Force Degradation Research Articles

Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method.

The use of analytical quality by design (AQbD) approach in the optimization of the high-performance liquid chromatography (RP-HPLC) method is a novel tool. Three factors and three levels of Box–Behnken statistical design (BBD) were used for method optimization and analysis of atorvastatin. The mobile phase (acetonitrile: water), flow rate (Rt), and UV wavelength were used as independent variables. Their effects were observed in the area of the chromatogram (AU), retention time (Rt, min), and tailing factor (%). The optimized HPLC condition was found as acetonitrile:water (50 : 50), flow rate (0.68 ml/min), and UV wave length (235 nm). It gives the retention time of 2.43 min with the linearity range of 5–30 μg/ml with a high regression value (r2 = 0.999). The method was found to be precise and accurate with low % RSD (<5%). The refrigeration stability indicated that atorvastatin was stable. The force degradation study showed that the atorvastatin was fully unstable in UV light and stable in 0.1 M basic condition. It concluded that this QbD optimized method is suitable for quantification of the atorvastatin from the formulation as well as pharmacokinetic parameters.

Numerical simulations on static Vertical Axis Wind Turbine blade icing

During the last decade, there was an increased interest in wind turbine icing. Most of the icing studies are related to horizontal axis wind turbine icing (HAWT). Vertical axis wind turbine (VAWT) icing is seldomly reported in the literature. Compared to the HAWT blade VAWT blade operates under various angles of attack. Therefore, ice accretion shapes on static VAWT blade must be considered under different angles of attack. In the present study, a novel approach to predict ice accretion shapes on VAWT is described. Ice accretion shapes are obtained at a range of angles of attack between −25° and 25° using FENSAP-ICE which is the state-of-art icing simulation tool. Moving reference frame (MRF) was used to consider rotating effect on droplet field. The present method helped to draw the following conclusions. Firstly, the whole leading edge is covered by ice. Secondly, in rime ice conditions smooth ice shape is obtained, which does not significantly affect aerodynamic performance. Whereas in glaze ice conditions bumpy ice shapes causing massive flow separation and lift force degradation. Finally, iced VAWT loses up to 60% of power performance due to rime ice conditions. In glaze ice conditions VAWT is unable to produce power.

The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress-Mediated Apoptosis in Pancreatic Cancer.

GRP78 (glucose-regulated protein, 78 kDa) is a key regulator of endoplasmic reticulum (ER) stress signaling. Cancer cells are highly proliferative and have high demand for protein synthesis and folding, which results in significant stress on the ER. To respond to ER stress and maintain cellular homeostasis, cells activate the unfolded protein response (UPR) that promotes either survival or apoptotic death. Cancer cells utilize the UPR to promote survival and growth. In this study, we describe the discovery of a series of novel hydroxyquinoline GRP78 inhibitors. A representative analogue, YUM70, inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues. YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis. A YUM70 analogue conjugated with BODIPY showed colocalization of the compound with GRP78 in the ER. Moreover, a YUM70-PROTAC (proteolysis targeting chimera) was synthesized to force degradation of GRP78 in pancreatic cancer cells. YUM70 showed a strong synergistic cytotoxicity with topotecan and vorinostat. Together, our study demonstrates that YUM70 is a novel inducer of ER stress, with preclinical efficacy as a monotherapy or in combination with topoisomerase and HDAC inhibitors in pancreatic cancer. SIGNIFICANCE: This study identifies a novel ER stress inducer that binds GRP78 and inhibits pancreatic cancer cell growth in vitro and in vivo, demonstrating its potential as a therapeutic agent for pancreatic cancer.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR STABILITY INDICATING HPTLC METHOD FOR ASSAY OF STIRIPENTOL IN BULK AND DOSAGE FORM

