Formation Of Inclusions Research Articles

The relative impact of traditional and digital financial inclusion on economic growth: a threshold regression-based comparative analysis

ABSTRACT This study examines the effect of traditional and digital financial inclusion on economic growth in 130 developed and developing countries in 2014 and 2017. The motivation behind this study emerges from the critical need to discern not only how traditional and digital financial inclusion individually influence economic growth, but also to compare their relative contributions. In addition, there exists a potential non-linear relationship between traditional and digital financial inclusion, wherein both forms of financial inclusion can exert a positive influence on economic growth up to a specific threshold. For this purpose, traditional and digital financial inclusion indices were developed as distinct measures to investigate the relative contribution of each to economic growth. Cross-sectional sample splitting and threshold estimation were utilised to analyse whether the effects of each financial inclusion index on economic growth varied across different levels of digital and traditional financial inclusion. This study yielded two notable findings. First, the effect of traditional financial inclusion on economic growth is pronounced in countries with low levels of inclusion. Second, digital financial inclusion has a greater positive impact on economic growth in countries with higher levels of digital financial inclusion.

Effect of sulfur content on precipitation behaviour of MnS-containing inclusions in X70 pipeline steel

The presence of oxide-MnS complex inclusions is beneficial for the improvement of hydrogen resistance in pipeline steel. The effect of S and Mg contents on the generation mechanism of MnS, MgAl2O4, and MgO inclusions, and the heterogeneous nucleation principle of MnS on the surfaces of MgAl2O4 and MgO were revealed using laboratory experiments, thermodynamic calculations, and density functional theory (DFT) computations. The inclusion characteristics in steel were evaluated by using a Scanning Electron Microscope in combination with an Energy Dispersive Spectrometer (SEM + EDS). It has been found that as the Mg content increased, MgAl2O4 transformed into MgO, which can be well predicted by thermodynamic calculations. It was found that MnS exhibited the ability to nucleate heterogeneously on the surfaces of MgO and MgAl2O4 inclusions. Furthermore, proper S content (approximately 30 ppm) can facilitate the formation of oxide-MnS complex inclusions, excess S content was not desired. The smaller the oxide inclusion, the easier to form wrapped MnS on the oxides. The nucleation ability of MnS and MgAl2O4 was identified by DFT calculations and found that they followed the order of (111)MnS//(111)MgAl2O4>(100)MnS//(100)MgAl2O4>(110)MnS//(110)MgAl2O4. Furthermore, the heterogeneous nucleation ability of MnS and MgO followed in the order of (111)MnS//(111)MgO > (100)MnS//(111)MgO > (100)MnS//(100)MgO. This study provides theoretical evidence supporting the heterogeneous nucleation ability of MnS on the surfaces of MgO and MgAl2O4. Moreover, it helps bridge the disparity between the calculation of MnS and MgO nucleation using the two-dimensional mismatch degree and the experimental findings.

Constraints on Crystallinity of Graphite Inclusions in Nephrite Jade from Xinjiang, Northwest China: Implications for Nephrite Jade Formation Temperatures

Graphite usually occurs in mineral/rock associations in the form of solid inclusions and plays an important role in tracing regional metamorphic degree, ore-forming temperature, fluid evolution, as well as the deep carbon cycle of the Earth. In this study, we investigate the placer black nephrite jade where the co-occurrence of abundant graphite inclusions and jade remains extraordinary. By employing petrographic, mineral-chemical, and Raman spectroscopic methods, we characterize the textures and crystallinity of graphite inclusions that exist in nephrite jade. EPMA and petrological data indicate that the main constituents of black jade are tremolite and graphite, with minor phases of diopside, calcite, dolomite, epidote, and apatite. Micro-Raman spectroscopic thermometry of carbonaceous material shows that most of the formation temperatures of graphite inclusions are between 378 and 556 °C, and only a few temperatures may be above 650 °C, indicating that graphite inclusions were formed at medium- to high-temperature metamorphic facies. The petrologic and spectral investigations of graphite inclusions in these nephrite jade samples show major metamorphic signatures with mixed features associated with fluid precipitation. Our results allow us to propose that primary nephrite jade was formed under multi-stage tectonic evolution conditions, and regional temperatures were predominately driven by the late continent–continent collision, while the ore-controlling temperatures of nephrite jade formation were found in a medium- to high-temperature environment.

Effect of the ati Gene Deletion on the Pathogenicity and Immunogenicity of the Vaccinia Virus.

