Cancer is a high mortality disease of public concern. Effectiveness of chemotherapy is often limited by toxicity to untargeted tissues among other serious side’s effects. Alternative therapy such as herbal remedies for cancer, which may have the potential to offer more efficacy and less side effects have, however, not been rigorously studied or tested. The Aim of this present study therefore was to validate the anti-cancer properties (using tumor cells) of some selected Nigerian medicinal herbal remedies used by the population in Watsilla, Michika LGA. Phytochemical analysis, Antimicrobial and antioxidant activities of the selected medicinal plants were carried out as preliminary studies. The selected herbal extracts revealed the presence of alkaloid, essential oil, phenol, glycosides, flavonoid, tanin, terpenoid, proteins and saponins. The medicinal plants demonstrated good antioxidant activity with IC50 ranging from 0.42-0.54 which is lower than IC50 of Ascorbic acid (IC50 0.60 and 0.66) in both DPPH and H2O2 free radical scavenging activity model used in this study.The brine shrimp toxicity results, a preliminary anti-cancer studies, indicated that 100% of the plant extracts tested had LC50 values lower than 1000 μg/mL; Heamatostaphisbarteri (LC50 23.31μg/mL),Cyanoglossum officinal’(LC50 50.32μg/mL), Ximenia americana (LC5086.57μg/mL) and Anchus officinalis(LC50 54.37μg/mL), are excellently none toxic and surely have no obvious danger of outright toxicity during acute exposure. Thus, from the analysis it was concluded that, thesemedicinal plants demonstrated good phytochemical constituents, antioxidant activities and notoxicity on brine shrimp, with a potential to reducing the risk of tumor causing diseases, thereby confirming folkloric information of the usage of the plant as a remedy for common maladies like tumors that lead to various cancers.From the results it was found that the antimicrobial, antioxidant and antitumor activities showed better results than the standard. Bergenin has been found to have some antimicrobial, antioxidants and anti-tumor activities. Key words: Medicinal plants, pyhtochemistry, anti-tumor, antioxidant activity, chemotherapy.