Longitudinal Study Research Articles

The association between hypothyroidism and cognitive function change in women across the menopause transition: The Study of Women's Health Across the Nation (SWAN).

Background Patients treated for hypothyroidism with levothyroxine (LT4) monotherapy may present with persistent hypothyroidism symptoms, including cognitive symptoms, despite having a normal thyroid stimulating hormone (TSH) level. It remains unclear whether LT4 monotherapy is sufficient to normalize cognitive function outcomes over time. Methods This is a multi-site longitudinal study of a diverse group of women during midlife representing 5 ethnic/racial groups from 7 enrollment sites across the US in the Study of Women's Health Across the Nation (SWAN). Women were screened for a history of thyroid disease and the use of LT4. The study consisted of two primary groups: women with LT4-treated hypothyroidism and control women without thyroid disease. Each participant completed up to 9 cognitive assessments over the study period testing processing speed, working memory, and episodic memory (immediate and delayed recall). Multivariable generalized linear mixed models of scores for each cognitive assessment were developed to determine the association between LT4-treated hypothyroidism and cognitive function trajectories. Covariates included sociodemographic, clinical characteristics, and menopausal status (pre/early peri-, late peri-, and surgical/post-). Sensitivity analyses were conducted to assess the impact of abnormal TSH levels and practice effects (i.e., improvements in scoring after repeated testing). Results Of the 2033 women who were included in the study, 227 (11.2%) met criteria for LT4-treated hypothyroidism. At baseline, both processing speed and working memory scores were higher in LT4-treated women (mean processing speed scores: 56.5 vs 54.4; p-value = 0.006; mean working memory scores: 6.8 vs 6.4; p-value = 0.018). However, when considering the effect of LT4-treated hypothyroidism over time, there were no significant differences in the rate of cognitive decline (in any measure) between the hypothyroidism and control groups with or without covariate adjustment. The results were similar when considering LT4-treated women with abnormal TSH levels or after minimizing practice effects. Conclusions We observed no difference in cognitive decline between women with LT4-treated hypothyroidism and women without thyroid disease. For similar-aged patients with cognitive complaints, if thyroid function testing is normal, clinicians should consider causes other than inadequate thyroid hormone treatment to explain these symptoms.

Does it stable? Intracranial aneurysm wall enhancement might be the warning signals: a meta-analysis of observational studies.

Magnetic resonance vessel wall imaging (MR-VWI) is an emerging imaging technology used to assess the progressive risk of unruptured intracranial aneurysms (UIAs). Unlike the standard evaluation model, MR-VWI is still debatable. This study aims to further define the potential relationship between aneurysm wall enhancement (AWE) and aneurysm stability. Using "intracranial aneurysm", "magnetic resonance", and "enhancement" as keywords, relevant studies were systematically searched in PubMed, Embase, and Cochrane, and the qualified studies were enrolled for further analysis. There were 13 case-control studies, 4 cohort studies, and 2,678 cases of intracranial aneurysms included in the meta-analysis. It was shown that AWE was correlated with intracranial aneurysm rupture (OR = 35.90, 95% CI: 15.58 to 82.75, p < 0.001), growth (OR = 6.69, 95% CI: 2.69 to 16.63, p < 0.001), and presence of symptoms (OR = 14.46, 95% CI: 9.07 to 23.05, p < 0.001). This finding had a high diagnostic value, but the correlation was probably not independent of aneurysm size. The pooled relative risks of the follow-up studies revealed that the risk of UIA progression was approximately 3.33 times higher with AWE than without AWE (RR = 3.33, 95% CI: 2.33 to 4.78, p < 0.001). In addition, the pooled results demonstrated that quantitative indices of VWI enhancement were equally linked with aneurysm stability (OR = 19.61, 95% CI: 10.63 to 36.17, p < 0.001). AWE is an effective imaging method to assess the stability of UIAs, and it can be a marker for the prophylactic treatment of small unruptured intracranial aneurysms in the future, which remains to be validated by prospective studies with large samples.

Maternal Accommodation of Adolescent Body Dysmorphic Disorder: Clinical Correlates and Association with Treatment Outcomes.

