Ghana has retained a substantial area of tropical forests in an extensive network of protected reserves. These forests are impacted by land uses such as logging, mining, and agriculture as well as wildfires. We studied forest disturbance and recovery from 2013 to 2020 using annual maps of forest cover derived from Landsat imagery. Fire-associated disturbance was distinguished using VIIRS active fire data. We used boosted regression trees to model disturbances in closed and open forests as a function of climate variability, human accessibility, and landscape structure. A total of 3562 km2 of forest reserves were disturbed, of which 17% (615 km2) were fire disturbances and 83% (2946 km2) were non-fire disturbances. Of the total disturbed area, 68% was degradation (change from closed to open forest), 28% was open forest loss, and only 4% was closed forest loss. Over the same period, 2702 km2 of forest reserves recovered, with 1948 km2 of these recovering to closed-canopy forests. Fire disturbances were strongly associated with precipitation anomalies and occurred mostly in drier years, whereas non-fire disturbances had weaker relationships with precipitation. Disturbances in closed forests occurred in landscapes where closed forest cover was already low. In contrast, disturbances in open forests were most common in locations with intermediate levels of population pressure from nearby cities and proximity to non-forest land cover. The results support the idea that forest disturbance in Ghana is a multi-stage process involving degradation of closed forests followed by loss of the resulting open forests. Although non-fire disturbance rates are consistent from year to year, sharp increases in fire disturbance occur in drought years. Locations with the highest disturbance risk are associated with measurable indicators of climate, human pressure, and fragmentation, which can be used to identify these areas for conservation and forest restoration activities.