With the development of economy and society, urban construction rose to a new level in China. High-rise and super high-rise building increase rapidly. In the high-rise and super high-rise buildings (H≥150 m), the structural system usually adopts the conventional reinforced concrete, including frame tube structure, tube in tube structure, steel frame with reinforced concrete core tube hybrid structure and tube in tube steel - concrete mixed structure. These traditional structural systems often lead to the problems of fat beam fat column and high expenditure, which is not economic and unfriendly to the environment. This paper not only presents a new type of concrete core wall and prefabricated space steel grid cassette tube in tube structure system, but also discusses the superiority of the new type structure through the innovation and practice of a super high (266 m) five-star hotel and office building integrated engineering construction.