Analogous Form Research Articles

Donald Davidson’s Critiques of Conceptual Relativism Applied to Non-adaptationist Evolutionary Epistemology and Refuted

Over the last three decades, non-adaptationism has developed as an alternative model to more traditional, adaptationist approaches within Evolutionary Epistemology (EE). Despite its great explanatory strength, non-adaptationist EE finds a potential Achilles heel in its adherence to conceptual relativism, namely the idea that empirical content can be relative to many different and radically incommensurable conceptual schemes. In his seminal essay “On the Very Idea of a Conceptual Scheme” (1974), Donald Davidson did in fact prove the unintelligibility of an analogous form of conceptual relativism. Although Davidson’s original intent was to debunk a conceptual relativist position which he discerned in the works of authors such as Kuhn, Quine, and Whorf, given the apparent similarity between the conceptual relativism supported by non-adaptationist EE and the one criticised by Davidson, one might well wonder if Davidson’s objections would have the same debunking effect if applied to non-adaptationist EE. In this paper I propose to answer this question by directing Davidson’s critiques of conceptual relativism to non-adaptationist EE and by testing to what extent the latter is de facto undermined by Davidson’s attacks. I demonstrate that Davidson’s arguments do not detract from the reliability of non-adaptationist perspectives and, to some extent, they appear to substantiate the non-adaptationist evolutionary epistemological cause anew.

Investigation of organoleptic and functional-technological parameters of meat breads using mechanically deboned poultry meat

Creation of combined meat products combining traditional consumer properties, as well as the possibility of using non-traditional raw materials in their recipes, is aimed at the expansion and rational use of the raw material base of the meat processing complex and solves the problem of reducing nutrient deficiency in the diet of the population. Therefore, the issue of the use of mechanically deboned poultry meat in meat bread technology and its impact on qualitative indicators and functional and technological properties is relevant. The aim of the research was to study the feasibility of the use of mechanically deboned poultry meat in the technology of combined products. Three model recipes based on the formula-meat analogue “Chainyyi” were developed. The possibility of replacing beef and pork meat with duck meat and mechanically deboned poultry meat of turkey was studied in the bread recipes. The total amount of duck meat and mechanically deboned poultry meat was 63%. As a protein ingredient able to bind moisture and relatively inexpensive compared to meat raw material, 20% of the pig's heart was added to the formulation, as well as 2% XB Fiber. Other components of the analogue formulation have not changed. Combination of duck meat with mechanically deboned poultry meat of turkey and pork hearts in the abovementioned ratios as part of meatcontaining bread stuffing systems allowed to improve the nutritional value of the product and its qualitative indices. The research confirmed the possibility of combining regional and relatively cheap raw materials to increase the nutritional value of meatcontaining products, namely breads. The bulk of proteins in the experimental samples increased by 6.57–10.38% and was within the range of 17.96–17.34%. On average, 4.98% decreased the fat content, the product became less calorie relative to the analogue by 15.98–16.76%. The formulations of model minced meat were distinguished by a higher index of the water-holding capacity, the content of binding moisture and the best indicators of plasticity. This affected the quantity of finished products, which amounted to 120.64–117.3% to the mass of raw materials, while in the control sample this figure was lower by 3.49–7.47%.

SAT-429 Final Results from the First in Man Phase 1 Clinical Trial of CRN00808, an Orally Bioavailable sst2-Selective, Nonpeptide Somatostatin Biased Agonist, for the Treatment of Acromegaly: Safety, Pharmacokinetics, Pharmacodynamics, and Midazolam Drug Interaction in Healthy Volunteers

