Common subspace learning methods only utilize local or global structure in feature extraction, and cannot obtain the global optimal discriminative projection matrix. For this reason, this paper proposes a discriminative sparse subspace learning method based on the manifold regularization framework (DSSL-MR), which introduces the graph Laplacian matrix that reflects the intrinsic geometric structure of the sample as a penalty term. DSSL-MR simultaneously uses both sub-manifold and multi-manifold information of samples for obtaining optimal projection to enhance the discriminability of different classes in subspace. DSSL-MR uses the sparse property of the L2,1-norm to constrain the projection matrix, which can eliminate redundant features and select features that are significant for classification. It is a linear supervised method, which belongs to the Fisher discriminant analysis framework. Experimental results on multiple real-world datasets show that the algorithm is very effective in classification and has high recognition rates.