Post System Research Articles

Pharmacokinetics and bioequivalence of a molnupiravir tablet formulation compared with the molnupiravir capsule formulation in healthy adult participants-a randomized, open-label, three-period, crossover study.

Molnupiravir, a prodrug of β-D-N4-hydroxycytidine (NHC), is administered orally as four 200 mg capsules twice daily for 5 days to treat COVID-19. This randomized, open-label, four-treatment sequence, three-period crossover study (NCT06615869) evaluated the bioequivalence of a new single 400 mg oral dose of the molnupiravir tablet Formulation 1 (F1) to a 400 mg oral dose of the currently authorized molnupiravir capsule formulation (administered as two 200 mg capsules) by comparing the plasma pharmacokinetics of NHC following administration to healthy participants. The effect of food on the plasma NHC pharmacokinetics following the administration of the molnupiravir F1 tablet, safety and tolerability of a single oral 400 mg dose of molnupiravir, and pharmacokinetics of a separate molnupiravir tablet Formulation 2 (F2) with a slower in vitro dissolution rate were also evaluated. The geometric mean ratio and 90% confidence intervals ([1 × 400-mg F1 tablet]/[2 × 200 mg reference capsules]) for plasma NHC area under the concentration-time curve (AUC) from time 0-infinity, AUC from time 0-last measurable time point, and maximum plasma concentration were 1.00 (0.97, 1.03), 1.00 (0.97, 1.03), and 0.98 (0.93, 1.03), respectively. All estimates were within prespecified limits (0.80, 1.25), demonstrating bioequivalence of the molnupiravir F1 tablet and reference capsules. Administration of the F1 tablet with a high-fat meal did not meaningfully impact the rate or extent of absorption. The pharmacokinetics of the F2 tablet were similar to the reference capsules. Administered in either formulation, molnupiravir was generally safe and well tolerated. In conclusion, a single 400 mg tablet of molnupiravir is bioequivalent to the reference capsule formulation in healthy adults.CLINICAL TRIALSThis study was registered at ClinicalTrials.gov as NCT06615869.

A Comparative Evaluation of Fracture Resistance of Three Post Systems and Their Mode of Failure: An In-Vitro Study

ABSTRACT Aim: To analyze the fracture resistance of three post systems and their mechanism of failure. Materials and Procedures: Forty-five newly excised human mandibular single-rooted pre-molar, for periodontal or orthodontic reasons, were used. The teeth were separated into three groups (n = 15) based on the post system utilized. Group A had teeth restored with custom cast post; Group B had prefabricated glass fiber posts (Angelus post); and Group C with edelweiss composite post (Edelweiss Post). Results: The custom cast posts provided the highest fracture resistance but exhibited more unfavorable fractures. The edelweiss posts exhibited the least fracture resistance. Conclusion: Further investigations should be targeted at elucidating the force dynamics of this newer post system.

GC-MS Evaluation of Bioactive Constituents of Hydroalcoholic Leaves Extract of Pongamia pinnata with Antibacterial Potential of Prepared Mouthwash Formulations

The leaves of Pongamia pinnata was extracted with 800 ml of 70% ethanol and 30% water (V/V) mixture for 48 hr. The hydroalcoholic extract of Pongamia pinnata leaves was subjected to preliminary phytochemical analysis. The presence of alkaloids, flavonoids, phenolic compounds, tannins and terpenoids was confirmed by preliminary phytochemical screening. The chemical composition of hydroalcoholic extract was determined by GC-MS analysis. The GC-MS investigation revealed the presence of sixteen different bioactive compounds in the Pongamia pinnata leaves extract. The least amount of constituents present in the hydroalcoholic extracts was dioctyl phthalate has the peak area 0.84 and maximum 38.17 peak area % was recorded for 3-Methoxy-1,2-propanediol. Three formulations (F-1), (F-2) and (F-3) of herbal mouthwash containing hydroalcoholic leaves extract of Pongamia pinnata were prepared. Then antibacterial activity of all three formulations of mouthwash were tested against Streptococcus mutans (oral pathogen). The results obtained were compared with standard mouthwash (Chlorhexidine). The findings revealed that prepared herbal mouthwash formulation 2 (F-2) showed significant zone of inhibition compared with standard Chlorhexidine.

