Deformation monitoring data provide a direct representation of the structural behavior of reservoir bank rock slopes, and accurate deformation prediction is pivotal for slope safety monitoring and disaster warning. Among various deformation prediction models, hybrid models that integrate field monitoring data and numerical simulations stand out due to their well-defined physical and mechanical concepts, and their ability to make effective predictions with limited monitoring data. The predictive accuracy of hybrid models is closely tied to the precise determination of rock mass mechanical parameters in structural numerical simulations. However, rock masses in rock slopes are characterized by intersecting geological structural planes, resulting in reduced strength and the creation of multiple fracture flow channels. These factors contribute to the heterogeneous, anisotropic, and size-dependent properties of the macroscopic deformation parameters of the rock mass, influenced by the coupling of seepage and stress. To improve the predictive accuracy of the hybrid model, this study introduces the theory of equivalent continuous media. It proposes a method for determining the equivalent deformation parameters of fractured rock mass considering the coupling of seepage and stress. This method, based on a discrete fracture network (DFN) model, is integrated into the hybrid prediction model for rock slope deformation. Engineering case studies demonstrate that this approach achieves a high level of prediction accuracy and holds significant practical value.