Fractional CO2 Research Articles

Thermodynamic Model of the Fluid System H2O–CO2–NaCl–CaCl2 at P-T Parameters of the Middle and Lower Crust

Based on the earlier obtained equations of state for the ternary systems H2O–CO2–CaCl2 and H2O–CO2–NaCl, an equation of state for the four-component fluid system H2O–CO2–NaCl–CaCl2 is derived in terms of the Gibbs excess free energy. A corresponding numerical thermodynamic model is built. The main part of the numerical parameters of the model coincides with the corresponding parameters of the ternary systems. The NaCl–CaCl2 interaction parameter was obtained from the experimental liquidus of the salt mixture. Similar to the thermodynamic models for H2O–CO2–CaCl2 and H2O–CO2–NaCl, the range of applicability of the model is pressure 1–20 kbar and temperature from 500 to 1400°C. The model makes it possible to predict the physicochemical properties of the fluid involved in most processes of deep petrogenesis: the phase state of the system (homogeneous or multiphase fluid, presence or absence of solid salts), chemical activities of the components, densities of the fluid phases, and concentrations of the components in the coexisting phases. The model was used for a detailed study of the phase state and activity of water on the H2O–CO2–salt sections when changing the ratio {{{{x}_{{{text{NaCl}}}}}} mathord{left/ {vphantom {{{{x}_{{{text{NaCl}}}}}} {({{x}_{{{text{NaCl}}}}} + {{x}_{{{text{CaC}}{{{text{l}}}_{{text{2}}}}}}})}}} right. kern-0em} {({{x}_{{{text{NaCl}}}}} + {{x}_{{{text{CaC}}{{{text{l}}}_{{text{2}}}}}}})}} from 1 to 0. Changes in the composition and density of coexisting fluid phases at a constant activity of water and changes in the total composition of the system are studied. A set of phase diagrams on sections H2O–NaCl–CaCl2 for different mole fractions of CO2 is obtained. Pressure dependencies of the maximal activity of water in the field of coexisting unmixable fluid phases are obtained for several salt compositions of the system. Due to removal of restrictions resulting from a smaller number of components in ternary systems, the thermodynamic behavior of systems with a mixed composition of the salt significantly differs from the behavior of those with a single salt component.

Investigation of the “Surgical Cuts CO2 Laser Therapy Technique” to Treat Minor Burn Scar Contractures in Children

Fractional carbon dioxide (CO2) laser therapy has been shown to improve scar contractures following burns. However, the benefits of using other CO2 laser techniques to treat burn scar contractures are relatively unknown. This pilot study investigated a CO2 laser technique in which a series of perpendicular “surgical cuts” were created along the contracture. The aim of this study was to evaluate the effectiveness of using the “surgical cuts CO2 laser technique” in pediatric patients. This study included 12 participants with minor hand burn scar contractures that received one CO2 laser treatment using the surgical cuts technique. Trained assessors measured contractures pre- and post-laser therapy by assessing range of motion (ROM), digit length, and/or hand-span. All contractures were secondary to contact burns with the mean participant age equal to 5.5 years (SD 3.9). For all participants, at least one of the measured characteristics (ROM, hand-span, and digit length) improved after treatment. This pilot study demonstrated the benefit of using the surgical cuts CO2 laser technique to treat minor burn scar contractures. Future investigations are needed to further evaluate its effectiveness in comparison to the fractional CO2 laser therapy technique.

Data repeatability for the Cosmed K4 b2 portable metabolic cart during non-steady state exercise

BACKGROUND: Portable metabolic carts are a popular tool to assess aerobic capacity and affirm many cardiorespiratory conditions. They may also measure strength training performance. Given their popularity and increased usage to assess strength training performance; their data accuracy and consistency are important to determine. OBJECTIVE: Measure Cosmed K4 b2 portable metabolic cart data repeatability from consecutive seated calf press workouts. METHODS: Fifteen women and twelve men did two workouts that began with a stationary cycling warm-up followed by calf presses. Gases were measured before the calf press portion of workouts to establish baseline VO2 and VCO2 values, as well as continually throughout and after the calf press protocol. Subjects were detached from the cart once gas values returned to baseline after workouts concluded. In addition to VO2 and VCO2, repeatability was quantified for: breaths per minute, tidal volume, ventilation, O2 uptake relative to body mass, expired O2 and CO2 fractions, percent fat and carbohydrate utilization, METS and total energy cost. Mean and peak values per variable were analyzed. Repeatability was assessed separately for male and female data, as well as with values pooled, by the following: intraclass correlation coefficients, eta squared, limits of agreement, coefficient of variation and smallest real difference percent. RESULTS: Per variable, repeatability values across workouts were low. Female intraclass correlation coefficient mean values were more repeatable for variables related to gas measurements, yet male data were generally more repeatable for those related to substrate usage. CONCLUSIONS: Results for some repeatability indices were influenced by measurement magnitude. Peak values were predictably less repeatable than those for mean values. Most smallest real differences percent scores are so high they were rendered irrelevant or meaningless to determine true differences among paired values. Results suggest low data repeatability that are likely appropriate and realistic for the exercise protocol, hardware and intensity examined.

