This study discusses the evolution of climate change and the use of indigenous methods of flood control in the Upper Nun Valley of Cameroon. The local farmers of the Ndop plain have developed and implemented extensive indigenous farming systems as adaptation strategies to reduce the vulnerability of climate variability over the years. However, these indigenous methods of flood control have not been sustainable enough to guard against severe flood incidences in the Ndop Plain as a result of climate change impact. This paper examines climate change evolution in the region and highlights some indigenous adaptation strategies practised in the Upper Nun Valley and the benefits of integrating such indigenous knowledge into formal climate change adaptation strategies. To ensure stability in food production and sustain food sufficiency in areas where local economies entirely depend on farming and the natural state of the environment, it is important to investigate the indigenous strategies put in place and the extent to which they combat floods in the Ndop Plain. Field surveys, focus group discussions, interviews, participant observation methods and secondary sources were used to collect data from selected villages where rice cultivation and market gardening products are on the increase. Based on climatic data for the region, the simple forecasting method using the forecasting line was used to predict future changes in climatic conditions for the region and the extent to which they may cause floods. The data collected were analyzed in both qualitative and quantitative terms to provide information for the discussion. The results reveal that changes in temperature and rainfall have altered the climatic conditions of the region leading to increased flood incidences in the Plain. The paper posited that a sustainable adaptation mechanism should take into consideration the widening of the drains as well as minimizing the cultivation of crops on the drains which serve as gateways to excessive water into the rice fields. The study also recommends the need to incorporate indigenous knowledge into climate change policies that can lead to the development of effective adaptation strategies that are cost-effective, participatory and sustainable.