Forced-choice Trials Research Articles

Developmental exposure to 17-α-hydroxyprogesterone caproate disrupts decision-making in adult female rats: A potential role for a dopaminergic mechanism

The synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC), is administered to pregnant individuals at risk for preterm birth and is likely transferred from mother to fetus. Yet, there is little information regarding the potential effects of 17-OHPC administration on behavioral and neural development in offspring. In rats, neonatal 17-OHPC exposure altered dopaminergic fiber distribution and density in the prelimbic medial prefrontal cortex (mPFC) in neonates and adolescents, respectively. Additionally, neonatal 17-OHPC exposure in male rats increased response omissions in a delay discounting task of impulsive decision-making. Because developmental 17-OHPC exposure has differential effects in males and females, investigating the effects of 17-OHPC on impulsive decision-making in female rats is necessary. The present study tested the effects of developmental 17-OHPC exposure (P1–P14) in a delay discounting task in which female rats chose between a small immediate reward and a larger delayed (0, 15 30, or 45 s) reward. 17-OHPC-exposed females made more omissions than controls. There was no effect of 17-OHPC on large reward preference nor on response time, and omissions were similar during both free- and forced-choice trials. The present study also aimed to investigate the neural mechanisms underlying omissions in 17-OHPC-exposed female rats. The dopamine transporter inhibitor, methylphenidate (MPH), was administered prior to delay discounting testing. MPH treatment did not reduce omissions in 17-OHPC-exposed females. If anything, MPH increased omissions in control females nearly fourfold during the longest delays. These results suggest that developmental 17-OHPC exposure increased omissions without affecting impulsivity or slowing decision-making. Furthermore, omissions may be regulated, at least in part, by dopaminergic mechanisms.

The effect of reward prediction errors on subjective affect depends on outcome valence and decision context.

The valence of an individual's emotional response to an event is often thought to depend on their prior expectations for the event: better-than-expected outcomes produce positive affect and worse-than-expected outcomes produce negative affect. In recent years, this hypothesis has been instantiated within influential computational models of subjective affect that assume the valence of affect is driven by reward prediction errors. However, there remain a number of open questions regarding this association. In this project, we investigated the moderating effects of outcome valence and decision context (Experiment 1: free vs. forced choices; Experiment 2: trials with vs. trials without counterfactual feedback) on the effects of reward prediction errors on subjective affect. We conducted two online experiments (N = 300 in total) of general-population samples recruited via Prolific to complete a risky decision-making task with an embedded high-resolution sampling of subjective affect. Hierarchical Bayesian computational modeling revealed that both outcome amount and reward prediction errors influenced subjective affect, but that the effects of reward prediction errors were moderated by both outcome valence and decision context. Specifically, we found evidence that only negative reward prediction errors (worse-than-expected outcomes) influenced subjective affect, with no significant effect of positive reward prediction errors (better-than-expected outcomes). Moreover, these effects were only apparent on trials in which participants made a choice freely (but not on forced-choice trials) and when counterfactual feedback was absent (but not when counterfactual feedback was present). These results deepen our understanding of the effects of reward prediction errors on subjective affect. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

An investigation on performance of human visual and tactile perception in machined surface inspection

Comparative determination of surface roughness by visual and tactile comparison is employed in preliminary part evaluation and quality control in the machining industry. This on-stand evaluation technique allows for quick verification of the product’s adherence with surface roughness specifications. While regarded as less precise than measurement with contact profilometers, it is a fast method that can be employed after basic training. The work conducted by the authors of this study concerned experimental trials under conditions resembling real-life part examination scenarios in industrial settings. Human test subjects were tasked with determining the rougher sample in a pairing in two-alternative forced choice trials, with employed samples taking the form of flat end milled surfaces. Three distinct modes of inspection were involved, namely visual inspection and combined visual and tactile inspection by vertical and horizontal sliding touch, respectively. The obtained results show that the majority of study participants were capable of correctly determining the rougher sample in the pairing, regardless of sensory conditions. Variability in the ratio of correct responses was observed, depending both on stimulus intensity and the employed inspection mode. Overall best performance in terms of ratio of correct responses and variability in responses between participants was noted for combined inspection using vision and vertical sliding touch.