The Fracture Resistance of Reconstructed Teeth with Three Different Post Systems (Casting Post, Pre-Fabricated Post, and Pre-Fabricated Post Modified with Amalgam) in Oval-Shaped Canals: An In Vitro Study

Introduction: This study compared the fracture resistance and fracture pattern of endodontically treated teeth restored with three different post systems. Materials and Methods: In this in vitro study, 30 extracted single-root human premolars with oval-shaped canals were selected. All teeth were endodontically treated and sectioned horizontally from the cement-enamel junction. Samples were randomly assigned into three groups; group 1- casting post cemented with glass-ionomer, group 2- pre-fabricated post cemented with glass-ionomer, and group 3- pre-fabricated post cemented with glass-ionomer and modified with amalgam. Fracture resistance (Newton) was measured under load on the universal load test machine. The fracture pattern was also recorded as restorable and unrestorable. The data was analyzed using SPSS version 24. ANOVA and post hoc (Tukey) were applied at the significance level of 0.05. Results: Mean fracture resistance was 999.2±278.21 (N), 501.6±246.74 (N), and 600.23±254.04 (N) in groups 1, 2, and 3, respectively. There was no statistically significant difference in fracture resistance between groups 2 and 3. However, the fracture resistance of group 1 was significantly higher than groups 2 and 3. 100% of the failure pattern in group 1 was unrestorable. 60% and 80% of failure patterns in groups 2 and 3 were restorable, respectively. Conclusion: Fracture resistance was higher for casting posts than for pre-fabricated posts; however, the fracture resistance of all three groups was acceptable. Using pre-fabricated posts decrease root fracture compared to casting posts. Modifying pre-fabricated posts with amalgam may minimize the occurrence of unrestorable fractures and root fracture.

Comparative Evaluation of Fracture Resistance in Different Post and Core Systems with Varying Ferrule Locations: An In Vitro Study.

Endodontically treated teeth often require 360° ferrule to retain post and core restoration. The literature support on scientific evidence of partial ferrule is limited, hence this study was conducted to evaluate the fracture resistance of two post and core systems, i.e., Edelweiss and glass fiber post and core system with varying ferrule locations. About 54 extracted mandibular 1st premolars were divided into Edelweiss post and core (Group A) and glass fiber post and core (Group B). They were further subdivided into 3 groups each (Partial functional, partial non-functional, and circumferential). A standardized endodontic procedure was carried out on all the specimens. For group A, an Edelweiss drill of 1.4 mm was used to prepare the post space. Canals were then etched, a bonding agent was applied and posts were luted with paracore resin. For group B, post space was prepared with a straight fissure bur, followed by the same procedure as that of group A. Core build-up was done with composite resin. Cast crowns were fabricated and cemented with GIC. Fracture resistance was evaluated with UTM with a compressive load capacity of 1000 N until fracture occurred. The results of this study stated that in the Edelweiss group partial functional ferrule showed higher fracture resistance and in the glass fiber group circumferential ferrule showed higher fracture resistance. The study also showed that MOF is favorable in all the groups. The type of ferrule was one of the factors that affected the fracture resistance of Edelweiss and Glass fiber post and core group of specimens. The study also concluded that there was a predominant favorable mode of fracture across all groups, in all different ferrule locations. This study opens multiple avenues and methods in tooth restoration and shows that even a partial functional ferrule is sufficient for restoration, provided the right system is used. How to cite this article: Jadhav PD, Shetty R, Mehta D, et al. Comparative Evaluation of Fracture Resistance in Different Post and Core Systems with Varying Ferrule Locations: An In Vitro Study. J Contemp Dent Pract 2024;25(5):480-485.

Integration of levofloxacin-loaded spanlastics and prednisolone into a buccal mucoadhesive sponge for combating severe pneumonia: In-vitro/ex-vivo assessment, qRT-PCR analysis, and quantification of the HMGB-1/NF-қB signaling pathway

