The topics of this special paper are mainly devoted to the most recent research, development and applications in the field of cloud computing, big data processing in the various fields, e.g. Web blog, search engine, image processing, and industry. Among all of the submitted manuscripts, 15 papers were selected and included in this special paper. Creative thoughts and interesting inspirations are presented, discussed, and disseminated in this paper. First, there are three papers on the cloud architecture and optimization for big data processing. J. Peng, et al. discussed the problems of load balance for massive data processing on cloud considering the data processing efficiency and nodes’ capability. A load balance approach for massive data, based on the consistent hashing method, was presented to improve the data processing equalization and high processing efficiency. Large-scale sensor networks and internet of things are one of the most important application fields in big data. Y. Sun, et al. proposed a cloud computing system to support PaaS in energy power applications—PROXZONE. PROXZONE provides the cloud services uniform monitoring and authorization, and cloud message service, which can support good performance when dealing with big data. Meanwhile, S. Xu, et al. discussed an improved cooperative dynamic cluster model in multitasks mobile network, and proposed a cooperative message forwarding mechanism to improve the network performance.