Introduction: This work is concerned with the stability-indicating method development and validation of Stiripentol in a bulk drug and formulation by high-performance thin-layer chromatographic method (HPTLC). Materials and Methods:The pre-coated silica gel 60 F254 aluminum plate was selected as the stationary phase, and the solvent system consisted of Ethyl acetate: Dichloromethane: Toluene (2:2:6 v/v) used as developing solvents. Analysis of Stiripentol was carried out at 301 nm with Stiripentol being detected at an R(f) of 0.63. The developed method was validated for linearity, accuracy, precision, limit of detection (LoD), limit of quantitation (LoQ), robustness parameters, and stability are determined by force degradation study. Results and Discussion: The correlation coefficient of Stiripentol was 0.994 observed. The calibration plot was linear between 50–300 ng/band, respectively. The average percentage recovery of Stiripentol was found to be 100.25 %. Intra and inter-day precision measured as %RSD was less than 2%. Hence stability study of Stiripentol, it was found to degrade in acidic condition(8.52% - 0.1N HCL for 30 minutes at room temperature), alkali condition(7.47%- 0.1 N NaOH for 30min at room temperature), Hydrolytic condition(4.73%– dist. Water for 30min at room temperature), thermal condition(7.69%-40°C for 30min ), oxidative condition(7.55% - 3% H2O2 for 30min at room temperature) and photolytic UV condition(7.54% -24hr UV radiation) respectively. Stiripentol was unstable in acidic condition and stable in normal dist. Water hydrolytic condition. Conclusion: The proposed method was found to be very sensitive and accurate for the determination of Stiripentol in bulk and formulation.

A New Validated Stability Indicating RP-HPLC Method for Simultaneous Quantification of Formoterol Fumarate Dihydrate and Mometasone Furoate in Metered Dose Inhalation Aerosol

Stability indicating reversed phase-HPLC method for simultaneous estimation of mometasone furoate (MAF) and formoterol fumarate (FFD) in metered dose inhalation aerosol (MDI) dosage formulation has been developed and discussed in the present work. The chromatographic separation was achieved using Hypersil ODS column (250 mm × 4.6 mm, 3 μm) using an isocratic separation mode at a flow rate of 1.2 mL/min, column temperature of 50 ºC. The system operates with a mobile phase comprising of solution-A (buffer): Solution-B (acetonitrile) mixed in the ratio of 70:30 %v/v at a UV detection wavelength of 214 nm. Retention times of mometasone furoate and formoterol fumarate found to be about 3 min and 7 min, respectively. All possible degradation products of both compounds were monitored at 214 nm and spectral purity along with % mass balance is assessed using PDA detector. Both analyte were subjected to force degradation studies, found all degradants were resolved from analyte peaks and also other process-related impurities. The proposed method is validated for specificity, linearity, accuracy, precision and robustness as per ICH guidelines and found to be adequate. Method stood to be robust with variation in column temperature, flow rate, pH of buffer and organic content in mobile phase.

OMPARATIVE STUDY BETWEEN DIFFERENT COLORS OF ELASTOMERIC CHAIN: ANIN VITROSTUDY

Este estudo, in vitro, teve como meta medir a influência das cores sobre a degradação da força de elásticos ortodônticos em cadeia da marca Morelli®, após estirados e submersos em saliva artificial. Os valores foram obtidos após mensuração imediata (tempo zero), 30 minutos, 1 hora e 24 horas de submersão. Foram analisadas vinte amostras, escolhidas aleatoriamente, de cada uma das cores de elásticos em cadeia sintéticos. Cada amostra, composta por 4 elos, foi inicialmente pré-estiradas, com o auxílio de duas sondas exploradoras, até o estresse. A determinação da quantidade de estiramento dos elásticos para aferição corresponde a 50% do valor do pré-estiramento inicial. Após a leitura inicial, cada um dos elásticos foi retirado do dinamômetro com o auxílio de uma pinça clínica e em seguida assentados sobre um gabarito com pinos desenvolvidos para acomodação dos elásticos. Os conjuntos (gabarito + elásticos) foram imersos em saliva artificial a 37 °C (histerese ± 1°). Nos intervalos de tempo 30 minutos, 1 hora e 24 horas. As amostras no tempo zero apresentavam diferenças significativas (p&lt;0,05) entre as cores, com maior variação para a cinza e menor para a cor preta. Todas as cores mostraram maior degradação de força na primeira hora.

A Novel Ultra Performance Liquid Chromatography-PDA Method Development and Validation for Darunavir in Bulk and Its Application to Marketed Dosage Form.