Pneumonia induced by Klebsiella pneumoniae (K. pneumoniae) is a grave pathological state that bears profound implications for morbidity and mortality rates. It is marked by an exaggerated inflammatory response in the lung tissue, resulting in lung damage. Accordingly, combining Levofloxacin hemihydrate (LV) with Prednisolone (PD) could potentially reduce the inflammatory response associated with severe pneumonia and save patients’ lives. Therefore, this study aimed to develop LV-loaded spanlastics (SPs)/PD buccal mucoadhesive sponge for the treatment of severe pneumonia. For LV SPs fabrication and optimization, a full 32 factorial design was utilized to examine the impact of the type of edge activator (EA) and Span 60: EA ratio on vesicle size (VS) and encapsulation efficiency percent (EE%). The optimum formula was determined by recording the minimum VS and maximum EE%. It was then tested microbiologically, followed by integration into a mucoadhesive sponge with the addition of PD, forming LV SPs/PD sponge that was evaluated via in-vivo study. The optimum LV SPs was formulation 3 (F3), which was fabricated using Tween 80 as an EA with a Span 60: EA ratio of 80:20. F3 exhibited an EE% of 92.40 ± 0.01 %, a VS of 248.60 ± 2.05 nm, highly elastic spherically shaped nanovesicles with a controlled release profile, and enhanced drug permeation. The minimum inhibitory concentration (MIC) of F3 was reduced by a factor of 8 compared to Levoxin®. Moreover, F3 revealed superiority over Levoxin® by 10, 20, and 10 percentage points increase in downregulating gyrA, gyrB, and parC gene expression in K. pneumoniae, respectively. The LV SPs/PD sponge revealed a spongy structure with well-defined pores. It had a surface pH of 6.93 ± 0.06, a swelling index of 3.52 ± 0.35, an ex-vivo mucoadhesion residence time of 3.01 ± 0.61 h, and a drug content of 97.39 ± 1.82 % for LV and 98.06 ± 1.34 % for PD. As well, the release pattern of the LV SPs/PD sponge was significantly slower than that of the F3 for LV and the Epicopred® for PD. The in-vivo study of the LV SPs/PD sponge demonstrated a prevalence effect in restoring the typical lung histology in rats. Additionally, it returns high mobility group box (HMGB)-1 and nuclear factor-kappa B (NF-қB) biomarkers to their normal levels, surpassing the effects observed with Levoxin®/Epicopred®. Collectively, the LV SPs/PD sponge might hold great potential as a promising treatment approach for the management of severe pneumonia.

Finite Element Analysis and Clinical Applications of Transverse Post for the Rehabilitation of Endodontically Treated Teeth.

Introduction The preservation of tooth structure during cavity preparation is crucial for maintaining tooth strength and longevity of restorations. The biomechanical behavior of teeth, especially those with mesio-occlusal-distal (MOD) cavity preparations, is significantly affected by the extent of cavity preparation and the type of restorative treatment employed. The aim of the current study was to evaluate and analyze the stress distribution seen in the mandibular molar with MOD cavity when restored with transverse post, using finite element analysis (FEA). Materials and methodology FEA was utilized to evaluate stress distribution in an endodontically treated mandibular first molar with MOD cavity preparation, restored using a transverse post and composite restoration. Three-dimensional models incorporating the tooth and the surrounding structures, along with the transverse post and composite restoration, were constructed based on known biomechanical properties. After meshing the models, loads were defined on the buccal and lingual cusps with a constant value of 600N and at an angle of 45 degrees. Preprocessing involved model preparation followed by postprocessing to obtain results representing the degree and type of stress distribution. Results FEA simulations revealed the distribution of stress within the tooth structure under functional occlusal forces. The transverse post system effectively reinforced the tooth by deflecting incident forces and providing uniform stress distribution. von Mises stresses were analyzed to assess the likelihood of material failure. The distribution of the stress in the restored tooth model was comparable to that seen in the intact model. Conclusion Transverse postalong with composite restoration provides a conservative and cost-effective alternative to fullcoverage crowns while providing a functional and aesthetic outcome. Further research and clinical studies are warranted to validate these findings and optimize the clinical application of transverse post systems in restorative dentistry.

Comparative evaluation of fracture resistance and push-out bond strength of glass fiber post with composite core and single-unit post and core system luted with two different resin cements: An in vitro study

ABSTRACT Aim: The aim of the study was to compare the fracture resistance and push-out bond strength of glass fiber post (GFP) with composite core and single unit post and core system luted with two different resin cements. Methods: Sixty-four mandibular premolars were chosen as the sample for the study. Sample preparation was done, and specimens were randomly divided into two groups (n = 32) each according to the type of post used: Group I – RelyX GFP, Group II – Edelweiss post and core. They were further subdivided in two subgroups based on luting cements: subgroup A: RelyX U200 Adhesive Resin cement and subgroup B: SoloCem resin cement. Fracture resistance was measured in half of the prepared specimens by subjecting a load of 1 mm/min. The load was subjected along the long axis of the tooth at an angle of 45° until failure occurred using the universal testing machine. Half of the samples were divided into three horizontal thirds, i.e., coronal, middle, and apical, and push-out bond strength was evaluated at a rate of 0.5 mm/min. The scores were subjected to statistical analysis using independent t-test and SPSS Version 22.0. Results: Group I showed nonsignificantly better fracture resistance than Group II irrespective of type of luting agent used. Subgroup B showed nonsignificantly higher fracture resistance than subgroup A irrespective of the post used. Subgroup B was nonsignificant better push-out bond strength than Subgroup A (P < 0.05). Push-out bond strength of Group II was significantly better than Group I irrespective of the luting agent. Conclusion: Fiber post showed nonsignificantly better fracture resistance than Edelweiss post and core system. SoloCem showed nonsignificantly better fracture resistance and push-out bond strength with Edelweiss than RelyX U200.

