Frequent Fish Research Articles

Dietary Oily Fish Intake is Inversely Associated with Severity of White Matter Hyperintensities of Presumed Vascular Origin. A Population-Based Study in Frequent Fish Consumers of Amerindian Ancestry

BackgroundOily fish is a major dietary source of omega-3 polyunsaturated fatty acids and other nutrients that may reduce the expression of cerebral small vessel disease (cSVD) biomarkers, including white matter hyperintensities (WMH) of presumed vascular origin. However, information on this relationship is limited. We aimed to assess the association between oily fish intake and WMH severity in a population of frequent fish consumers. MethodsThe study included 572 individuals aged ≥60 years living in three neighboring rural villages of coastal Ecuador. Dietary oily fish intake was calculated and all participants received a brain MRI. Logistic regression models, adjusted for demographics, level of education, cardiovascular risk factors and other cSVD biomarkers, were fitted to assess the independent association between amounts of oily fish intake and WMH severity. ResultsOverall, the mean intake of oily fish was 8.5 ± 4.7 servings per week, and 164 individuals (29%) had moderate-to-severe WMH (according to the modified Fazekas scale). A multivariate logistic regression model disclosed a significant inverse association between the amount of oily fish intake and the presence of moderate-to-severe WMH (OR: 0.89; 95% C.I.: 0.85–0.94; p < 0.001). Predictive margins revealed an almost linear inverse relationship between quartiles of oily fish intake and probabilities of WMH severity, which became significant when the 1st quartile was compared with the 3rd and 4th quartiles. ConclusionsIncreased amounts of oily fish intake are inversely associated with WMH severity. Further studies are warranted to determine whether oily fish intake reduces the risk of cSVD-related cerebrovascular complications.

Interaction between APOE ε4 and dietary protein intake on cognitive decline: A longitudinal cohort study

To exam the association of cognitive decline with APOE ε4 allele carriage and dietary protein intake and investigate whether there is a gene-diet (GxD) interaction of APOE ε4 allele carriage and dietary protein intake on cognitive decline in a nationwide cohort of older adults. A cohort study of participants from Chinese Longitudinal Healthy Longevity Survey was conducted from 2008 to 2014. A total of 3029 participants (mean age of 77.0 years, SD=9.0; 49.3% were women) was enrolled. We genotyped APOE ε4 allele for each participant and calculated the diversity of dietary protein intake (DDPI) by summing up the frequency of intake of the 6 protein-rich foods (meats, fish, eggs, nuts, dairy products, and bean products). We assessed cognitive function using the Mini-Mental State Examination (MMSE). We used ordinal regression model to estimate the independent and joint effects of APOE ε4 carrier and dietary protein intake on cognitive decline, adjusting for potential confounders of age, sex, education, socio-economic status, lifestyles, BMI, and cardiometabolic conditions. There was significant association between carrying APOE ε4 allele and faster cognitive decline (Odds ratio: 1.19, 95% CI=1.00-1.42), independent of potential confounders. While the associations of DDPI and the intake of 6 protein-rich foods with cognitive decline did not reach any statistical significance. We observed significant interactions of APOE ε4 with DDPI and fish intake, at multiple correction-adjusted Ps<0.05. In those who were APOE ε4 carriers rather than non-carriers, both high DDPI (OR=0.54, 95% CI: 0.34-0.88) and daily fish intake (OR=0.43, 95% CI: 0.22-0.78) were significantly associated with slower cognitive decline, respectively. We also found that frequent intake of fish benefits women more than men regarding the mitigating of cognitive decline among APOE ε4 allele carriers (P for interaction=0.016). The results of this study support the hypothesis that diversified protein food intake in addition to frequent fish intake may reduce the detrimental effect of APOE ε4 on cognitive health.

Antioxidants in Fish Sperm and the Potential Role of Melatonin.