Injected depot formulations of somatostatin peptide analogs are routinely used to treat acromegaly and neuroendocrine tumors (NETs). CRN00808 is a small molecule nonpeptide selective somatostatin receptor 2 agonist whose safety, pharmacokinetics (PK), and pharmacodynamics (PD) has been characterized in preclinical studies. This study describes the final results from a first-in-human, single and multiple ascending dose Phase 1 study in healthy volunteers to measure the safety, PK, PD, and midazolam drug interaction potential of CRN00808 (NCT03276858; preliminary results with blinded safety data presented at ENDO 2018). In the single dose arm of the study, cohorts of 8 subjects (6 active: 2 placebo) received CRN00808 as an oral solution or capsules (1.25 mg to 60 mg, or placebo). The effect of food on CRN00808 PK was also evaluated. In the multiple dose arm, cohorts of 9 subjects (6 active: 3 placebo) received CRN00808 capsules once daily (5 mg to 30 mg, or placebo) for 7-10 days. In the drug-interaction arm, a single cohort of 8 subjects received 20 mg of CRN00808 for 7 days; midazolam PK was assessed before (Day -2) and after (Day 7) administration of CRN00808. Safety and PK were assessed in all phases of the study. Suppression of GHRH-induced GH secretion and suppression of serum IGF-1 were measured as PD endpoints in the single and multiple dose phases of the study, respectively. Once daily administration of 5-30 mg CRN00808 capsules exhibited dose-dependent increases in peak (Cmax) and total (AUC) plasma exposures. The apparent terminal elimination half-life was determined to be of 42-50 hours and steady state was achieved in 3-5 days. Capsules taken with a standard high fat, high calorie meal resulted in a markedly lower plasma CRN00808 AUC (83%). Oral administration of CRN00808 resulted in dose-dependent suppression of both GHRH stimulated GH and IGF-1 secretion; a single 10 mg dose was found to cause 91% suppression of GHRH-stimulated GH and 10 mg once per day for 10 days resulted in maximal suppression of serum IGF-1. Midazolam PK was unaffected by co-administration of 20 mg CRN00808, suggesting little or no risk of drug interaction with CYP3A4/5 substrates. Treatment emergent adverse events associated with CRN00808 were generally mild and transient, and consistent with those reported with other somatostatin agonists. In conclusion, results from this Phase I clinical trial in healthy volunteers support further clinical development of CRN00808 as a once-daily oral treatment of patients with acromegaly.

Encompassing the Horse: Analogy, Category, and Scale in the Yijing

The canonised Yijing had a decisive influence over the development of so-called “correlative cosmology” in China’s early imperial period, presenting the cosmos as knowable through sixty-four hexagrams and classifiable according to eight trigrams. The exact nature of these correlative categories continues to inspire debate. On the one hand, they appear to be defined relationally, but on the other they purport to describe everything in the cosmos in terms of fixed principles. These apparently discordant properties can be reconciled by paying due attention to the role of scale. This is revealed through a focus on the hexagram images as two distinct but interrelated forms of analogy, as human constructs for symbolic manipulation and as empirical descriptors of cosmic circumstances. Adopting perspectives from cognitive linguistics and anthropology, this symbolic manipulation allows unknown situations to be understood metaphorically via the hexagrams, and then metonymically incorporated into a natural category of cosmic circumstances. This transition between metaphoric and metonymic relations is a function of scale, and is reflected in the Yijing’s correlative categories. These correspond to perceived absolute natural kinds, but maintain a relational character dependant on the salience of metaphorical and metonymic relations at different scales.
 At time of publication, the journal operated under the old name. When quoting please refer to the citation on the left using British Journal of Chinese Studies. The pdf of the article still reflects the old journal name; issue number and page range are consistent.

Modal Expansion Approach for Electromagnetic Propagation in Street Canyons

We present a simple and efficient model to compute electromagnetic (EM) propagation in urban street canyons, when transmitting and receiving antennas are located below the rooftop level. A parallel-plate dielectric hollow waveguide model of the street canyon is proposed, and propagation is analyzed by using the modal expansion approach. Obtained results for the case of line-of-sight (LoS) propagation are substantially equivalent to those obtained with the ray-optics method, but, with respect to the latter, our method presents important advantages: it is more efficient from a computational viewpoint, it allows deriving a very simple and reasonably accurate formulation of the average received signal strength, and it provides a fairly simple way to compute coupling at cross-junctions, exploited to obtain an analogous formulation for the non-LoS case. Obtained results are compared with simulations of a ray-tracing-based EM solver and with experimental measurements available in the literature.

Leptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects.

Background: Leptin (LEP) is a human analogous form of the mouse obese gene and plays a critical role in energy expenditure as well as the progression of carcinogenesis. Many studies exploring the relationship between the LEP rs7799039 (G2548A) polymorphism and cancer risk have observed controversial results. To extensively evaluate this potential association, we conducted this meta-analysis.Methods: All eligible studies published up to August 2018 on the relationship between the LEP rs7799039 G>A polymorphism and cancer risk were obtained by searching PubMed, EMBASE, and the China Biology Medicine databases. The association of LEP rs7799039 G>A polymorphism with cancer risk was evaluated by crude ORs together with their 95% CI's.Results: Thirty-one case–control studies involving 25,799 subjects were included for meta-analysis. We identify a significant correlation with an overall cancer risk when these eligible case–control studies were pooled for analysis: for AA vs GG: an OR = 1.22, 95% CI = 1.01–1.48, P = 0.042 and for AA/GA vs GG: an OR = 1.16, 95% CI = 1.02–1.33, P = 0.026. A significant association was also detected in Asians, prostate cancer, other cancers, and hematopoietic malignancy subgroups. Sensitivity analysis was conducted by deleting an individual study in turn and calculation of the pooled ORs and CIs of the remainders. The results of sensitivity analyses indicated that no eligible study influenced the pooled ORs and CIs materially. Begg’s and Egger’s tests revealed that there was no evidence of publication bias.Conclusion: In conclusion, our study suggests that the LEP rs7799039 G>A polymorphism might contribute to the development of cancer. In order to further verify or refute our findings, large and well-designed epidemiological studies are needed.

PERANCANGAN INTERIOR RESTORAN JUNG JAVA DI PESISIR PANTAI JEPARA

ABSTRACTThe restaurant’s interior design Jong Java will be designed with the theme “Ship Jung Java” which takes the form of objects that were on board until the vessel Jung Java it self, and packed with style metaphor. The style can be identified by visual metaphor real and philosophically in the shape that gives an appropriate form of intact objects analogy. Making style is an embodiment of architectural styles to provide imagery on a building along with presented nuance ship Jung Java along with the history of the town of Jepara in an Interior Design Jung Java Restaurants in Coastal Jepara. Advantages in terms of facilities and style, “ Perancangan Interior Restoran Jung Java di Pesisir Pantai Jepara “ more interesting to be one of the culinary tourism in Jepara, as well as an effort to preserve one of the seafood dishes typical Jepara and Jepara maritime history.Keywords: Interior Design, Jung Java, Coastal Restaurant, Jepara

Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice

Whereas carbohydrates and lipids are stored as glycogen and fat, there is no analogous inert storage form of protein. Therefore, continuous adjustments in feeding behavior are needed to match amino acid supply to ongoing physiologic need. Neuroendocrine mechanisms facilitating this behavioral control of protein and amino acid homeostasis remain unclear. The hepatokine fibroblast growth factor-21 (FGF21) is well positioned for such a role, as it is robustly secreted in response to protein and/or amino acid deficit. In this study, we tested the hypothesis that FGF21 feeds back at its receptors in the nervous system to shift macronutrient selection toward protein. In a series of behavioral tests, we isolated the effect of FGF21 to influence consumption of protein, fat, and carbohydrate in male mice. First, we used a three-choice pure macronutrient-diet paradigm. In response to FGF21, mice increased consumption of protein while reducing carbohydrate intake, with no effect on fat intake. Next, to determine whether protein or carbohydrate was the primary-regulated nutrient, we used a sequence of two-choice experiments to isolate the effect of FGF21 on preference for each macronutrient. Sweetness was well controlled by holding sucrose constant across the diets. Under these conditions, FGF21 increased protein intake, and this was offset by reducing the consumption of either carbohydrate or fat. When protein was held constant, FGF21 had no effect on macronutrient intake. Lastly, the effect of FGF21 to increase protein intake required the presence of its co-receptor, β-klotho, in neurons. Taken together, these findings point to a novel liver→nervous system pathway underlying the regulation of dietary protein intake via FGF21.

