Frequency Of Hyperuricemia Research Articles

Clinical and instrumental characteristics of psoriatic arthritis in men depending on testosterone levels

The aim – to study the incidence of hypogonadism in men with psoriatic arthritis (PsA) and to assess its impact on PsA and comorbidities.Materials and methods. A cross-sectional continuous study included 128 men with PsA who were hospitalized at the V.A. Nasonova Research Institute of Rheumatology. The patients underwent determination of their total testosterone levels and subsequent division into subgroups with normal (≥12.0 nmol/l) and reduced levels. An intergroup comparison was conducted for the main indicators used in clinical rheumatology practice to assess the stage, activity, and other medical and demographic characteristics of PsA, as well as for comorbidities. A correlation analysis was performed between the level of total testosterone and some clinical and laboratory parameters.Results. The incidence of reduced total testosterone levels was 36.7%. Patients with testosterone deficiency were older (47.9±10.3 vs 40.1±12.1 years; p<0.001), had a higher body mass index (31.2±5.2 vs 27.2±6.1 kg/m2; p<0.001) and were more often obese (48.9% vs 23.4%; p=0.001). They had higher mean glucose levels (5.9±1.39 vs 5.34±0.57 mmol/l; p=0.001) and frequency of impaired fasting glycemia with similar frequency of type 2 diabetes mellitus. Patients with hypogonadism were characterized by higher uric acid levels (402.9±99.3 vs 354.0±81.5 μmol/L; p=0.003) and the frequency of hyperuricemia. A lower proportion of HLA-B27 positive patients was noted in the hypogonadism group, as well as a more frequent occurrence of stage III sacroiliitis (p=0.004) and a smaller amplitude of lateral flexion in the spine (10.3±3.3 vs 12.4±4.3 cm; p=0.014). Significant negative relationships were found between total testosterone levels and age, body mass index, glucose and uric acid levels, as well as a positive relationship with the amplitude of lateral flexion and chest excursion.Conclusion. Hypogonadism was detected in one third of patients with PsA. Decreased testosterone levels were observed in older individuals and were associated with metabolic disorders, as well as with decreased spinal mobility and the presence of stage III of sacroiliitis.

Is there an association between osteoporosis and uric acid?

The aim – to study the association between serum uric acid (SUA) level, bone mineral density (BMD) and osteoporosis (OP) in postmenopausal women.Materials and methods. 394 postmenopausal women were examined (median age – 62 [56; 68] years). Examination and anthropometric measurements, a biochemical blood test, including level of SUA, dual-energy X-ray absorptiometry of the lumbar spine (L1–L4), femoral neck (FN) and total hip (TH) were carried out.Results. In women with OP, the level of SUA and the frequency of hyperuricemia were lower than in those without OP (p=0.005 and p=0.019, respectively). SUA was weakly positively correlated with BMD in L1–L4 (r=0.20; p<0.001), FN (r=0.12; p=0.021) and TH (r=0.17; p=0.001). A weak negative correlation was found between the level of SUA and the presence of OP (r=–0.13; p=0.008). Multiple logistic regression analysis showed that the independent factors associated with OP in postmenopausal women were age (odds ratio (OR) – 1.06 (95% confidence interval (95% CI): 1.02–1.10); p=0.003) and body mass index (OR=0.83 (95% CI: 0.77–0.89); p<0.001). There was no significant relationship between the level of SUA and OP.Conclusion. Thus, in postmenopausal women, the effect of SUA on the risk of OP was not revealed.

Association between Hyperuricemia and Ischemic Stroke in patients admitted in Medical ward in a tertiary care hospital Multan