Transforming and Reforming the Indian Education System with Artificial Intelligence

India’s growing economy and population proves its significant stake in the Artificial lntelligence (AI) revolution. India's education and technology sector has grown exponentially over the last few years, particularly in times of Covid-19 pandemic but owing to various reasons, it is accessible to only one in four students in India. AI has proven to be of benefit to all stakeholders alike by (a) enhancing teachers' efficiency and effectiveness in managing Multi Levelled or Multi Graded Learning Units and enabling automated development of customised teaching content; (b) using Intelligent Tutoring Systems to tailor the learning materials to a child's level of competence, style and pace of learning for improving student interactivity and attention rates; and (c) for effective teacher posting and transfer systems and predicting likely student activities such as dropout rates in government schools. The research provides a comprehensive review of the rigorous inclusion of Al in India's education sector through various policy measures. According to the findings, Al increases the efficiency of grading and encourages critical thinking and analytical skills among students. Further studies can assess effective integration of AI with educational practices and policies to increase learning needs.

A Push-out Bond Strength Study and Interface Analysis of New Porous Titanium Dental Post Luted with Resin Cement

This study aimed to compare the push-out bond strength (PBS) between a new porous titanium post (PTP) and other marketed dental posts cemented with two types of dual-cure resin cement. A total of 96 extracted single-rooted human teeth were recruited. Four types of dental posts (n = 24 each), namely: stainless steel post (SSP), commercially-pure titanium post (CTP), fibre glass post (FGP), and PTP were cemented with two types of resin cements (RelyX U200 and ParaCore) and then sectioned at coronal and middle root levels. The specimens were subjected to a PBS test at a crosshead speed of 0.5 mm/min. The interface analysis was performed using a stereomicroscope and scanning electron microscope. A p-value < 0.05 was considered significant for all statistical tests. PBS recordings showed that the highest PBS mean value in RelyX group was 2.68±1.10 MPa for PTP. The differences in PBS between PTP and SSP and FGP were not significant (p = 0.098 and p = 0.075, respectively). The null hypothesis for RelyX group at both coronal and middle sections of the root was retained (p > 0.05). No failure at the post-cement interface was found in the PTP group, which was founder superior over the other posts (no gap for this interface was observed). The PTP showed similar bonding strength and adhesion to the other tested posts when using RelyX U200 cement. The PTP can be considered a new alternative option for the dental post system.

UNVEILING THE POST AND CORE WONDERS IN PRIMARY TEETH-A SERIES OF CASE REPORT

Pediatric dentists face significant challenges when dealing with the aesthetic concerns of severely damaged primary anterior teeth due to early childhood caries, which is the most common chronic disease among preschool children. The cases presented here involves children under 4 years of age with severely decayed maxillary anterior teeth. Following pulp therapy treatment, various posts including modified omega posts, glass fiber posts, and prefabricated post and core systems were used to reinforce the primary maxillary incisors, followed by composite restoration to rebuild the teeth. This technique provides a straightforward and efficient approach of restoring severely decayed primary anterior teeth, restoring their shape, function, and aesthetics effectively.

Comparative Evaluation of Fracture Resistance of Carbon Fiber Posts and Glass Fiber Posts in Permanent Anterior Teeth: An In Vitro Study.

