Frequency Of Chronic Complications Research Articles

Frecuencia de complicaciones crónicas en pacientes con diabetes mellitus tipo 2 en un hospital de tercer nivel

Frecuencia de complicaciones crónicas en pacientes con diabetes mellitus tipo 2 en un hospital de tercer nivel

Prévalence des complications chroniques de la drépanocytose au CHU de Bobo-Dioulasso, Burkina Faso

This is a descriptive cross-sectional unicentric study, with a prospective collection of data on the frequency of chronic complications of sickle cell disease in patients monitored at Souro Sanou University Hospital in Bobo-Dioulasso in the department of medicine conducted from April 1, 2017 to July 31, 2018. Patients with confirmed adult sickle cell disease, at least 16 years of age, who had given oral consent, was seen at least twice in the inter-critical period during the study, and who had performed a biological and / or radiological screening for chronic complications. Out of 144 sickle cell patients seen, 79 met our inclusion criteria. The mean age of the patients was 28.8 ± 10.3 years with extremes of 16 and 63 years. Females predominated in 68% of cases (N = 54). Sickle cells were of SC phenotype in 68% of cases, SS in 24%, Sβ + in 5% of cases and Sβ0 in 3% of cases. The overall prevalence of complications was 54% (43/79), 68% (13/19) in SS individuals and 50% in SC individuals (27/54). The observed chronic complications were ocular, bony, renal, cardiac, cutaneous respectively in 19%, 13%, 6.3%, 5% and 4% of cases, biliary and neurological in 3% each, ENT and pulmonary in 1.3% each. The mean age of patients with at least one chronic complication was 30.9 ± 10.4 years; it was 32.1 ± 10.3 years old in the SC and 25.3 ± 7.8 years old in the SS. Complications were unique in 72%, double in 23% and triple in 5%. The prevalence of chronic complications of sickle cell disease is high in patients with major sickle cell syndrome. Systematic screening and evaluation of organ damage are required to interrupt or delay their evolution.

Cohort study of adult patients with haemoglobin SC disease: clinical characteristics and predictors of mortality.

Haemoglobin (Hb) SC disease is the second most common subtype of sickle cell disease and is potentially fatal. This study aimed to determine the clinical characteristics, outcome and predictors of mortality in HbSC disease patients, and to compare these findings with patients followed-up in different centres. Clinical, laboratory and outcome data were collected from a cohort of adult patients with HbSC disease followed between 1991 and 2103. Cox regression multivariate analysis was used to determine predictors of mortality. One hundred and fifty-five patients were followed-up over 20years: 9% died and 70·8% had at least one complication. The most common complications were: painful crises (38·3%), retinopathy (33·8%), cholelithiasis (30·3%), osteonecrosis (24·8%) and sensorineural hearing disorders (9·7%). Frequency of chronic complications was similar in most studies. In multivariate analysis, hearing disorders remained an independent predictor of mortality (Odds Ratio 9·26, 95% confidence interval 1·1-74·8; P=0·03). It was concluded that patients with HbSC disease receive a late diagnosis and there is remarkable similarity between the studies conducted in different centres around the world. Sensorineural hearing disorders were an independent predictor of mortality, suggesting that it may be useful to implement routine diagnostic screening.

Chronic complications of type 1 diabetes mellitus in children

Abstract Objectives: To evaluate the frequency of chronic complications and identify thepredicting factors that may be used for their early detection. Material and Method: The research group included 144 T1DM children with disease duration > 5 years ordisease onset during puberty. Complication screening included: full ophthalmologicexamination, UAE level determination, diabetic neuropathy assessment. Results: Retinopathy prevalence was 12.5 %. Factors associated with retinopathy were:hyperglycemia, duration of diabetes and dyslipidemia. Microalbuminuria wasdetected in 23 patients (15.97%) and correlated with HbA1c or insulin therapyregimen. Diabetic neuropathy prevalence (45.8%) was studied in relation to UAE.Peripheral somatic neuropathy was significantly correlated with the diabeticnephropathy stage. Autonomic neuropathy was detected only in 13.8% patients, yetits prevalence increased with the increase in UAE. Conclusions: Chronic diabeticcomplications are relatively less frequent as compared to adults, yet their evolutionis distinct due to the age-specific characteristics.

Patterns of diabetic complications at jimma university specialized hospital, southwest ethiopia.

Diabetes Mellitus is common metabolic disease worldwide. Its complications in the Ethiopian care setup has not been well documented. The objective of this study was to assess the pattern and distribution of diabetic complications among patients having follow-up at Jimma University specialized Hospital diabetic clinic. A cross sectional study based on record review of 305 patients, selected using systematic sampling with replacement was carried out in October 2008. The data were analyzed using SPSS for Windows version 13.0. Larger proportion, 189 (62.0%), of patients had type II diabetes and 163 (53.4%) of them were diabetic for less than 5 years. Seventy three of the 76 (96.1%) patients with type II diabetes mellitus had hypertension. Acute complications were observed in 93 (30.5%) of the patients of which Diabetic Ketoacidosis was documented in 66(71.0%). Forty eight (45.7%) of patients had proteinuria, 90 (29.5%) had peripheral neuropathy, 13(6.8%) had impotence. Diabetic foot ulcer, skin and/or subcutaneous tissue infection, dental problems and tuberculosis were documented in 14(4.5%), 31(10.0%), 31(10.0%), and 17(5.6%) patients, respectively. Any of the chronic complications were not different by sex of the patient but age had statistically significant association with hypertension, visual disturbance and neuropathy (p< 0.05). Type of diabetes had statistically significant association with all the tested complications except infection (P<0.05) where most of the complications occurred in type II diabetics. Statistically significant association was observed between the duration of the diabetes and impotence and visual disturbances (p < 0.05). The majority of patients were type II diabetics. Acute complications were observed more commonly among type I diabetics and DKA was the commonest acute complication. The frequency of chronic complications was high. Increased occurrence of retinopathy, peripheral neuropathy, hypertension and nephropathy was observed with longer duration of illness. Impotence and diabetic nephropathy were more common in type II diabetics. The study showed that age, sex, type of diabetes mellitus and duration of diabetes were significantly associated with the development of diabetic complications.