Objective: To assess the association of Hyperuricemia with Ischemic Stroke Methodology: This case-control study was carried out at the department of Medicine Nishtar 2 Tertiary Care Hospital in Multan from June 2023 to Dec 2023. At the time of admission, the serum uric acid level was tested in addition to other standard laboratory tests. Patients' information was gathered using a pre-made proforma only after written informed permission was obtained from the individuals, their spouses, or relatives in the case of patients with aphasia or decreased awareness. Version 24 of the statistical program for the social sciences (SPSS) was used to analyze the data. A p-value of less than 0.05 and an OR greater than one were deemed statistically significant. Results: In the current study, 60 patients were cases and 60 were healthy control. In cases there were 33 (55%) males and 27 (45%) females while in healthy control, the males were 30 (50%) while females were also 30 (50%). In patients with ischemic stroke, the frequency of hyperuricemia was 26 (43.33%), while in controls, it was 15 (25%). Compared to controls, ischemic stroke patients had a 3.11-fold increased incidence of hyperuricemia. Accordingly, hyperuricemia (p=0.002) is a substantial risk factor for ischemic stroke. In individuals aged 30 to 50, ischaemic stroke and hyperuricemia were significantly associated (p = 0.001). Additionally, ischaemic stroke patients had a 4.15-fold increased incidence of hyperuricemia compared to control subjects. On the other hand, there was no significant correlation (p = 0.29) between hyperuricemia and ischaemic stroke in the 51–70 age range. Additionally, there was a 2.1-fold increased incidence of hyperuricemia in ischaemic stroke patients. Conclusion: Patients with ischemic stroke had a considerably greater prevalence of hyperuricemia (43.33%). Furthermore, those who have had an ischemic stroke are 3.11 times more likely to get hyperuricemia. Hyperuricemia may thus be looked at as an additional ischemic stroke risk factor. However, further study is required before regular uric acid levels may be advised.

Association between hyperuricemia and coronary artery disease severity among patients undergoing coronary angiography

Aim: To determine the association between hyperuricemia and coronary artery disease severity among patients undergoing coronary angiography. Methods: This study was conducted at multi centers including Al- Aleem Medical College (Gulab Devi Teaching Hospital) Lahore and Fatima Memorial Hospital Lahore in the duration from December, 2022 to May, 2023. Total 180 patients were presented with Coronary Artery Disease, Coronary angiography was performed to determine the presence of coronary artery disease, with patients having luminal stenosis of greater than 50% in at least one of the coronary arteries. Relation between hyperuricemia and coronary artery disease was assessed using Chi Square test keeping P < 0.05 as significant. Results: The mean age was 49.59±6.11 years. The frequency of hyperuricemia was 120 (66.7%), around 32.3% patients had mild CAD, about 37.2% patients had moderate CAD while 30.6% patients had severe CAD. We found a significant association between hyperuricemia and severity of CAD. Conclusion: We conclude that hyperuricemia is significantly associated with the severity of coronary artery disease (CAD).

Case Study: Determination of Incidence of Hyperuricemia among patients suffering from Acute Coronary Artery Syndrome

In the vast majority of nations across the globe, coronary artery disease (CAD) remains the leading cause of mortality. It is among the most widely recognized global health concerns affecting both sexes. The worldwide impact of CAD is severe, and its consequences are particularly pronounced in countries with higher incidence rates. In Western nations, myocardial infarction outcomes are often linked to socioeconomic status, with those in lower socioeconomic positions disproportionately affected by the burden of this disease. Given the high rates of morbidity and mortality associated with acute myocardial infarction (MI), this condition continues to be a major focus of cardiovascular therapy. The present study sheds new light on the issue, as the findings differ from previous research due to demographic, nutritional, and lifestyle differences. The dissemination of these findings to the medical community will be critical to informing future research and better understanding how to recognize and treat hyperuricemia in ACS patients. This study has important implications for public health policy and clinical practice. By improving our understanding of the complex interplay between socioeconomic factors and cardiovascular health, we can develop more targeted interventions and improve outcomes for those at the highest risk of CAD and related conditions. This study was performed at the Cardiology Department of Khyber Teaching Hospital, Peshawar for six months, from 19th July 2022 to 19th January 2023. It was a cross-sectional study in which 360 male and female patients aged between 30-60 years were included with acute coronary syndrome. Clinical history, physical examination, and laboratory investigations, including troponin test and ECG results, were adequately monitored. At the time of admission, all patients’ blood samples were collected and biochemically analyzed to determine serum uric acid (SUA) levels at Khyber Teaching Hospital. Men with uric acid levels over 7 mg/dl and women with uric acid levels exceeding 6 mg/dl have hyperuricemia. This study reveals a mean age of 52 years with a SD ±11.74. 63 % of patients were male, and 37% were female. Moreover, 35% of patients had hyperuricemia, and 65% didn’t. Our study concludes that the frequency of hyperuricemia was 35% in patients presenting with acute coronary syndrome to the Cardiology Department of Khyber Teaching Hospital, Peshawar.