Family accommodation (FA) is widely-recognised as an important clinical phenomenon in obsessive-compulsive disorder (OCD) and anxiety disorders, and is related to poorer treatment outcomes. However, FA has not been quantitatively explored in Body Dysmorphic Disorder (BDD). The aim of this study was to investigate the patterns and correlates of maternal accommodation in adolescent BDD, and its association with treatment outcomes. Participants were 131 adolescents with BDD and their mothers who completed the Family Accommodation Scale-Parent Report (FAS-PR) as part of routine clinical practice in a National and Specialist Service for Young People at the Maudsley Hospital, London. Seventy-six (58%) young people received specialist cognitive behavioural therapy for BDD and had post-treatment data available. All mothers engaged in at least one form of accommodation. Providing reassurance (98.5%) and assisting avoidance (88.5%) were the most commonly endorsed behaviours. Levels of accommodation were positively associated with clinician-rated BDD symptom severity (r = 0.18, p = 0.041) and maternal symptoms of anxiety, depression and stress (r = 0.41, p < 0.001), and negatively associated with child global functioning (r = -0.38, p < 0.001). Maternal accommodation did not predict treatment outcomes (β = 0.055, p > 0.05). The findings indicate that maternal accommodation is common and has important clinical correlates, but does not impact on treatment response. Consequently, the relationship between maternal accommodation and BDD symptoms may differ to that evidenced in paediatric OCD. Future longitudinal research exploring maternal and paternal accommodation, and assessing variables of interest at multiple time-points throughout treatment, is needed to advance understanding of the role of FA in adolescent BDD.

Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity.

Our objective was to interrogate infant mesenchymal stem cell (MSC) lipid metabolism and gestational exposures that may contribute to child obesity risk. MSCs were cultured from term infants of mothers with obesity (n=16) or normal-weight (n=15). In MSCs undergoing myogenesis in vitro, we used lipidomics to distinguish phenotypes by unbiased cluster analysis and lipid challenge (24h excess fatty acid, 24hFA). We measured MSC AMP-activated protein kinase (AMPK) activity and fatty acid oxidation (FAO), and a composite index of maternal glucose, insulin, triglycerides, free fatty acids, tumor necrosis factor-α, high density lipoprotein- and total- cholesterol in fasting blood from mid- and late-gestation (~17, ~27wks). We measured child adiposity at birth (n=29), 4-6m (n=29), and 4-6y (n=13). Three MSC clusters were distinguished by triacylglycerol (TAG) stores, with greatest TAGs in Cluster-2. All Clusters increased acylcarnitines and TAGs with 24hFA, though Cluster-2 was more pronounced and corresponded to AMPK activation and FAO. Maternal metabolic markers predicted MSC Clusters and child adiposity at 4-6y (both highest in Cluster-3). Our data supports that MSC phenotypes are predicted by comprehensive maternal metabolic milieu exposures, independent of maternal BMI, and suggest utility as an at-birth predictor for child adiposity, though validation with larger longitudinal samples is warranted.

Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of blaKPC-carbapenemase-producing Enterobacterales in a hospital setting

Abstract Background Healthcare-associated wastewater and asymptomatic patient reservoirs colonized by carbapenemase-producing Enterobacterales (CPE) contribute to nosocomial CPE dissemination, but the characteristics and dynamics of this remain unclear. Methods We systematically sampled wastewater sites (n = 4488 samples; 349 sites) and patients (n = 1247) across six wards over 6–12 months to understand blaKPC-associated CPE (KPC-E) diversity within these reservoirs and transmission in a healthcare setting. Up to five KPC-E-positive isolates per sample were sequenced (Illumina). Recombination-adjusted phylogenies were used to define genetically related strains; assembly and mapping-based approaches were used to characterize antimicrobial resistance genes, insertion sequences (ISs) and Tn4401 types/target site sequences. The accessory genome was evaluated in some of the largest clusters, and those crossing reservoirs. Results Wastewater site KPC-E-positivity was substantial [101/349 sites (28.9%); 228/5601 (4.1%) patients cultured]. Thirteen KPC-E species and 109 strains were identified using genomics, and 24% of wastewater and 26% of patient KPC-E-positive samples harboured one or more strains. Most diversity was explained by the individual niche, suggesting localized factors are important in selection and spread. Tn4401 + flanking target site sequence diversity was greater in wastewater sites (P &amp;lt; 0.001), which might favour Tn4401-associated transposition/evolution. Shower/bath- and sluice/mop-associated sites were more likely to be KPC-E-positive (adjusted OR = 2.69; 95% CI: 1.44–5.01; P = 0.0019; and adjusted OR = 2.60; 95% CI: 1.04–6.52; P = 0.0410, respectively). Different strains had different blaKPC dissemination dynamics. Conclusions We identified substantial and diverse KPC-E colonization of wastewater sites and patients in this hospital setting. Reservoir and niche-specific factors (e.g. microbial interactions, selection pressures), and different strains and mobile genetic elements likely affect transmission dynamics. This should be considered in surveillance and control strategies.

