Foundation Platform Research Articles

Addressing the knowledge gap of Indigenous public health: reflections from an Indigenous public health graduate

Abstract The current agenda in public health training in higher education works to produce well-trained public health professionals. Operating within a western pedagogical framework it aims to build a cohort of critical and analytical thinkers, skilful problem solvers and extraordinary communicators across key disciplines in health. Many graduates possess interdisciplinary specialities, skills and knowledge transferable within health and other sectors. Core competencies in the curricula, which notably does not currently include Indigenous health, are considered the foundational platform of theory and practical understandings of public health and the health system. Despite a framework that aims to produce health professionals capable of improving the health of the population as a whole; the lack of engagement with an Indigenous health criticality maintains a longstanding Australian public health tradition of failure when it comes to addressing the health disparities experienced by Indigenous people. As a recent Indigenous public health graduate with practical training and experience working in the public health system, I consider possibilities for decolonising the curricula through an Indigenist approach to health, including theories of transformative learning which could strengthen public health practice and in turn facilitate the changes necessary to improving Indigenous health outcomes.

Особенности семантики лакун-модификаций. К идее создания словаря лакун (на материале глаголов звучания)

The article examines the insufficiently explored phenomenon in word-formation synthesis – the intra-linguistic affixal lacunae i.e. lexical gaps. The nature of lacunar units is described as a unique type of semantic modifications that display a similar structure, semantics, and characteristics. From the standpoint of derivative codification, the major lacunae groups are identified, analyzed, and mapped out based on their lexicographic properties. The glossary selection criteria for the experimental Lacunae – Modifications Dictionary are determined. Relying on the data from the Russian National Corpus, nearly 5,000 lacunae and sound verb modifications, combined, were researched using a web-scraping algorithm from a special project at Missouri S&T. The results of this study may serve as a foundational platform for this novel dictionary of affixal lexical gaps in the Russian language.

Application of Power Load Forecasting in Urban Distribution Network Planning Based on 3D Real Scene Platform

The 3D real-view platform technology builds a power load forecasting platform in urban distribution network planning. The completion of this system can provide integrated support for power load forecasting in power distribution line planning, and further provide a three-dimensional foundation platform for power load forecasting analysis and calculation software in power distribution planning. Urban distribution network planning is an important task for power supply companies. The quality of its construction directly affects the development of urban economy and the improvement of people’s quality of life. This paper combines the years of work experience to introduce the importance of power distribution network planning, which optimizes the structure of the power distribution network, which can ensure the safe operation of the power grid, reduce power loss, improve power supply reliability, and accurately predict power loads. To meet the needs of urban power load development.

Monitoring the Complexity of IT Architectures: Design Principles and an IT Artifact

Monitoring the complexity of a firm’s IT architecture is imperative to ensure a stable and flexible platform foundation for competing in the era of digital business strategy. However, IT architects lack IT support for dealing with this important problem. We engaged with five companies in a significant design science research (DSR) program and drew on the heuristic theorizing framework both to solve this problem through evolving IT artifacts and to accumulate nascent design knowledge. We base the design knowledge development on a conceptual framework involving three essential concepts for understanding and solving this problem: structural complexity, dynamic complexity, and problem-solving complexity. Drawing on this foundation, we address the research question: How can IT support be provided for reducing the problem-solving complexity of monitoring the structural and dynamic complexity of IT architectures in the context of a digital business strategy? To answer this question, we present a set of design principles that we derived from our iterative process of IT artifact construction and evaluation activities with five companies. Our nascent design knowledge contributes to the research on IT architecture management in the context of digital business strategy. In addition, we also contribute to the understanding of how, through the use and illustration of the heuristic theorizing framework, design knowledge can be accumulated systematically on the basis of generalization from IT artifact construction and evaluation outcomes generated across multiple contexts and companies.