Children’s selective information transmission in STEM and non-STEM domains

Two studies examined what information American children ages 4–6 (n = 120; 56 boys; 64 girls; 81% White) transmit to a naïve listener after hearing testimony from previously accurate and inaccurate informants. The informants provided conflicting information in four domains (physical science, life science, mathematics, and object labels). Children chose one informant’s testimony to transmit (Study 1) or had an open-ended opportunity to transmit information (Study 2). Children transmitted information from the accurate informant in 73% of forced-choice trials. However, they only transmitted the accurate informant’s testimony in 40% of open-ended trials. Thus, although children selectively endorse information received from accurate informants, they may not necessarily transmit information received from a previously accurate informant to a naïve listener.

Bias effects in a two-stage recognition paradigm: A challenge for "pure" threshold and signal detection models.

We explored a two-stage recognition memory paradigm in which people first make single-item "studied"/"not studied" decisions and then have a chance to correct their errors in forced-choice trials. Each forced-choice trial included one studied word ("target") and one nonstudied word ("lure") that received the same previous single-item response. For example, a studied-studied trial would have a target that was correctly called "studied" and a lure that was incorrectly called "studied." The two-high-threshold (2HT) model and the unequal-variance signal detection (UVSD) model predict opposite effects of biasing the initial single-item responses on subsequent forced-choice accuracy. Results from two experiments showed that the bias effect is actually near zero and well out of the range of effects predicted by either model. Follow-up analyses suggested that the model failures were not a function of experiment artifacts like changing memory states between the two types of recognition trials. Follow-up analyses also showed that the dual process signal detection model made better predictions for the forced-choice data than 2HT and UVSD models. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Enhancing free choice masked priming via switch trials during repeated practice.

The masked priming paradigm has been extensively used to investigate the indirect impacts of unconscious stimuli on conscious behaviors, and the congruency effect of priming on free choices has gained increasing attention. Free choices allow participants to voluntarily choose a response from multiple options during each trial. While repeated practice is known to increase priming effects in subliminal visual tasks, whether practice increases the priming effect of free choices in the masked priming paradigm is unclear. And it is also not clear how the proportions of free choice and forced choice trials in one block will affect the free choice masked priming effect. The present study applied repeated practice in the masked priming paradigm and found that after training, the participants were more likely to be influenced by masked primes during free choice, but this training process did not alter the visibility of masked stimuli. In addition, this study revealed that when the proportions of free choice and forced choice trials were equal during the training stage, this enhanced effect by practice was the strongest. These results indicated that practice could enhance masked stimulus processing in free-choice, and that the learning effect may mainly be derived from the early selection and integrated processing of masked stimuli.

Keep flexible—Keep switching? Boundary conditions of the influence of forced task switching on voluntary task switching.

Frequent forced switching between tasks has been shown to reduce switch costs and increase voluntary switch rates. So far, however, the boundary conditions of the influence of forced task switching on voluntary task switching are unknown. Thus, the present study was aimed to test different aspects of generalizability (across items, tasks, and time) of switching-induced flexibility established in forced-choice trials on voluntary switching in free-choice trials. To this end, stimuli and tasks were systematically varied between forced- and free-choice trials in a hybrid task-switching paradigm. In a series of three experiments, we manipulated forced-choice switch probability (25% vs. 75%) and found that switching-induced flexibility generalizes to new items, but arguably not to new tasks. This task-specific effect is rather short-lived, limited to the first free-choice trial following a forced-choice trial. Underlying mechanisms of switching-induced flexibility, the versatility of flexibility and implications for the trainability of cognitive flexibility are discussed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Does speed of recognition predict two-alternative forced-choice performance? Replicating and extending Starns, Dubé, and Frelinger (2018).