Improving the Quality of Climate Change Adaptation Planning Through State Mandate: The Case of California

Problem, research strategy, and findings As communities everywhere experience accelerating climate change impacts, local governments must proactively plan and implement adaptation or resilience strategies. A significant challenge is effectively scaling up these efforts in diverse communities. In 2015, the State of California passed Senate Bill 379 (SB379), requiring climate change adaptation and resilience strategies in local plans, making it the first U.S. state to broadly mandate such requirements locally. Our study measured the effects of SB379 on the quality of local plans that address climate change adaptation or resilience and assessed which types of plans jurisdictions selected to meet the requirements. Using a longitudinal study, we analyzed plan quality before and after SB379 took effect using criteria developed for earlier studies of voluntary climate adaptation plans. We found that California plans have significantly improved when assessed against theoretical criteria, and most jurisdictions have chosen their local hazard mitigation plans to meet the requirements. The flexible and cooperative design of the mandate and its loose enforcement suggest local jurisdictions are willing to address climate change, even when challenged with more stringent requirements if incentives align. As a natural policy experiment, California’s experience offers a unique opportunity to examine the effects of a state planning mandate and the choices local jurisdictions make to comply. Takeaway for practice Cooperative mandates that require local governments to address climate change adaptation and resilience in their plans but offer flexibility in how they do so may improve the quality of plans. Practitioners should seek to leverage flexibility in such mandates to the advantage of their local communities.

Empowering Moroccan University Students Through Extracurricular Involvement in Collegiate Clubs: A Longitudinal Study

Extracurricular clubs stand out as transformative and accommodating hubs in the academic experience of university students, thereby offering opportunities for personal growth, community building, and effective academic engagement. This research investigates the profound influence of academic club participation on Moroccan university students, with a specific focus on experiences within clubs such as the Bookworms and Public Speaking Clubs at Ibn Zohr University. Employing a qualitative longitudinal approach, including qualitative case studies and longitudinal analysis, the research reveals three main themes: empowerment through inclusivity, increased academic engagement and excellence, and a sense of agency and achievement. Findings indicate that club participation fosters a sense of belonging, enhances academic motivation, and develops essential soft skills, leadership orientations and community engagement. The study calls for institutional support and integration of clubs into the curriculum to promote educational research and practice within Moroccan universities.

Multilayer intermediation: Exploring the organization of cultural intermediaries in social media entertainment

This article investigates the phenomenon of the platformization of cultural production within social media entertainment, describing the peculiar interaction between creators and publishing groups. It relies on the case of the Italian video-making company The Jackal and their distinctive economic, organizational, and creative connection with the publishing group CiaoPeople. Starting from Bourdieu’s definition of cultural intermediaries, the article interrogates the role of social media creators as new cultural intermediaries occupying spaces between creativity and economy, acting as co-producers, tastemakers, selectors, and managers of cultural goods and services. Through a longitudinal study, the article argues that social media entertainment enacts a “multilayer intermediation” between brands, creators, consumers, and digital platforms, where legacy media companies may provide creators with tools to resist the entrance of platforms into creative production.

