The extensive research project Cambio (2020) by the Italian designer duo Formafantasma focuses on the tree, the forest in its function of securing the existence of humans, animals and other plants. The project uses various forms of critical representation and storytelling to explore the connections between exploitation, consumer culture and colonialism in the face of the industrial timber industry. The question is: What responsibility do we bear in relation to the treatment of trees and what response-ability do trees themselves have? Based on three essayistic short films and other objects from the Cambio exhibition, my contribution addresses these questions of responsibility and respons-ability with regard to the relationship between humans and trees. In the sense of Donna Haraway, the what and how of artistic representation and narration itself becomes a question of response-ability - i.e. the possibility of becoming responsible in responding. Here, with Haraway in mind, the ethically necessary perspective unfolds of not having to distinguish between a real world and a world of stories and narratives, but of being able to think material-semiotic worlds in a (responsible) situated way and allow them to emerge. This paper proposes response-ability as a conceptual and analytical rubric and as a guiding ethical practice for the new materialist-inspired endeavor to rethink human and non-human interdependency in relation to trees. I will intruduce the exhibition Cambio and three of its films as an exemplary site of narrative and representational modes that have the potential to sensitize us to those relations of interdependency.