The Influence of pH and Electrolyte Concentration on Fractional Protonation and CO2 Reduction Activity in Polymer-Encapsulated Cobalt Phthalocyanine

The Influence of pH and Electrolyte Concentration on Fractional Protonation and CO₂ Reduction Activity in Polymer-Encapsulated Cobalt Phthalocyanine

Efficacy and safety of microneedling, fractional CO2 laser, and cryotherapy combined with 5-aminolevulinic acid photodynamic therapy in the treatment of actinic keratosis: A multicenter prospective randomized controlled study

BackgroundPhotodynamic therapy (PDT) for actinic keratosis (AK) is limited by the depth of treatment. Microneedling or fractional CO2 laser can facilitate the penetration of photosensitizer, while cryotherapy can treat deeper tissues but is not suitable for field cancerization. ObjectiveTo investigate the efficacy of microneedling, fractional CO2 laser, and cryotherapy in combination with PDT for AK. MethodsPatients with AK were randomized into 4 groups, including group A with microneedling + PDT, group B with fractional CO2 laser + PDT, group C with cryotherapy + PDT, and group D with PDT. After 12 weeks, the clinical, dermoscopic, and reflectance confocal microscopy (RCM) outcomes were assessed. ResultsA total of 129 patients were included in this study, with 31, 30, 35, and 31 patients in each group, yielding clinical response rates of 90.3%, 93.3%, 97.1%, and 74.2%, respectively (P=0.026). The RCM response rates were 71.0%, 80.0%, 85.7%, and 54.8%, respectively (P=0.030). The dermoscopic response rates were 77.4%, 83.3%, 88.6%, and 60.0%, respectively (P=0.039). Group C showed the best efficacy in terms of clinical, dermoscopic, and RCM outcomes. ConclusionsAll three treatments improved the efficacy of PDT and were well tolerated, with cryotherapy + PDT showing the best efficacy.

Safety and efficacy of human platelet extract in skin recovery after fractional CO2 laser resurfacing of the face: A randomized, controlled, evaluator-blinded pilot study.

Fractional carbon dioxide (CO2 ) laser resurfacing is used successfully for facial rejuvenation. Post procedure skincare is a variable that influences downtime caused by pain/tenderness, erythema, crusting, and bruising. The primary objective of this pilot study was to demonstrate the benefits of human platelet extract (HPE) (plated)™ CALM Serum, a new topical cosmetic product, following fractionated CO2 ablative laser resurfacing treatment to the entire face versus standard of care. In a single-center, randomized, evaluator-blinded pilot study, a total of 18 subjects were randomized into two groups, CO2 facial resurfacing followed by post-procedural standard of care (Stratacel silicone gel) or CO2 facial resurfacing with the addition of HPE renewosomes in the CALM Serum. CALM Serum demonstrated statistically significant less crusting at Day 10 compared to the control group (p = 0.0193) with less downtime in the first 14 days (p = 0.03). Subjects treated with CALM Serum had statistically significant brighter appearing skin at 14 days (p = 0.007) and more youthful looking skin on Days 14 and 30 (p = 0.003 and 0.04, respectively). This study demonstrates that Renewosome™ technology provides statistically significant post-laser clinical recovery over silicone gel for reducing crusting, and downtime. Subjects reported less diary days of symptoms of pain/tenderness, redness, crusting/flaking, bruising, and itching in the first 14 days compared to the control group. CALM also demonstrated statistically significant improvements in brighter and more youthful appearing skin. CALM is safe and well tolerated.

A decrease in plant gain, namely CO2 stores, characterizes dysfunctional breathing whatever its subtype in children.

