Focal Areas Research Articles

Closing the gap between biology and classification in splenic B-cell lymphomas.

The mature splenic B-cell lymphomas are an enigmatic group of lymphoid neoplasms that have long caused significant difficulty for the practicing pathologist due to overlapping diagnostic features among entities and the decreasing availability of splenic tissue for assessment. While some entities have highly characteristic and specific clinicopathological features (e.g. hairy cell leukaemia), others are substantially more difficult to recognise (e.g. splenic diffuse red pulp lymphoma). At the same time, classification systems have been evolving, resulting in multiple changes to the boundaries among these entities and even the existence of some entities in their own right. Moreover, unbiased multi-omic interrogation (whole genome/transcriptome sequencing, methylome) of the splenic B-cell lymphomas over the past decade has given us significant insights into the underling biology of these neoplasms. We present a clinicopathological perspective on the historical, current and future state of the diagnosis and classification of splenic B-cell lymphomas integrating multi-omic data and highlighting areas of focus for the field in order to continue to strive to improve patient outcomes through accurate diagnosis.

Navigating Global Research Trends on Seafoods-Related Foodborne Diseases: A Decadal Bibliometric Analysis

Ensuring seafood safety has become a critical area of focus due to its strong association with foodborne diseases. Despite the critical nature of this field, an in-depth understanding of global research trends in this field remains limited. Our study conducted an extensive bibliometric analysis to track the evolution and thematic focus of research on seafood safety from 2013 to 2023. Utilizing Scopus for publication and citation data, along with VOSviewer for visualizing keyword networks, this study highlights key developments and scholarly efforts aimed at mitigating risks associated with seafoods consumption. The analysis pinpoints the United States, China, the United Kingdom, France, South Korea and Malaysia as leading contributors. Their extensive research outputs and collaborations have markedly shaped the field's evolution. The overall positive trajectory in research volume experienced a minor setback in 2022, suggesting a complex and dynamic research landscape. "Food Control" is identified as a principal journal for the dissemination of research works, anchoring a dynamic co-citation network that fosters extensive international dialogue. We categorize seven principal research clusters: epidemiology, molecular detections, microbial resistance, bacteriophage applications, toxin detection methodologies, predictive modelling and biofilm studies. These clusters encompass the scopes and the breadth of current investigations. This decade-long review highlights the necessity for cohesive global research strategies to enhance the knowledge and control of foodborne pathogens in seafoods. This strategy is critical for improving food safety measures and safeguarding public health globally.

Molecular Testing Prevents Overdiagnosis of Epithelioid Hemangioma

Abstract Introduction/Objective Epithelioid hemangiomas (EH) are mostly solitary benign vascular tumors commonly involving the dermal and subcutaneous areas of the head and neck. However, reports of multifocality are increasing, specially in same anatomic region. Some reported cases of EH show morphologic features that may mimic malignant vascular tumors such as hemangioendotheliomas or angiosarcomas. However, there are no reported overlaps in the molecular characteristics of these tumors. We describe a multifocal EH with atypical features, suspicious for angiosarcoma, which needed molecular testing to resolve the diagnosis. Methods/Case Report The patient is a previously healthy 42-year-old male with a 5-month history of multiple growing painless penile nodules. Biopsy of one of the nodules was done. Histologic examination showed multifocal dermal- based ill-circumscribed nodules with interspersed inflammatory infiltrates and focal areas of necrosis. Tumor periphery shows vasoformative growth with intraluminal and extravasated red blood cells. Neoplastic cells were large and ovoid with abundant eosinophilic cytoplasm, large vesicular pleomorphic nuclei and prominent nucleoli. Immunohistochemical stains showed strong expression of ERG, FLI-1, and CD31 and negativity for AE1/AE3, CD34, HHV8 and EMA. The morphologic and immunohistochemical features of the specimen showed significant overlap of two primary differential diagnoses - epithelioid angiosarcoma and epithelioid hemangioma. Ultimately, molecular testing revealed ZFP36-FOSB fusion, confirming the diagnosis of EH. Results (if a Case Study enter NA) NA Conclusion Differentiating benign and malignant epithelioid vascular neoplasms can sometimes be challenging. There can be overlap in terms of architectural variety, presence of necrosis, vasoformation, inflammatory cell components and cytologic features, especially in EH with atypical features and epithelioid angiosarcoma (EA). Both of these tumors show positive immunoreactivity for CD31, CD34, FLI1 and ERG, and negativity for most keratins. Currently, the most reliable way to distinguish each tumor is molecular testing, with EH having FOS/FOSB rearrangements and EA with MYC or FLT4 amplification. Benign and malignant epithelioid vascular tumors can be indistinguishable morphologically and immunohistochemically. Molecular tests can help differentiate these neoplasms to better tailor patient management.

