This paper introduces a novel Riemann–Liouville (RL) conformable fractional derivative based Adaptable-Shifted-Fractional-Rectified-Linear-Unit, briefly called RLASFReLU, and evaluates its efficacy in enhancing the performance of convolutional neural network (CNN) models for pneumonia and skin cancer detection. The study conducts a comprehensive comparative analysis against traditional activation functions and state-of-the-art CNN architectures. The results show that RLASFReLU consistently outperforms other functions, achieving higher accuracy. Comparative evaluations with various neural network architectures reveal that the model equipped with RLASFReLU exhibits superior performance despite its simplicity and fewer trainable parameters, highlighting its efficiency and effectiveness. The findings suggest that RLASFReLU holds promise in improving diagnostic accuracy and efficiency in medical imaging applications, contributing to advancements in healthcare technology and facilitating better patient care. The proposed fractional nonlinear transformation can offer high performance with reduced computational cost, making it practical for deployment in healthcare settings.
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