IMPROVEMENT OF VERTICAL EQUIPMENT INSTALLATION TECHNOLOGY USING MODERN MECHANISMS

The life of the vast majority of domestic oil refineries is more than 50 years, while the depreciation of the fixed assets of these facilities is 80 %. Satisfying the requirements for consumers in order to expand production and quality products, respectively, leads to compliance with the requirements for the operation of equipment and the need to improve oil and gas processing technologies, taking into account the revision of quantitative indicators of the operating parameters of technological processes. There are problems of increasing the service life of equipment, taking into account factors affecting the operational properties of equipment at all stages of its life cycle. The article presents the results of studies of the stress-strain state of a distillation column and hydraulic lifting during the installation process of the equipment, the calculation of the so-called hydraulic lifting force in order to form the initial data. From the obtained initial data, the installation process was simulated, which includes: a foundation platform with a mounting hinge for columns; foundation area for two racks of a hydraulic lift; two racks of a hydraulic lift; column apparatus, consisting of two bottoms, supports, shells; saddles; two carriages with a jack. Modeling SolidWorks and SolidWorks Motion to obtain data (epilation) on stress and deformation in bottlenecks using a distillation column and hydraulic lift. The results of SolidWorks Motion and structural analysis of SolidWorks Simulation allow us to determine the maximum stress and strain in narrow structures when lifting column equipment with a hydraulic lift based on design training. The initial data from the analysis of the obtained data (stress-strain state) allow us to conclude the nature of static loads in narrow structures and give recommendations on the development of measures aimed at reducing or eliminating their negative consequences for the life and operation of a distillation column and hydraulic lift.

Live Semantic 3D Perception for Immersive Augmented Reality.

Semantic understanding of 3D environments is critical for both the unmanned system and the human involved virtual/augmented reality (VR/AR) immersive experience. Spatially-sparse convolution, taking advantage of the intrinsic sparsity of 3D point cloud data, makes high resolution 3D convolutional neural networks tractable with state-of-the-art results on 3D semantic segmentation problems. However, the exhaustive computations limits the practical usage of semantic 3D perception for VR/AR applications in portable devices. In this paper, we identify that the efficiency bottleneck lies in the unorganized memory access of the sparse convolution steps, i.e., the points are stored independently based on a predefined dictionary, which is inefficient due to the limited memory bandwidth of parallel computing devices (GPU). With the insight that points are continuous as 2D surfaces in 3D space, a chunk-based sparse convolution scheme is proposed to reuse the neighboring points within each spatially organized chunk. An efficient multi-layer adaptive fusion module is further proposed for employing the spatial consistency cue of 3D data to further reduce the computational burden. Quantitative experiments on public datasets demonstrate that our approach works 11× faster than previous approaches with competitive accuracy. By implementing both semantic and geometric 3D reconstruction simultaneously on a portable tablet device, we demo a foundation platform for immersive AR applications.

Design and simulation analysis of an aerospace damper

In this paper, viscoelastic materials are used to attenuate vibration for the optical remote sensor and satellite base. Flexible-base single-degree-of-freedom vibration attenuate system model is built considering that the satellite base is not rigid. The transfer ratio of the vibration damping system when the satellite platform foundation is non-rigid is obtained by using the four-terminal parameter method and the mechanical impedance method. Furthermore, the effects of mass ratio, fundamental frequency ratio, basic damping ratio and damper damping ratio on the vibration attenuate efficiency are discussed. According to the properties of integrated space optical remote sensor and satellite base, the optimum parameter combination between damping ratio and vibration attenuate efficiency is obtained. The design schemes of the viscoelastic material damper are refined using the simulation analysis results.

A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008.