U-Space Social and Environmental Performance Indicators

The social potential of Urban Air Mobility (UAM) as a greener and faster transportation system in and around urban environments is indisputable. Nevertheless, the success of UAM introduction and its wide use will strongly depend on acceptance by the citizens and future UAM users. The impact on overall quality of life, as a multidimensional concept that encompasses physical health, mental and emotional well-being, economic status, education, and the environment, is becoming a significant issue. This paper aims to describe the performance framework for the assessment of the social and environmental impact of UAM. The specific objectives are to identify the full range of UAM’s impacts on citizens’ quality of life and to propose a set of indicators that enables the quantification and assessment of the identified impacts. Firstly, the main issues (focus areas) were identified, namely, noise, visual pollution, and privacy concerns, followed by access and equity, economic aspect, emissions, public safety, and impact on wildlife. In the next step, for each identified focus area, performance indicators were defined along with the several cross-cutting areas for a geographical, temporal, demographic, socioeconomic, and behavioral resolution. The proposed performance framework could enable more efficient mitigation measures and possibly contribute to wider adoption of the UAM operations.

Trends and predictors of severe and moderate anaemia among children aged 6–59 months in India: an analysis of three rounds of National Family Health Survey (NFHS) data

BackgroundChildhood anaemia remains a significant public health problem in India, as it adversely affects child development and overall health outcomes. This study aimed to analyse the prevalence of severe and moderate anaemia among children aged 6–59 months and identify consistent predictors of this condition over the past 15 years.MethodsData from the three most recent rounds of the NFHS were used for this analysis. The final weighted sample included 40,331 children from the NFHS-3 (2005–2006), 200,093 from the NFHS-4 (2015–2016), and 178,909 from the NFHS-5 (2019–2021). Descriptive and bivariate analyses were conducted, followed by binary logistic regression to identify factors associated with severe and moderate anaemia in children aged 6–59 months. All statistical analyses were performed using Stata version 14.ResultsOver the past 15 years, the prevalence of severe and moderate anaemia among children in India has shown a slight decline. However, the influence of various predictors has changed over time. Young children (aged 6–23 months), those from Scheduled Caste (SC) and Scheduled Tribe (ST) communities, and children born to mothers with high parity and low educational attainment remain particularly vulnerable to anaemia. Additionally, short-term illness significantly increases the risk of anaemia. Furthermore, women’s autonomy, indicated by higher education and lower fertility rates, along with maternal nutrition education, have emerged as key factors in reducing anaemia burden in the future. Notably, children whose mothers had no education were 1.4 times more likely to suffer from severe or moderate anaemia. Similarly, children born to mothers with four to five children (OR 1.1, p < 0.05) and those with six or more children (OR 1.2, p < 0.05) had an elevated risk of anaemia.ConclusionThe findings highlight three key areas for programmatic focus to accelerate anaemia reduction in India: [1] targeting young children (aged 6–23 months); [2] ensuring the inclusion of SC and ST communities in all relevant interventions; and [3] promoting women’s autonomy. These strategies are essential for reducing the burden of anaemia across the country.

The amended international health regulations: Implications and challenges for domestic legal frameworks.

The World Health Organisation's International Health Regulations were amended in May 2024, with a number of implications for countries to amend their legal and institutional frameworks. This perspective highlights two key areas of focus in the amendments-the importance of multisectoral coordination and subnational work - and explores their links to health security challenges and to concrete country experiences. National legal and institutional frameworks constitute a key enabling mechanism for effective public health systems capable of preventing, detecting, and responding promptly to public health events and emergencies, and the recent IHR amendments provide a new impetus for WHO Member States to make these changes.