Diabetes mellitus: development of technologies in diagnostics, treatment and prevention

Diabetes mellitus is a most serious socio-medical and economic problems facing health authorities throughout the world. A major threat is vascularcomplications of the disease. The currently available diagnostic tools, up-to-date means for monitoring glycemia, introduction of innovative insulinpreparations and hypoglycemic agents, development of high-technology therapeutic modalities may greatly improve disease prognosis, reduce the frequencyof chronic complications, related disablement and mortality rates. The targeted control of major risk factors, viz. hyperglycemia, hypertension,and dyslipidemia, during the patients lifetime starting from the onset of diabetes remains the most promising strategy for the prevention of diabeticcomplications. An indispensable condition for efficacious management of diabetes is the elaboration of active screening programs for the early diagnosisof complications and optimal organization of the clinico-diagnostic process in the framework of multidisciplinary approach.

FREQUENCY OF CHRONIC DIABETES COMPLICATIONS IN CHILDREN AND ADOLESCENTS IN THE SOUTHERN REGION OF UKRAINE ACCORDING TO THE DATA OF THE REGISTER

We investigated frequency of chronic complications, their dependence on the diabetes mellitus duration and the age of children who reside in the southern region of Ukraine according to on the data of the register of children patients with diabetes mellitus. Chronic complications are more frequent when combined with neuropathy, retinopathy, hairopathy. The frequency of chronic complications has a dependence upon diabetes mellitus duration and increase in the HbA1c level. The level HbA1c is higher in more grown children with longer duration of the disease.

Frequency of chronic complications of type II diabetes.

To assess the frequency of chronic complications of type II diabetes in subjects attending a tertiary care unit in Karachi, Pakistan. A cross-sectional analytical study. First visit of all type II diabetic subjects attending the outpatient department of Baqai Institute of Diabetology and Endocrinology from September 1996 to December 2001. Computerized clinical records of 2199 type II diabetic subjects were analyzed for this study. The clinical and laboratory variables were statistically evaluated with significance at p. Means of glycosylated hemoglobin HbA1c, fasting and random plasma glucose levels, systolic blood pressure, triglycerides and high density lipoproteins (HDL) were higher than the risk indicator value for both genders (p <0.005). Mean body mass index and total blood cholesterol was higher for females only. Hyperglycemia was present in 88%, high HbA1c in 81%, low HDL in 81%, obesity in 66% and hypertriglyceridemia in 54%, neuropathy in 36%, proteinuria in 28% and hypertension in 50% of the subjects. Frequency of obesity, low HDL and hypertension was higher among females (p < 0.001 in each case). Retinopathy (p<0.05), nephropathy (p<0.005), neuropathy (p<0.005) and foot ulcers (p<0.001) were higher among males. Frequency of obesity was significantly higher among those with shorter duration and in younger group while frequency of other complications was higher among those with longer duration and in the older groups. Higher rates of complications were observed compared to previous studies. Certain variables showed significant association with gender and age as described above.

Diabetes Mellitus in Saudi Arabia: The Clinical Pattern and Complications in 1,000 Patients

A retrospective and prospective study of 1,000 ambulatory and hospitalized diabetic patients was done in Riyadh, Saudi Arabia. Saudis completed 777 (77.7%) and non-Saudis 223 (22.3%). Sex distribution was equal among Saudis, males 389 (50.1%) and females 388 (49.9%), but non-Saudi males were predominant at 153 (68.6%), non-Saudi females 70 (31.4%) reflecting the preponderant male expatriate labor force. A proportion of different types of diabetes was: IDDM 115 (11.7%), non-obese non-insulin dependent diabetes mellitus (NIDDM) 405 (41.0%), obese NIDDM 412 (42.1%), and early onset non-insulin dependent diabetes (diagnosis under 30 years of age), 43 (4.4%). Regarding treatment, 388 (40.6%) received insulin followed by sulfonylurea, alone in 330 (33.5%), diet only 117 (12.0%), combination sulfonylurea and biguanide in 113 (11.6%), biguanide alone in 13 (1.3%) and insulin plus tablets in 7 (0.8%). Of 472 and 426 patients, 29.7% and 30.0% had elevated total cholesterol or triglycerides respectively, while 77.2% of 373 patients had elevated glycosylated hemoglobin (HbA1). At least once in 998 patients, diabetic ketoacidosis occurred in 7.6%.