The heat and mass transfer investigation of the boundary layer flow of chemically reactive Casson nanoparticles (Ag and MgO) is done by the existence of magnetic dipole and gyrotactic microorganism through a stretching cylinder. The generalized Fourier and Fick law and the thermal radiation effect are taken into account to analyze energy transportation. The stratification conditions are executed on the boundary of the surface of the stretching cylinder. The main idea behind this investigation is to empower the heat transport phenomenon and thermal conductivity of fluid by the inclusion of nanoparticles into the base fluid. The flow equations (PDEs) are changed into nonlinear coupled ODEs by the usage of suitable transformations. The solution of transferred coupled equations is established by the succor of the Bvp4c MATLAB approach. The emerging parameter results are obtained graphically along the velocity, concentration, temperature, and microorganism density profile. The microorganism transport rate and the skin friction coefficient rate are analyzed with the help of tabulated data. It is worth interesting to see that due to the enlargement of (curvature parameter), the velocity of the fluid is boosted, although the decreasing trend is seen in the velocity of fluid by the stronger estimation of slip and magnetic parameters.