The frequency of hyperuricemia with left ventricular hypertrophy in patient with primary hypertension in Erbil city-Iraq

Background: High serum uric acid level is common in hypertension and it may be correlatedwith left ventricular hypertrophy. The frequency of hyperuricemia is not previously wellinvestigated in Erbil city. Objectives: The objective of this study was to investigate thefrequency of hyperuricemia and the association between serum uric acid levels and leftventricular hypertrophy in a group of hypertensive patients in Erbil-Iraq. Patients and methods:A cross-sectional study was conducted in Rizgary teaching hospital between September 2015and September 2016. A total of 150 consecutive adult patients presenting with primaryhypertension were included. Based on the results of the echocardiography, the patients wereclassified into two groups; Group I (patients with left ventricular hypertrophy) and Group II(patients with non- left ventricular hypertrophy). The effects of high serum uric acid level on leftventricular mass and geometry were evaluated in both groups. Results: High serum uric acidlevel was present in 38 patients (25.3%). Based on the results of echocardiographic examination,left ventricular hypertrophy was present in 78 patients (52%), 25 of them (32 %) hadhyperuricemia. The mean of serum uric acid level, means of age, systolic blood pressure,diastolic blood pressure and lipid profile significantly higher in group I patients compared tothose in group II patients. Regarding echocardiographic parameters, There were significantlyhigher in hyperuricemic patients compared to patients without hyperuricemia the means ofinterventricular septal thickness, left atrium and left ventricular mass. Conclusions: In this study,high serum uric acid level was common in hypertensive patients and it was positively associatedwith left ventricular hypertrophy and dyslipidemia.

Hyperuricemia may be associated with muscle wellness in older adults.

Sarcopenia, associated with morbidity and mortality, is a common geriatric syndrome in older adults. In this study, we investigated the relationship between uric acid, which is a powerful antioxidant and has intracellular proinflammatory activity, and sarcopenia in older adults. This is a cross-sectional retrospective study involving a total of 936 patients. The diagnosis of sarcopenia was evaluated based on the EGWSOP 2 criteria. The patients were divided into two groups according to hyperuricemia (for females > 6mg/dl, for males > 7mg/dl); hyperuricemia and control. The frequency of hyperuricemia was 65.40%. Patients with hyperuricemia were older than the control group and female gender frequency was higher (p = 0.001, p < 0.001, respectively). Sarcopenia was negatively associated with hyperuricemia as a result of the adjustment analysis made according to demographic characteristics, comorbidities, laboratory results, malnutrition, and malnutrition risk. (p = 0.034). Besides, muscle mass and muscle strength were associated with hyperuricemia (p = 0.026 and p = 0.009, respectively). Considering the positive effect of hyperuricemia on sarcopenia, avoiding aggressive uric acid-lowering therapy may be a good option in older adults with asymptomatic hyperuricemia.

Frequency of hyperuricemia and fetal outcome in preeclampsia.

Objective: To determine the frequency of hyperuricemia and fetal outcome in pre-eclamptic pregnant patients. Study Design: Cross-Sectional Study. Setting: Department of OBG Allied Hospital Faisalabad. Period: January 15, 2022 to January 15, 2023. Material &amp; Methods: Total 200 preeclamptic patients were enrolled and 5c.c of blood was drawn for serum uric acid level. The normal values took 3.1-6.3 mg/dl. Fetal outcome were intrauterine death, premaurity, intrauterine growth restriction with low birth weight recorded. Results: Frequency of hyperuricemia was calculated as 42% (n=84) where normal uric acid levels were recorded in 58% (n=116). IUD in hyperuricemia was 8.33%(n=7) and 2.59%(n=3) in normal uric acid levels, p=0.06, preterm delivery in hyperuricemia was 52.38%(n=44) and 20.69%(n=24) in normal uric acid level, p=0.000, CS in 55.95%(n=47) in hyperuricemia and 22.41%(n=26) in normal uric acid levels whereas SVD was 44.05%(n=37) in hyperuricemia and 77.59%(n=90) in normal uric acid levels, p=0.000, low birth weight was recorded in 52.38%(n=44) in hyperuricemia whereas 14.66%(n=17) in normal uric acid levels, p=0.000. Conclusion: the frequency of fetal outcome is adverse in hyperuricemia in pre-eclamptic patients as compared to normal serum uric acid levels.