Among the nonvirion proteins of the vaccinia virus (VACV), a 94-kDa long protein is most abundantly present; the protein is a truncated form of the 150-kDa A-type inclusion (ATI) protein of the cowpox virus encoded by the ati gene. This VACV protein does not form intracellular ATIs, being as it is a major immunogen upon infection/immunization of humans or animals with the VACV. Antibodies specific to this protein are not virus-neutralizing. The present study focused on the effect of the production of this nonstructural major immunogenic VACV protein on the manifestation of pathogenicity and immunogenicity of the virus in the BALB/c mouse model of infection. In order to introduce a targeted deletion into the VACV LIVP genome, the recombinant integration/deletion plasmid pΔati was constructed and further used to generate the recombinant virus LIVPΔati. The pathogenicity of the VACV LIVP and LIVPΔati strains was studied in 3-week-old mice. The mice were intranasally infected with the viruses at a dose of 107 pfu; 50% of the animals infected with the parent LIVP strain died, while infection with the LIVPΔati strain led to the death of only 20% of the mice. Intradermal vaccination of mice aged 6- weeks with the LIVPΔati virus statistically significantly increased the production of VACV-specific IgG, compared to that after intradermal vaccination with VACV LIVP. Meanwhile, no differences were noted in the cell-mediated immune response to the vaccination of mice with VACV LIVP or LIVPΔati, which was assessed by ELISpot according to the number of splenocytes producing IFN-γ in response to stimulation with virus-specific peptides. Intranasal infection of mice with lethal doses of the cowpox virus or the ectromelia virus on day 60 post-immunization with the studied VACV variants demonstrated that the mutant LIVPΔati elicits a stronger protective response compared to the parent LIVP.

Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2

Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein share enigmatic roles in the pathobiology of Parkinson's disease (PD). LRRK2 mutations are a common genetic cause of PD which, in addition to neurodegeneration, often present with abnormal deposits of α-synuclein in the form of Lewy-related pathology. As Lewy-related pathology is a prominent neuropathologic finding in sporadic PD, the relationship between LRRK2 and α-synuclein has garnered considerable interest. However, whether and how LRRK2 might influence the accumulation of Lewy-related pathology remains poorly understood. Through stereotactic injection of mouse α-synuclein pre-formed fibrils (PFF), we modeled the spread of Lewy-related pathology within forebrain regions where LRRK2 is most highly expressed. The impact of LRRK2 genotype on the formation of α-synuclein inclusions was evaluated at 1-month post-injection. Neither deletion of LRRK2 nor G2019S LRRK2 knockin appreciably altered the burden of α-synuclein pathology at this early timepoint. These observations fail to provide support for a robust pathophysiologic interaction between LRRK2 and α-synuclein in the forebrain in vivo. There was, however, a modest reduction in microglial activation induced by PFF delivery in the hippocampus of LRRK2 knockout mice, suggesting that LRRK2 may contribute to α-synuclein-induced neuroinflammation. Collectively, our data indicate that the pathological accumulation of α-synuclein in the mouse forebrain is largely independent of LRRK2.

In situ study on nucleation mechanism and surface morphology of zinc thiourea sulfate crystals

Different nucleation phenomena and defect formation were observed in scanning experiments on the (100) faces of zinc thiourea sulfate (ZTS) crystals using Atomic Force Microscopy (AFM). It was found that nucleation is easily induced near microcrystals, but two-dimensional nuclei do not appear continuously. Edge dislocation can be preferred for nucleation, but the time of occurrence of two-dimensional nuclei near the surface of the edge dislocation is not the same as the growth rate. When two-dimensional nuclei and dislocations co-exist, the step heights have a significant impact on which growth mechanism ultimately dominates. In addition, the experimental results show that the defects produced on the surface of ZTS crystals mainly include hollow defects, pits and liquid inclusions. The causes of the different defects are discussed. It is found that the height of the step has an important influence on the formation of liquid inclusions and their possible influence on the surface morphology is analysed.