Introduction Dental caries and traumatic injuries often lead to tooth loss in adolescents and adults, necessitating endodontic treatment and subsequent restoration. Restoring such teeth presents a challenge due to varying degrees of substance loss. After endodontic treatment, the choice of an appropriate post is crucial for long-term stability. While metal posts are sturdy, they lack aesthetics and may cause root fractures. Fiber posts, such as carbon and glass fiber, offer improved aesthetics and mechanical properties, but their comparative performance warrants investigation. Materials and methods A total of 30 extracted anterior single-rooted teeth were divided into two groups to receive either carbon fiber or glass fiber posts. After endodontic treatment and post-space preparation, the posts were cemented using a dual polymerizing adhesive resin composite. Fracture resistance was assessed using a universal testing machine. Results The mean fracture resistance of the carbon fiber post group was recorded at 271.2 N, whereas the glass fiber post group exhibited a significantly higher mean fracture resistance of 416.133 N. This difference in fracture resistance between the two groups was found to be statistically significant (p < 0.05). Conclusion Glass fiber post systems demonstrated superior fracture resistance compared to carbon fiber post systems in anterior single-rooted teeth. These findings support the clinical preference for glass fiber posts in restoring endodontically treated anterior teeth, offering both mechanical reliability and aesthetic advantages. However, further research, including long-term clinical trials, is warranted to validate these findings and assess the overall clinical performance and longevity of fiber post systems in real-world settings.

Fracture Resistance of Endodontically Treated Teeth Restored Using Multifiber Posts Compared with Single Fiber Posts

Purpose. The aim of this in vitro study was to evaluate the fracture resistance and type of failure of two adhesive fiber post systems used to restore endodontically treated teeth. Material and Methods. Twenty-seven extracted premolars were selected and divided into three groups (n=9): a control group restored with direct composite core (group 1), teeth restored with single fiberglass posts (group 2), and teeth were restored with multifiber posts (Biolight Plus System) (group 3). Fracture resistance was measured by applying axial compressive loads parallel to the longitudinal axis of the tooth until failure. Data was analyzed with one-way ANOVA followed by post hoc Turkey tests. Results. The results showed that the mean forces to failure of the control group (0.068 kN) were significantly lower than those restored with either fiberglass post systems (p=0.013). There was no significant difference between the multifiber and the single fiberglass post system in terms of resistance to fracture (p=0.097). Although there are more teeth fractured favorably (above the CEJ) in the Biolight Plus group (77.7%) compared to both the control and fiberglass post groups, it was not statistically significant (p=0.226). Conclusion. Within the limitations of this study, restoring endodontically treated with a multifiber post system is an adequate alternative to single fiberglass post system in terms of resistance to fracture.

Improved stability of aluminum surface plasmon resonance sensor by protective gold layer

The surface plasmon resonance (SPR) sensing in the ultraviolet (UV) region, achieved through the optimization of aluminum (Al) film conditions, has attracted attention due to its heightened energy levels and more plentiful molecular electronic transitions compared to the visible region. In this research, the stability of the UV-SPR sensor is improved by applying a protective thin layer of gold (Au) onto the Al film. This reduces spectral alterations observed when the Al film was uncoated in water pre and post flow system measurements. This exploration presents the initial experimental confirmation of the reliability of Al-Au bilayer coatings as SPR sensors in the UV region, highlighting advancements in UV-SPR sensor technology.

Comparison of Push-Out Bond Strengths of Different Fiber Post Systems Bonded with Resin Cement

Aim: This study compares the push-out bond strengths of 3 different fiber post systems bonded with resin cement to root canal dentin. Material and Methods: The study used 15 extracted single-rooted mandibular canine teeth. After the endodontic treatment of the teeth, they were randomly divided into three groups to apply different post-systems (n=5). Reforpost glass-fiber, Polydentia glass-fiber, and AAA Transparent fiber post systems were used in this study. The posts have adhered to the root canal with Panavia F2.0. A total of 6 slices of 1 mm thickness in the transversal direction were obtained, two from each of the coronal, middle, and apical sections of the prepared samples. The push-out test was performed from apical to coronal at a 0.5 mm/min speed. ANOVA and Tukey HSD tests were used for statistical analysis (p&lt;0.05). Results: The highest push-out binding values were observed in Polydentia (5.04±0.54); the lowest was seen in Reforpost (1.5±1.03). There was no statistical difference between the push-out binding values of the samples' apical, middle, and coronal regions for Reforpost and Transparent groups. In Polydentia group, the push-out binding values of the coronal region samples were significantly higher than those in the middle region. When the post groups were compared, the difference between the push-out binding values of all groups was statistically significant. Conclusion: The surface properties of the posts can affect the push-out bonding values. Polydentia showed the highest push-out binding values. In addition, the push-out attachment values of the posts may vary in different root canal regions.

Restoration of Bilateral Premolars Using Custom Made Cast Post and Core: A Case Report

When grossly carious teeth need to be restored after endodontic treatment, long term success depends on the choice of the post and core systems. A custom-cast post and core is recommended when the remaining tooth structure is compromised and an insufficient ferrule is present. The following case report depicts the restoration of bilateral grossly carious premolar teeth by using custom-cast posts followed by PFM crowns. The patient presented with bilateral severely carious premolars with pulpal necrosis. The treatment plan included endodontic treatment followed by custom-cast posts and cores with PFM crowns. In this way, aesthetics and function for the patient can be achieved by using cast metal posts and metal ceramic crowns for the restoration of premolars.