In recent years, the effects of novel antioxidants have played an important role in the research focusing on fish cell protection. As food demand grows, aquaculture production becomes more intensive, and fish are more exposed to oxidative stress conditions, like high densities, temperature shifting, frequent fish handling and samplings, and prophylactic or disease treatments, which expose fish to a different environment. Particularly in reproduction, germ cells lose antioxidant capacity with spermatogenesis, as spermatozoa are more prone to oxidative stress. Antioxidants have been used in a variety of fish physiological problems including in reproduction and in the establishment of cryopreservation protocols. From the most used antioxidants to natural plant food and herbs, and endogenously produced antioxidants, like melatonin, a review of the literature available in terms of their effects on the protection of fish spermatozoa is presented here in a classified structure. Several direct and indirect approaches to improve gamete quality using antioxidants administration are mentioned (through feed supplementation or by adding in cryopreservation media), as well as factors affecting the efficiency of these molecules and their mechanisms of action. Special attention is given to the unclear melatonin pathway and its potential scavenger activity to prevent and counteract oxidative stress damage on fish spermatozoa.

Draft Genome Sequence of Yersinia ruckeri Strain FMV-22, Isolated from Diseased Rainbow Trout (Oncorhynchus mykiss) in Peru.

Yersinia ruckeri is a significant and frequent bacterial fish pathogen in Peru. We report the draft genome sequence of strain FMV-22, isolated from a diseased rainbow trout, which consists of 3.84 Mb, with a G+C content of 47.45% and 3,765 protein-coding genes.

Influencing factors for depressive symptoms in the elderly aged 65 years and older in 8 longevity areas in China

Objective: To analyze influencing factors for depressive symptoms in the elderly aged 65 years and older in 8 longevity areas in China. Methods: We recruited 2 180 participants aged 65 years and older in 8 longevity areas from Healthy Aging and Biomarkers Cohort Study, a sub-cohort of the Chinese Longitudinal Healthy Longevity Survey in 2017. Multivariate logistic regression analysis was performed to evaluate the relationships of socio-demographic characteristics, behavioral lifestyle, chronic disease prevalence, functional status, family and social support with depressive symptoms in the elderly. Results: The detection rate of depression symptoms was 15.0% in the elderly aged 65 years and older in 8 longevity areas of China, and the detection rate of depression symptoms was 11.5% in men and 18.5% in women. Multivariate logistic regression analysis results showed that the detection rate of depressive symptoms was lower in the elderly who had regular physical exercises (OR=0.44, 95%CI: 0.26-0.74), frequent fish intakes (OR=0.57, 95%CI: 0.39-0.83), recreational activities (OR=0.65, 95%CI: 0.44-0.96), social activities (OR=0.28, 95%CI: 0.11-0.73) and community services (OR=0.68, 95%CI: 0.50-0.93). The elderly who were lack of sleep (OR=2.04, 95%CI: 1.49-2.80), had visual impairment (OR=1.54, 95%CI: 1.08-2.18), had gastrointestinal ulcer (OR=2.97, 95%CI: 1.53-5.77), had arthritis (OR=2.63, 95%CI: 1.61-4.32), had higher family expenditure than income (OR=1.80, 95%CI: 1.17-2.78) and were in poor economic condition (OR=4.58, 95%CI: 2.48-8.47) had higher detection rate of depressive symptoms. Conclusion: The status of doing physical exercise, fish intake in diet, social activity participation, sleep quality or vision, and the prevalence of gastrointestinal ulcers and arthritis were associated with the detection rate of depressive symptoms in the elderly.

Frequent false‐negative FIP1L1‐PDGFRA FISH analyses of bone marrow samples from clonal eosinophilia at diagnosis

Frequent false-negative FIP1L1-PDGFRA FISH analyses of bone marrow samples from clonal eosinophilia at diagnosis

459P - Fish intake, dietary polyunsaturated fatty acids, and lung cancer: systematic review and dose-response meta-analysis of 1.7 million men and women