The Effect of the Addition of Aluminum Nitride to the Composition of NiAl2O4 Ceramics on Hydrogenation Processes and the Increase in Resistance to Swelling and Degradation

This work examines the effects of the formation of impurity inclusions in the structure of NiAl2O4 ceramics when aluminum nitride is added to them and the occurrence of a reinforcement effect that prevents hydrogenation processes and the subsequent destruction of conductive and thermophysical characteristics. The appeal of ceramics possessing a spinel crystal structure lies in their potential use as ceramic fuel cells for both hydrogen generation and storage. Simultaneously, addressing the challenges related to ceramic degradation during hydrogenation, a critical aspect of hydrogen production, can enhance the efficiency of these ceramics while lowering electricity production costs. The selection of aluminum nitride as an additive for ceramic modification is based on its remarkable resistance to structural damage accumulation, its potential to enhance resistance to high-temperature degradation, and its ability to bolster strength properties. Moreover, an examination of the alterations in the strength characteristics of the examined samples subjected to hydrogenation reveals that the stability of two-phase ceramics is enhanced by more than three to five times compared to the initial ceramics (those without the addition of AlN). Additionally, it was noted that the most significant alterations in both structure and strength become apparent at irradiation fluences exceeding 1014 proton/cm2, where atomic displacements in the damaged ceramic layer reach over 5 dpa. During the evaluation of thermophysical properties, it was discerned that ceramics featuring an impurity phase in their composition exhibit the highest stability. These ceramics demonstrated a reduction in the thermal conductivity coefficient of less than 1% at the peak irradiation fluence.

Deconstructing and Reconstructing Englishness: National Symbolism of the County House in McEwan’s Atonement

ABSTRACT This article extends previous readings of Atonement’s representation of the English country house by examining it in relation to a nostalgic version of Englishness that still appeals to a contemporary audience. It argues that the novel both deconstructs and reconstructs the idea of rural Englishness endorsed by the heritage culture. By disclosing the constructedness of the timeless England, Atonement shows that rural Englishness is crafted out of a fantasy of seamless historical continuity that has never existed. McEwan indicates that the projection of the aristocratic patriarch’s private property as a repository of English values and culture obscures the class and gender oppression embedded in the country-house power structures. The progressive politics of Atonement is further seen in its refiguration of the elitist, exclusive version of Englishness as a more democratic and inclusive form of Britishness. It justifies the vision of multicultural British identity by appealing to the shared past of Heritage England and immigrants from the old empire. This shared past is revealed in the novel through subtle allusions to the hidden connections between English estate houses and Britain’s colonial enterprise.

Genesis of submarine volcanic iron deposits in the Central Asian Orogenic Belt: Insights from the texture and chemical composition of magnetite from the Langwashan iron deposit in the Beishan orogenic belt, NW China

Carboniferous submarine volcanic rocks hosting iron deposits are widely distributed in the Tianshan and Beishan orogenic belts. However, the genesis of these deposits remains unresolved, with contrasting magmatic and magmatic-hydrothermal models being proposed. The Langwashan iron deposit (83.18 Mt @ 37% Fe) is one of the largest iron deposits in the Beishan orogenic belt. In this paper, we present detailed textural and trace-elemental properties of magnetite from the Langwashan iron deposit to elucidate the genesis and evolution of iron mineralization hosted in Lower Carboniferous submarine volcanic rocks. The Langwashan iron deposit has various types of iron ore that are closely associated with skarn minerals, including garnet and epidote. Magnetite in these samples can be classified into two distinct types, early-stage mushketovite (Mag1) and late-stage granular magnetite (Mag2), both of which show oscillatory zoning, with low Ti (mean of 0.03–0.07 wt%) and V (mean of 0.03–0.04 wt%) contents, and variable Si contents (mean of 0.74–6.50 wt%). These textural and compositional data classify the Langwashan deposit as a typical Fe-skarn deposit. Results also reveal that iron oxides in the Langwashan deposit underwent a complex evolution comprising three episodes: (1) early-stage influx of low-oxygen-fugacity, calcium-rich hydrothermal fluids, causing the transformation of original hematite to mushketovite (Mag1-1) and the formation of scheelite inclusions; (2) subsequent dissolution–reprecipitation between high-temperature magmatic-hydrothermal fluids and Mag1-1, generating trace-element-rich mushketovite (Mag1-2) and the precipitation of trace-element-rich granular magnetite (Mag2-1) from magmatic-hydrothermal fluids; and (3) final multiple fluid metasomatism under the influence of trace-element-poor hydrothermal fluids, involving dissolution–reprecipitation that produced trace-element-deficient Mag1-3, Mag2-2, and Mag2-3. Results also highlight that the submarine volcanic iron deposits from both the Tianshan and the Beishan orogenic belts were probably formed in a similar geological setting, with similar timing of formation, mechanism of mineralization, and evolution, and they are likely Fe-skarn deposits.

