Rational Framework Research Articles

MO682TAILORING AI-BASED REFERRAL TO INTENSIFIED INTERVENTION PROGRAMS FOR PERITONITIS PREVENTION WITH COST-EFFECTIVENESS SIMULATION

Abstract Background and Aims Peritonitis is a common and potentially severe complication for peritoneal dialysis (PD) patients. It is associated with mortality and technique failure risk and contributes significantly to their healthcare cost. Despite several peritonitis prevention programs based on education and training have been implemented worldwide, it has been reported a large variability of efficacy across patients groups and healthcare settings. In order to avoid unnecessary treatment of low risk patients, healthcare prevention programs should be personalized based on accurate patients’ risk profiling, so that high risk patients may be addressed with intensified prevention programs. However, referral strategy (i.e. defining when risk is too much and deserves special attention) depends the availability, efficacy and cost of medical interventions. In this study, we demonstrate through a program implementation simulator, how different referral strategies to inform peritonitis prevention program among PD patients informed by AI-based risk stratification tools, produce different healthcare and health economics outcomes. In particular, the simulation considers a prevention program characterized by standard of care, which affects all patients as well as an intensive intervention for a subset of high-risk patients (e.g. special training or medical treatment). Method The Peritonitis Risk Score model was trained and validated among 9325 PD patients treated in FMC network (Model accuracy, AUC=0.86). The pharmaco-economic model simulation was performed considering a cohort of 22,900 adult PD patients, treated in Fresenius Medical Care dialysis network between January 1, 2011 and December 31, 2018, for which the Peritonitis Risk Score was computed at a given date. The occurrence of an acute peritonitis in the month after prediction has been registered. We simulated the program outcomes in terms of proportion of referrals to the intensified prevention program, false omission rate, peritonitis risk reduction, overall cost-savings, number needed to treat. We considered the following scenario based on previous cost-effectiveness analysis on peritonitis risk prevention: Results Given the action threshold selected, 5.3% of patients entered the intensified intervention program (PPV=9.5%); the false omission rate was 2.2%. Cost savings for the intensified healthcare where generated when the effect size of the intensified intervention exceeded 1.4 (figure 1A). For that effect size the number needed to treat for each prevented peritonitis was NNT=23.4. Overall, 162 peritonitis/month could be prevented in the whole network (peritonitis with no intervention=592; Peritonitis after intervention=430). When a less conservative threshold was selected, 12.2% of patients entered the intensified prevention program (PPV=7.3%), generating a false omission rate=1.9%. Cost savings were never generated (i.e. the intensified program needed investment to be sustained) but with the same effect size of 1.4 additional 24 peritonitis/months could be saved in the whole network (peritonitis with no intervention=592; Peritonitis after intervention=406). The number needed to treat for the intensified program was NTT=30.4 (figure 1B). Conclusion Cost-effectiveness simulating tool provides a rational evaluation framework for AI-based referral to peritonitis preventive programs. This tool can be easily adapted for any healthcare program based on patient risk score.

A systems engineering perspective on electrochemical energy technologies and a framework for application driven choice of technology

Electrochemical energy, being a safe and clean renewable energy source, is gaining considerable attention in recent years. The electrochemical energy technologies available are numerous and the choice of technology is usually guided by heuristics. The paper presents a critical review and comparison of three competing electrochemical energy technologies (secondary batteries, fuel cells and flow batteries) based on various characterization criteria like energy & power densities, cost, weight, efficiency, controllability, reliability etc. A rational framework is proposed to characterize the technology best suited for a particular application to achieve the best energy utilization. The idea is posed as a constrained multi objective optimization of design, followed by choice based on gravimetric and volumetric cost comparison of the three systems under consideration. For various combinations of characterization criteria, optimal choice of technology for an extensive scope of power and energy is found using the proposed framework and presented as area plots for easy understanding. This framework is then used to examine the prospects and directions of improvement for emerging technologies. Discussions are presented using the example of Vanadium Redox Flow Battery (VRFB).

