The article presents the results of many years of research by the authors on the evolution of theoretical and methodological approaches to substantiate the prerequisites and conditions for the creation of preferential regimes in various countries and regions. Based on a generalization of a large array of information sources, it was concluded that the applied forms of these regimes (free and special economic zones, free ports, territories of rapid socio-economic development, etc.) are components of regional systems in which special conditions for the functioning of entrepreneurial enterprises are legally established. structures to achieve strategic goals of economic growth. The above study notes the negative experience of creating free economic zones in the Russian Federation in the 90s of the last century due to organizational and economic omissions in the ongoing state policy, with an emphasis on the need for a more informed approach to managing the effectiveness of the implementation of such national projects in the current conditions of stagnation of the Russian economy. Paying special attention to the specifics of the stages of development of preferential regimes, the authors of the article propose a systematization of numerous factors influencing their effectiveness based on the characteristics of spatial localization, level of management, and degree of distribution. The theoretical and practical significance is represented by the author's approach to the formation of a system for managing the effectiveness of preferential regimes, starting with its main component — setting goals for their creation, consistent with the strategic goals of the development of regions and the country. Recognizing the existing imperfection of the holistic system for assessing the effectiveness and efficiency of preferential regimes that are in the process of formation in Russia, the authors emphasize the timeliness and importance of developing appropriate methodological tools, especially taking into account modern external challenges.