“Everybody’s searching their roots”: centering Black nature-cultures of belonging in non-compulsory computer science education

ABSTRACT Background & context Inspired by the nature-cultures of belonging from Black hair care, we conducted a design experiment to bridge computer science (CS) education, urban gardening, and cosmetology in a culturally responsive computing (CRC) library program. Objective The design was oriented around a small-scale aquaponics system to grow mint and lavender for making natural cosmetic products. We hypothesized that this could inform the design and implementation of computational thinking and computer programming educational activities. Methods We analyzed qualitative and quantitative data from the design experiment to theorize the processes of using the aquaponics system to enroll Black nature-cultures of belonging in the CRC program. Findings Given that the program supported children’s self-confidence in and knowledge of CS, nature-culture inspired CS education appears feasible. Implications Through respectful engagement with the discourses and practices of Black hair care, we provide insight into how nature-cultures can contribute to more diverse, inclusive, and pluralistic forms of CS education.

Phase analysis of complex non-metallic inclusions in Al-deoxidized 42CrMo4 steel after contact with MgO–C refractories

This study extensively investigated characteristic non-metallic inclusions in oxidized and deoxidized 42CrMo4 steel after contact to MgO–C refractories, proposing possible formation and modification mechanisms of non-metallic inclusions. The structures and compositions of different inclusion species were analyzed, revealing various types: crystalline, amorphous, and complex inclusions containing both crystalline and amorphous phases. The latter always consisted of an amorphous Mn–Si–Al–O matrix containing various crystalline phases such as Al2O3, MnAl2O4 and/or MnTiO3. The formation of amorphous Mn–Si–Al–O inclusions was attributed to steel melt oxidation, while pure crystalline corundum inclusions resulted from both the steel melt oxidation and deoxidation. Alumina inclusions exhibited different shapes, likely because of variations in aluminum and oxygen supersaturation in the steel melt during their formation. Complex inclusions were suggested to form through precipitation on existing inclusions and mutual collision of pre-existing inclusions, facilitated by the non-wetting behavior of solid alumina inclusions in the steel melt.

Rethinking ritual: how rituals made our world and how they could save it★

AbstractIn this Henry Myers Lecture, I summarize several decades of collaborative research on the role of ritual in group bonding and co‐operation, ranging from psychology experiments in university laboratories to field research among indigenous groups, and from surveys with armed revolutionaries to extended interviews with religious adherents. This body of work is helping to clarify the mechanisms by which social cohesion and prosocial behaviour are generated in a variety of groups, such as mothers experiencing traumatic births, football fans suffering defeat at crucial matches in Brazil and Australia, and Muslim fundamentalists in Indonesia contemplating insults to Islam in faraway conflicts. These findings also shed light on changes in ritual life from the palaeolithic to the first farmers and from archaic states to the first moralizing religions. In keeping with the forward‐looking theme of the 2022 RAI conference, I consider the implications of these findings for various practical problems facing humanity today, such as how to reduce crime and to prevent violent extremism and how to foster more inclusive forms of leadership and motivate action on environmental issues.

A Brief Analysis and Interpretation on Arithmetic Operations of Fuzzy Numbers

Fuzzy set theory is a generalized form of crisp set theory where elements are binary inclusion forms. In fuzzy set, it differs with degree of membership for every element in the set. There are several strategies for arithmetic operations on fuzzy numbers. Previous studies show that there are many approaches, such as the α−cut technique, extension principle, vertex method, etc., to execute arithmetic operations on fuzzy numbers. In this study we perform details analysis and interpretation on arithmetic operations based on the α−cut method in a new way.

Backscattering of Ultrasonic Waves as the Basis of the Method of Control of Structure and Physicо-Mechanical Properties of Cast Irons

Increasing the reliability of control of cast iron structure and its physical and mechanical characteristics is an important scientific and technical task of the machine-building industry. The paper studies the possibilities of controlling the structure of cast irons using structural noise created by ultrasonic scattering on graphite inclusions of different shapes. The subject of the present studies was such characteristics of structural noise as amplitude-temporal A(t) and as root mean square value of the amplitude of the ultrasonic waves backscattering field AN, compared with the data on ultrasonic velocity and strength or tensile strength of cast iron samples. As a result of the studies, a significant difference between the amplitude parameters of the AN structural noise obtained for samples with different shapes of graphite inclusions at 5 MHz was revealed for the first time. So, for example, for samples of gray cast iron (Russian: СЧ10, СЧ15, СЧ20, СЧ25), having predominantly plate-like form of graphite inclusions, the value of AN on 14–15 dB exceeds that measured in high-strength specimens of the cast iron with the prevailing form of spherical graphite inclusions ВЧ50 (Russian), etc. At the same time growth of longitudinal ultrasonic velocity amounted to 20–25 %. The method of rejection of gray cast iron from high-strength cast iron according to the data of amplitude parameters of structural noise AN at unilateral and local sounding of the object without using an additional reference signal reflected from its oppositional wall is suggested.