Sublating Rationality: The Eucharist as an Existential Trial

The Eucharist as a pillar of Christian life and faith stands at the center of the Mass. It carries multi-dimensional meanings and functions, each of which addresses different aspects of the Christian life and mindset. The main question that we will attend to is what happens to the rational framework of the believer or non-believer as s/he affirms or denies that the consecrated bread and wine are Christ’s body and blood. Following Edward Schillebeeckx’s phenomenological approach, it will be argued that such a reformulation of the rational framework accords with Heidegger’s reevaluation of the question of Being. The present reading limits itself to the encounter between the mind and the phenomenon and does not proceed to the meaning of the Eucharist as part of the Mass and the crucifixion of Christ. As such this study is not a historical study nor a sociological or anthropological one.

The hidden impacts of the ICC: An innovative assessment using Google data

AbstractCommentators now regularly declare that the International Criminal court (ICC) – and international criminal law as a whole – is in crisis. It is certainly the case that the ICC faces a number of operational challenges, and that these challenges worry its defenders. However, one unexamined rationalist assumption is that the Court’s inability to deliver consistent outputs will mean waning influence. This article explores an alternative constructivist theory that the ICC produces diffuse social impacts that are not necessarily tied to its operating effectively. This theory is tested statistically using Google Trends data. Specifically, the article examines whether ICC intervention in a country is associated with more internet search for ‘human rights’. Taking this to be a measure of changing discourse in countries, the article finds that some types of ICC involvement are associated with a far higher interest in human rights, and that this interest only increases as ICC involvement extends in time. In short, despite its disappointments, evidence suggests that the ICC still serves a socio-pedagogical function. Though it does not fit well within a rational evaluation framework, this kind of information should be considered in ICC performance reviews.

Defining the Landscape of the Pauling-Corey Rippled Sheet: An Orphaned Motif Finding New Homes.

ConspectusWhen peptides are mixed with their mirror images in an equimolar ratio, two-dimensional periodic structural folds can form, in which extended peptide strands are arrayed with alternating chirality. The resultant topography class, termed the rippled β-sheet, was introduced as a theoretical concept by Pauling and Corey in 1953. Unlike other fundamental protein structural motifs identified around that time, including the α-helix and the pleated β-sheet, it took several decades before conclusive experimental data supporting the proposed rippled β-sheet motif were gained. Much of the key experimental evidence was provided over the course of the past decade through the concurrent efforts of our three laboratories. Studies that focused on developing new self-assembling hydrogel materials have shown that certain amphiphilic peptides form fibrils and hydrogel networks that are more rigid and have a higher thermodynamic stability when made from racemic peptide mixtures as opposed to pure enantiomers. Related interrogation of assemblies composed of mixtures of l- and d-amphiphilic peptides confirmed that the resulting fibrils were composed of alternating l/d peptides consistent with rippled β-sheets. It was also demonstrated that mirror-image amyloid beta (Aβ) could act as a molecular chaperone to promote oligomer-to-fibril conversion of the natural Aβ enantiomer, which was found to reduce Aβ neurotoxicity against different neuronal cell models. With a cross-disciplinary approach that combines experiment and theory, our three laboratories have demonstrated the unique biophysical, biochemical, and biological properties that arise upon mixing of peptide enantiomers, in consequence of rippled β-sheet formation. In this Account, we give an overview of the early history of the rippled β-sheet and provide a detailed structural description/definition of this motif relative to the pleated β-sheet. We then summarize the key findings, obtained on three unique sets of aggregating mirror-image peptide pairs through independent efforts of our three laboratories, and use these results to delineate the landscape of the rippled β-sheet structural motif to inspire future studies. Peptide sequence parameters that favor rippled β-sheet assembly are described, along with the accompanying kinetic and thermodynamic properties, as well as the resulting emergent physical properties of the assemblies. The Account then concludes with a brief overview of some key unresolved challenges in this nascent field. There is much potential for future applications of this unique supramolecular motif in the realm of materials design and biomedical research. We hope this Account will stimulate much-needed discussion of this fascinating structural class to eventually produce a fully quantitative, rational framework for the molecular engineering of rippled β-sheets in the future.