Beyond medications: a multifaceted approach to alleviating comorbid anxiety and depression in clinical settings

BackgroundComorbid anxiety and depression are common and can make the problems more complex and sometimes resistant to pharmacological treatment. In existing research, the diagnoses are often studied separately, and physical activity, healthy nutrition, psychoeducation, and social support have shown good effects. The aim of the present study was to explore the longitudinal effects of a comprehensive treatment on patients with comorbid anxiety and depression in a clinical context.MethodEighty inpatients (15 men and 65 women) in age range 23–65 years receiving psychiatric treatment in Norwegian clinic participated in the longitudinal study. Treatment was person-centered and was most frequently given for anxiety and depression, e.g., pharmacological treatment and psychotherapy, individually and in groups. In combination with this, physical activity, healthy nutrition, psychoeducation and social support in contacts with authorities and relatives were also a part of treatment. Depression and anxiety were assessed using the Beck Anxiety Inventory and Beck Depression Inventory at three points in time: baseline, at the end of treatment, and 3 months after treatment. The answers were categorized and combined into four groups according to severity of anxiety and depression to measure effects on comorbidity. Mann Whitney U test, Chi-square, Friedmans test, and McNemar test were used to analyze the data.ResultThe results showed a significant increase of frequencies in the group with mild anxiety and depression 3 months past treatment compared to baseline.ConclusionThrough the comprehensive, person-centered treatment more patients had low levels of both anxiety and depression 3 months after treatment. We suggest that clinics working with comorbid depression and anxiety patients should add physical activity, nutrition advice, social support, and psychoeducation to the traditional treatment regimes. More research concerning comorbid anxiety and depression are urgent to further expand the treatment possibilities.

THE RELATIONSHIP BETWEEN COGNITIVE DEFICITS AND CLINICAL CHARACTERISTICS IN PATIENTS WITH SCHIZOPHRENIA

Introduction: Schizophrenia is an endogenous psychotic disorder with a chronic course, which is characterized by dysfunction in multiple domains: perceptions, thinking, emotions, and cognition. Objective: The main aim of the study was to introduce the relationship between clinical characteristics and cognitive deficits in patients with schizophrenia. Methods: The research involved 53 randomly selected male and female respondents from 18 to 60 years of age, who suffer from schizophrenia according to the diagnostic criteria of the International Classification of Diseases – ICD 10, acute schizophrenia treated in the Psychiatric Hospital Skopje - Skopje. We used the following measuring instruments: the Positive and Negative Syndrome Scale (PANSS) and the Schizophrenia Cognition Rating Scale (SCoRS). Results: The results indicated that the acute schizophrenic patients had higher rating scores in the SCoRS assessment (M=45.736, SD=8.908) in the first week after psychosis onset. A high degree of positive and negative symptoms was a strong predictor of higher cognitive deficits in patients with schizophrenia. A positive relationship was observed between the PANSS-Positive and ScoRS level (F (53) =0.559, sig. =.001, p&lt;.01). At the same time, positive relationship was observed between the PANSS-Negative and ScoRS level (F (53) =0.283 sig. =.001, p&lt;.01). Conclusions: In the course of our longitudinal prospective study, we found that clinical characteristics of schizophrenia had a great impact on the cognitive dysfunction, whereby this is evident in the acute stage of the disease.

The impact of board composition and internationalisation on strategic change: Longitudinal empirical evidence

This study looks at the effect of board composition on a firm’s propensity for strategic change. We hypothesise that board composition influences strategic change and internationalisation moderates this relationship. We do a longitudinal study of 433 listed firms in the United States. The findings indicate that the board composition represented by two variables, namely board size and CEO duality, leads to less strategic change. In contrast, the third variable, interlocking directorships, leads to more strategic change. Our results also suggest that internationalisation mitigates the negative impact of board size and CEO duality on strategic change and strengthens the positive impact of interlocking directorships. JEL Classification: C12, L20, L21, M10

Factors influencing kindergarten Families' perceptions of home–school interactions

AbstractThe transition to and through kindergarten is consequential for the academic, social, and emotional wellbeing of children. Policies and practices are in place to smooth that transition. Researchers are working to understand which practices work best and for whom, particularly as the student population in U.S. schools continues to diversify. In this study, we analysed data from a large longitudinal study of racially, ethnically, and linguistically diverse families, children, and their teachers. We used multi‐level modelling to examine the factors associated with families' reports of strong home–school interactions at the transition to and through kindergarten on the Family Involvement Questionnaire. We found that children having attended preschool and lower class size were associated with family reports of strong interactions. Surprisingly, we also found that teacher–family language match, teachers' self‐efficacy for working with families, and teachers' beliefs about children were not significantly associated with families' reports of strong or weak interactions. This work has implications for family engagement policy and practice as children transition to and through kindergarten.