STUDY OF THE INFLUENCE OF MgO DOPING ON THE THERMOPHYSICAL PROPERTIES OF CERAMICS BASED ON LITHIUM METAZIRCONATE

The paper presents the results of studying the effect of doping with magnesium oxide (MgO) of lithium-containing ceramics based on lithium metazirconate (Li2ZrO3) on the change in the thermophysical parameters of ceramics. The method of mechanochemical synthesis followed by high-temperature annealing at a temperature of 1300 °C, used to initiate the processes of phase transformations from structural ordering, was chosen as the main method for obtaining ceramics, as well as for performing MgO doping processes. In the course of the studies, it was found that an increase in the concentration of the MgO dopant above 0.10 mol leads to the formation of impurity inclusions in the structure of ceramics in the form of a tetragonal phase MgLi2ZrO4, the content of which increases with an increase in the concentration of the dopant. In the case of a dopant concentration of 0.25 mol, the phase composition of ceramics is an equiprobable distribution of two phases, monoclinic Li2ZrO3 and tetragonal MgLi2ZrO4. In the course of measuring thermophysical parameters, it was found that the formation of the MgLi2ZrO4 phase in the composition of ceramics leads to an increase in the thermal conductivity by 5–10%, and in the case of an equiprobable distribution of phases in two-phase MgLi2ZrO4– Li2ZrO3 ceramics, the increase in thermal conductivity is more than 25% in comparison with undoped ceramics. An increase in the efficiency of heat-conducting properties for two-phase ceramics is due to an increase in the rate of phonon heat transfer due to additional interfacial boundaries, as well as an increase in the degree of structural ordering and density of ceramics.

Colocalization of TDP-43 and stress granules at the early stage of TDP-43 aggregation in amyotrophic lateral sclerosis.

TDP-43 aggregates (skeins and round inclusions [RIs]) are frequent histopathological features of amyotrophic lateral sclerosis (ALS). We have shown that diffuse punctate cytoplasmic staining (DPCS) is the earliest pathologic manifestation of TDP-43 in ALS, corresponding to nonfibrillar TDP-43 located in the rough endoplasmic reticulum. Previous in vitro studies have suggested that TDP-43 inclusions may be derived from stress granules (SGs). Therefore, we investigated the involvement of SGs in the formation of TDP-43 inclusions. Formalin-fixed spinal cords of six ALS patients with a disease duration of less than 1 year (short duration), eight patients with a disease duration of 2-5 years (standard duration), and five normal controls were subjected to histopathological examination using antibodies against an SG marker, HuR. In normal controls, the cytoplasm of anterior horn cells was diffusely HuR-positive. In short-duration and standard-duration ALS, the number of HuR-positive anterior horn cells was significantly decreased relative to the controls. DPCS and RIs were more frequent in short-duration ALS than in standard-duration ALS. The majority of DPCS areas and a small proportion of RIs, but not skeins, were positive for HuR. Immunoelectron microscopy showed that ribosome-like granular structures in DPCS areas and RIs were labeled with anti-HuR, whereas skeins were not. These findings suggest that colocalization of TDP-43 and SGs occurs at the early stage of TDP-43 aggregation.

Feedback digitalization preferences in online and hybrid classroom: Experiences from lockdown and implications for post-pandemic education

PurposeThis research aims to explore digital feedback needs/preferences in online education during lockdown and the implications for post-pandemic education.Design/methodology/approachAn empirical study approach was used to explore feedback needs and experiences from educational institutions in the Netherlands and Germany (N = 247) using a survey method.FindingsThe results showed that instruments supporting features for effortless interactivity are among the highly preferred options for giving/receiving feedback in online/hybrid classrooms, which are in addition also opted for post-pandemic education. The analysis also showed that, when communicating feedback digitally, more inclusive formats are preferred, e.g. informing learners about how they perform compared to peers. The increased need for comparative performance-oriented feedback, however, may affect students' goal orientations. In general, the results of this study suggest that while interactivity features of online instruments are key to ensuring social presence when using digital forms of feedback, balancing online with offline approaches should be recommended.Originality/valueThis research contributes to the gap in the scientific literature on feedback digitalization. Most of the existing research are in the domain of automated feedback generated by various learning environments, while literature on digital feedback in online classrooms, e.g. empirical studies on preferences for typology, formats and communication channels for digital feedback, to the best of the authors’ knowledge is largely lacking. The findings and recommendations of this study extend their relevance to post-pandemic education for which hybrid classroom is opted among the highly preferred formats by survey respondents.