ABSTRACTAims and Objective:The aim of this study was to develop and validate a novel ultra-performance liquid chromatographic method for estimation of darunavir in a bulk and tablet dosage form.Materials and Methods:The chromatographic separation was achieved using DIKMA Endoversil (2.1mm x 50mm, 1.7 µm) column. A mixture of 40% buffer (0.1% octa sulfonic acid) and 60% acetonitrile was used as a mobile phase with the isocratic elution mode and eluent was monitored at 281nm using UV detector. The method was continued and validated in accordance with International Conference on Harmonization Guidelines. Validation study revealed the specificity and reliability of the method.Results:In this method, darunavir was eluted with retention time of 0.516 min. Calibration curve plots were found linear over the concentration ranges 10–50 μg/mL for darunavir. Limit of detection was 0.02 μg/mL and limit of quantification was found 0.07 μg/mL. The present method was also found stable in force degradation study.Conclusion:The empirical evidences of all the study results revealed the suitability of the estimation of darunavir in bulk and tablet dosage form without any interference from the excipients.

A novel stability indicating RP-HPLC Method for the estimation of ulipristal - A Selective Progesterone Receptor Modulator

The present research article described the novel HPLC technique that was developed for the estimation of ulipristal in an API and tablet formulation. Symmetry, C18, 250mm x 4.6mm .i.d., 5 µm Particle size, column with 0.4 ml/min flow rate, was used for the chromatographic separation. Phosphate buffer, pH 4.6 and methanol as a mobile phase (20:80) with a flow rate of 1 mL/min and eluent at 304 nm was monitored for the mobile phase. In compliance with ICH guidelines, the method was validated. Ulipristal was eluted in this technique with a retention time of 1.516 minutes. The limit of detection was 0.075μg/ml and the limit of quantification was found 0.25 μg/mL. The calibration curve plot was found linear over the concentration ranges 5-150 μg/mL, with the regression coefficient (R2) of 0.990. The % assay of the marketed dosage form was found at 97.40 %, which is within the acceptance level. The present method of ulipristal force degradation study was performed as per the guidelines. The results of the force degradation study show the highest 11.39% degradation in an acidic stressed condition, in comparison to alkaline, peroxide, thermal and photolytic stressed conditions. The experiential evidence of all the study results revealed the suitability of the quantification of ulipristal in API and tablet formulation routinely.

Cost Effective, Efficient and Stability indicating analytical method validation for Ranolazine related by Reverse Phase High Performance Liquid Chromatography in drug substances

A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Ranolazine in drug substances. Isocratic elution at a flow rate of 1.4ml/min was employed on Hypersil BDS C18, 150 x 4.6 mm, 5µm or Equivalent at 40°C column temperature. The mobile phase consisted of Mobile phase-A: Mobile phase-B (55:45) (Disodium hydrogen orthophosphate buffer with pH 7.0 and Acetonitrile). The UV detection wavelength was at 205 nm. Linearity was observed in concentration range of 0.07-0.82 ppm for ranolazine impurity-I and concentration range of 0.07-0.78 ppm for ranolazine impurity-II. The retention time for Ranolazine was 7.6 min. The method was validated for validation parameter like specificity, force degradation, linearity, accuracy, precision and robustness as per the ICH guidelines. The proposed method can be successfully applied for the estimation of Ranolazine in pharmaceutical dosage forms.&#x0D; Keywords: Ranolazine, Method Validation, Drug Substances, HPLC

A Novel Ultra Performance Liquid Chromatography-PDA Method Development and Validation for Alectinib in Bulk and its Application to Tablet Dosage Form

Objectives: To develop a novel ultra-performance liquid chromatographic technique for the estimation of alectinib in a API and tablet. Methods: The chromatographic separation was achieved using DIKMA Endoversil (2.1 x 50mm, 1.7μm) column, mobile phase was phosphate buffer, pH 4.6 and methanol as a mobile phase (45:55) with a flow rate of 0.4 mL/min and eluent was monitored at 265 nm. The method was continued and validated in accordance with International conference on harmonization guidelines. Validation study revealed the specificity and reliability of the method. Results: In this method alectinib was eluted with retention time of 0.418 min. Calibration curve plots were found linear over the concentration ranges 1-100 μg/mL for alectinib. Limit of detection was 0.015μg/ml and limit of quantification was found 0.07μg/mL. The % assay of the marketed dosage form was found 97.80 %, even the present approach was found to be effective in the analysis of alectinib in force degradation condition. Conclusion: The experiential evidences of all the study results revealed the suitability of the estimation of alectinib in API and tablet formulation.