Does the speed of single-item recognition errors predict performance in subsequent two-alternative forced-choice (2AFC) trials that include an item with a previous error response? Starns, Dubé, and Frelinger found effects of this kind in two experiments and accounted for them in terms of continuous memory-strength signal guiding recognition decisions. However, the effects of error speed might just as well only reflect an artefact due to an error-correction strategy that uses response latency as a heuristic cue to guide 2AFC responses, elicited through confounding factors in their experimental design such as error-correction instructions and feedback. Using two conditions, a replication condition, replicating the procedure from Starns et al., and an extension condition (each n = 130), controlling for the named shortcomings, we replicated the error speed effect. In both conditions, speed of errors in a single-item recognition task was predictive of subsequent 2AFC performance, including the respective error item. To be more precise, fast errors were associated with decreased 2AFC performance. As there was no interaction with the factor condition, the results support the idea that speed of single-item recognition responses reflects the amount of memory information underlying the respective response rather than being used for a simple error-correction strategy to improve 2AFC performance.

Ultraviolet-reflective film applied to windows reduces the likelihood of collisions for two species of songbird.

Perhaps a billion birds die annually from colliding with residential and commercial windows. Therefore, there is a societal need to develop technologies that reduce window collisions by birds. Many current window films that are applied to the external surface of windows have human-visible patterns that are not esthetically preferable. BirdShades have developed a short wavelength (ultraviolet) reflective film that appears as a slight tint to the human eye but should be highly visible to many bird species that see in this spectral range. We performed flight tunnel tests of whether the BirdShades external window film reduced the likelihood that two species of song bird (zebra finch, Taeniopygia guttata and brown-headed cowbird, Molothrus ater) collide with windows during daylight. We paid particular attention to simulate the lighting conditions that birds will experience while flying during the day. Our results indicate a 75–90% reduction in the likelihood of collision with BirdShades-treated compared with control windows, in forced choice trials. In more ecologically relevant comparison between trials where all windows were either treated or control windows, the estimated reduction in probability of collision was 30–50%. Further, both bird species slow their flight by approximately 25% when approaching windows treated with the BirdShades film, thereby reducing the force of collisions if they were to happen. Therefore, we conclude that the BirdShades external window film will be effective in reducing the risk of and damage caused to populations and property by birds’ collision with windows. As this ultraviolet-reflective film has no human-visible patterning to it, the product might be an esthetically more acceptable low cost solution to reducing bird-window collisions. Further, we call for testing of other mitigation technologies in lighting and ecological conditions that are more similar to what birds experience in real human-built environments and make suggestions for testing standards to assess collision-reducing technologies.

The surplus identification task and limits to multiattribute consumer choice.

We introduce and demonstrate a novel experimental method for investigating the accuracy of consumer decision making. The Surplus Identification (S-ID) task exploits techniques from detection theory. Experimental control over surpluses is established by incentivizing participants to adopt a predetermined, objectively defined preference function. Surplus is then manipulated across multiple forced-choice trials in which participants decide whether a product does or does not confer a surplus at a given price. The S-ID task can be used to investigate how precision, bias, and learning vary with multiple properties of prices, attributes, and contexts. We demonstrate the task via a series of experiments that test the ability to apply a weighted adding decision strategy (with equal weights) as the number of product attributes increases. Imprecision increases sharply with additional attributes and larger trade-offs between them. Participants display persistent biases across the price range. These vary systematically with the number of attributes, implying a precision-bias trade-off. The findings have implications for models of multiattribute choice and for consumer policy. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Correction to: Using a Touchscreen Paradigm to Evaluate Food Preferences and Response to Novel Photographic Stimuli of Food in Three Primate Species (Gorilla gorilla gorilla, Pan troglodytes, and Macaca fuscata)