Exploring Pathways from Community Involvement to Empowerment in Sexual and Reproductive Health: A Public Health Perspective

The intersection of community involvement and empowerment in sexual and reproductive health (SRH) initiatives represents a critical area in public health. This scoping review aimed to explore the pathways from community involvement to empowerment within SRH initiatives, providing a comprehensive understanding of how public health strategies engage and build the capacity of communities. The literature from databases such as PubMed, Scopus and Web of Science were reviewed systematically, focusing on studies published between 2000 and 2023. The review identified various public health interventions that initially engage communities through participation, consultation and collaboration. These interventions often serve as the foundation for subsequent empowerment, characterised by capacity building, autonomy and advocacy. Key findings highlight that effective SRH initiatives involve community members in programme activities and foster environments where they can gain the skills, knowledge and confidence needed to take control of their health outcomes. Our analysis revealed that successful pathways from involvement to empowerment are multifaceted, requiring sustained commitment, resources and culturally sensitive approaches. The review underscores the importance of integrating community involvement and empowerment in designing and implementing SRH programmes to ensure sustainable and impactful health outcomes. This scoping review contributes to the existing literature by mapping the relationship between community involvement and empowerment, offering insights for public health practitioners and policymakers aiming to enhance SRH initiatives. Future research should focus on longitudinal studies to better understand the long-term impacts of these pathways on community health and well-being.

Alterations in Thyroid Hormones in Obese Patients are Associated with Body Composition Changes after Bariatric Surgery.

This study investigates how metabolic/bariatric surgery (MBS) affects thyroid hormone (TH) levels and TH resistance in obese euthyroid individuals, focusing on their correlation with changes in body composition. We included 470 obese individuals and 118 controls for baseline assessment, and 125 obese patients receiving MBS for longitudinal study. Data on body composition and thyroid function were collected. Correlations between baseline and changes in thyroid function and body composition were assessed. In the obese group, thyroid stimulating hormone (TSH), free triiodothyronine (fT3) levels, and thyroid feedback quantile-based index (TFQI) were elevated and significantly decreased post-MBS, along with visceral fat area (VFA) and body fat percentages, while skeletal muscle mass (SMM) percentage increased. Preoperative partial correlation analysis adjusted for age and sex revealed that TSH positively correlated with VFA (r=0.109, P=0.019), body fat percentage (r=0.114, P=0.013), and negatively correlated with SMM percentage (r=-0.104, P=0.024). Similar correlations were observed between central TH resistance indices and body composition, but no significant correlations were found in the control group. Post-MBS, decreased TSH positively correlated with decreased VFA (r=0.251, P=0.006) and increased SMM percentage (r=0.233, P=0.011). While reductions in VFA and body fat percentage were linked to improved central thyroid hormone resistance, a decrease in peripheral TH conversion was noted. MBS significantly impacts thyroid function and TH resistance, with notable correlations to changes in body composition.

The association between preserved-ratio impaired spirometry and depression: results from a prospective population-based study.