Kant's universal conception of natural history

Scholars often draw attention to the remarkably individual and progressive character of Kant's Universal Natural History and Theory of the Heavens (1755). What is less often noted, however, is that Kant's project builds on several transformations that occurred in natural science during the seventeenth and eighteenth centuries. Without contextualising Kant's argument within these transformations, the full sense of Kant's achievement remains unseen. This paper situates Kant's essay within the analogical form of Newtonianism developed by a diverse range of naturalists including Georges Buffon, Albrecht von Haller and Thomas Wright. It argues that Kant's universal conception of natural history can be viewed within the free-thinking and anti-clerical movement associated with Buffon. This does not mean, however, that it breaks from the methodological rules of Newtonianism. The claim of this paper is that Kant's essay contributes to the transformation of natural history from a logical system of classification to an explanation for the physical diversity of natural products according to laws.

Resisting Clarity/Highlighting Form: Comparing Vanguard Approaches in Poetry and Programming

This article contributes to the study of an esoteric programming language, brainfuck. It proposes a novel view that brainfuck embodies a poetic turn in computer programming, which could be viewed in relationship to Giambattista Vico's historical concept of ricorso—return to an earlier age that Vico, without derogation, identified as barbaric and characterized by the prevalence of poetic forms. Ricorso presupposes a previous existence of an analogous form of communication, which resurfaces in a transformed but recognizable shape in the current time. This article suggests that this older form of poetics is the Russian Futurists' Zaum poetry theorized by the Russian formalist Viktor Shklovsky among others.

The Optics and Optimal Control Theory Interpretation of the Parametric Resonance

The aim of the article is the elaboration of parametric resonance theory at piecewise constant frequency modulation. The investigation is based on the analogy with optics and optimal control theory (OCT) application. The exact expressions of oscillation frequency, gain/damping coefficients, dependencies of these coefficients on the modulation depth, duty ratio and initial phase are derived. First of all, the results obtained on the basis of the energy behavior analysis (at the conjunction conditions execution) in frictionless systems are presented. The well-known parametric resonance triggering condition is revised and adjusted. The heuristic feedback introduction (based on the energy behavior analysis) in the oscillation equation permits one to prove that the frequency modulation satisfying the parametric resonance condition is not necessary and sufficient condition of the oscillations unlimited increase. Their damping/shaking up formally corresponds by the frequency and duty ratio to the condition of the equality of optical paths to the quarter-wavelength characteristic of the interference filter or mirror. The unity of space-time coordinates shows itself in this specific form of the optical-mechanical analogy due to the general Hill’s equation description. It is marked that this equation theory underlies most of metamaterials advantages because all transport phenomena imply different wave – electromagnetic, acoustic, spin etc. propagation one way or another. The question about control uniqueness arises that is modulating frequency, duty ratio and signature sign uniqueness. Another question of characteristic index extremum at different controls is tightly bound with the former. The answers to these questions are obtained on the basis of OCT. The similarity of the optimal control problem solution and the one obtained at the heuristic feedback introduction through fundamental solutions product permits one to introduced the new form named general or mixed Hamiltonian along with the ordinary and OCT Hamiltonians. Besides this mixed Hamiltonian equality to zero together with the Wronskian constancy (almost everywhere) is the useful analogous in form to the Liouville’s theorem equation. The nonlinearity accounting using the OCT formalism is described too.

