Nucleus accumbens shell dopamine mediates outcome value, but not predicted value, in a magnitude decision-making task.

Abstract

Effective decision-making depends on an animal's ability to predict and select the outcome of greatest value, and the nucleus accumbens (NAc) and its dopaminergic input play a key role in this process. We previously reported that rapid dopamine release in the NAc shell preferentially tracks the "preferred" (i.e., large reward) option during cues that predict the ability to respond for rewards of different sizes, as well as during reward delivery itself. The present study assessed whether shell dopamine release at these discrete times selectively mediated choice behavior for rewards of different magnitudes using optogenetics. Here, using Long Evans TH:Cre± rats we employed selective optogenetic stimulation of dopamine terminals in the NAc shell during either reward-predictive cues (experiment 1) or reward delivery (experiment 2) in a magnitude-based decision-making task. We found that in TH:Cre± rats, but not littermate controls, optical stimulation during low-magnitude reward delivery during forced choice trials was sufficient to bias preference for this option when given a choice. In contrast, optical stimulation of shell dopamine terminals during low-magnitude reward-predictive cues in forced choice trials did not shift free choice behavior in TH:Cre± rats or controls. The findings indicate that preferential dopamine signaling in the NAc shell during reward outcome (delivery), but not reward-predictive cues are sufficient to influence choice behavior in our task supporting a causal role of dopamine in the NAc shell in reward outcome value, but not value-based predictive strategies.