Understanding captive animals’ preferences is important for their care and management. However, pairwise testing for preference can be time consuming, open to bias, and typically restricted to stimuli that can be presented manually. We tested the efficacy of using touchscreens to test zoo-housed primates’ food preferences and evaluated the primates’ understanding and interpretation of photographic stimuli. We showed 18 subjects (six gorillas, five chimpanzees, and seven Japanese macaques) four food stimuli (digital photographs of familiar foods presented via touchscreens) to test their preferences in a forced-choice paradigm. We presented preliminary single-food training trials before paired forced-choice test trials, which revealed subjects’ relative preferences for the four foods. To distinguish whether the primates’ responses represented conditioned associations between the stimuli and rewards, or a true understanding of the food photographs, we ran a follow-up study with novel stimuli (novel photographs of familiar foods). We combined the two novel stimuli with the four stimuli presented in the first experiment in pairwise forced-choice trials (importantly, without training trials). Subjects did not preferentially select or avoid the novel stimuli, suggesting they spontaneously interpreted the stimuli without training. While there was interindividual variation in preferences, subject choices were consistent across studies, even with the addition of novel stimuli. These results suggest that preferences for a variety of stimuli could be tested quickly, efficiently, and accurately using touchscreens.

Detecting feigned traumatic brain injury with eye tracking during a test of performance validity.

Eye-tracking is a promising technology to enhance assessment of performance validity. Research has established that ocular behaviors are reliable biomarkers of (un)conscious cognitive processes, and they have distinguished deceptive from honest responding in experimental paradigms. This study examined the incremental utility of eye-tracking on a clinical performance validity test (PVT) in distinguishing adults with verified TBI from adults coached to feign cognitive impairment. Participants were 49 adults with moderate-to-severe TBI (TBI), 47 healthy adults coached to simulate TBI (SIM), and 67 healthy comparisons providing full effort (HC). A PVT linked to eye-tracking was completed in the context of a full neuropsychological battery. Kruskal-Wallis tests revealed that eye-tracking indices did not differ among the groups during presentation of stimulus items but did differ during forced-choice trials. Compared to TBI and HC, SIM had significantly more transitions, fixations, and time spent looking at correct and incorrect response options. Logistic regressions and ROC curve analyses showed that accuracy was the best predictor of SIM versus HC. For SIM versus TBI, eye-tracking indices exceeded accuracy in distinguishing the groups. Eye-tracking added incremental predictive value to accuracy for both SIM-HC and SIM-TBI discriminations. Eye-tracking indicated that persons feigning TBI showed multiple signs of greater cognitive effort than persons with verified TBI and healthy comparisons. In the comparison of greatest interest (SIM vs. TBI) eye-tracking best predicted group status and yielded excellent discrimination when combined with accuracy. Eye-tracking may be an important complement to traditional accuracy scores on PVTs. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Does temporal predictability of tasks influence task choice?

Task performance improves when the required tasks are predicted by the preceding time intervals, suggesting that participants form time-based task expectancies. In the present study, we pursued the question whether temporal predictability of tasks can also influence task choice. For this purpose, we conducted three experiments using a hybrid task-switching paradigm (with two tasks) combining forced-choice and free-choice trials. Each trial was preceded by either a short (500 ms) or a long (1500 ms) foreperiod. In forced-choice trials, the instructed task was predicted by the length of the foreperiod (Exp. 1A and 1B: 100% foreperiod-task contingencies; Exp. 2: 80% foreperiod-task contingencies). In the remaining trials, participants were free to choose which task to perform. In all three experiments, we found that participants’ task choice was influenced by the foreperiod-task contingencies implemented in forced-choice trials. Specifically, participants were overall biased to choose tasks compatible with these contingencies; these compatible choice rates were larger for the short compared to the long foreperiod. Our findings suggest that learned time-based task expectancies influence subjects’ voluntary task choice and that an initially present task bias toward the “short” task is not always overcome at the long foreperiod. We discuss potential underlying mechanisms against the background of voluntary task switching and interval timing.

Nucleus accumbens shell dopamine mediates outcome value, but not predicted value, in a magnitude decision-making task.