Valienamine is the key functional component of many natural glycosidase inhibitors, including the crop protectant validamycin A and the clinical antidiabetic agent acarbose. Due to its important biomedical activity, it is also the prominent lead compound for the exploration of therapeutic agents, such as the stronger α-glucosidase inhibitor voglibose. Currently, the main route for obtaining valienamine is a multistep biosynthetic process involving the synthesis and degradation of validamycin A. Here, we established an alternative, vastly simplified shunt pathway for the direct synthesis of valienamine based on an envisioned non-natural transamination in the validamycin A producer Streptomyces hygroscopicus 5008. We first identified candidate aminotransferases for the non-natural ketone substrate valienone and conducted molecular evolution in vitro. The WecE enzyme from Escherichia coli was verified to complete the envisioned step with >99.9% enantiomeric excess and was further engineered to produce a 32.6-fold more active mutant, VarB, through protein evolution. Subsequently, two copies of VarB were introduced into the host, and the new shunt pathway produced 0.52 mg/L valienamine after a 96-h fermentation. Our study thus illustrates a dramatically simplified alternative shunt pathway for valienamine production and introduces a promising foundational platform for increasing the production of valienamine and its valuable N-modified derivatives for use in pharmaceutical applications.

超表面中的奇异点

Exceptional points are special points in non-Hermitian systems, and there are many novel physical phenomena in the parameter space near the exceptional points. In recent years, metasurface has been a popular topic in physics. A large number of devices with superior performance have been designed based on metasurface platform. The appearance of the metasurface provides an easy platform for the study of exceptional points. By precisely controlling the structural parameters of the metasurface, it is convenient to study the parameter space of the exceptional points. The research on exceptional points in non-Hermitian metasurface also provides a foundation platform for studying new laws of physics. Firstly, the basic theory of exceptional points and the exceptional point in metasurface was introduced. Secondly, the recent research on the exceptional points in metasurface was introduced. Finally, the current problems needing to be solved were analyzed and the development of the field in the future was prospected.

The foundation platform of a Roman temple in the ancient city of Oba (Jimena de la Frontera, Cádiz). Initial study

We present an initial study based on a foundation platform of a temple, which due to its size and construction system, is a key to approach the architecture of the Roman Spain. Conclusions exposed are the result of several archaeological campaigns supporting the restoration at the site known as castle of Jimena, old Oba, where the origin of the village is situated. Some archaeological excavations and an initial analysis of the construction process were accomplished in the surrounding area, following the usual methodology in our investigations (Tabales Rodriguez 2002). This has exposed the construction complexity of the settlement since the roman days to the last reforms carried out during the War of Independence. The vaulted platform is one of the structures that stand out from the complex because of its size and building characteristics. Its location, at a vaulted artificial terrace on the western slope, involved a great constructive effort included in a general urban planning of public areas and the fortress of the small village that was carried out during the 1st century B.C. and the 1st century A.D., which marks the beginning of the roman golden age in that area

Oestradiol, threat conditioning and extinction, post-traumatic stress disorder, and prolonged exposure therapy: A common link.

The accumulating evidence regarding the impact of estradiol on learning and memory synergized studies to examine its influence on enhancing animal's ability to quell fear and anxiety. In this review, we first provide a foundational platform regarding the impact of oestradiol on cellular mechanisms of learning and memory and we review recent advances from rodent and human data showing that oestrogen enhances extinction learning across species. We then propose clinical application to these data. We discuss the potential role of oestradiol variance on the aetiology, maintenance and treatment for post-traumatic stress disorder. Specifically, we argue that the use of oestradiol as an adjunct to prolonged exposure (PE) therapy for PTSD may provide a new treatment approach for enhancing the efficacy of PE in women with PTSD. This could advance our understanding of the mechanisms of PTSD and help tailor sex-specific treatments for this disorder.

A Ptolemaic-Roman Temple Foundation at Tell Timai

The mission of the University of Hawai’i at Tell Timai in 2009 began excavating the remains of a limestone temple foundation platform in the north-west area of the site. The foundations had been partially recorded in survey work conducted in 1930 by Alexander Langsdorff and Siegfried Schott, and again in the 1960s by New York University, however no known investigations of the structure were conducted. In 2017 as part of an Egypt Exploration Society Fieldwork and Research Grant, excavations were renewed to finalise the understanding of the temple’s construction techniques, and the date of the temple. The foundations were of a casemate design with internal fills of alternating silt and limestone chips. The ceramic evidence from within the construction fills dates its construction from the end of the Ptolemaic to the early Roman Period, and the temple’s superstructure was most likely taken down and the blocks reused in the late Roman Period (fourth to fifth century ce).

