Objective: A Prospective and retrospective analysis of POSEIDON stratification to predict low prognosis patients during assisted reproductive technique (ART) cycles in Indian Population. Design: Bidirectional Study (Prospective as well as Retrospective). Setting: Southend fertility and IVF centre, New Delhi. Patient Selection: All Low prognosis patients according to POSEIDON stratification. Duration of Study: 06 Months. Outcome: Prevalence of Low prognosis patients in Indian Population and Clinical Pregnancy Rate in whom fresh embryo transfer was done. Results: In this bidirectional study we enrolled a total 456 patients who underwent ovarian stimulation for ART at Southend Fertility and IVF Centre from Jan 2017 to Dec 2018. Out of these patients 218 (47%) patients were classified as ‘low prognosis’ according to the POSEIDON criteria. Overall in all four groups Clinical Pregnancy rate was approximately 20.6% in low prognosis patients who underwent fresh ET. Conclusion: Providing IVF pregnancy with autologous oocytes to low ovarian responders is the most challenging part of fertility care. The new POSEIDON concept is helping the clinicians in medical management and in counselling patients what to expect, helping in reducing time to pregnancy.