In order to reduce bone tissue damage, the effect of crescent texture parameters on the axial force during bone drilling was investigated. The biomimetism micro-texture shape was selected from a bionic point of view. A laser marking machine was used to process biomimetism crescent texture on the rake face of the drill bit, and then a theoretical model of axial force is established to determine the relationship between axial force and texture parameters according to actual chip-tool contact area. A test platform for drilling bone was built to prove the theoretical model. The novelty of the study involved predicting the change of the axial force according to the true chip-tool contact area. The experimental results showed that a biomimetism crescent texture on the rake face of a drilling tool significant reduced the axial force during bone drilling compared with that of a non-textured tool. Within the range of the experiment data, during the stage of drill entry and stabilization, the measured axial force of a micro-textured tool was more stable and the fluctuation in stress was lower, compared to the response from a conventional drilling tool.