Operationalizing stakeholder theory and prioritizing ethics in MBA programs: The utility of a trust approach

AbstractAt a time when some are questioning the relevancy of business education in general, others are now asking whether MBA programs should be blamed for society’s declining trust in business and the numerous corporate ethical failures of recent decades. Whether the full blame lies with business schools or not, MBA instructors are actively seeking more effective ways to help students adopt more practical and ethical managerial paradigms. Because trust theory is simple and robust and outlines the basic mental processes that drive economic exchange while simultaneously prioritizing ethical behavior, in this article, we argue that it is distinctively suited to operationalize stakeholder theory in the classroom, providing MBA students with both a principled and a practical foundation or thematic platform for their MBA coursework and subsequent careers. We also discuss potential challenges and limitations and provide recommendations for future research.

Research on the Development of Micro-Tourism Market in Changsha City Under the Background of the Internet Era

With the advent of the 21st century, China has entered the era of the Internet, and the tourism industry has continued to develop. The demand for domestic tourism and national leisure consciousness has been continuously improved. As the transformation of tourism forms has gradually shifted to leisure, experience and diversification, micro-tourism springs up. In 2011, micro-tourism was officially put on the agenda as an emerging form of tourism. After that, it became popular and developed rapidly. Large numbers of micro-tourism products dominated by 1-2 days of hot spring tour, ancient town tour, island tour, country tour, and suburb tour were launched online instantly. This paper first expounds the background, formation, development and characteristics of micro-tourism and then interprets the current development of micro-tourism from online survey data, finding that the development of micro-tourism market is good, but the related facilities and systems are comparatively lagging behind. Finally, the paper analyzes the micro-tourism resources and development conditions of Changsha city, finding that the foundation and market platform for developing micro-tourism in Changsha is sound. Given the actual development, the paper then puts forward development strategy for micro-tourism of Changsha City under the background of the Internet era, which may provide reference for other cities with similar conditions to develop micro-tourism.

Construction and verification of an integrated test system for underwater vehicle testing

Integrated test architecture (ITA) is a testing infrastructure developed for overcoming the design deficiency of stovepipe system based on current construction situation of underwater vehicle equipment. The general infrastructure of ITA is given at first, and then the design of ITA-based foundation platform infrastructure (IFPI) of underwater vehicle testing (UVT) is presented with details, mainly including development of middleware and the design of ITA testing process tool (TTCT). Moreover, an integrated test system for underwater vehicle testing (ITSUVT) is constructed by developing or integrating testing resource on IFPI. Finally, the performance of VBFPI is tested according to the designed testing schemes, and the function of ITSUVT is verified by field and virtual UVT.

