Urban area regeneration is a matter of every municipality over time. Regeneration projects are usually cost-intensive and directly affect many vulnerable members of society. Public-private-people partnership (PPPP) is one of the adopted methods by various municipalities in these projects. Multiple players with different backgrounds and uncertainties involved complicate the development process of PPPP projects. A carefully designed framework is required to successfully deliver these projects. This research develops a holistic PPPP framework for the old urban neighborhood regeneration projects in Iran. The collective experience of urban area regeneration projects from the literature and field experts is employed in the proposed framework. The framework outlines the requirements of the feasibility study that the government needs to perform in the initial stages of the projects. Three standard form contracts designed in the framework adjust the stakeholders' relations over the project’s life cycle. The field experts verified the capabilities of the framework and found it beneficial for future urban regeneration projects in the country. Although the identified issues are addressed in the proposed framework, prospective implementations of the framework need to be closely viewed to identify possible points of improvement.