Digital Health Interventions Are Effective for Irritable Bowel Syndrome Self-Management: A Systematic Review.

Digital health interventions (DHIs) could be a valuable self-management tool for patients with irritable bowel syndrome (IBS), but little research exists on IBS-focused DHIs and their effectiveness. This review aimed to identify DHIs for IBS and evaluate their characteristics, effectiveness, and feasibility. Our study team, including patient partners, conducted a systematic review using Medline, PsycINFO, Embase, Web of Science, and CINAHL from database inception to May 2024. Experimental and observational studies evaluating DHIs designed for use by IBS patients were included. Data extraction and assessment included study and DHI characteristics, effectiveness outcomes (symptom severity, quality of life, psychological indices, patient empowerment), and feasibility measures (adherence, usability, user satisfaction). Study quality and bias were assessed using a modified checklist of Downs and Black. Of the 929 identified, 13 studies of DHIs were included and deemed good quality on average (21,510 total participants) with six primary areas of focus: education, diet, brain-gut behavior skills, physiological support, health monitoring, and community engagement. Most DHIs were self-directed and reported statistically significant improvements in most effectiveness outcomes. Evidence suggests that DHIs focusing on brain-gut behavior skills or health monitoring may be most effective compared to other types of DHIs. However, their feasibility remains unclear, and the generalization of their impacts is limited. This review underscores the potential of DHIs in supporting IBS patients and improving their outcomes. However, additional research is warranted for continued intervention use in this population, including assessments on feasibility, safety, cost-effectiveness, and patient empowerment and experiences.

Aggression in psychiatry: a bibliometric analysis

BackgroundAggression is a common problem in psychiatric clinics, and many studies have been conducted on the issue over the years. This study bibliometrically examines the characteristics and trends of aggression studies in psychiatry, such as the branches, publication years, types, publishers, and impact factors, and compares the focus areas of psychiatry and psychiatric nursing on aggression, to guide future research and readers on this topic. Bibliometric analysis was performed with network metrics, citation analysis, co-authorship analysis, science mapping, and network visualization techniques using WoS analysis reports and the VOSviewer program with data obtained from the Web of Science database on January 11, 2024.ResultsMost studies on aggression in psychiatry were published in 2019 as English articles. Then, 3.37% of these studies are in psychiatric nursing, mainly from Australia. In contrast, most psychiatric studies are from the USA. Psychiatry studies focus on causes, types, and relationships with psychiatric disorders, while psychiatric nursing studies emphasize aggressive attitudes, risk assessment, and aggression management.ConclusionsIt appears that studies on aggression continue to remain current in the literature and will continue to do so, considering that aggression is an ongoing clinical problem worldwide. Despite this, studies on assessing and managing the risk of aggression are still lacking. Future studies should prioritize the management of aggression. While the study showed the presence of multidisciplinary and international collaborations, it is recommended that these collaborations be further expanded. Findings may inform researchers’ keyword and journal choices.

Safety Trends in the Automobile Industry in India

The automobile industry in India has experienced significant advancements in recent years, driven by rapid technological innovations and evolving consumer expectations. Safety has emerged as a critical focus area, with stakeholders ranging from government bodies to manufacturers and consumers increasingly emphasizing the need for stringent safety measures. This paper explores the key safety trends shaping the Indian automotive sector, including the adoption of advanced driver-assistance systems (ADAS), the implementation of new crash test standards, and the increased integration of passive and active safety features in vehicles. Additionally, it highlights the regulatory changes brought forth by the Indian government, such as the Bharat New Vehicle Safety Assessment Program (BNVSAP) and mandatory safety norms like airbags and anti-lock braking systems (ABS). The study also examines the role of technological innovations, including connected vehicle technologies and the potential of autonomous driving in enhancing road safety. By analyzing these trends, the paper aims to provide insights into how safety measures in the Indian automobile industry are evolving to meet global standards and reduce the rising number of road accidents in the country.