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

AbstractSoluble thrombomodulin plasma concentrations are elevated in steroid-resistant graft-versus-host disease (GVHD), implying endothelial hypofunctioning for thrombomodulin-dependent generation of activated protein C’s (APC) anticoagulant, anti-inflammatory, and antiapoptotic functions. Recombinant thrombomodulin or APC administration decreases acute GVHD, manifested by intense inflammation and tissue destruction. Here, we administered recombinant murine wild-type (WT) APC to mice with established chronic GVHD (cGVHD), a less-inflammatory autoimmune-like disease. WT APC normalized bronchiolitis obliterans–induced pulmonary dysfunction. Signaling-selective APC variants (3A-APC [APC with lysine 191-193 replaced with 3 alanines] or 5A-APC [APC with lysine 191-193 replaced with 3 alanines and arginine 229/230 replaced with 2 alanines]) with normal cytoprotective properties, but greatly reduced anticoagulant activity, provided similar results. Mechanistically, WT APC and signaling-selective variants reduced T follicular helper cells, germinal center formation, immunoglobulin, and collagen deposition. WT APC can potentially cleave protease-activated receptor 1 (PAR1) at Arg41 or Arg46, the latter causing anti-inflammatory signaling. cGVHD was reduced in recipients of T cells from WT PAR1 or mutated Gln41-PAR1 donors but not from mutated Gln46-PAR1 donors. These data implicate donor T-cell APC-induced noncanonical cleavage at Arg46-PAR1, which is known to confer cytoprotective and anti-inflammatory activities. Together, these data indicate that APC anticoagulant activity is dispensable, whereas anti-inflammatory signaling and cytoprotective cell signaling by APC are essential. Because a phase 2 ischemic stroke clinical trial did not raise any safety issues for 3A-APC treatment, our studies provide a foundational platform for testing in clinical cGVHD therapy.

Advances in Nanosensors for Biological and Environmental Analysis: Book Review. Akash Deep, Sandeep Kumar (Eds.); Elsevier 2019; ISBN: 978-0-12-817456-2

A book entitled “Advances in Nanosensors for Biological and Environmental Analysis” published by Elsevier in 2019, is reviewed carefully and critically in this report. In this book, editors explored nanotechnology assisted approaches to develop smart and efficient nanosensors for biological and environmental analysis. Fundamental approaches to prototype development and a focus towards designing miniaturized sensing systems and for point-of-care application, along with considering commercial aspects are key features of this book. This book has potential to serve as a foundation platform for scholars of various disciplines to plan and manage multi-display research in the field of biomedical nanotechnology for diagnostics and environmental monitoring.

Ice-resistant performance analysis of the bucket foundation offshore platform with concrete pillar

The steel bucket foundation platform is an important engineering design for small-scale oil/gas field developments due to its economic and structural characteristics. Severe ice-induced vibrations were observed during an ice sheet interaction with the fixed ice-breaking cone of JZ9-3WHPB platform in the Bohai Sea, China. The steel pillar was replaced by a concrete pillar in order to reduce the ice-induced vibrations for JZ9-3WHPB platform. A good comparison was obtained between the calculated and full-scale observation data; the numerical results show that ice-induced vibrations could be reduced effectively for JZ9-3WHPB platform with concrete pillar.

Tectonics and deep structure of Yugan-Koltogor zone of West Siberia Platform foundation

Research subject. The deep structure of the Yugan-Koltogor zone located in West Siberia was investigated with the purpose of detecting prospective oil and gas bearing areas.Materials and methods. The methods of lineament extraction and the computer modelling of rock density were employed. Lineament extraction was conducted on the basis of geophysical data, including detailed (1 : 200 000) maps of anomalous magnetic and gravity fields. In order to detect faults, telemetering methods were used, along with the results of studies conducted to investigate core materials from wells in the region. The modelling of the deep structure of the pre-Jurassic basement was performed on the basis of its geological map by solving a direct problem while fitting geological body densities.Results. Six largest faults of the Yugan-Koltogor zone identified on the geological map by a special sign “deep faults and regional schistosity zones” are of particular interest as possible oil bearing areas.Conclusions. The modelling of the deep structure of the pre-Jurassic basement of the West Siberian Platform has shown the granite decompaction areas of the Yugan zone to be highly promising in terms of oil and gas deposits.

Research and Practice on Campus Big Data Foundation Platform

Universities at home and abroad have reached a consensus on the importance of big data research and application. The importance of education data has been promoted to the national strategic level. The construction of education data centre, the sharing and application of regional data have become the main practice mode. Our work is on the research and exploration from the shared database to the big data foundation platform in the university information construction. In addition to the existing educational administration system, we design and develop a series of application subsystems based on big data foundation platform, which can be presented to readers as cases, hoping to serve as an inspiration to each other.