Гиперурикемия и ее клиническое значение

The issues of the pathogenesis of hyperuricemia currently remain relevant due to the steady increase in the frequency of hyperuricemia and gout in polymorbid pathologies. Currently, a sufficient number of scientific papers have been accumulated on the association of hyperuricemia with cardiovascular diseases and their consequences (stroke and myocardial infarction), metabolic syndrome, arterial hypertension, insulin resistance, type 2 diabetes mellitus, chronic kidney disease, lipid metabolism disorders, atrial fibrillation, with the risk of mortality.

ВЗАИМОСВЯЗЬ ГИПЕРУРИКЕМИИ СО СТРУКТУРНО-ФУНКЦИОНАЛЬНЫМИ ПОКАЗАТЕЛЯМИ СЕРДЦА У ПАЦИЕНТОВ С АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ И ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ

Background. Cardiovascular diseases predominate in overall morbidity, disability and mortality of the population both in Belarus and in many other countries. The study of additional risk factors for the development of cardiovascular diseases including hyperuricemia is of undoubted interest. A rise in serum uric acid level is increasingly associated not only with the possible risk of such a classic disease as gout, but also with such pathological processes as hypertension and atrial fibrillation. The aim of the study is to study purine metabolism and the frequency of hyperuricemia in patients with hypertension and atrial fibrillation. Material and methods. The study results of products of purine metabolism in 104 patients with hypertension and/or atrial fibrillation under the age of 65 are presented. The serum uric acid level was determined by an enzymatic colorimetric method. The activity of the xanthine oxidase enzyme was measured via solid phase “sandwich” method using ELISA Kit Cat. for enzyme immunoassay. Xanthine, hypoxanthine, adenosine, inosine was measured by a highperformance liquid chromatography. Results. High serum uric acid level was revealed in 22.1% of 154 patients in the study. The patients with persistent and permanent atrial fibrillation had higher uricemia than the ones with paroxysmal atrial fibrillation. The patients with hyperuricemia were more likely to have permanent (33.3%) and persistent (39.4%) atrial fibrillation. Xanthine oxidase activity in 54% of subjects with hypertension and atrial fibrillation exceeded normal values. A significant correlation was found between elevated uric acid levels and left atrial dilatation (U=1616.0, p=0.002, rrb=-0.379). Hyperuricemia may be associated with the value of the left ventricular ejection fraction in patients with hypertension and atrial fibrillation (U=831.0, p=0.017, rrb=0.291). Conclusion: Hyperuricemia occurs in 22.1% of patients with hypertension and atrial fibrillation and is associated with cardiac remodeling.

Correlation of Serum Uric Acid Level with Blood Pressure in Middle-aged Population: A Cross-Sectional Study from Public Sector Hospital of Islamabad

In Pakistan hypertension is the leading cause of mortality and morbidity and is affecting approximately one‐third of the population, meanwhile hyperuricemia is also highly prevalent and has important clinical implications, but association of hypertension and hyperuricemia is still a matter of debate in Pakistani population. To determine the correlation between serum uric acid and Hypertension. Cross-sectional analytical study of six month duration was carried out at at tertiary care public sector hospital of Islamabad from February to August 2019. After taking the informed written consent 100 middle-aged (40 to 65 years) asymptomatic individuals visiting tertiary care hospital for the test of serum uric acid for the first time were enrolled. Beckman Coulter AU analyzers and uriucase method was used to measure uric acid as per manufacturer’s instructions. Blood pressure of all enrolled participants was measured through a mercury sphygmomanometer. Demographic information of the study participant, clinical history, height, weight, family history, uric acid level and blood pressure were recorded on pre-structured questionnaire. BMI was calculated by using WHO formula. Among 100 enrolled study participants, 50 (50%) were males and 50 (50%) were females. The mean age was 50±8 years. The frequency of hyperuricemia was 16.0% and among these 93.8% were hypertensive with a significant Pearson correlation coefficientp value of 0.014. There is a significat correlation between hyperuricemia and hypertension. Our findings remain to be confirmed in future prospective studies.