Background: Whether dysfunctional breathing (DB) subtype classification is useful remains undetermined. The hyperventilation provocation test (HVPT) is used to diagnose DB. This test begins with a 3-min phase of hyperventilation during which fractional end-tidal CO2 (FETCO2) decreases that could be an assessment of plant gain, which relies on CO2 stores. Our aim was to assess 1) whether the children suffering from different subtypes of DB exhibit decreased plant gain and 2) the relationships between HVPT characteristics and plant gain. Methods: We retrospectively selected 48 children (median age 13.5years, 36 females, 12 males) who exhibited during a cardiopulmonary exercise test either alveolar hyperventilation (transcutaneous PCO2 < 30mmHg, n = 6) or inappropriate hyperventilation (increased VE'/V'CO2 slope) without hypocapnia (n = 18) or dyspnea without hyperventilation (n = 18) compared to children exhibiting physiological breathlessness (dyspnea for sports only, n = 6). These children underwent tidal-breathing recording (ventilation and FETCO2 allowing the calculation of plant gain) and a HVPT. Results: The plant gain was significantly higher in the physiological group as compared to the dyspnea without hyperventilation group, p = 0.024 and hyperventilation without hypocapnia group, p = 0.008 (trend for the hyperventilation with hypocapnia group, p = 0.078). The slope of linear decrease in FETCO2 during hyperventilation was significantly more negative in physiological breathlessness group as compared to hyperventilation without hypocapnia group (p = 0.005) and dyspnea without hyperventilation group (p = 0.049). Conclusion: The children with DB, regardless of their subtype, deplete their CO2 stores (decreased plant gain), which may be due to intermittent alveolar hyperventilation, suggesting the futility of our subtype classification.

Thermodynamic Model of the Fluid System H&lt;sub&gt;2&lt;/sub&gt;O–CO&lt;sub&gt;2&lt;/sub&gt;–NaCl–CaCl&lt;sub&gt;2&lt;/sub&gt; at &lt;i&gt;P-T&lt;/i&gt; Parameters of the Middle and Lower Crust

Based on the earlier obtained equations of state for the ternary systems H2O–CO2–CaCl2 and H2O–CO2–NaCl, an equation of state for the four-component fluid system H2O–CO2–NaCl–CaCl2 is derived in terms of the Gibbs excess free energy. A corresponding numerical thermodynamic model is build. The main part of the numerical parameters of the model coincides with the corresponding parameters of the ternary systems. The NaCl–CaCl2 interaction parameter was obtained from the experimental liquidus of the salt mixture. Similar to the thermodynamic models for H2O–CO2–CaCl2 and H2O–CO2–NaCl, the range of applicability of the model is pressure 1–20 kbar and temperature from 500°C to 1400°C. The model makes it possible to predict the physicochemical properties of the fluid involved in most processes of deep petrogenesis: the phase state of the system (homogeneous or multiphase fluid, presence or absence of solid salts), chemical activities of the components, densities of the fluid phases, and concentrations of the components in the coexisting phases. The model was used for a detailed study of the phase state and activity of water on the H2O–CO2–salt sections when changing the ratio \( {{{{x}_{{{\text{NaCl}}}}}} \mathord{\left/ {\vphantom {{{{x}_{{{\text{NaCl}}}}}} {\left( {{{x}_{{{\text{NaCl}}}}} + {{x}_{{{\text{CaC}}{{{\text{l}}}_{{\text{2}}}}}}}} \right)}}} \right.} {\left( {{{x}_{{{\text{NaCl}}}}} + {{x}_{{{\text{CaC}}{{{\text{l}}}_{{\text{2}}}}}}}} \right)}} \) from 1 to 0. Changes in the composition and density of coexisting fluid phases at a constant activity of water and changes in the total composition of the system are studied. A set of phase diagrams on sections H2O–NaCl–CaCl2 for different mole fractions of CO2 is obtained. Pressure dependencies of the maximal activity of water in the field of coexisting unmixable fluid phases are obtained for several salt compositions of the system. Due to removal of restrictions resulting from a smaller number of components in ternary systems, the thermodynamic behavior of systems with a mixed composition of the salt is significantly differ from the behavior of those with a single salt component.

Efficacy of Fractional Carbon Dioxide Laser versus Fractional Carbon Dioxide Laser with Platelet-Rich Plasma in Treatment of Striae Distensae in a Tertiary Care Center: A Comparative Study.

