New geological and morphotectonic surface data coupled with the revision of the ENI-Exploration & Production seismic lines, made it possible to review the tectonic structure of the Pliocene-Quaternary front of the eastern Southern Alps in the area between the Cellina River and the Tagliamento River (central Carnic Prealps, NE Italy). The eastern Southern Alps are a SE-verging fold and thrust belt in activity from the middle Miocene to the Present. The presence of Paleogene structural inheritances influenced the current structural arrangement of the thrust-belt and the potential seismogenesis, supporting segmentation of the Neoalpine external front. In particular, the presence of the NW-SE trending Mt.Ciaurlec – Palmanova – Pozzuolo structural high, inherited from the W-ward propagation of the External Dinarides during Paleogene, generated lateral lithological facies change and influenced not only the undulation between the Neogene-Quaternary Maniago-Meduno and Toppo-Forgaria Thrusts, but also the segmentation of the outermost portion of the Neoalpine external front consisting into two segments with different geometric and structural characteristics: 1) the ENE-WSW striking Arba-Sequals segment that runs buried under the upper Pleistocene sequences of the piedmont Friuli plain; 2) the W-E Ragogna segment that shows widespread evidence of surface deformation of the Last Glacial Maximum (LGM) alluvial plain. In particular, the long-lasting activity of the Ragogna segment is testified by the late Miocene-Middle Pleistocene angular unconformities, forced drainage anomalies and tilted and uplifted Quaternary palaeosurfaces. A discussion on the seismogenic potential of the investigated structures is proposed.