The fourth ecology: Hikikomori, depressive hedonia and algorithmic ubiquity

In this article we expand upon the conceptual framework of Félix Guattari’s 1989 essay, The Three Ecologies. Here Guattari examines changes in subjectivity that have come about due to scientific and technological advances which, as he sees it, brought about an “ecological disequilibrium” ([1989]2000, 27) and deteriorated individual and collective modes of being. In response to this Guattari proposes a kind of holistic therapy or ‘ecosophy’ between three ecological registers: “the environment, social relations and human subjectivity” (ibid., 28). Guattari cautions that we not only take note of these macro determinations, but also heed the libidinal impulses of desire – what captures it, what directs it, and what shuts it down. Since the publication of The Three Ecologies, the rise of digital technologies has dramatically influenced the ways in which people think, live and communicate. Technological infrastructures, for instance, are used to spread disinformation at a vast speed and scale, and because social networks are often homophile many people infrequently encounter critical disagreement and debate. The increase in media and digital communications usage has also led to new forms of social inclusion and exclusion, the most exacerbated form of which is probably the phenomenon known as hikikomori – acute, prolonged social withdrawal. Taking hikikomori as our focus, we describe what we see as a general set of symptoms of society and trace its myriad intersections with an ever-increasing algorithmic ubiquity, which we posit as the new form of hyper-modulation following from Foucault’s disciplinary societies and Deleuze’s control societies.

Memories and Musings: My Experiences with Marcia Gentry and More

ABSTRACT Marcia Gentry personified a life well-lived. In this tribute to her work and legacy, her early ideas are highlighted. The author describes her professional experiences with Marcia during the years when Marcia was a doctoral student at the University of Connecticut. Recalling her initial motivation for a more inclusive form of identification of gifted students, the author shares Marcia’s experiment with cluster grouping while still working in a public school in Michigan and describes how that experience grew into one of Marcia’s major lines of inquiry in her quest for more inclusive and authentic strategies for identifying gifted and talented youngsters. The author relates how this line of inquiry mirrored her own work in identifying twice-exceptional students using more authentic identification methods. Also explored is Marcia’s early experience with authentic learning as she developed curriculum for Project High Hopes, and how this problem-based curriculum was a precursor for Marcia’s extensive work with Enrichment Clusters as a means to extend gifted pedagogy to all students. The author then details her own research in using authentic learning as a research-based intervention for twice-exceptional students.

Trehalose consumption ameliorates pathogenesis in an inducible mouse model of the Fragile X-associated tremor/ataxia syndrome

ABSTRACT Trehalose is a naturally occurring sugar found in various food and pharmaceutical preparations with the ability to enhance cellular proteostasis and reduce the formation of toxic intracellular protein aggregates, making it a promising therapeutic candidate for various neurodegenerative disorders. Objectives Here, we explored the effectiveness of nutritional trehalose supplementation in ameliorating symptoms in a mouse model of Fragile X-associated tremor/ataxia syndrome (FXTAS), an incurable late onset manifestation of moderately expanded trinucleotide CGG repeat expansion mutations in the 5’ untranslated region of the fragile X messenger ribonucleoprotein 1 gene (FMR1). Methods An inducible mouse model of FXTAS expressing 90 CGG repeats in the brain had been previously developed, which faithfully captures hallmarks of the disorder, the formation of intracellular inclusions, and the disturbance of motor function. Taking advantage of the inducible nature of the model, we investigated the therapeutic potential of orally administered trehalose under two regimens, modelling disease prevention and disease treatment. Results and Discussion Trehalose's effectiveness in combating protein aggregation is frequently attributed to its ability to induce autophagy. Accordingly, trehalose supplementation under the prevention regimen ameliorated the formation of intranuclear inclusions and improved the motor deficiencies resulting from the induced expression of 90 CGG repeats, but it failed to reverse the existing nuclear pathology as a treatment strategy. Given the favorable safety profile of trehalose, it is promising to further explore the potential of this agent for early stage FXTAS.