Sparse code multiple access (SCMA) is one of the promising implementations of non-orthogonal multiple access (NOMA) methods. SCMA provides high spectral efficiency and a large number of network resources. We describe a communication system with SCMA, space-time block coding (STBC), multiple input multiple output (MIMO) technology, and orthogonal frequency division multiplexing (OFDM). The architecture of such systems, including algorithms of formation and processing of signals is considered. A method for adapting signals to the state of the spatial channel transmission based on information about the matrix of channel coefficients is proposed. The application of such adaptation allows to compensate the influence of the channel and to reduce the probability of bit errors. We consider the bit error rate (BER) performance of the communication system in different channel models and show the effectiveness of the proposed methods.