BACKGROUND: Hospital-based registry plays an important role in providing statistics regarding the occurrence of cancer in a defined population and a framework for assessing and controlling the impact of cancer in the community. Central nervous system (CNS) tumors represent a major public health problem, and their epidemiological data in Egypt have been rather incomplete except for some regional reports. The objective of this study was to set up a model of cancer registry form to be used in the establishment of a computerized hospital-based registry system and provide hospital-based data of cancer cases for a whole year and to use the National Cancer Registry Program of Egypt (NCRPE) to estimate the incidence of CNS tumors. METHODOLOGY: We introduced the software program of National Cancer Registry Program of Egypt (NCRPE) in the Clinical Oncology department of Ain Shams University Hospitals. All newly diagnosed cases with CNS tumors have been registered from 30 May 2012 to 1st June 2013 using the NCRPE registry form followed by its entry in the software program. RESULTS:The software program of the NCRPE was introduced in the Clinical Oncology department which is a web-based application developed by the registry and centrally stored on the main server of the ministry of Communication and Information Technology. “Double Minus” program was developed to detect duplicate cases to complete the data processing cycle. Duplicate forms were shown on the screen for the data manager to complete one form and discard the other or include the 2nd form as double primary with adjustment of sequence number. The program store all data entered allows exporting the data at any time into an excel file in a way that facilitate direct analysis of the data for research purposes. The total number of registered newly diagnosed patients received during the study period was 943 cases. CNS tumors accounted for 53 newly diagnosed cases(5.6%)and was ranked as the fourth common cancer in both sexes. 54.7% of CNS tumors occurred in males . The mean age was 43.1 years +/- 19.5 SD. 62.3% of the cases were from Cairo, 20.8% were from Upper Egypt and 8% were from Lower Egypt. 54% of the lesions were overlapping and 13% of the cases were presented with frontal lobe lesions at time of diagnosis. Glioblastoma Multiforme was the most common pathology occurring in about 43.3% of the presented cases. CONCLUSION: Hospital-based cancer registry is a corner stone for cancer burden assessment through providing accurate incidence data.This study drew attention to the incidence of the CNS tumors that requires further epidemiological studies for possible risk factors association.