BackgroundLung cancer is the most frequently diagnosed cancer and the leading cause of cancer death among males and females. There is evidence that diet habit may influence lung cancer risk. To determine the association between fish intake and dietary polyunsaturated fatty acids (PUFA) and incidence of lung cancer, we identified all available studies to clarify the dose-response relationship between fish and PUFA and lung cancer risk, evaluated the potential effects of frequent fish and PUFA intake on lung cancer mortality, and studied the ability of their supplementations during chemotherapy in patients with lung cancer. MethodsWe systematically reviewed and meta-analyzed the published studies in MEDLINE, EMBASE databases, Cochrane Library database (Cochrane central register of controlled trials) and ClinicalTrials, supplemented with manual screening. Large-scale prospective cohort study and randomized control trials quantifying the associations of fish and PUFA consumption with risk of lung cancer were included. Two investigators dependently assessed studies for inclusion and extracted data on methods, interventions, outcomes and study quality. Relative risk (RR) with 95% confidence interval (CI) was calculated. Results13 population-based prospective cohort studies involving 1,785,000 participants and 2 randomized control trials were included. Our study demonstrated that dietary PUFA significant reduced risk of lung cancer for men (RR 0.99, 95%CI 0.98 to 1.00) and USA population (RR 0.99, 95%CI 0.98 to 1.00). Dose-response analysis indicated that a 5g/day increment of dietary PUFA was associated with 5% lower risk of lung cancer (RR 0.95, 95%CI 0.91 to 0.99). In addition, PUFA supplementation is significant improved overall survival in patients with lung cancer (RR 1.98, 95%CI 1.09 to 3.59). ConclusionsOur study showed an inverse association between dietary PUFA and risk of lung cancer in males and among USA population. Although smoking cessation is the single biggest factor associated with lung cancer risk reduction, this study adds to a growing body of evidence that diet may have a role in modestly reducing lung cancer risk. Editorial acknowledgementThis work was supported by program for the National Natural Science Foundation of China (grant number 81700025), the Medical and Health Science and Technology Project of Zhejiang (grant number 2018245859), the Medical Science and Technology Plan Projects of Ningbo (grant number 2016A03), the Science Foundation of Zhejiang (grant number LY15H010002) and the Beijing Medical Health Foundation (grant number YWJKJJHKYJJ-HX32). Legal entity responsible for the studyThe authors. FundingHas not received any funding. DisclosureAll authors have declared no conflicts of interest.

Dietary Oily Fish Intake and Frailty. A Population-Based Study in Frequent Fish Consumers Living in Rural Coastal Ecuador (the Atahualpa Project)

Oily fish are recommended as part of a healthy diet due to their high content of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), proteins, and other nutrients. There is preliminary evidence of beneficial effects of ω-3 PUFAs in the prevention of sarcopenia (a major component of frailty). In this study, we aimed to assess the relationship between dietary oily fish intake and a measure of frailty – the Edmonton Frail Scale (EFS) score – in community-dwelling older adults living in rural coastal Ecuador. A total of 363 Atahualpa residents were enrolled. The mean fish servings per week were 8.8 ± 5.2 and mean EFS score was 5 ± 2.8 points. A linear regression model showed no association between the amount of oily fish intake and EFS scores. However, an interaction model, with participants stratified according to their median age and fish intake in quintiles, showed a significant effect for both variables on the EFS score (ß coefficient = 0.104; 95% C.I.: 0.003–0.206; p = 0.044). At the lowest quintile of fish intake, younger individuals have lower EFS scores than their older counterparts. As the consumption of oily fish increases, mean EFS scores margins were found to be progressively reduced in subjects aged 60–69 years but were largely unaffected in persons aged ≥70 years. It appears that oily fish intake has a positive effect on the frailty status of younger subjects but is superseded by the effects of age in the older population.

Altered polyunsaturated fatty acid levels in relation to proinflammatory cytokines, fatty acid desaturase genotype, and diet in bipolar disorder

Inflammation and altered polyunsaturated fatty acid (PUFA) levels have been implicated in bipolar disorder (BD). A recent genome-wide association study identified a locus in the fatty acid desaturase (FADS) gene cluster conferring susceptibility to BD. In this study, we examined PUFA levels in patients with BD in relation to proinflammatory cytokines, FADS genotype, and dietary habits. We enrolled 83 patients with BD and 217 healthy controls who underwent plasma PUFA measurement. A subsample of 65 patients and 90 controls underwent plasma interleukin (IL)-6 and tumor necrosis factor alpha (TNFα) measurement, and three FADS single nucleotide polymorphisms (SNPs) were genotyped. Information on fish consumption was obtained by a self-reported diet history questionnaire. In comparing PUFA levels between patients and controls, significant differences were found for all 7 PUFAs tested. Specifically, n-3 eicosapentaenoic acid (EPA) level was decreased, and n-6 arachidonic acid level was increased in the patients (p < 0.0001 for both). Plasma IL-6 and TNFα levels were both significantly increased in the patients. Plasma EPA level was negatively correlated with IL-6 and TNFα levels. The FADS genotype, which was associated with increased n-6 PUFA levels, was also associated with marked elevation in TNFα levels. Less frequent fish intake was associated with low EPA and high IL-6 level. Taken together, our results provide strong evidence for altered plasma PUFA and proinflammatory cytokine levels in patients with BD. Furthermore, FADS genotype and fish consumption may contribute not only to altered PUFA levels but also to inflammation in BD.