Ground surface rock buckling: analysis of collected cases and failure mechanisms

The potential for spontaneous failure of quarry pit floors by various buckling modes has increasingly become a concern because of the potential impacts on safety, the environment, and mining operations. The most notable and concerning form of buckling failure is referred to as a “pop up” which is a nearly-instantaneous and violent event similar to a rock burst. A means to evaluate potential risk from this hazard within a rational engineering framework is required to aid with licensing and operations decisions. A first step in understanding the likelihood of buckling event occurrence under various conditions is the review of a thorough compilation of past observed in situ events. The objective of this study is the development of a database of observed cases to provide insight into the various buckling failure modes and associated geotechnical conditions. Although available documented historic case study details vary significantly, the collected data, as a whole, is of value. All available, information on the geological environment, rock type, mechanical properties, in situ stresses, and buckle dimensions are documented within the database. The database has been analyzed and revealed trends relating buckling orientation and in situ stress orientation/magnitude. In addition, the database has been used to develop a categorization of the main buckling-related failure modes which is presented along with a summary of their associated typical analysis methods.

Temel Olumsuz Duygular Kişilerin Siyasi Karar Sürecini Nasil Etkiliyor? : "Korku, Kaygi Ve Öfke

In the post-modern era, the mobilization of previously large masses has been replaced by micro-groups dominated by new and distinct identities. As a result, the analysis and predictability of electorate behavior have decreased. The political decision-making processes of individuals have therefore been subjected to detailed analyzes. Emotions have become a significant subject of political psychology in terms of their effects on the political decision-making process of individuals. Emotions have also become an important topic in political psychology. Researches revealed that emotions have important effects on thoughts and decision-making processes. In this context, the article primarily aims to draw a rational framework on this subject by including modern “emotion” definitions and the impacts of people’s emotions on political decisions. Afterward, the article investigated the effect of negative emotions on political decision-making. In this context, anxiety, fear and anger are emphasized by using a descriptive approach. The article argues that negative emotions that are anxiety, fear, and anger, in particular, have positive contributions to the political decision-making process of individuals.

Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin

Encapsulins containing dye-decolorizing peroxidase (DyP)-type peroxidases are ubiquitous among prokaryotes, protecting cells against oxidative stress. However, little is known about how they interact and function. Here, we have isolated a native cargo-packaging encapsulin from Mycobacterium smegmatis and determined its complete high-resolution structure by cryogenic electron microscopy (cryo-EM). This encapsulin comprises an icosahedral shell and a dodecameric DyP cargo. The dodecameric DyP consists of two hexamers with a twofold axis of symmetry and stretches across the interior of the encapsulin. Our results reveal that the encapsulin shell plays a role in stabilizing the dodecameric DyP. Furthermore, we have proposed a potential mechanism for removing the hydrogen peroxide based on the structural features. Our study also suggests that the DyP is the primary cargo protein of mycobacterial encapsulins and is a potential target for antituberculosis drug discovery.

Creating collaboration for contentious projects on managed aquifer recharge: two cases from Finland

In Finland, community water supply has increasingly relied on natural groundwater and artificially recharged groundwater as the raw water source. Several managed aquifer recharge (MAR) projects have been co-created with involved parties and have proceeded well, while some cases have raised considerable resistance among the stakeholders. It seems that success or failure in MAR cooperation is related to management cultures and the ways in which various interests are taken into account, from the very beginning and throughout the process. Empirically, this paper builds on comparison between two conflictual case studies in Finland: one in the Tampere region and the other in the Turku region. The study analyses the major constraints of these projects through the lens of collaborative rationality, also drawing upon discourse analysis and negotiation theory. The material is gathered through thematic interviews of stakeholders, newspaper articles and a stakeholder workshop. The results indicate that conventional management approaches, drawing from expert-based instrumental rationality, were insufficient in both cases. The collaborative rationality framework suggests that legitimacy for the groundwater projects should be gained through joint knowledge production and inclusive multiparty interaction for creating options for collaboration. Both cases lacked the tools and know-how for authentic dialogue and collaboration. The emerging paradigm emphasizes more collaborative approaches for natural resources management and urban planning. While MAR projects operate inside these areas and are highly complex in nature, it is essential to embrace the emerging paradigm in order to promote MAR systems along with their huge potential.

