The article presents the results of the analysis of the rate of mayonnaise resistance to oxidative poisoning, depending on the combination of polymer films used in doy-pack packaging, and its storage modes. The object of the study was mayonnaise with a mass fraction of fat of 67%. In the course of the studies, packaging with a combination of PET12/PE90 films was used; PET12/PE100; PET12/PE110; PET12/PE120; PET12/PE130; PET12/RE_VBS120; PETp12/PE120; RETFp12/RE_VBS120, including those with a "transparent window". The rate of oxidative poisoning was controlled using the indicator "Peroxide number", the values of which were determined by the standard method for 120 days of storage with a frequency of 15 days. Resistance to oxidative poisoning of mayonnaise was determined in the temperature range from +10 to +15°C; from +15 to +25°С and from +25 to +30°С. The results of the study showed that the resistance of mayonnaise to oxidative poisoning is directly dependent on the thickness of the packaging material - the smaller the thickness of the polyethylene, the higher the peroxide value. The combination of PET12/PE120 films used for packaging mayonnaise is able to ensure compliance with the regulated standards in terms of "Peroxide number" in all three studied temperature ranges with different durations: in the range from +25 to +30°C for 45 days, from +15 up to +25°С - for 60 days, and at a temperature from +10 to +15°С for 90 days. The use of high-barrier materials for packing mayonnaise makes it possible to reduce the intensity of the oxidative poisoning process by a factor of 2 or more and thereby increase its shelf life. The presence of a “transparent window” in the design of the packaging material does not significantly affect the intensity of oxidative processes and the shelf life of mayonnaise.