Effects of Different Commercially Available Mouth Rinses on The Force Degradation of Orthodontic Elastomeric Chain

Aim of the study: To evaluate the effects of different commercial type of mouthwashes on the force decay of the orthodontic elastomeric chain. Materials and methods: two hundred pieces of the elastomeric chains with two different configurations were divided into five groups (one control group and four different mouthwashes groups). after one-day immersion in artificial saliva then immersion in the specific mouthwashes (kin, Vitis, perio_aid, splat) for one minute twice daily and time intervals after 7 days, 14 days, 21 days, and 28 then washed and kept in artificial saliva at 37°C again. Force decay was calculated by Instron measured, digital force gauge - Instron universal testing machine then compared different force decay of elastic types. Results: A significant difference was found among between the four types of mouth wash and control group, according to close and short elastic chain the kin mouth wash was shows a significant difference (0.002), while splat mouthwash was shown a no significant difference. Conclusion: splat mouth wash groups showed no significant influence on the force degradation of the chain elastics tested. Kin mouthwash exhibit the highest force decay and found different significant effects.

Idealized force decay of orthodontic elastomeric chains follows Nutting Equation

AbstractThe force decay of orthodontic elastomeric modules has been of considerable interest since these biomechanical force‐generating appliances were introduced five decades ago. Two mathematical approaches, a power‐law equation and a Maxwell–Weichert model, have been used by previous investigators to predict the in vitro force degradation under idealized conditions. In this study, the principal sensor approach had the test specimen being strained continuously using a digital force gauge. Test specimens of 13 products from 8 manufacturers were stretched to 25 mm and tested in an artificial saliva at 37°C in both the as‐received condition and after 24 h conditioning. Measurements for specimens strained continuously on the digital force gauge were compared with intermittent measurements for other specimens transferred to this gauge after 19.2 h ageing on a stretching rack, the approach in most past studies. Force data at equally spaced logarithmic time points, normalized to initial force and induced strain, were used to present degradation curves for individual products. Nonlinear regression analyses were used to fit both mathematical models to each product and conditioning state. Statistical analyses show that the power‐law equation (historically the Nutting equation) provides a more accurate prediction of idealized in vitro force decay for the elastomeric products.

218 Impact of diet and quality grade on tenderness of beef steaks

Abstract Research was conducted to evaluate the effects of feeding different types of processed corn, with or without distiller grains with solubles, and differing quality grade on tenderness of beef steaks. Steers (n=240) were finished on Dry Rolled Corn (DRC), DRC + 30% Dried Distillers Grains with Solubles (DDGS), Steam Flaked Corn (SFC), or SFC + 30% DDGS. Cattle were fed 10 per pen. Only pens with upper 2/3 Choice and Select-grade carcasses were sampled, with a goal of two (and a minimum of one) of each grade per pen. Three pens per treatment met the selection criterion and 36 carcasses were chosen (21 upper 2/3 Choice and 15 Select). Pen was considered the experimental unit. Both strip loins were collected from each carcass, halved, and aged for 2, 9, 16, or 23 d. After aging, steaks were placed under retail display for 7 d. Warner-Bratzler shear force (WBSF), slice shear force (SSF), sarcomere length, sarcoplasmic calcium, and troponin-T (Tn-T) degradation were determined. Minimal to no impacts on sarcomere length and calcium were found (P &amp;gt;0.05). For both WBSF and SSF, Choice steaks were more tender than Select. Significantly more Tn-T was degraded at 23 d of aging compared to 2 d of aging. Beef steaks from cattle fed DRC were more tender than SFC, regardless of the presence or absence of DDGS. For 2 d aged samples, Tn-T degradation was higher when cattle were fed DDGS compared to no DDGS. Overall, these data suggest that steaks from cattle fed DRC are more tender than steaks from cattle fed SFC and Choice-grade steaks are more tender than Select-grade steaks.

Development and validation of simultaneous estimation of drugs in combination from pharmaceutical formulation by RP-HPLC method

Metformin is recommended as a first-line agent for monotherapy and combination therapy for patients with type 2 diabetes mellitus (T2DM). Patients whose glycaemic control deteriorates over time with metformin monotherapy will require additional anti-diabetic medication. The development of HPLC method for simultaneous estimation of anti-diabetic drugs in combination from solid dosage form by HPLC method. To validate the developed HPLC method as per ICH guidelines. The System suitability test ,Capacity factor, Tailing factor, Resolution, Selectivity, Separation factor, Theoretical plates, Regression coefficient, STD for intercept, LOD (limit of detection), LOQ (limit of quantification, Repeatability, Precision studies (Intra-day and Interday/Intermediate), Linearity/Calibration studies, Robustness, Force degradation/Stability indicating studies, Specificity, Drug recovery/accuracy studies are performed. The system suitability test performed for saxagliptin and metformin hydrochloride has achieved all guideline criteria; including tailing factor (T), separation factors (α), theoretical plates (N), capacity factor (k’), resolution (R) and RSD (%), force degradation studies were also performed for both these drugs. So combinedly we concluded that the proposed reverse phase chromatographic (RP-HPLC) analytical method for the simultaneous estimation in both bulk and tablet formulation have complied the ICH and US-FDA guidelines.