Biochemical Indicators of Algal Bloom in Sewage-Contaminated Lakes

AbstractPollution of Bengaluru lakes with partially treated sewage and stormwater runoffs has led to frequent algal blooms and fish kills in the lakes. This study examined the biochemical parameter...

Dietary Patterns and Age-Related Macular Degeneration in Korea: The Korea National Health and Nutrition Examination Survey 2010\u20132011

This study was performed to reveal dietary patterns and age-related macular degeneration risk association in general Korean population. A retrospective cross-sectional database analysis using the data collected from January 2010 to December 2011 at a Korea nationwide survey was conducted. The present analysis was performed from December 2016 to November 2017. Detailed grading with fundus photographs was performed by observers blinded to the patient characteristics. The current study focused on subjects forty year and older who had fundus photographs that is assessable from at least one eye (7,899 participants). Participants were excluded if they reported extreme energy intake (142 participants) or if they were likely to have changed dietary behavior (1,171 participants), or with missing data (n = 764). After exclusion, 5,843 participants data were analyzed in the current study. As the result, 6.8% of the participants exhibited early stages of age-related macular degeneration and 0.6% exhibited late stages. Furthermore, relatively more frequent fish consumption was associated reduced odds of early age-related macular degeneration when comparing the third quartile with the first quartile groups, however, relatively more frequent legume consumption was associated with reduced odds of late age-related macular degeneration when comparing the third quartile with the first quartile groups. In conclusion, the current study insists that the diet pattern rich in fish and legume might have protective effect against age-related macular degeneration in Korean population.

Congruence in riverine conditions and associations between native fish and several species of amphibians in a region prone to fish invasions

The relationship between fish and amphibians is thought to be antagonistic because of the frequent amphibian extirpations after fish introductions, although some field observations show that amphibians and fish often co-occur in rivers. Here, we used surveys in north-eastern Spain (99,700 km2, 15 river catchments, N = 535 sites) to identify the most frequent fish–amphibian associations and the riverine conditions that might concurrently promote the diversity of native fish and of five widely distributed amphibian species. Overall, there was little congruence between native fish and amphibian-diversity measures (species richness and the Shannon, Simpson and Pielou diversity indices). Different riverine conditions appeared to be important for the two vertebrate groups. Alien fish richness, which was highly correlated with alien fish abundance, was negatively associated with amphibian richness and Shannon diversity but was positively associated with native fish richness. River water depth was negatively associated with amphibian occurrence. While our snap-shot surveys may be a transitional stage in the fish–amphibian relationships, we found that some widely distributed amphibian species co-occur with fish in rivers in north-eastern Spain. Small rivers, such as tributaries often have the most intact fish assemblages, and probably are the best locations to explore fish–amphibian associations in greater depth.

Association of fish intake and smoking with risk of rheumatoid arthritis and age of onset: a prospective cohort study

BackgroundPrior studies suggest that fish may be protective for rheumatoid arthritis (RA) risk perhaps through the anti-inflammatory effect of omega-3 fatty acid, but this relationship has not been clearly established. Therefore, we investigated fish intake and RA risk by serologic status, age of onset, and smoking using a prospective cohort study with large sample size, repeated measures of dietary intake, and lengthy follow-up.MethodsWe studied fish intake and RA risk among 166,013 women in two prospective cohorts, the Nurses’ Health Study (NHS, 1984–2014) and NHSII (1991–2015). Fish intake was assessed using food frequency questionnaires at baseline and every 4 years. Incident RA during follow-up and serologic status were determined by medical record review. Pooled Cox regression models estimated hazard ratios (HR) and 95% confidence intervals (CI) for RA (overall and by serologic status and age at diagnosis) for fish intake frequency. We tested for a smoking-fish interaction for RA risk.ResultsDuring 3,863,909 person-years of follow-up, we identified 1080 incident RA cases. Increasing fish intake was not associated with all RA (≥4 servings/week: multivariable HR 0.93 [95%CI 0.67–1.28] vs. < 1 serving/month; p for trend = 0.42), seropositive RA (p for trend = 0.66), or seronegative RA (p for trend = 0.45), but had increased risk for RA diagnosed > 55 years old (p for trend = 0.037). Among women ≤55 years old, frequent fish intake (vs. infrequent) had HRs (95%CIs) of: 0.73 (0.52–1.02) for all RA, 0.85 (0.55–1.32) for seropositive RA, and 0.55 (0.32–0.94) for seronegative RA. Ever smokers with infrequent fish intake had highly elevated risk for RA onset ≤55 years (HR 2.59, 95%CI 1.65–4.06), while ever smokers with frequent fish intake had modestly elevated RA risk (HR 1.29, 95%CI 1.07–1.57; vs. never smokers/frequent fish intake; p for smoking-fish interaction = 0.039).ConclusionIn this large prospective cohort study, we found no clear protective effect of fish or marine omega-3 fatty acid intake on RA risk, overall or by serologic status. We found that fish intake attenuated the strong association of smoking for RA diagnosed ≤55 years of age, but this requires further study.