Striae distensae are atrophic scars that are often cosmetically distressing. The efficacy of fractional carbon dioxide (CO2) laser and platelet-rich plasma (PRP) in treating striae individually has been evaluated previously. However, not many studies described the combined efficacy of both. The aim of this study was to compare the efficacy and safety of fractional CO2 laser alone and in combination with PRP. Twenty-four patients with striae presenting bilaterally in the abdomen, upper limbs, and lower limbs were included. PRP was prepared by double-spin method and cell count was done to ensure at least fourfold concentration of platelets. The patients were treated CO2 laser on both sides and PRP on the left side along with laser, every month for three sessions. Digital photography and dermoscopy were done at baseline, every treatment session, and 6 months after treatment. Clinical improvement was assessed by comparing photographs and patient satisfaction before and after treatment. All patients showed improvement on both sides. In CO2-laser-treated patients, responses in 6 patients (25%) were moderate, 14 (56%) were good, and 4 (16.6%) were excellent. In CO2-laser and PRP-treated patients, responses in 5 patients (20.8%) were moderate, 11 (45.8%) were good, and 8 (33.3%) were excellent. Hyperpigmentation was the most common side-effect seen (19 patients) on both sides, which resolved spontaneously by 6 months. These results support the use of ablative CO2 fractional laser as effective and safe treatment modalities for striae. However, slightly better efficacy was noted with the addition of PRP.

A Comparative Study to Evaluate the Efficacy of Fractional CO2 Laser + PRP Vs. Fractional CO2 Laser Alone in Patients with Vitiligo.

Vitiligo is a multifactorial acquired disorder clinically characterized by amelanotic lesions on the skin, due to destruction of melanocytes. The course of vitiligo is unpredictable. Vitiligo causes significant psychological impact and cosmetic disfigurement. Treatment of vitiligo is challenging and requires a multidisciplinary approach. A prospective comparative interventional study was carried out from October 2018 to March 2020. The study enrolled 60 stable vitiligo patients divided into groups A and B. Group A (30 patients) was treated with both fractional CO2 laser and autologous platelet-rich plasma (PRP) injection. Group B (30 patients) was treated with fractional CO2 laser alone. A total of four sessions were conducted in each group at 1-month interval along with photographic assessment. Final assessment was done 1 month after the completion of four sessions. In group A, the median values of repigmentation and visual-analog score (VAS) were 3 and 7, and in group B, the median values of repigmentation and VAS were 1 and 2, respectively. Lesions over the trunk showed the best response followed by face and extremities lesions. Acral lesions showed the least response. A combination of fractional CO2 laser and PRP is superior to fractional CO2 laser alone in the treatment of stable vitiligo.

Fractional CO2 Laser-induced Delivery of Topical Corticosteroids Hastens Resolution of Localized Plaque Sarcoidosis.

Fractional CO2 Laser-induced Delivery of Topical Corticosteroids Hastens Resolution of Localized Plaque Sarcoidosis.

Atrophic Acne Scar Fractional CO2 Laser Treatment; Comparative Whole versus Focal Area Study

Atrophic Acne Scar Fractional CO2 Laser Treatment; Comparative Whole versus Focal Area Study

Nevus of Ota: Combination Treatment with Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser and Fractional CO2 Laser.

Nevus of Ota is a facial dermal melanocytic hamartoma occurring more commonly in Asians. The mainstay of treatment is 1064-nm Q-Switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, which has shown variable results in pigmented skin. The aim of this study was to determine whether Q-Switched Nd:YAG laser treatment combined with fractional CO2 laser is more efficacious than Q-Switched Nd:YAG laser alone. This was a prospective study with 81 patients. The patients were randomly divided into two groups. Group 1 received 1064-nm Q-Switched Nd:YAG laser alone and group 2 in addition received a fractional CO2 laser as well. Both groups received six sittings at monthly intervals. The treatment response was documented with physician global assessment (PGA) and patient's treatment satisfaction on Wong-Baker Facial Pain Scale (WBFPS). Dermoscopic evaluation was done to see subsurface pigment clearance. In the combination group, 25% of patients had more than 50% improvement as compared with 5.71% in group 1. To achieve a mean PGA score of 1.4, it took six sessions for group 1 versus only four for group 2. Dermoscopic evaluation showed faster pigment clearance in the combination group. Combining two lasers shows statistically significant faster and greater degree of improvement as compared with Q-Switched Nd:YAG laser monotherapy in nevus of Ota.

The Comparison between Microneedling and Fractional CO2 Laser for Amniotic Membrane Stem Cell-Conditioned Medium and Vitamin C in Photoaging Treatment.

