Fully developed laser speckle patterns are, due to their high contrast and statistical nature, well suited to measure strain and displacement via an appropriately designed measurement system. Laser speckle patterns are formed when a sufficiently coherent light source, such as a HeNe-laser, illuminates an optically rough surface. Therefore, methods based on laser speckle patterns can be applied to any surface scatterer with a minimum mean surface roughness of about a quarter of the laser’s wavelength. This includes also materials such as thin natural and technical fibres as well as foils, for which the presented measurement system, including the digital signal processing, was designed. In order to achieve the best possible resolution of a speckle-based measurement system, combined with a sufficiently small measurement uncertainty, all available design parameters must be optimised. One of these parameters is the speckle size, which is dependant on the properties of the imaging optics. In this paper a subjective laser speckle-based measurement system based on a so-called 4f-optical setup is presented. This setup allows the speckle size to be controlled in both axial and lateral dimensions separately, which is achieved with the help of an aperture in the Fourier plane of the optics. It is shown that the optimal speckle size for the presented measurement system, not only depends on the physical setup, but also on the signal processing applied. The signal processing routine estimates displacements of the speckle pattern, leading to an estimate for the strain. Additionally, it is demonstrated that the optimal speckle size can be lower than the commonly reported optimum between two and five pixel pitches, necessary to circumvent aliasing in the image data. While this is shown for a measurement setup using 4f-optics, the results are of general importance to speckle-based strain or displacement measurement systems and should thus be taken into account.