Evaporative cooling pads are clean media for cost-effective temperature management. However, the spatially integrated microclimate resulting from heat and mass transfer in the evaporative cooling pad is an uncertain and nonlinear complexity. Therefore, this purpose of this study is to present an innovative prediction model with computational fluid dynamics and evaluate the operating scenarios and geometrical properties of wet pads from quantitative metrics such as saturation efficiency and pressure drop. The reliability of the established numerical model of wet pads was verified by wind tunnel experiments and existing experiments, which predicted the outlet conditions in satisfactory conformity. The results showed that a wet pad with 8 mm ripple height and 19.6 mm ripple distance exhibits the best prospective, with energy consumption and specific water consumption reduced by 45.28 % and 26.26 %, respectively. Meanwhile, the cross strategy of 45_45° corrugation obliquity reduces the pressure drop by 18.95 %, providing uniform supply air distributions. The heat exchange of the wet pad is mainly concentrated within the first 35 mm from the inlet section, while the mass exchange of the wet pad is concentrated within the first 60 mm. The range of frontal air velocity with 0.9–2.5 m/s is recommend for the evaporative cooling system.