FREQUENCY OF HYPERURICEMIA IN HYPERTENSIVE PATIENTS AND ITS ASSOCIATION WITH AGE OF PATIENT

Objective: To determine the frequency of hyperuricemia in hypertensive patients and its association with the age of patients.&#x0D; Study Design: Cross sectional analytical study.&#x0D; Place and Duration of Study: Combined Military Hospital Abbottabad, from Sep 2016 to Feb 2017.&#x0D; Methodology: All patients of 18-70 years of age with either gender presenting in and out patient departmentswith hypertension were enrolled. Serum uric acid was measured. Analysis of serum uric was done with SelectraXL chemical analyzer having normal references range of 2.52-6.97 mg/dl for males and 1.51-6.0 mg/dl forfemales. Reports were verified by Pathologist.&#x0D; Results: A total of 137 patients were selected for the study. Mean age of the patients was 56.09 ± 09.36 years.There were 76 (55.50%) patients with &gt;55 years of age while 61 (44.50%) patients were presented with ≤55 years of the patients. Male preponderance was higher 83 (61%) as compared to females 54 (39%). Mean weight, height and Body Mass Index of the patients was 67.99 ± 6.91 kilograms, 1.63 ± 0.08 meters and 25.32 ± 2.15 kg/m2 respectively. Mean systolic blood pressure of the patients was 166.71 ± 13.67 mmHg. Mean Diastolic blood pressure was 100.15 ± 8.84 mmHg. Mean serum uric acid level was 6.96 ± 0.82 mg/dl. Frequency of hyperuricemia was found in 102 (74.45%) while normouricemia in 35 (25.55%) patients.&#x0D; Conclusion: Frequency of hyperuricemia was found higher in hypertensive patients and it was not associatedwith the age of patients.

Association between Hyperuricemia and Ischemic Stroke: A Case-Control Study.

To find the association between hyperuricemia and ischemic stroke. Case-control study. Departments of Medicine and Neurology, Mayo Hospital, Lahore, from October 2015 to September 2016. A total of 100 patients were recruited in the study. Fifty cases were of acute ischemic stroke and fifty were age- and gender-matched healthy controls. Serum uric acid level was estimted by photometry method at the time of admission. Hyperuricemia was defined as the serum uric acid level of more than 6 mg/dl. Mean serum uric acid levels in cases and controls were 5.996 ±1.99 mg/dl and 5.042 ±0.91 mg/dl, respectively. Hyperuricemia was present in 23 (46%) patients with ischemic stroke and in 10 (20%) controls. Among ischemic stroke patients, the frequency of hyperuricemia was significantly higher than in controls (p-value =0.006, Odds Ratio (OR) =3.41.) Conclusion:Serum uric acid was found significantly elevated in ischemic stroke patients versus controls with 3.41 times more risk of having hyperuricemia in ischemic stroke patients. Key Words: Hyperuricemia, Ischemic stroke, Serum uric acid (SUA).

Serum uric acid level in Bangladeshi adults with essential hypertension

Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN). The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p&lt;0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p&lt;0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p&lt;0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.

Frequency of Hyperuricemia in the patients with Acute Myocardial Infarction.

Objectives: This study aims to scientifically fill the gap and provide the scientific data regarding frequency of hyperuricemia in the patients with acute myocardial Infarction admitted at Liaquat University of Medical &amp; Health Sciences, Hyderabad. Study Design: Prospective descriptive case series. Setting: Department of Cardiology, Liaquat University of Medical &amp; Health Sciences, Hyderabad. Period: From 7th Feb 2016 to 6th August 2018. Material and Methods: Was conducted on either gender having age ≥35 to ≤70 years presented with ST elevation myocardial infarction was included in the study. ECG and laboratory investigations were carried out. Relevant investigation like serum uric acid was sent to laboratory. Final outcome was assessed at the end of 5th day, hyperuricemia was labeled if serum uric acid levels above 6.5 mg/dl. All the information was noted in proforma and analyzed using SPSS version 21.0. Results: There were 95 male and 50 female patients. The mean age was 49.57 ± 8.53 years, with range 35 (35 - 70) years. The age of 49 (33.8%) patients was ≤45 years and age of 96 (66.2%) patients was &gt;45 years. 17.9% patients were obese and 50.3% patients were hypertensive. The hyperuricemia was present in 27 (18.6%) patients. Among patients who were found with hyperuricemia, the mean age was 49.41 ± 8.34 years. The results showed that significant association of hyperuricemia was observed with obesity. No significant association of hyperuricemia was observed with gender, age, and hypertension. Conclusion: Based on the findings of our study, raised serum uric acid levels are associated with adverse cardiovascular outcome. The prevalence of hyperuricemia is high in a population of patients with acute myocardial infarction.