The relationship between preserved-ratio impaired spirometry (PRISm) and depression remains unclear. This study aimed to assess the bidirectional relationship between PRISm and depression using data from a national cohort. Data from Wave 2 (2004-2005) to Wave 4 (2008-2009) of the English Longitudinal Study of Ageing (ELSA) were analyzed. Lung function and depressive symptoms were measured at baseline and follow-up. Cox proportional hazard models were used to calculate the hazard ratio (HR) of PRISm with depression (Study 1) and depression with PRISm (Study 2). Studies 1 and 2 included 2,934 and 2,277 participants, respectively. The follow-up period extended from Wave 2 to Wave 4. In univariate analyses, a bidirectional association between PRISm and depression was observed, with unadjusted HRs of 1.49 (95% confidence interval [CI], 1.12-1.99; P=0.007) in Study 1 and 1.69 (95% CI, 1.13-2.52; P=0.010) in Study 2. However, in multivariable Cox models, baseline PRISm was not associated with subsequent depression development (adjusted HR 1.26; 95% CI, 0.94-1.69; P=0.128). Conversely, participants with depression had a significantly higher risk of developing PRISm compared to those without depression (adjusted HR 1.54; 95% CI, 1.03-2.32; P=0.038). These findings were consistent with z-score-based interpretive strategies, with an adjusted HR of 1.30 (95% CI, 0.95-1.77; P=0.105) in Study 1 and 1.59 (95% CI, 1.03-2.47; P=0.038) in Study 2. Depression was associated with an increased risk of developing PRISm, whereas PRISm did not increase the risk of developing depression. Physicians should be vigilant for potential PRISm development in patients with depression.

The longitudinal patterns of depression subtypes and stressors in depression severity in the Canadian longitudinal study on aging (CLSA).

The current study aims to characterize the longitudinal patterns of depression subtypes and investigate the associations among the stability of depression subtypes, COVID-19-related stressors, and depression severity. The study utilized data from the Canadian Longitudinal Study on Aging, which is a national, long-term study of Canadian adults aged 45 and older (n = 12,957). Latent profile analysis was used to identify latent depression subtypes. Latent transition analysis was then applied to assess the stability of these subtypes over time. Hierarchical multivariate linear regression was used to explore the relationships among these identified depression subtypes, COVID-19-related stressors, and depression severity among males and females, respectively. Distinct depression subtypes were identified. Except for atypical depression, other depression subtypes showed greater stability over time. We also found that melancholic depression (B = 9.432) and typical depression (B = 6.677) were strongly associated with depression severity during the pandemic. Health-related stressors (B = 0.840), conflict (B = 3.639), difficulties accessing resources (B = 0.927), separation from family (B = 0.840), and caregiving experience (B = 0.764), were significantly associated with increased depression severity. Sex-specific analyses also revealed differences in the associations between stressors and depression severity between males and females. This study contributes valuable insights into the latent clustering of depression subtypes and their stability. Stressors were associated with increased depression severity, with distinct associations observed among males and females. These findings have implications for targeted early interventions and integrated clinical management strategies by providing the evidence base for tailored mental health care during and after the pandemic.

Advancing Sustainable Hospitality Education: A Systematic Literature Review

Global challenges such as climate change and social inequality have heightened the emphasis on sustainability across various sectors, with higher education institutions (HEIs) playing a pivotal role in fostering sustainable practices. This systematic literature review assesses the evolution of sustainable hospitality education (SHE) research over the past two decades, highlighting trends and identifying gaps to synthesize the current scholarly discourse. Using a comprehensive search strategy across multiple databases, we identified 39 key articles through a structured screening process. Our findings reveal that SHE is a dynamic and inclusive field, characterized by a diverse array of research methods, educational levels, and sample sizes. The analysis of delivery modes and subject domains underscores the importance of cross-domain issues in SHE research. The review concludes by proposing future directions for SHE, including the development of localized curricula, faculty development programs, and interdisciplinary research initiatives. It also emphasizes the need for longitudinal studies to assess the long-term impact of educational strategies on students&amp;#39; sustainability knowledge and practices. Implementing these recommendations will enable SHE to contribute significantly to the sustainable transformation of the hospitality industry and inspire educational innovation, advancing a greener and more equitable future.

Intimate Partner Violence Predicts Child Marriage and Pregnancy Among Adolescents in Malawi.