A case report on the rehabilitation anterior teeth using custom made post and pre fabricated fiber post and core

Posts are recommended to fortify weak, endodontically treated teeth against intra-oral forces by channeling torquing forces through the radicular dentin to supportive tissue along the roots. The subsequent case studies demonstrate an interdisciplinary approach that employed custom cast posts and complete veneer crowns to repair severely damaged treated teeth, restoring both their appearance and functionality. Coordinating prosthetic and endodontic treatments, while carefully considering the patient's expectations and requirements, played a pivotal role in achieving positive outcomes and ensuring patient satisfaction. Traditionally, the cast metal post and core system has been widely used as the foundational restoration for a prosthetic crown, benefiting from a natural extension of the post within the core. The post's function is to bolster the core restoration, which rebuilds the compromised coronal structure. This article explores the utilization of cast post and core systems alongside porcelain-fused-to-metal restorations for addressing injured maxillary central incisors.

Behavior of monostrand anchors in unbonded post tension flat slab system

Generally, the monostrand anchor, which is made of cast iron and used in the global market, has a rectangular shape. It is commonly used when low concrete stresses are induced and minimum slab thickness is needed. Multiple monostrand anchors can be used adjacent to each other at one or more horizontal levels in slabs to replace a multistrand anchor system, which combines two or more strands in the same anchor. Monostrand anchor has a proper stress distribution, while the multistrand has greater overlap zone stresses in post tension slabs. An experimental study was conducted on round monostrand anchors to investigate anchorage and anchor bearing zones. Concrete blocks were prepared, and tested at different ages. The goal is to evaluate the contribution of the concrete's strength improvement against bursting pressure caused by jacking forces at the edge zone of a flat slab. The blocks were stressed using jacking machine. Strands with two diameter sizes (12.7 mm and 15.7 mm) were used. A rigid steel framework was developed as an abutment that can withstand all jack's response forces on the tested concrete blocks. On the other hand, this framework serves as a fixation for the cables' dead ends. The concrete blocks were attached to this framework. After that, they were stressed up to failure. Hairpin reinforcement were used to strengthen the blocks, and resist the applied stresses. Multiple round monostrands were also placed adjacent to each other to produce stress concentration in the concrete blocks. Numerical models were also constructed using finite element to simulate the experimental tests and validate the obtained results. The results were also compared to ACI provision.

Evaluation of the push out bond strength of fiber post system and PolyEtherEtherKetone (PEEK) post after different surface treatments. (An Invitro study)

Evaluation of the push out bond strength of fiber post system and PolyEtherEtherKetone (PEEK) post after different surface treatments. (An Invitro study)

Comparative evaluation of dental integrity using three computer-aided design/computer-aided manufacturing customized post systems

Background Endodontically treated teeth (ETT) are considered structurally compromised due to significant changes in their biomechanics.The purpose of this in vitro study was to evaluate fracture resistance using three computer-aided design/computer-aided manufacturing (CAD/CAM) customized post systems. Methods Forty extracted intact maxillary central incisors were used in the study, and the teeth were endodontically treated and randomly divided into four equal groups (n = 10): control group without any post and accessed cavity was restored with direct composite restoration. Test groups were prepared for a post and restored according to the material type. The posts and cores were fabricated with computer-aided design/computer-aided manufacturing technology using titanium, vita enamic, and biological dentin materials. The posts were luted using self-adhesive resin cement, and then, zirconia crowns were fabricated, cemented, teeth in all groups were mounted to universal testing machine and subjected to compressive load in Newton at crosshead speed 0.5 mm/min. Results Control group exhibited the highest fracture resistance (727 ± 172.05) followed by biological dentin posts with mean value (712.29 ± 298.58) then group titanium posts with mean value (678.59 ± 132.83) and the least fracture resistance was for group vita enamic with mean value 331.84 ± 74.27. Regarding to fracture favorable it was significantly higher in vita post group than titanium post group (70% vs. 30%) and control group (70% vs. 10%) but it was significantly higher in biological dentin group than titanium group (80% vs. 70%). Conclusion According to type of material, teeth restored with the biological dentin posts showed highest fracture resistance followed by titanium posts, the least fracture resistance was vita enami posts.