Rational inattention and tonic dopamine.

Slow-timescale (tonic) changes in dopamine (DA) contribute to a wide variety of processes in reinforcement learning, interval timing, and other domains. Furthermore, changes in tonic DA exert distinct effects depending on when they occur (e.g., during learning vs. performance) and what task the subject is performing (e.g., operant vs. classical conditioning). Two influential theories of tonic DA—the average reward theory and the Bayesian theory in which DA controls precision—have each been successful at explaining a subset of empirical findings. But how the same DA signal performs two seemingly distinct functions without creating crosstalk is not well understood. Here we reconcile the two theories under the unifying framework of ‘rational inattention,’ which (1) conceptually links average reward and precision, (2) outlines how DA manipulations affect this relationship, and in so doing, (3) captures new empirical phenomena. In brief, rational inattention asserts that agents can increase their precision in a task (and thus improve their performance) by paying a cognitive cost. Crucially, whether this cost is worth paying depends on average reward availability, reported by DA. The monotonic relationship between average reward and precision means that the DA signal contains the information necessary to retrieve the precision. When this information is needed after the task is performed, as presumed by Bayesian inference, acute manipulations of DA will bias behavior in predictable ways. We show how this framework reconciles a remarkably large collection of experimental findings. In reinforcement learning, the rational inattention framework predicts that learning from positive and negative feedback should be enhanced in high and low DA states, respectively, and that DA should tip the exploration-exploitation balance toward exploitation. In interval timing, this framework predicts that DA should increase the speed of the internal clock and decrease the extent of interference by other temporal stimuli during temporal reproduction (the central tendency effect). Finally, rational inattention makes the new predictions that these effects should be critically dependent on the controllability of rewards, that post-reward delays in intertemporal choice tasks should be underestimated, and that average reward manipulations should affect the speed of the clock—thus capturing empirical findings that are unexplained by either theory alone. Our results suggest that a common computational repertoire may underlie the seemingly heterogeneous roles of DA.

On the objectivity of the nonlinear along-fibre shear stress\u2013strain relationship for unidirectionally fibre-reinforced composites

The nonlinear along-fibre shear stress–strain relationship for unidirectionally fibre-reinforced composites has been investigated in this paper aiming at its applications in general 3D stress conditions in a consistent manner. So far, such relationship has only been addressed in plane stress conditions. In this paper, it has been shown that its straightforward generalisation to 3D stress states lacks objectivity, which is a basic requirement for all theoretical studies of physical problems. A new formulation is proposed based on the stress invariants and the complementary strain energy guided by the rational theoretical framework of nonlinear elasticity. A consistent and objective stress–strain relationship has been obtained and verified through an example of application to a torsion problem.

Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody

Vaccine-based elicitation of broadly neutralizing antibodies holds great promise for preventing HIV-1 transmission. However, the key biophysical markers of improved antibody recognition remain uncertain in the diverse landscape of potential antibody mutation pathways, and a more complete understanding of anti-HIV-1 fusion peptide (FP) antibody development will accelerate rational vaccine designs. Here we survey the mutational landscape of the vaccine-elicited anti-FP antibody, vFP16.02, to determine the genetic, structural, and functional features associated with antibody improvement or fitness. Using site-saturation mutagenesis and yeast display functional screening, we found that 1% of possible single mutations improved HIV-1 envelope trimer (Env) affinity, but generally comprised rare somatic hypermutations that may not arise frequently in vivo. We observed that many single mutations in the vFP16.02 Fab could enhance affinity >1,000-fold against soluble FP, although affinity improvements against the HIV-1 trimer were more measured and rare. The most potent variants enhanced affinity to both soluble FP and Env, had mutations concentrated in antibody framework regions, and achieved up to 37% neutralization breadth compared to 28% neutralization of the template antibody. Altered heavy- and light-chain interface angles and conformational dynamics, as well as reduced Fab thermal stability, were associated with improved HIV-1 neutralization breadth and potency. We also observed parallel sets of mutations that enhanced viral neutralization through similar structural mechanisms. These data provide a quantitative understanding of the mutational landscape for vaccine-elicited FP-directed broadly neutralizing antibody and demonstrate that numerous antigen-distal framework mutations can improve antibody function by enhancing affinity simultaneously toward HIV-1 Env and FP.

Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome

To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. To define the mechanistic basis of clonal hematopoiesis in SDS, we investigate somatic mutations acquired by patients with SDS followed longitudinally. Here we report that multiple independent somatic hematopoietic clones arise early in life, most commonly harboring heterozygous mutations in EIF6 or TP53. We show that germline SBDS deficiency establishes a fitness constraint that drives selection of somatic clones via two distinct mechanisms with different clinical consequences. EIF6 inactivation mediates a compensatory pathway with limited leukemic potential by ameliorating the underlying SDS ribosome defect and enhancing clone fitness. TP53 mutations define a maladaptive pathway with enhanced leukemic potential by inactivating tumor suppressor checkpoints without correcting the ribosome defect. Subsequent development of leukemia was associated with acquisition of biallelic TP53 alterations. These results mechanistically link leukemia predisposition to germline genetic constraints on cellular fitness, and provide a rational framework for clinical surveillance strategies.

The case for research on the marketing–finance interface: A commentary

The aim of this article is to comment on the proposals set out by Hanssens in his article ‘The case for research on the marketing–finance interface’. For each insight, we present the main aspects of finance theory and discuss the scope as well as the possible research avenues. We think it would be interesting to conduct research on the investor figure. Indeed, although marketing easily considers the consumer as an actor subject to biases, and who acts within the framework of a limited rationality, finance still struggles to define the investor as an economic actor subject to individual and collective biases.

Catcher in the lie: resisting bovine ordure in social epistemology

ABSTRACT This paper takes Lee McIntyre’s argument for post-truth and uses it to explain the contemporary rise of bad faith and bullshitting social actors. The paper then posits the critical realist metatheoretical framework of ontological realism, epistemic relativity, and judgemental rationality as a means of understanding the societal placement and the operation of bullshit and bad faith. Utilizing the CR concept of alethic truth (i.e. the correspondence of statements to reality) enables epistemologies to be judged on a standard of truth separate from the epistemology itself. Using this separation of truth from truth seeking techniques, the social processes inherent in epistemic communities and their translation into social epistemology are then examined in order put bullshit in its social place. The conclusion then discusses some suggested actions to begin to bolster epistemic communities and their associated institutional forms, as well as supporting the production and use of individuals’ judgmental rationality.

The quality premium with leverage and liquidity constraints

This research analyzes the causes of the quality premium, one of the most intriguing and successful investment strategies in equity markets. While previous research has argued that psychological biases explain the performance of the quality minus junk factor, our paper analyzes a leverage constraint explanation within a rational risk-based framework. The quality factor is multidimensional in nature, which suggests that a combination of risk, frictions, and behavioral biases is a reasonable explanation. Once we incorporate margin requirements and liquidity restrictions, we find that tighter conditions result in a higher intercept and a lower slope for the empirically implemented capital asset pricing model when using 10 quality-sorted portfolios. Our paper shows that, indeed, not only behavioral biases explain quality, but also market frictions account for its performance.