A sizeable literature has shown that child marriage is associated with an increased risk for intimate partner violence (IPV). However, this research has been cross-sectional, and the temporality of the association has not been investigated. Specifically, no study has yet examined whether IPV is a predictor of child marriage and adolescent pregnancy. This study uses prospective longitudinal data on a cohort of adolescent girls from the Malawi Longitudinal Study of Families and Health to evaluate whether IPV victimization predicts child marriage or adolescent pregnancy. Using survival models, we find that adolescent girls who experienced physical IPV (measured at survey baseline, in 2017-2018) are more likely to enter child marriages (measured at survey follow-up, in 2021) (hazard ratio [HR] = 2.7 [1.44, 5.08]). Experiencing sexual IPV is also significantly associated with adolescent pregnancy (HR = 1.97 [1.16, 3.33]). These findings indicate the need for greater intervention to ensure healthy adolescent relationships, as well as further research to understand how abusive relationships shape early transitions to adulthood.

Trends in Malaysian Adolescents’ Mathematics Performance Across Two Decades: What Factors Matter?

The relationship between individual and school factors plays a crucial role in shaping adolescents' mathematics achievement. Individual factors, such as a student's motivation and educational expectation, directly influence their engagement and persistence in mathematical learning. Concurrently, school factors, including teacher quality and the availability of resources, create an environment that either fosters or hinders students' academic success in mathematics. Together, these factors underscore the need for a holistic approach to education that recognizes the interconnectedness of personal and institutional influences on student performance. Thus, this study investigates what individual and school factors have been associated with adolescents’ mathematics achievement over the last two decades. We examined six-wave data of Malaysia from the Trends in International Mathematics and Science Study (TIMSS). Multilevel modeling technique was employed for data composed of 5557, 5314, 4466, 5733, 9726, and 7065 eighth-grade students participating in 1999, 2003, 2007, 2011, 2015, and 2019, respectively. The results showed that 65.17%, 57.44%, 65.89%, 73.00%, 43.16%, and 61.69% of the total variance in mathematics achievement was due to school differences in these years. The findings also indicated that students with higher mathematics motivational beliefs scored higher. Students who more frequently spoke the language of the test at home achieved lower scores in the four waves of TIMSS; however, this trend changed in 2015 and 2019. Student educational aspiration emerged as a positive predictor of mathematics achievement in the last two assessments of TIMSS. Home educational resources and book ownership also significantly correlated with mathematics achievement. At the school level, teacher gender was negatively associated with achievement in all TIMSS waves except 2019. Students whom female teachers taught outperformed those whom male teachers taught. The longitudinal study of Malaysian students' mathematics performance reveals critical insights for educational stakeholders. The findings indicate that 43.16% to 73.00% of the variance in mathematical achievement is linked to school differences, underscoring the importance of equitable resource distribution. Moreover, students' motivational beliefs significantly influence their mathematics scores, suggesting a need for interventions that foster positive attitudes. The evolving correlation between home language proficiency and achievement emphasizes the necessity of integrating language support into educational strategies. Additionally, promoting educational aspirations is vital for enhancing performance, while the role of gender dynamics in teacher effectiveness warrants further exploration.

Brain structure and activity predicting cognitive maturation in adolescence.

Cognitive abilities of primates, including humans, continue to improve through adolescence. While a range of changes in brain structure and connectivity have been documented, how they affect neuronal activity that ultimately determines performance of cognitive functions remains unknown. Here, we conducted a multilevel longitudinal study of monkey adolescent neurocognitive development. The developmental trajectory of neural activity in the prefrontal cortex accounted remarkably well for working memory improvements. While complex aspects of activity changed progressively during adolescence, such as the rotation of stimulus representation in multidimensional neuronal space, which has been implicated in cognitive flexibility, even simpler attributes, such as the baseline firing rate in the period preceding a stimulus appearance had predictive power over behavior. Unexpectedly, decreases in brain volume and thickness, which are widely thought to underlie cognitive changes in humans 5 did not predict well the trajectory of neural activity or cognitive performance changes. Whole brain cortical volume in particular, exhibited an increase and reached a local maximum in late adolescence, at a time of rapid behavioral improvement. Maturation of long-distance white matter tracts linking the frontal lobe with areas of the association cortex and subcortical regions best predicted changes in neuronal activity and behavior. Our results provide evidence that optimization of neural activity depending on widely distributed circuitry effects cognitive development in adolescence.