THE RELATIONSHIP BETWEEN BLOOD LIPID PROFILE AND URICEMIA LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ACCORDING TO GENDER

The purpose of the study was to determine the incidence of hyperuricemia and to analyze the relationship between blood lipid profile and uric acid values in patients with type 2 diabetes mellitus according to gender. 161 patients with type 2 diabetes (67 men and 94 women) who received oral glucose-lowering therapy were examined. In the overall sample, 88 % of men and 95.7 % of women were over 50 years of age. Given the level of uric acid in the blood, patients were divided into groups: 1A (n = 43) — with blood uric acid level within the reference values for men (&lt; 420 мmol/l), 1B (n = 24) — the blood uric acid level was above the upper limit of the reference value for men (&gt; 420 мmol/l), 2A (n = 54) — with blood uric acid level within the reference values for women ( 350 мmol/l). BMI in women was significantly higher than in men (33.83 ± 6.6) and (30.83 ± 4.5) kg/m2 (P = 0.001); IOT/ OS was significantly higher in males ((1.03 ± 0.11) and (0.97 ± 0.10) cu, respectively (P = 0.003). Significantly higher levels of cholesterol were observed in women than in men ((1.17 ± 0.29) and (1.06 ± 0.16) mmol/l, respectively (P = 0.006). Hyperuricemia was diagnosed in 39.8% of patients in the total sample. Comparison of the frequency of hyperuricemia in men and women revealed no significant differences (35.8 and 42.6%, respectively). In normouricemic male patients with type 2 diabetes mellitus, the level of CHD was associated with the age and blood level of uric acid; HDL-cholesterol level — with age, disease duration and blood level of uric acid; TG level — with the level of uric acid in the blood. In normouricemic female patients with type 2 diabetes mellitus, CSF level was associated with HbAc1 level; the level of HDL-cholesterol — with age and BMI; TG level — with the blood level of uric acid. The level of HDL-cholesterol was associated with hyperuricemia in male patients with type 2 diabetes mellitus. The level of CHD, HDL-cholesterol and TG were independently associated with the level of glycemic control of the disease in «hyperuricemic» female patients with type 2 diabetes mellitus.

Frequency of Hyperuricemia and its Risk Factors in the Adult Population.

IntroductionHyperuricemia (HU) does not only predispose to gouty arthritis but also increases the risk of major cardiovascular events and chronic kidney disease and decreases the overall quality of life. Although the incidence of hyperuricemia is increasing in the Asian population, prevalence studies from healthy asymptomatic adults are still scarce. The aim of this study was to determine the frequency of HU in the general population of Karachi, Pakistan.MethodsA cross-sectional study was conducted in various out-patient clinics across Karachi in January 2019. Serum uric acid (SUA) levels were recorded using UASure Blood Uric Acid Monitoring System. Age, gender, body mass index (BMI), the frequency of activity, the frequency of meat consumption, and the presence of hypertension were noted. For hypertensives, the use of thiazide diuretics was noted. Data were entered and analyzed using SPSS v. 22. ResultsThis study was completed by 375 individuals including 208 (55.5%) men and 167 (44.5%) women. Their mean age was 48.78 ± 13.399 years and the mean SUA level was 5.92 ± 1.73 mg/dl. There were 83 (39.9%) men and 30 (17.9%) women with elevated SUA levels. The overall prevalence of HU was 30.1%. Patient characteristics including gender, hypertension, the use of diuretics frequency of meat consumption, sedentary lifestyle, and BMI showed statistical significance with mean SUA levels. Eta-squared indicated a weak effect of SUA with gender, age, and use of thiazide diuretics. A moderate effect was seen with hypertension, the frequency of meat consumption, sedentary lifestyle, and BMI.ConclusionHyperuricemia is a health hazard and its incidence is high in Pakistan. Patients who have risk factors for elevated SUA levels must be monitored for hyperuricemia at regular intervals.