Effective decision-making depends on an animal's ability to predict and select the outcome of greatest value, and the nucleus accumbens (NAc) and its dopaminergic input play a key role in this process. We previously reported that rapid dopamine release in the NAc shell preferentially tracks the "preferred" (i.e., large reward) option during cues that predict the ability to respond for rewards of different sizes, as well as during reward delivery itself. The present study assessed whether shell dopamine release at these discrete times selectively mediated choice behavior for rewards of different magnitudes using optogenetics. Here, using Long Evans TH:Cre± rats we employed selective optogenetic stimulation of dopamine terminals in the NAc shell during either reward-predictive cues (experiment 1) or reward delivery (experiment 2) in a magnitude-based decision-making task. We found that in TH:Cre± rats, but not littermate controls, optical stimulation during low-magnitude reward delivery during forced choice trials was sufficient to bias preference for this option when given a choice. In contrast, optical stimulation of shell dopamine terminals during low-magnitude reward-predictive cues in forced choice trials did not shift free choice behavior in TH:Cre± rats or controls. The findings indicate that preferential dopamine signaling in the NAc shell during reward outcome (delivery), but not reward-predictive cues are sufficient to influence choice behavior in our task supporting a causal role of dopamine in the NAc shell in reward outcome value, but not value-based predictive strategies.

A Forced-Choice Procedure to Assess the Acute Relative Reinforcing Effects of Nicotine Dose per se in Humans.

A method to assess acute reinforcement due to nicotine may aid identification of doses needed to maintain dependence. After describing development of a forced-choice procedure, results are presented from two studies using it to determine the relative reinforcing effects of nicotine dose per se. Choice between a higher versus a very low or no nicotine option, via smoking (Study 1, n = 59) and via nasal spray (Study 2, n = 42), was assessed in nontreatment-seeking dependent smokers abstinent overnight. Using a within-subject design, different nicotine levels for each product were administered under blind conditions, initially to assess their discriminability (Study 1: 1.3-17 mg/g each vs. 0.4 mg/g nicotine Spectrum cigarettes; Study 2: 2.5 µg/kg vs. 0 µg/kg nicotine per spray). At the end of sessions for each study, participants engaged in forced-choice trials to assess preference, requiring a fixed number of puffs/sprays for one and/or the other. Confirming the procedure's validity, the choice of the higher nicotine option was significantly greater than that for the very low or no nicotine option in both studies. In Study 1, choice relative to 0.4 mg/g was greater for cigarettes 5.3 mg/g or more but not 2.3 mg/g or less (p = .003 for the interaction of higher content vs. 0.4 mg/g comparison). In Study 2, choice was greater for the nicotine versus placebo spray (p < .005), as nicotine was preferred nearly twice as much as the placebo. This forced-choice procedure may efficiently determine the relative reinforcing value of a nicotine dose per se. The forced-choice procedure described here may identify nicotine doses that are acutely reinforcing in dependent smokers. A priori research of choice comparisons between small versus zero nicotine doses could inform clinical research in larger and more diverse samples to determine nicotine contents in cigarettes, and perhaps in other commercial products, that are not reinforcing and, thus, likely to reduce the risk of their addictiveness. This procedure may also be applicable to assessing changes in acute nicotine reinforcement due to different product formulations, novel drugs, or other manipulations, perhaps helping inform development of new interventions for cessation or harm reduction.

The Abused Inhalant Toluene Impairs Medial Prefrontal Cortex Activity and Risk/Reward Decision-Making during a Probabilistic Discounting Task