E-Learning Impact on Higher Education Institutions during COVID-19 Pandemic: A Bibliometric Analysis

The COVID-19 pandemic forced a rapid shift to online learning in higher education. To understand this evolving field better, this study employed a powerful technique called bibliometrics. Researchers analyzed scholarly publications between 2020 and 2023 in Web of Science, focusing on keywords related to e-learning, universities, and the pandemic's impact. This data-driven approach provided a more comprehensive picture than traditional reviews, revealing connections between research topics, researchers, and specific studies. Furthermore, the VOSviewer tool was employed to identify frequently co-occurring keywords, thus uncovering the major themes within the research. This analysis of keyword co-occurrence allowed the study to pinpoint key trends and areas of focus in e-learning for higher education institutions. Ultimately, this research offers valuable insights for researchers, educators, and policymakers navigating the changing educational landscape and the future of e-learning in higher education.

Embracing tomorrow: global insights on corporate commitment to the 2030 Agenda

Purpose The 2030 Agenda represents a unique and historic opportunity to achieve sustainable development by establishing high-priority issues to be addressed, such as the eradication of extreme poverty, the reduction of inequalities, and inclusive economic growth with decent work for all. This study aims to analyze the commitment of the world’s leading companies to the sustainable development goals (SDGs) set out in this roadmap. Design/methodology/approach To provide a dynamic and global view of corporate commitment to the 2030 Agenda, the authors identified the 3,910 companies that have reported on various initiatives related to the SDGs over the period 2019–2022 (15,640 observations), based on the Refinitiv database. The companies that make up the sample are located in 71 countries across eight geographic regions. Findings The results show a positive evolution in the actions and initiatives that companies are developing to contribute to the protection of people, the planet, prosperity, universal peace, and access to justice. However, there are differences between regions and countries and between the 17 objectives. Originality/value The authors’ approach allows for a detailed understanding of business preferences, how these sustainable business practices contribute to achieving the SDGs in different regions and what contextual factors influence this contribution. In this sense, the analysis of the regional distribution of corporate commitments to the SDGs provides valuable information on the priority areas of focus in different regions of the world.

Emerging and Conventional Water Desalination Technologies Powered by Renewable Energy and Energy Storage Systems toward Zero Liquid Discharge

The depletion of fossil fuels has become a significant global issue, prompting scientists to explore and refine methods for harnessing alternative energy sources. This study provides a comprehensive review of advancements and emerging technologies in the desalination industry, focusing on technological improvements and economic considerations. The analysis highlights the potential synergies of integrating multiple renewable energy systems to enhance desalination efficiency and minimise environmental consequences. The main areas of focus include aligning developing technologies like membrane distillation, pervaporation and forward osmosis with renewable energy and implementing hybrid renewable energy systems to improve the scalability and economic viability of desalination enterprises. The study also analyses obstacles related to desalination driven by renewable energy, including energy storage, fluctuations in energy supply, and deployment costs. By resolving these obstacles and investigating novel methodologies, the study enhances the understanding of how renewable energy can be used to construct more efficient, sustainable, and economical desalination systems. Thermal desalination technologies require more energy than membrane-based systems due to the significant energy requirements associated with water vaporisation. The photovoltaic-powered reverse osmosis (RO) system had the most economically favourable production cost, while MED powered via a concentrated solar power (CSP) system had the highest production cost. The study aims to guide future research and development efforts, ultimately promoting the worldwide use of renewable energy-powered desalination systems.

Survival and Evolutionary Adaptation of Populations Under Disruptive Habitat Change: A Study With Darwinian Cellular Automata.