Independent Determinants of Urinary Albumin Excretion and Confounding Variables in Type 2 Diabetic Patient

Background: Microalbuminuria is a known risk factor for the development of clinical nephropathy in diabetes and also an independent risk factor for cardiovascular disease. Microalbuminuria is a marker of a pathophysiological process that causes both increased renal albumin loss and atherothrombosis. Microalbuminuria is hallmark for early detection of diabetic nephropathy. An elevated urinary albumin excretion is a marker of endothelial dysfunction that symbolizes the kidney’s way to translate the existence of vascular damage. The aim of this study was to evaluate the independent determinants of urinary albumin excretion, and association between biochemical parameters and socio-demographic factors in Diabetic patients. Materials and Methods: This is a hospital based cross sectional study included diagnosed case of Diabetic patients. Serum uric acid concentrations were measured by enzymatic method (uricase-peroxidase), HbA1c was measured using the principle of dry chemistry, Blood Sugar measured by Glucose oxidase peroxidase (GOD/POD) method and urinary albumin excretion was measured with an immunoturbidometric assay. Results: Based on categorization of Urinary albumin excretion, 65% normoalbuminuric, 27% microalbuminuric and 8% macroalbuminuric are found in our study population. The frequency of hyperuricemia was found to be 43%. The prevalence of albuminuria ncreased significantly with increasing glycaemia. Pearsons Correlation coefficient by bivariate analysis of Urinary albumin excretion with confounding variables shows significant positive correlation with onset of DM (r=0.203, P=0.013), Systolic Blood Pressure (r=0.355, P=0.001), Diastolic Blood Pressure (r=0.405, P=0.001), Uricacid (r=0.352, P=0.001), HbA1c (r=0.212, P=0.005) and Smoking (r=0.265, P=0.01). Multiple regression test shows that independent determinant of UAE are Blood Pressure {Diastolic (β=0.313, P=0.006) /Systolic (β=0.309, P=0.002)}, HbA1c (β=0.187, P=0.010), Uric acid (β=0.331, P=0.0001) and Onset of DM (β=0.199,P=0.041). Conclusion: Albuminuria is therefore an important risk factor to measure in patients at risk. The findings extend the relationship between confounding variables and the urinary albumin excretion which emphasize on the importance of screening for icroalbuminuria, Serum Uric Acid to prevent renal dysfunction, HbA1c measurement on a regular interval for good glycemic control and the other variables for regular physiological process of body. Further examination is needed in a large population size to clarify the validity between the biochemical parameters

Admission Serum Uric Acid Levels and In-Hospital Outcomes in Patients with Acute Coronary Syndrome

Background: Uric acid is an independent risk factor for cardiovascular disease. Hospital admission for ischemic heart disease (IHD) is increasing rapidly in our country. Although studies were conducted abroad regarding association of serum uric acid with in-hospital outcomes in patients with acute coronary syndrome (ACS), no data is yet available to show the association in our country. Objective: The objective of this study was to assess the association of serum uric acid level on admission with in-hospital outcomes of the patients with ACS. Materials and Methods: This cross sectional comparative study was done in the Department of Cardiology, Dhaka Medical College Hospital (DMCH) from January to December 2012. After proper ethical consideration total 93 ACS patients were enrolled in the study by nonrandom sampling. Serum uric acid of all subjects was measured within 24 hours of admission. Then in-hospital outcomes were observed in all subjects. Results: The frequency of hyperuricemia among ACS patients was 24.7% (22.54% in male and 31.82% in female). Hyperuricemic patients significantly developed heart failure (30.4% vs 11.4%, p=0.032) and conduction defect (13.0% vs 1.4%, p=0.017) than normouricemic subjects. The mean ejection fraction was significantly lower in hyperuricemic patients than patients with normal uric acid level (50.87 ± 10.27% vs 55.94 ± 6.66%). The mean ± SD duration of hospital stay of hyperuricemic group was significantly longer in patients with ACS (8.26 ± 1.18 vs 7.51±1.18 days, p=0.010). Conclusion: The measurement of serum uric acid level, an easily available and inexpensive biochemical tool, might turn out as a valuable risk marker for prediction of in-hospital outcomes in patients with ACS. DOI: http://dx.doi.org/10.3329/jemc.v5i1.21492 J Enam Med Col 2015; 5(1): 15-22

AB0826 Hyperuricemic patients with systemic sclerosis do not present higher incidence of pulmonary hypertension but have worse echocardiographic parameters

BackgroundUric acid (UA) serum levels are increased in conditions that affect the oxidative metabolism. Several studies have demonstrated increased UA levels in patients with pulmonary hypertension (PH) and its relation...