Force degradation of nickel-titanium closed coil springs: an in vitro

Objective: evaluation of the forces resulting from the initial stretching of closed Nickel-titanium springs and the degradation of these forces after 28 days of stretching. Methodology: The sample comprised 80 Morelli Nickel-titanium closed coil springs, divided into 4 groups of 20 according to their length, 7, 9, 12 and 15mm. In each group, 10 spring coils suffered distension in 50 and 100% of its original length and were maintained in devices to simulate the distension. The resulting forces were measured with a tensiometer and compared with the force described by the manufacturer on the spring packaging (200 grams force). Measurements were performed in 2 time-points; right after the initial strain (T1) and after 28 days (T2), when the devices were kept in artificial saliva at a temperature of 37°C. For the statistical analysis, the Mann-Whitney test was applied to compare the forces in T1 with the manufacturer's value and the paired t test to compare the forces between T1 and T2. In all statistical tests, a significance level of 5% was adopted. Result: In T1 the springs of 9, 12 and 15mm stretched by 50% showed significantly lower values ​​and the springs of 7 and 15mm stretched by 100% showed significantly higher values, both compared with the manufacturer's recommendation. All groups of springs showed significant degradation of forces between T1 and T2, with percentage rates of force degradation from 7.1 to 21.9%. Conclusion: It is necessary to measure the forces of the springs during orthodontic treatment, aiming to establish an optimal force for tooth movement and thus optimizing the total treatment time.

Hyphenated Techniques, an Important Tool for Force Degradation Study

The pharma market is getting flooded with many new drug formulations as well as fixed dose combination formulations in which different API are there. Each of this is going to contain different types of impurities as well as they are bound to undergo process of degradation by different mechanisms leading to formation of degradation products. All of these are going to be present as impurities. Though the impurities will be within limit in accordance to regulatory authorities, still in case of disease like diabetes and hyper tension the patient is going to be on medicine for rest of his life hence bound to get over exposure to these. Some of which may cause adverse effects like cytotoxic and genotoxic. Hence indeed there is need for identification. In previous era it was ok with regulatory authorities if components in formulation were 99% pure. But know they are insisting on identification of that remaining 1%.

Evaluation of the force degradation and deformation of the open-closed and open springs of NiTi: An in vitro study

The aim of this study was to evaluate the force degradation and deformation over time of an open-closed and open coil spring. 40 NiTi springs were divided into 2 groups according to the manufacturer (20 specimens per group): Morelli™ (Sorocaba, SP, Brazil) and Orthopli™ (Philadelphia, PA, USA). Then, they were subdivided into 2 groups according to the type of spring (n=10): open spring and open-closed spring. The springs were submitted to the initial compression test in a Universal Test Machine (Instron) in 43.3% of the initial length and analyzed in 3 points (0.5mm, 3.25mm and 6.5mm). After this, the springs were activated with a 240 gf and those maintained for 4 weeks in artificial saliva in the oven at 37°C, and analyzed by a new compression test with the same initial parameters. Scanning Electron Microscopy/Energy Dispersive X-Ray Spectroscopy (SEM/EDS) analyzed the spring's morphology. Two-way repeated measures Analysis of Variance was applied for each brand and extension of compression. Student t-test with correction of Bonferroni was used to compare open spring vs open-closed springs and pairwise t-test was used to compare initial vs final period. The level of significance was set at 95% in all tests. The most representative images were selected (SEM/EDS). The Orthopli™ open-closed spring showed a statistically higher deformation (14.52±0.37) in relation to open spring (14.85±0.19) after 4 weeks (P<0.05). No statistical difference was observed between the types of Morelli™ springs (P>0.05). Orthopli™ open-closed spring showed force values statistically higher than the open spring in the initial and final time (P<0.05). Regardless of the type of spring, the initial force was significantly higher than the final force (P<0.05). The orthodontist should not rely on the indicated force range without considering the type of spring (open or open-closed), the manufacturer and the amount of compression of the spring.