Do central banks respond to exchange rate movements? A Markov-switching structural investigation of commodity exporters and importers

We analyse whether central banks in small open commodity exporting and importing countries respond to exchange rate movements, taking into consideration that there may be structural changes in parameters and volatility. Using a Markov Switching Rational Expectations framework, we estimate the model for Australia, Canada, New Zealand, Norway, Sweden and the UK. We find that the size of policy responses, and the volatility of structural shocks, have not stayed constant over the estimation sample. Furthermore, monetary policy has responded strongly to the exchange rate for many commodity exporters, most notablyNorway. This has had a stabilizing effect on the exchange rate. In particular, although the terms of trade are highly volatile among commodity exporters, the exchange rate has about the same volatility across all importers and exporters in the recent period. • Analyse if central banks in commodity exporters and importers respond to the exchange rate, allowing for time-varying policy rule and shocks. • Find strong evidence that neither policy responses nor the volatility of structural shocks have remained constant. • Central banks in three commodity exporting countries, Canada, New Zealand and Norway, respond strongly to the exchange rate in periods. • For Norway, the central bank also responds strongly to the exchange rate after adopting inflation targeting. • Policy rules with a high response to the exchange rate exacerbate the effects of external shocks on the domestic variables in advanced economies.

Analysis of fertilizer-use optimization under the joint framework of economic rationality and environmental sustainability: Evidence from wheat farmers in Handan, Hebei rovince

Analysis of fertilizer-use optimization under the joint framework of economic rationality and environmental sustainability: Evidence from wheat farmers in Handan, Hebei rovince

Digitalization in the system of methods of scientific knowledge

The study aims to clarify the methodological status of digitalization in the framework of the philosophical theory of knowledge. The subject of the study: explication of the instrumental and methodological nature of digitalization. The problem is solved by employing the categorical and conceptual apparatus of philosophy of science, particularly in paradigm analysis. A comparative analysis of the concepts of “information” and “digitalization” is carried out. Information within the framework of classical scientific rationality coincides with the phenomenon of absolute-relative knowledge. In non-classical rationality, it represents a movement of meaning and expresses the value-valued nature of information technology. In postnonclassical science, the phenomenon of information is associated with intrasystemic communications. Digitalization as a mode of data transmission is incorporated into the deductive and inductive logic of classical science and leads to an essential limitation of the source base. In modern science, data selection entails the creation of systematic factual meaning, and digitalization coincides with analytical activity. In addition to general logical functions, digitalization points to new perspectives on such types of systems methodology as modeling and design. In relation to the information as a methodology, digitalization acts as a meta-methodology. That is, the digital world is defined as an observing reality. In the framework of digitalization, information is identical to knowledge in its postnonclassical meaning. In digitalization, the process of cognition is incorporated into reality itself, forming an intersubjective field of meaning. In this context, digitalization serves as an inter-paradigmatic method of scientific knowledge. Digitalization refers to the rational side of cognition and is a type of systematic methodology and general logical methods.

О ВОЗМОЖНОСТИ ЭФФЕКТИВНОГО ОТВЕТА НА ИНДУСТРИАЛЬНЫЙ ВЫЗОВ В КОНТЕКСТЕ ВЗАИМОДЕЙСТВИЯ ЧЕЛОВЕКА И ПРИРОДЫ

. The report shows that natural rent-generating factors with significant transaction costs are suppressed by institutional and spatially related factors. The law of spatial inequality of opportunities and prospects for the development of territories is formulated. The law leads to cognitive dissonance (in the methodology of measuring economic and natural capital) and decupling (in the practice of interaction between the center and the periphery). In order to start moving towards a real resolution of the contradiction between economy and nature, it is necessary to revise the approach within the framework of a new rationality, when the focus is not on production structures, but on the reproductive territorial structures of social relations (considered in the key of geosystems in the context of understanding the co-evolution of social systems and ecosystems). The study emphasizes the need to take into account the institutional matrix, the balance of extractive and inclusive institutions and other spatially related factors within the framework of the center-periphery interaction model.