Accurate prediction of multi-label protein subcellular localization through multi-view feature learning with RBRL classifier.

Abstract

Multi-label proteins can participate in carrier transportation, enzyme catalysis, hormone regulation and other life activities. Meanwhile, they play a key role in the fields of biopharmaceuticals, gene and cell therapy. This article proposes a prediction method called Mps-mvRBRL to predict the subcellular localization (SCL) of multi-label protein. Firstly, pseudo position-specific scoring matrix, dipeptide composition, position specific scoring matrix-transition probability composition, gene ontology and pseudo amino acid composition algorithms are used to obtain numerical information from different views. Based on the contribution of five individual feature extraction methods, differential evolution is used for the first time to learn the weight of single feature, and then these original features use a weighted combination method to fuse multi-view information. Secondly, the fused high-dimensional features use a weighted linear discriminant analysis framework based on binary weight form to eliminate irrelevant information. Finally, the best feature vector is input into the joint ranking support vector machine and binary relevance with robust low-rank learning classifier to predict the SCL. After applying leave-one-out cross-validation, the overall actual accuracy (OAA) and overall location accuracy (OLA) of Mps-mvRBRL on the training set of Gram-positive bacteria are both 99.81%. The OAA on the test sets of plant, virus and Gram-negative bacteria datasets are 97.24%, 98.55% and 98.20%, respectively, and the OLA are 97.16%, 97.62% and 98.28%, respectively. The results show that the model achieves good prediction performance for predicting the SCL of multi-label protein.