Inhalant (e.g., toluene) misuse is linked to behavioral and cognitive deficits in humans, yet preclinical studies of the effect of inhalants on higher-order cognition are limited. We addressed this gap in the literature by examining the effect of toluene vapor exposure on risk/reward decision-making in male and female Sprague-Dawley rats using a probabilistic discounting task. In this task, rodents chose a risky/large reward or a safe/small reward, with the odds of risky reinforcement descending or ascending throughout the test session. We observed a dose-dependent, sex-independent deficit in behavioral flexibility during probabilistic discounting caused by acute toluene exposure. Rats exposed to toluene vapor during adolescence and tested as adults performed comparably to air-treated controls and were susceptible to the effects of an acute toluene challenge. These behavioral flexibility deficits observed suggests dysfunctional medial prefrontal cortex (mPFC) activity. To address this hypothesis, we virally expressed the genetically encoded calcium sensor GCaMP6f in glutamatergic mPFC neurons and monitored calcium transients in real-time using in vivo fiber photometry. mPFC activity peaked before either lever press during free-choice trials in toluene- and air-treated animals. During forced-choice trials, GCaMP6f transients shifted from pre-risky to pre-safe choice, an effect mitigated by acute toluene exposure. mPFC activity decreased during rewarded trials, with larger decreases following risky/large wins compared with safe/small wins. Toluene-treated animals also had decreased mPFC activity during rewarded trials, but there was no distinction between risky/large wins and safe/small wins. These results provide physiological evidence for mPFC-dependent behavioral deficits caused by toluene.SIGNIFICANCE STATEMENT Inhalants (e.g., toluene) are an understudied class of drugs of abuse that cause devastating behavioral and cognitive deficits in humans. Understanding the neurobiological interactions of toluene vapor using animal models is important for developing effective treatment strategies for inhalant addicts. Here we find that toluene vapor reduces behavioral flexibility in rodents making risk/reward-based decisions. The medial prefrontal cortex (mPFC) drives behavioral flexibility during this type of decision-making and we show that toluene reduces the ability of mPFC neurons to track optimal choices as reward probabilities change. Toluene also reduces these neurons' ability to distinguish between small and large rewards. A combination of these factors likely leads to the impaired performance in probabilistic discounting following acute toluene exposure.

Negative Mood Induction Increases Choice of Heroin Versus Food Pictures in Opiate-Dependent Individuals: Correlation With Self-Medication Coping Motives and Subjective Reactivity.

Acute growth in negative affect is thought to play a major role in triggering relapse in opiate-dependent individuals. Consistent with this view, three lab studies have demonstrated that negative mood induction increases opiate craving in opiate-dependent individuals. The current study sought to confirm these effects with a behavioral measure of heroin seeking, and test whether the effect is associated with self-reported opiate use to cope with negative affect and subjective reactivity to mood induction. Participants were heroin-dependent individuals engaged with treatment services (n = 47) and control participants (n = 25). Heroin users completed a questionnaire assessing reasons for using heroin: negative affect, social pressure, and cued craving. Baseline heroin choice was measured by preference to enlarge heroin versus food thumbnail pictures in two-alternative forced-choice trials. Negative mood was then induced by depressive statements and music before heroin choice was tested again. Subjective reactivity was indexed by negative and positive mood reported at the pre-induction to post-test timepoints. Heroin users chose heroin images more frequently than controls overall ( p = .001) and showed a negative mood-induced increase in heroin choice compared to control participants (interaction p < .05). Mood-induced heroin choice was associated with self-reported heroin use to cope with negative affect ( p < .05), but not social pressure ( p = .39) or cued craving ( p = .52), and with subjective mood reactivity ( p = .007). These data suggest that acute negative mood is a trigger for heroin seeking in heroin-dependent individuals, and this effect is pronounced in those who report using heroin to cope with negative affect, and those who show greater subjective reactivity to negative triggers. Interventions should seek to target negative coping motives to build resilience to affective triggers for relapse.

Prelimbic Cortical Neurons Track Preferred Reward Value and Reflect Impulsive Choice during Delay Discounting Behavior.

