance is found at a 0.67 energy system weight fraction, and if batteries are improved from 180 Wh/kg to 350 Wh/kg, the energy system mass threshold from where fuel cells are superior rises from 7.4 kg to 8.5 kg. At 700 bar, a 3 L hydrogen cylinder can replace a 6 L at 300 bar, provide a 72-min endurance, and is the preferred option to reach minimum system volume. This work provides guidance in early conceptual stages and insights on how fuel cell based powerplants for multirotors can be improved and optimized to increase their value proposition. Further research can expand the work to cover other system variations and do experimental testing of system performance.