Effects of Preservative on the Meibomian Gland in Glaucoma Patients Treated with Prostaglandin Analogues.

This study compared the effect of preservative-containing (PC) and preservative-free (PF) prostaglandin analogue (PGA) formulations on the ocular surface, especially on the meibomian gland (MG) in patients with open-angle glaucoma (OAG). This is a retrospective study of treatment-naïve patients with OAG (n=80) and healthy controls (n=40). OAG patients were randomized into groups using either PC-PGA or PF-PGA for 12 months. All participants underwent ocular surface and MG examinations including their meibum score, meiboscore, and lid margin abnormality score (LAS). Eighty OAG patients were randomized into two groups (n=42 in PC, n=38 in PF). All PGA and control groups showed similar ocular surface and MG parameters at the baseline. Both PC- and PF-PGA groups showed increased meibum scores, meiboscores, and LASs at 12 months compared to the baseline (all p<0.05). At the 12-months visit, PC-PGA group showed severe OSDI, shorter TBUT, greater OSS, and worse MG parameters than those of the other two groups (all p<0.05). In addition, PF-PGA group showed worse meiboscores, meibum scores, and severe OSS scores than those of the control group (all p<0.05). Both PC and PF formulations can cause damage to the MG in patients using PGA. However, PC formulations induced more ocular discomfort, poorer ocular surface, and more severe MG loss compared to PF formulations. Therefore, it would be advisable to use PF formulations in patients with a preexisting or concomitant ocular surface disease or MGD.

Theoretical investigation of alteration and radiation of large-scale structures due to jet impingement

Jet flows impinge on launch pad structures and aircraft carrier deck blast deflectors. Turbulent structures are deformed and acoustic radiation is reflected by the deflector. The coupling of reflected acoustic waves with the instability waves of the jet turbulence increases their amplitude and causes a feedback loop. Resultant far-field acoustic radiation is amplified. This amplification results in additional tones with significant spectral broadening occurring at frequencies corresponding to the constructive interference. We present a simple prediction methodology in the form of an acoustic analogy. The analogy accounts for reflected acoustic waves through a tailored Green’s function and models the large-scale structures as spatially and temporarily growing and decaying instability waves. The predictions are compared with two experimental datasets. Predictions compare favorably with measured frequencies and spectral broadening in the far-field.

Ludwig Hilberseimer and Metropolisarchitecture: The Analogue, the Blasé Attitude, the Multitude

This article close-reads Modernist architect Ludwig Hilberseimer’s early architectural projects, which employed a language of uniform fenestration, repetition and geometrically reduced typical forms, as embodying Georg Simmel’s blasé attitude in analogical form, and places this reading in relation to Aldo Rossi’s concept of the analogical city and the political theorist Paolo Virno’s notion of the multitude. The first part outlines the discourse around Simmel, Hilberseimer and Rossi to note salient connections between these figures, their thought and the process of modernization. The second part discusses Simmel’s and Hilberseimer’s readings of the metropolis and interprets Hilberseimer’s formal language as embodying the blasé attitude. The third part places Hilberseimer in dialogue with Rossi and interprets Rossi’s analogical city as inhabited by another of Simmel’s figures, the stranger. The article concludes by tracing a line from Simmel’s figures of the blasé and the stranger via Hilberseimer’s metropolis architecture and Rossi’s analogical city toward the contemporary multitude, a collective linguistic subject. In doing so Hilberseimer’s and Rossi’s grammar of the metropolis can be rethought in relation to contemporary subject positions as a critical project toward an architectural theory of the multitude pushing back against the increasingly individualised city and market urbanism prevalent today.