Photoaging correlates with ultraviolet radiation (UVR). In addition to direct and indirect DNA damage, UVR leads to a breakdown of collagen, resulting in enlarged pores, visible wrinkles, also uneven skin tones and pigmentations. Amniotic membrane stem cell (AMSC) can be a useful modality in cell regeneration. Vitamin C has been known as an agent of depigmentation, antioxidants, and collagen synthesis. A topical combination of amniotic membrane stem cell-conditioned medium (AMSC-CM) and vitamin C is expected to improve photoaging. Fractional CO2 laser and microneedling served as transdermal drug delivery. To compare between microneedling and fractional CO2 laser for the administration of AMSC-CM and vitamin C in photoaging treatment. Sixty Indonesian women with photoaged skins participated in this experimental analytic, controlled, matching research and were divided into two groups. Thirty women received fractional CO2 laser, and others received microneedling. All participants received a topical combination of AMSC-CM and vitamin C. Three treatment sessions were repeated at a four-week interval for fractional CO2 laser and a two-week interval for microneedling. We evaluated the progression and side effects using a skin analyzer on weeks 0, 4, and 8 for the microneedling group and for the fractional CO2 laser group on weeks 0, 4, and 12. Assessment of wrinkles, UV spots, skin tone, and pore revealed a statistically significant effect of a topical combination of AMSC-CM and vitamin C after fractional CO2 laser (p < 0.05). Combination of AMSC-CM and vitamin c using fractional CO2 laser can improve photoaging and is better compared to microneedling.

Long term CO2 laser: evaluation of satisfaction in women with iatrogenic menopause for BRCA mutations or gynecological and breast cancer treatments

Background: Genitourinary syndrome of menopause (GSM) is one of the most frequent complaints in menopausal women. This syndrome is very common and prominent. One of the most active treatments for GSM is fractional CO2 Laser that acts on the vaginal mucosa through a special device stimulating a process production of new collagen.

Simulation of turbulent non-premixed combustion in pulverized coal from Kalimantan Indonesia

A computational simulation was created to investigate pollutants during coal combustion in a Drop Tube Furnace using Kalimantan coal. Previous research has explored Drop Tube Furnace combustion with Kalimantan coal, but lacked an understanding of combustion phenomena and pollutants, which are challenging to observe experimentally. This study utilized three samples of Kalimantan coal, namely RP, MB, and KC, acquired from various mining sources. This research is new study of simulation combustion coal in Drop Tube Furnace using non-premixed turbulent combustion and the Probability Density Function model with structured grid. The study reports on the temperatures and mass fractions of pollutants, including NOX, SO2, and CO2, along the centerline of the domain. The findings show that RP coal produced the highest combustion temperature, while KC coal produced the lowest. MB coal had the highest CO2 mass fraction, KC coal had the highest NOx value, and RP coal had the highest SO2 value.

"Multiple Mode Procedures" of Ultra-Pulse Fractional CO2 Laser: A Novel Treatment Modality of Facial Atrophic Acne Scars.

Fractional CO2 laser is therapeutic for acne atrophic scar, but its effect usually is limited after multiple sessions, with occasional adverse reactions. This study aimed to evaluate the efficacy and safety of a new modality combining ultra-pulse CO2 laser and fractional CO2 laser (multiple mode procedures [MMP]) in the treatment of acne atrophic scars. From December 2017 to January 2023, a total of 103 patients with facial acne atrophic scars treated with MMP technique were retrospectively analyzed. MMP was performed for 1-4 sessions with an interval of approximately three months. Based on photographs taken before and after treatment, overall atrophic scar improvement was assessed according to the ECCA grading scale, the modified Manchester Scar Scale and the 4-point Global Assessment Scale (GAS). The safety was evaluated by the degree of pain during treatment and postoperative adverse reactions. All the 103 patients received treatment and completed follow-up, with an average of two sessions. The mean ECCA score decreased from 162.7 to 93.1 with statistically significant difference (p < 0.001). The mean GAS score increased by an average of 2.3 ± 0.9. The GAS improvement more evident for "boxcar" atrophic scars (2.7 ± 0.8) than for "rolling" (2.3 ± 0.8) and "icepick" scars (1.7 ± 0.8) (p < 0.001). The average improvement scores for color, distortion and texture were 2.0 ± 0.9, 2.2 ± 0.9 and 2.3 ± 0.8, respectively. The mean pain score during treatment was 3.9 ± 0.8, and the mean duration of erythema was 30.7 ± 3.5 days. Only three patients developed hyperpigmentation at the treated site within a few months. Ultra-pulse CO2 fractional laser MMP technique can effectively improve the condition of facial atrophic acne scars with limited adverse reactions.

