A detailed analysis of the variations of the stratospheric and mesospheric ozone over Bulgaria, in the period 1996 to 2012, is presented in the article on the basis of ground and satellite measurements of the total ozone column (TOC). The dynamics of the most important components has been studied. Their mean values for the period and the existing long-term trends have been found. The time evolution of the most basic components of the seasonal course has been studied, including the existing long-term trends and their relations to the stratospheric temperature and quasi-biennial oscillation. Based on these studies and analyses, an empirical model for a daily forecast of TOC over Bulgaria has been created. The main aim of the model is monitoring of the ozone layer and, respectively, the biologically harmful ultraviolet radiation of the sun related to it which has an effect on human health and life.