In delay discounting, individuals discount the value of a reward based on the delay to its receipt. The prelimbic cortex (PrL) is heavily interconnected with several brain regions implicated in delay discounting, but the specific contributions of the PrL to delay discounting are unknown. Here, we used multineuron electrophysiological recording methods in Long-Evans male (n = 10) and female (n = 9) rats to characterize the firing dynamics of PrL neurons during discrete cue and lever press events in a delay discounting task. Rats' initial preference for the large reward decreased as delays for that outcome increased across blocks, reflecting classic discounting behavior. Electrophysiological recordings revealed that subgroups of neurons exhibited phasic responses to cue presentations and lever presses. These phasic neurons were found to respond to either large/delay, small/immediate, or both trial types and the percentage of these neurons shifted across blocks as the expected value of the reward changed. Critically, this shift was only seen during trials in which animals could choose their preferred option (free choice trials) and not during trials where animals could choose only one option (forced choice trials). Further, this shift was dependent on rats' inherent impulsivity because high impulsive rats demonstrated a greater percentage of small/immediate-responsive neurons as the task progressed. Collectively, these findings suggest a unique role for the PrL in encoding reward value during delay discounting that is influenced by individual differences in impulsivity.SIGNIFICANCE STATEMENT In delay discounting, individuals discount the value of a reward based on the delay to its receipt. Here, we used electrophysiology to investigate the role of the prelimbic cortex (PrL) in this process. We found that subsets of neurons shifted activity as a function of the changing expected delay and reward magnitude, but this shift was only evident during trials in which animals could choose their preferred option. Further, this dynamic neural activity depended on rats' inherent impulsivity, with impulsive rats exhibiting a stronger neural shift toward the immediate reward as the task progressed. These findings suggest a role for the PrL in encoding reward value during delay discounting that is influenced by goal-directed context and individual differences in impulsivity.

Negative mood-induced alcohol-seeking is greater in young adults who report depression symptoms, drinking to cope, and subjective reactivity.

Acute negative mood powerfully motivates alcohol-seeking behavior, but it remains unclear whether sensitivity to this effect is greater in drinkers who report depression symptoms, drinking to cope, and subjective reactivity. To examine these questions, 128 young adult alcohol drinkers (ages 18–25) completed questionnaires of alcohol use disorder symptoms, depression symptoms, and drinking to cope with negative affect. Baseline alcohol choice was measured by preference to enlarge alcohol versus food thumbnail images in two-alternative forced-choice trials. Negative mood was then induced by depressive statements and music, before alcohol choice was tested. Subjective reactivity was indexed by increased sadness pre- to post-mood induction. Baseline alcohol choice correlated with alcohol dependence symptoms (p = .001), and drinking coping motives (ps ≤ .01). Mood induction increased alcohol choice and subjective sadness overall (ps < .001). The mood-induced increase in alcohol choice was associated with depression symptoms (p = .007), drinking to cope (ps ≤ .03), and subjective reactivity (p = .007). The relationship between mood-induced alcohol choice and drinking to cope remained significant after covarying for other drinking motives. Furthermore, the three predictors (depression, drinking to cope, and subjective reactivity) accounted for unique variance in mood-induced alcohol choice (ps ≥ .03), and collectively accounted for 18% of the variance (p < .001). These findings validate the pictorial alcohol choice task as sensitive to the relative value of alcohol and acute negative mood. The findings also accord with the core prediction of negative reinforcement theory that sensitivity to the motivational impact of negative mood on alcohol-seeking behavior may be an important mechanism that links depression and alcohol dependence.

Response priming with motion primes: negative compatibility or congruency effects, even in free-choice trials.

How actions are chosen, and what they are influenced by, has been the focus of several research traditions. Influences on actions are often studied using compatibility paradigms, such as response priming. Here, a first stimulus (i.e., the prime) is presented shortly before a second stimulus (i.e., the target) which has to be classified. Reaction times to the target are often reduced when primes and targets are compatible compared to incompatible primes and targets-i.e., a positive compatibility effect (PCE). There are, however, some conditions in which reliably negative compatibility effects (NCEs), with faster reactions to incompatible targets, are found. Actions in real life are often influenced by perceived motion and are less determined by following (target) stimuli as it is the case in typical response priming studies with predetermined stimulus-response mappings. Thus, in the current experiment we used motion primes in forced-choice trials (with >> and << as targets) as well as in free-choice trials (with <> and >< as targets). Essentially, we found PCEs in the short-SOA condition and NCEs in the long-SOA condition. The pattern was not qualified by task (i.e., forced choice/free choice). The results provide evidence that NCEs with motion primes are found even without strong links between target stimuli and responses and that especially PCEs can be found with simpler and smaller targets than have been used in previous experiments.