Clinical Evaluation and Experience in Treatments Performed with Fractional CO2 Laser on Latin American Skin: An Observational Retrospective Study.

Background: The carbon dioxide (CO2) laser is an ablative system that evaporates, remodels, and coagulates tissues, becoming therefore a gold standard piece of equipment for the treatment of dermatological pathologies and esthetic imperfections. Objective: To evaluate the efficacy and safety of CO2 laser treatments in different patients' skin pathologies. Methods: A total of 705 patients with an age range between 18 and 70 years, with phototypes on the Fitzpatrick scale III, IV, V, and VI, were enrolled from October 2021 to May 2022, and were treated using the CO2 laser system. Results: Ninety-six patients were treated with fractional CO2 laser, used for skin rejuvenation and stretch marks. One patient presented reactivation of herpes simplex, 10 postinflammatory hyperpigmentation that resolved after 3 months with depigmenting agents, 6 with persistent erythema. A total of 13 patients with rhinophyma were treated, and no complications were observed; a total of 64 patients with wrinkles were treated. They improved in 6 months. A total of 340 patients were treated for seborrheic keratosis, papulosa nigra dermatosis, fibropapillomas, sebaceous hyperplasias, verruca vulgaris, and condylomata acuminata. One patient presented with a complication hypopigmented macule. A total of 136 patients underwent treatment for laser ablation of intradermal nevi and verrucous epidermal nevi, without complications. A total of 56 patients were treated with keloids and hypertrophic scars. One patient presented with ulceration of a keloid that resolved with the application of clostridiopeptidase A and chloramphenicol after 2 weeks. Conclusions: The use of the CO2 laser in any phototype and race, which are factors with a high incidence in Latin America, provides a safe and effective result for different dermatological pathologies.

Cross-Scale Seepage Characteristics of Fractured Horizontal Wells in Tight Gas Reservoirs.

Tight gas reservoirs are rich in microscale pores and fractures. The effect of microscale gas seepage in tight sandstone matrix on gas well productivity cannot be ignored. At present, the effect of microscale gas flow on the well testing model of fractured horizontal wells has not been systematically studied. In this paper, first, the coupling influence mechanism of "multicomponent gas effect-fracture geometry characteristics" is expounded, second, a seepage model coupling the flow in the fracture and the flow in the gas reservoir is established on the fracture wall surface, and third, an unsteady pressure analysis model for fractured horizontal wells in tight gas reservoirs is established. Results show that (a) when the microscale fracture is at a quite small level, the Knudsen diffusion plays a dominant role at a wide range of pressures; (b) the mass transfer rate of multicomponent shale gas through macrofractures increases with increasing CO2 fraction; (c) the unsteady flow process is divided into six stages in turn: microscale diffusion stage, linear flow stage in fractures, linear flow stage between fractures, early radial flow stage in gas reservoirs, linear flow stage in gas reservoirs, and late radial flow stage in gas reservoirs; and (d) with an increase of dimensionless bottom-hole storage coefficient, the second and third stages of flow are gradually covered up.

Rapid fCO2 rise in the northern Barents Sea and Nansen Basin

Maps of surface water fugacity of CO2 (fCO2) over eastern Fram Strait, south-western Nansen Basin, and the north-western Barents Sea (73–84°N, 5–46°E) from September 1997 to December 2020 were made and used to investigate seasonal and temporal trends. The mapping utilized a neural network technique, the self-organizing map (SOM), that was trained with different combinations of satellite/observational/model data of sea surface temperature (SST), sea surface salinity (SSS), mixed layer depth (MLD), chlorophyll a (Chl a), sea ice concentration, and atmospheric mole fraction of CO2 (xCO2). The trained SOM was labelled with available surface ocean fCO2 data, and the labelled SOM was subsequently used to map the fCO2. The produced maps reveal that fCO2 in northern Barents Sea, at the border of the Nansen Basin, has increased significantly over the last decades by between 4.2 and 5.5 ± 0.6–1.1 µatm yr−1 over the winter to summer seasons. These rates are twice the rate of atmospheric CO2 increase, which was about 2 µatm yr−1. The spatial pattern coincides with the strongest decreases in sea ice concentration as well as with a salinification of the surface water. The former allows for a prolongation of the air-sea CO2 flux with resultant oceanic CO2 uptake in previously ice-covered waters, and the latter is caused by a shift from Arctic Water dominance to more saline waters containing more dissolved inorganic carbon, most likely of Atlantic Water origin although brine-release influenced deep water may also contribute.