Leave forever or return home? The case of the whitemouth croaker Micropogonias furnieri in coastal systems of southeastern Brazil indicated by otolith microchemistry

Movements of coastal fish species between estuarine systems (rearing grounds) and adjacent platforms (spawning grounds) are complex and can be influenced by multiple biotic and abiotic factors associated with the life cycle of each species. Understanding fish movement patterns between these habitats is crucial for sustainable management of these resources. We aimed to identify movement patterns of the whitemouth croaker Micropogonias furnieri, an important fishery resource along the southeastern Brazilian coast, through characterization of elemental concentration profiles in otoliths. Signal intensity ratios of Sr86:Ca43 and Ba138:Ca43, measured by a Laser ablation inductively coupled to a plasma mass spectrometry (LA-ICPMS), were analysed. Juveniles and adults fish from three semi-enclosed systems (two bays and one coastal lagoon) and adults from nine adjacent coastal areas were examined. Three main behavioural patterns were identified: 1) Marine Migrant, with a unique and definitive movement from the estuarine area towards the adjacent platform when adult; 2) Estuarine Visitor, with movements from the estuarine area towards the adjacent platform when adult but also performing excursions back to the estuarine areas and back again to the adjacent platform; and 3) Nearshore Resident, with occurrence in the adjacent coastal areas that are influenced by estuarine systems. Estuarine areas with large sea connections (e.g., bays) favour more frequent fish entrances and exits compared with coastal lagoons that have a narrow sea connection. The high eurioic condition and capacity related to adapting to different environmental conditions were detected in this study for M. furnieri, a likely strategy to maintain variation in life histories and successfully adapt to coastal marine systems.

Exposure of Inorganic Mercury in the General Population and Ethnic Minorities in New York City and Its Associations with Skin Lightening Practice

Skin lightening practice (SLP) was identified as a source of inorganic mercury exposure among Caribbean-born blacks and Dominicans, who had geometric mean urine mercury concentration ([GMuHg]) &amp;#8805;1 ng/ml compared to 0.69 ng/ml among the general population in the 2004 New York City Health and Nutrition Examination Survey (NYC HANES). We assessed such a pattern using the 2013-2014 HANES (n&amp;#61;1408), which also asked about the usage of skin lightening cream in the past 30 days. In addition, we present the preliminary results from a pilot study on SLP among NYC women of African and Afro-Caribbean ancestries (n&amp;#61;74) who have been bleaching their skin for a year.The population-weighted SLP prevalence was 5.5% overall and 8.1% among the Caribbean population (n&amp;#61;355). The overall [GMuHg] and its 95th percentile was 0.37 and 1.7 ng/ml, similar to the levels found among subgroups such as participants with SLP, the Caribbean population, or the Caribbean participants with SLP. Among those with SLP (n&amp;#61;75), 70% were female, 37% were Hispanic, 36% were Caribbean, and their [uHg] ranged from 0.063 ng/ml to 11ng/ml. Significant factors (p&amp;lt;0.05) associated with [uHg] were being non-US born, higher family income (&amp;#8805;$100,000), having silver-colored dental fillings and frequent fish or shellfish consumption (&amp;#8805;3 times in the past 30 days). In our pilot study, 81% participants were non-US born, about 50% from Jamaica or the Ivory Coast, 89% reported more than 3 years of SLP, 77% used daily, and 12% used while pregnant/breastfeeding.We observed an overall decrease in the population level [GMuHg] in NYC compared to the previous study, and did not find elevated [GMuHg] among the Caribbean or SLP population. Our SLP-focused pilot study showed that SLP is a habitual practice, and the existence of prenatal and postnatal exposures related to SLP may warrant further investigation especially among vulnerable subgroups (e.g., Jamaicans and West Africans) where SLP is more prevalent.

