ABSTRACT The research on entropy generation in a mechanical system is quite imperative owing to its immense applications in the production of advanced cooling devices and medical appliances. The basic need on this research is how to optimize the irreversibilities within the systems and channelize that energy towards the benefit. This study elucidates the entropy generation analysis of a Casson nanofluid near a stagnation point over a lubricated vertical wall. A thin film of shear-thinning liquid with power law index of 0.5 is employed on the wall to ensure the lubrication. The effect of induced magnetic field and the chemical reaction stimulated by the activation energy is also incorporated within the flow. The non-linear PDEs of the substantive problem along with the compatible interfacial and boundary conditions are reverted into ODEs with the aid of suitable similarity transformation, and then cracked numerically using the sixth-order Runge Kutta method assisted with Nachtsheim–Swigert shooting practice. One of the significant findings reveals that the fluid friction irreversibilities in the entropy generation are diminished with the magnetic parameter and the Casson parameter, whereas the thermal irreversibility predominates over the total entropy generation for the escalating values of the activation energy parameter.