High performance liquid chromatographic assay of amlodipine, valsartan and hydrochlorothiazide simultaneously and its application to pharmaceuticals, urine and plasma analysis

A Simple, Specific, Precise, Accurate, Linear, Rugged, Robust High Performance Liquid Chromatographic method of analysis for simultaneous determination of assay of Amlodipine, Valsartan and Hydrochlorothiazide drugs in the pharmaceuticals tablet formulations using Pioglitazone as a common internal standard was developed and validated. The assay was accomplished using a mixture of acetonitrile & methanol in the volume ratio of 20:80 v/v (mobile phase B) and Ammonium acetate buffer (Mobile phase A) in gradient flow as mobile phase on an Hibar RP-18e, 250 × 4.6 mm, 5µ as chromatographic column at a flow rate of 1.300 mLmin-1, injection volume 10 µL and at a wavelength 235 nm with UV detector. Linearity of the analytical method was evaluated at a concentration range of 2.5–45.3 µg/ml for Amlodipine, 32.0–720.1 µg/ml for valsartan and 5.0–112.6 µg/ml for Hydrochlorothiazide respectively with Correlation coefficient (r) value more than 0.9997. The limit of detection (LOD) for Amlodipine, Valsartan and Hydrochlorothiazide was found to be 1.1 µg/ml, 8.0 µg/ml & 1.0 µg/ml respectively. Specificity, Method Precision, System Precision, Ruggedness, Robustness, Recovery, Stability of analytical solution, Filter paper selection study, Stress testing (Force Degradation) at various conditions were performed as per the ICH (Q2) recommendations. The chromatographic method may also be applied for simultaneous estimation of analytes in plasma and urine.

Comparison of the force decay over time of four different brands of elastomeric chains (elongated to 25 mm grey/transparent and closed/open): An in-vitro study

The present study was designed to compare the force degradation of closed, open, grey and transparent power chains from four orthodontic companies (American orthodontics® (AO®), Dentsply®, Ormco® and Rocky Mountain Orthodontics® (RMO®)) over time. Universal testing machine was used to measure the force of the power chains elongated to 25mm at 0hours, and after storage in artificial saliva at 24hours, 1 week, 2 weeks, 3 weeks, and 4 weeks. A Tukey's honestly significant difference test was performed. Most of the power chains showed less than 30% of force decay at 24hours of elongation. The AO® transparent open elastomeric chains presented the lowest percentage of force remaining at almost all times: 24hours (58.9%), 1 week (67.7%), 2 weeks (43.2%), 3 weeks (72.4%), and 4 weeks (63%). Most of the power chains had an increase of force measured after 2 weeks of storage in artificial saliva. Three of the sixteen groups (Ormco® grey open, RMO® grey and transparent closed) displayed an increase in the force at 4 weeks of elongation compared to the force registered at 0hours. The results indicated that the force generated by elastomeric chains at 4 weeks remains optimal for a physiologic tooth movement.

Efficient nonlinear modeling of strong wood frame shear walls for mid-rise buildings

Designing mid-rise timber buildings in seismic areas requires stronger wood frame shear walls compared to those required in low-rise structures. Despite some experimental research has been conducted lately to demonstrate the difference between the lateral response of such 'strong' walls and conventional ones, investigations on numerical models that could reproduce their nonlinear behavior under seismic loads are limited. This paper presents an efficient nonlinear modeling approach to better understand such behavior under large displacement demands. The numerical model was validated using a set of twelve real-scale experiments. The model predictions showed an accuracy of ±8% for 1:1 walls and proved its suitability to capture the post-peak phenomena such as force degradation, stiffness degradation, and pinching. For the aspect ratios investigated, anchorage system demands were found to remain 50% below the failure capacity. It was also shown that redesigning the nailing pattern can increase the capacity of strong wood frame walls by up to 10%. Finally, the application of the developed numerical model in calibrating simpler single-degree-of-freedom (SDOF) models for reproducing the hysteretic response of strong walls was discussed. Since shear behavior governs the deformation of wood frame walls, the parameters of the SDOF model can be defined proportionally to the wall length. This may be used as a simple and easy-to-use tool to compute the dynamic behavior of mid-rise timber buildings with strong wood frame walls.