Analogical proportion-based methods for recommendation – First investigations

Analogy making is widely recognized as a powerful kind of common-sense reasoning. This paper primarily addresses the relevance of analogical reasoning for recommender systems, which aim at providing suggestions of interest for end-users. A well-known form of analogy is that of analogical proportions, which are statements of the form “a is to b as c is to d“. Encouraged by good results obtained in classification by analogical proportion-based techniques, we study the potential use of analogy as the main underlying principle for implementing rating prediction algorithms. We investigate two ways of using analogical proportions for that purpose. First, we exploit proportions between four users, each described by their respective ratings on items that they have commonly rated. The second prediction method only relies on pairs of users and pairs of items, and leads to better performances. Finally, in order to know to what extent it may be meaningful to apply analogical methods in data analysis, we address the problem of mining analogical proportions between users (or items) in ratings datasets. Altogether, this paper initiates a general investigation of the potential use of analogical proportions for recommendation purposes.

Development of meat-containing semi-smoked sausages with Muscovy duck meat and white carp

The article is devoted to the substantiation of expediency of combining white carp (Hypophthalmichthys molitrix) with Muscovy duck meat (Cairina moschata), grown in farms of the Sumy region. The recipes of meat-containing minced sausage systems for the production of meat-containing semi-smoked sausages have been developed. A complex of research of nutritional value and functional and technological indices of perfume systems and finished products was carried out. It was shown that the protein content in samples of meat- containing semi-smoked sausages increased by 4.00–5.16% and amounted to 16.75–16.93 g/100 g. The fat content of the developed samples of meat-containing semi-smoked sausages decreased for 41.40–50.92%. The energy value of the prototype samples decreased and ranged from 212 to 241 kcal per 100 g, which is 32.30–40.45% less compared to the analogue formulation. On the basis of the analysis of functional and technological indicators, the possibility of obtaining high functional and technological indicators of the model minced meat-containing semi-smoked sausages. The moisture-bonding ability was in the range of 91.65–94.05%, and wet-binding index – up to 51.69%. The use of duck meat with freshwater fish does not negatively affect the physic-chemical parameters of finished semi-smoked sausages, and allows products with parameters that meet the standard to be obtained. Meat-containing semi-smoked sausages with Muscovy duck meat and white carp have high organoleptic characteristics. The conducted researches show that the developed recipes of meat and fish meat-containing semi-smoked sausages can be recommended for production by enterprises of meat industry.

N-alkylamino analogs of Vitamin K3: Electrochemical, DFT and anticancer activity of their oxidized and one electron reduced form

Synthesis, characterization and anticancer activity of reduced form of n-alkylamino analogs of Vitamin K3 (1Na to 8Na) are undertaken. Molecular structure and molecular association of oxidized form of 2-ethylamino-3-methyl-1,4-naphthoquinone (2) and 2-hexylamino-3-methyl-1,4-naphthoquinone (6) were studied by single crystal X-ray analysis. 2 crystallize in monoclinic C2/c and 6 in P21 space group. The reduced form of eight homologated analogs of 2-(n-alkylamino)-3-methyl-1,4-naphthoquinone (1Na to 8Na) were synthesized using sodium metal as reductant at 0 °C in methanol. The formations of naphthosemiquinone radical in 1 to 6 have been confirmed from their EPR spectra. Polycrystalline powder X-band EPR spectra of 1 to 6 shows signals ∼2.0020 ± 0.0026 at 133 K. Anticancer activity of 2-(n-alkylamino)-3-methyl-1,4-naphthoquinone (1Na to 8Na) and one electron reduced forms have been evaluated against breast cancer (HeLa) cell line, 1 and 1Na showed promising anticancer activity.

Criteria for indication and treatment modification in a cohort of patients with prostate cancer treated with hormone therapy.