Tracking Declines in Mercury Exposure in the New York City Adult Population, 2004\u20132014

Mercury is a toxic metal that can be measured in human blood and urine. Population-based biomonitoring from 2004 guided New York City (NYC) Department of Health and Mental Hygiene (DOHMH) efforts to reduce exposures by educating the public about risks and benefits of fish consumption—a predominant source of exposure in the general population—and removing mercury-containing skin-lightening creams and other consumer products from the marketplace. We describe changes in exposures over the past decade in relation to these local public health actions and in the context of national changes by comparing mercury concentrations measured in blood (1201 specimens) and urine (1408 specimens) from the NYC Health and Nutrition Examination Survey (NYC HANES) 2013–2014 with measurements from NYC HANES 2004 and National Health and Nutrition Examination Surveys (NHANES) 2003–2004 and 2013–2014. We found that NYC adult blood and urine geometric mean mercury concentrations decreased 46% and 45%, respectively. Adult New Yorkers with blood mercury concentration ≥ 5 μg/L (the New York State reportable level) declined from 24.8% (95% CL = 22.2%, 27.7%) to 12.0% (95% CL = 10.1%, 14.3%). The decline in blood mercury in NYC was greater than the national decline, while the decline in urine mercury was similar. As in 2004, Asian New Yorkers had higher blood mercury concentrations than other racial/ethnic groups. Foreign-born adults of East or Southeast Asian origin had the highest prevalence of reportable levels (29.7%; 95% CL = 21.0%, 40.1%) across sociodemographic groups, and Asians generally were the most frequent fish consumers, eating on average 11 fish meals in the past month compared with 7 among other groups (p < 0.001). Fish consumption patterns were similar over time, and fish continues to be consumed more frequently in NYC than nationwide (24.7% of NYC adults ate fish ten or more times in the past 30 days vs. 14.7% nationally, p < 0.001). The findings are consistent with the hypothesis that blood mercury levels have declined in part because of local and national efforts to promote consumption of lower mercury fish. Local NYC efforts may have accelerated the reduction in exposure. Having “silver-colored fillings” on five or more teeth was associated with the highest 95th percentile for urine mercury (4.06 μg/L; 95% CL = 3.1, 5.9). An estimated 5.5% of the adult population (95% CL = 4.3%, 7.0%) reported using a skin-lightening cream in the past 30 days, but there was little evidence that use was associated with elevated urine mercury in 2013–14.

EARLY DETECTION OF BREAST CANCER IN WOMEN EXPOSED TO ENVIRONMENTAL ESTROGE

We aim in this research to evaluate the role of screening of women for exposure to environmental estrogens and to determine its predictive value for early detection of cancer breast.Recognition of the potential harmful effects related to cancer breast, may facilitate screening, and early detection of cancer breast.Fifty adult women with breast cancer who were referred to the radiology department were included as the study group. The cases were compared to control group of fifty women who were referred to the radiology department for routine screening for breast cancer and had no breast complaint or abnormalities detected.All women in both groups were subjected to a comprehensive structured questionnaire including the following: age, residency, marital status, parity, occupation, breast feeding, family history, age of menarche, age at menopause, hormone replacement therapy, contraceptive pills/injections, applications of cosmetics (body lotion, cream, make up, foundations, perfumes), wearing bras, implant, use of plastic wrappings, use of bottles/foams, dietary habits (fast/fresh food), chest irradiation, complaint of women (breast mass, pain, nipple discharge, skin discharge), history of exposure to other possible risk factors such as smoking, exposure to chest irradiation, radon, asbestos, pesticides and children toys. The collected data were organized, tabulated and statistically analyzed using statistical package for social science, version 16.Results were a significant relationship was found between incidence of breast cancer and exposure to cosmetics, smoking, physical inactivity, frequent fish consumption and low fruit intake.Exposure toxenoestrogens (e.g., insecticides, food preservatives) was a serious factor to breast cancer incidence.Some environmental factors showed rather insignificant relationship with exposure to radon or asbestos, wearing bra, or plastic use to incidence of cancer breast.Conclusion wasBreast cancer has currently no available cure so perhaps the best strategy to combat breast cancer perhaps relies on early detection and prevention through avoiding the exposure to high risk factors.

Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis.

To assess whether more frequent fish consumption is associated with lower rheumatoid arthritis (RA) disease activity scores among participants in an RA cohort. We conducted a cross-sectional analysis using baseline data from participants in the Evaluation of Subclinical Cardiovascular Disease and Predictors of Events in Rheumatoid Arthritis cohort study. Frequency of fish consumption was assessed by a baseline food frequency questionnaire assessing usual diet in the past year. Multivariable, total energy-adjusted linear regression models provided effect estimates and 95% confidence intervals (95% CIs) for frequency of fish consumption (i.e., never to <1 time/month, 1 time/month to <1 time/week, 1 time/week, and ≥2 times/week) on baseline Disease Activity Score in 28 joints (DAS28) using the C-reactive protein (CRP) level. We also estimated the difference in DAS28-CRP associated with increasing fish consumption by 1 serving per week. Among 176 participants, the median DAS28-CRP score was 3.5 (interquartile range 2.9-4.3). In an adjusted linear regression model, subjects consuming fish ≥2 times/week had a significantly lower DAS28-CRP compared with subjects who ate fish never to <1 time/month (difference -0.49 [95% CI -0.97, -0.02]). For each additional serving of fish per week, DAS28-CRP was significantly reduced by 0.18 (95% CI -0.35, -0.004). Our findings suggest that higher intake of fish may be associated with lower disease activity in RA patients.

Spatiotemporal variation in the structure of reef fish and macroalgal assemblages in a north-east Atlantic kelp forest ecosystem: implications for the management of temperate rocky reefs

Temperate rocky reefs and kelp forest ecosystems have been severely affected by overfishing, pollution and habitat destruction, and climate change is a major driver of kelp decline in many regions. Although necessary for management, ecological interactions between kelp and fish remain largely unknown in the north-east Atlantic. In the present study, underwater visual censuses (UVC) and univariate and multivariate multiple regression models were used to analyse the spatiotemporal variations in the abundance and habitat use of the rocky reef fish and macroalgae assemblages of Galicia (north-west Spain). The underwater seascape was dominated by large rocks and kelp forests of Laminaria hyperborea, L. ochroleuca and Saccorhiza polyschides. Fish assemblages were ruled by gadids, labrids and sparids. The most frequent fish species were Labrus bergylta (counted in 90% of UVC) and Pollachius pollachius (in 100% of UVC), whereas the most abundant were Boops boops (mean±s.d., 556.4±39.7 individuals ha–1) and L. bergylta (432.10±440.05 individuals ha–1). Fish and macroalgal assemblages showed different spatial preferences and responded strongly to seasonality, wave exposure and depth. To a lesser degree, fish and macroalgal assemblages showed preferences for habitat structure. Moreover, because the findings of the present study indicate that L. bergylta is a good indicator species of the health of rocky reef and kelp forests ecosystems, monitoring of this fish can be helpful for management and conservation actions.

The mediating role of sleep in the fish consumption \u2013 cognitive functioning relationship: a cohort study

Greater fish consumption is associated with improved cognition among children, but the mediating pathways have not been well delineated. Improved sleep could be a candidate mediator of the fish-cognition relationship. This study assesses whether 1) more frequent fish consumption is associated with less sleep disturbances and higher IQ scores in schoolchildren, 2) such relationships are not accounted for by social and economic confounds, and 3) sleep quality mediates the fish-IQ relationship. In this cohort study of 541 Chinese schoolchildren, fish consumption and sleep quality were assessed at age 9–11 years, while IQ was assessed at age 12. Frequent fish consumption was related to both fewer sleep problems and higher IQ scores. A dose-response relationship indicated higher IQ scores in children who always (4.80 points) or sometimes (3.31 points) consumed fish, compared to those who rarely ate fish (all p < 0.05). Sleep quality partially mediated the relationship between fish consumption and verbal, but not performance, IQ. Findings were robust after controlling for multiple sociodemographic covariates. To our knowledge, this is the first study to indicate that frequent fish consumption may help reduce sleep problems (better sleep quality), which may in turn benefit long-term cognitive functioning in children.