Background:No published studies have specifically assessed whether treatment modifications to androgen deprivation therapy (ADT) for prostate cancer (PCa) are frequently carried out in routine clinical practice. The current study was conducted to determine what proportion of patients who had initiated hormone therapy with a gonadotropin-releasing hormone (GnRH) analogue then had their treatment regimen modified during the first 24 months.Methods:A prospective, noninterventional study was carried out in routine clinical practice in France. Patients with locally advanced or metastatic PCa were followed up for 2 years after treatment initiation with a GnRH analogue. The primary endpoint was the proportion of patients with a modification to their initial hormone therapy.Results:In total, 1301 patients were enrolled into the study by 204 physicians, and the primary endpoint could be evaluated for 891 patients. The GnRH analogue treatment was initiated for metastatic PCa (24.2%), locally advanced PCa without planned local treatment (20.6%), locally advanced PCa in association with radiotherapy (31.6%), and biochemical recurrence after local treatment (21.4%). Hormonal treatment was modified in 43.8% (390/891) of patients during the 24-month follow-up period after GnRH analogue initiation. In 61.3% of cases (239/390), the type of modification involved a change of GnRH analogue formulation or switch to another GnRH analogue. A total of five significant predictive factors for GnRH analogue treatment modification were identified: metastatic stage; physician sector; physician speciality; presence or absence of urinary symptoms; and intermittent versus continuous ADT.Conclusions:This study shows that in 43.8% of the patients with advanced PCa, ADT is modified in the first 2 years after initiation in routine clinical practice. Predictive factors for alteration of ADT were metastatic stage and the choice of an intermittent schedule.

The spin-Brauer diagram algebra

We investigate the spin-Brauer diagram algebra, denoted ${\bf SB}_n(\delta)$, that arises from studying an analogous form of Schur-Weyl duality for the action of the pin group on ${\bf V}^{\otimes n} \otimes \Delta$. Here ${\bf V}$ is the standard $N$-dimensional complex representation of ${\bf Pin}(N)$ and $\Delta$ is the spin representation. When $\delta = N$ is a positive integer, we define a surjective map ${\bf SB}_n(N) \twoheadrightarrow {\rm End}_{{\bf Pin}(N)}({\bf V}^{\otimes n} \otimes \Delta)$ and show it is an isomorphism for $N \geq 2n$. We show ${\bf SB}_n(\delta)$ is a cellular algebra and use cellularity to characterize its irreducible representations.

Hydrogen Peroxide Generation of Copper/Ascorbate Formulations on Cotton: Effect on Antibacterial and Fibroblast Activity for Wound Healing Application.

Greige cotton (unbleached cotton) is an intact plant fiber that retains much of the outer cotton fiber layers. These layers contain pectin, peroxidases, and trace metals that are associated with hydrogen peroxide (H2O2) generation during cotton fiber development. When greige cotton is subjected to a nonwoven hydroentanglement process, components of the outer cotton fiber layers are retained. When hydrated, this fabric can generate H2O2 (5–50 micromolar). This range has been characterized as inducing accelerated wound healing associated with enhanced cell signaling and the proliferation of cells vital to wound restoration. On the other hand, H2O2 levels above 50 micromolar have been associated with bacteriostatic activity. Here, we report the preparation and hydrogen peroxide activity of copper/ascorbate formulations, both as adsorbed and in situ synthesized analogs on cotton. The cooper/ascorbate-cotton formulations were designed with the goal of modulating hydrogen peroxide levels within functional ranges beneficial to wound healing. The cotton/copper formulation analogs were prepared on nonwoven unbleached cotton and characterized with cotton impregnation titers of 3–14 mg copper per gram of cotton. The copper/ascorbate cotton analog formulations were characterized spectroscopically, and the copper titer was quantified with ICP analysis and probed for peroxide production through assessment with Amplex Red. All analogs demonstrated antibacterial activity. Notably, the treatment of unbleached cotton with low levels of ascorbate (~2 mg/g cotton) resulted in a 99 percent reduction in Klebsiella pneumoniae and Staphylococcus aureus. In situ synthesized copper/ascorbate nanoparticles retained activity and did not leach out upon prolonged suspension in an aqueous environment. An assessment of H2O2 effects on fibroblast proliferation are discussed in light of the copper/cotton analogs and wound healing.