The evolution of living beings with continuous and consistent progress toward adaptation and ways to model evolution along principles as close as possible to Darwin's are important areas of focus in Artificial Life. Though genetic algorithms and evolutionary strategies are good methods for modeling selection, crossover, and mutation, biological systems are undeniably spatially distributed processes in which living organisms interact with locally available individuals rather than with the entire population at once. This work presents a model for the survival of organisms during a change in the environment to a less favorable one, putting them at risk of extinction, such as many organisms experience today under climate change or local habitat loss or fragmentation. Local spatial structure of resources and environmental quality also impacts the capacity of an evolving population to adapt. The problem is considered on a probabilistic cellular automaton with update rules based on the principles of genetic algorithms. To carry out simulations according to the described model, the Darwinian cellular automata are introduced, and the software has been designed with the code available open source. An experimental evaluation of the behavioral characteristics of the model was carried out, completed by a critical evaluation of the results obtained, parametrically describing conditions and thresholds under which extinction or survival of the population may occur.

Examining noncommunicable diseases using satellite imagery: a systematic literature review

IntroductionNoncommunicable diseases (NCDs) are the leading cause of morbidity and mortality worldwide, accounting for 74% of deaths annually. Satellite imagery provides previously unattainable data about factors related to NCDs that overcome limitations of traditional, non-satellite-derived environmental data, such as subjectivity and requirements of a smaller geographic area of focus. This systematic literature review determined how satellite imagery has been used to address the top NCDs in the world, including cardiovascular diseases, cancers, chronic respiratory diseases, and diabetes.MethodsA literature search was performed using PubMed (including MEDLINE), CINAHL, Web of Science, Science Direct, Green FILE, and Engineering Village for articles published through June 6, 2023. Quantitative, qualitative, and mixed-methods peer-reviewed studies about satellite imagery in the context of the top NCDs (cancer, cardiovascular disease, chronic respiratory disease, and diabetes) were included. Articles were assessed for quality using the criteria from the Oxford Centre for Evidence-Based Medicine.ResultsA total of 43 studies were included, including 5 prospective comparative cohort trials, 22 retrospective cohort studies, and 16 cross-sectional studies. Country economies of the included studies were 72% high-income, 16% upper-middle-income, 9% lower-middle-income, and 0% low-income. One study was global. 93% of the studies found an association between the satellite data and NCD outcome(s). A variety of methods were used to extract satellite data, with the main methods being using publicly available algorithms (79.1%), preprocessing techniques (34.9%), external resource tools (30.2%) and publicly available models (13.9%). All four NCD types examined appeared in at least 20% of the studies.ConclusionResearchers have demonstrated they can successfully use satellite imagery data to investigate the world’s top NCDs. However, given the rapid increase in satellite technology and artificial intelligence, much of satellite imagery used to address NCDs remains largely untapped. In particular, with most existing studies focusing on high-income countries, future research should use satellite data, to overcome limitations of traditional data, from lower-income countries which have a greater burden of morbidity and mortality from NCDs. Furthermore, creating and refining effective methods to extract and process satellite data may facilitate satellite data’s use among scientists studying NCDs worldwide.

Multi-qubit gates and Schrödinger cat states in an optical clock.

Many-particle entanglement is a key resource for achieving the fundamental precision limits of a quantum sensor1. Optical atomic clocks2, the current state of the art in frequency precision, are a rapidly emerging area of focus for entanglement-enhanced metrology3-6. Augmenting tweezer-based clocks featuring microscopic control and detection7-10 with the high-fidelity entangling gates developed for atom-array information processing11,12 offers a promising route towards making use of highly entangled quantum states for improved optical clocks. Here we develop and use a family of multi-qubit Rydberg gates to generate Schrödinger cat states of the Greenberger-Horne-Zeilinger (GHZ) type with up to nine optical clock qubits in a programmable atom array. In an atom-laser comparison at sufficiently short dark times, we demonstrate a fractional frequency instability below the standard quantum limit (SQL) using GHZ states of up to four qubits. However, because of their reduced dynamic range, GHZ states of a single size fail to improve the achievable clock precision at the optimal dark time compared with unentangled atoms13. Towards overcoming this hurdle, we simultaneously prepare a cascade of varying-size GHZ states to perform unambiguous phase estimation over an extended interval14-17. These results demonstrate key building blocks for approaching Heisenberg-limited scaling of optical atomic clock precision.

A bibliometric analysis of Oropouche virus.

Oropouche virus (OROV) causes systemic infections including the nervous and blood systems, posing a significant and growing public health challenge. However, a comprehensive review of the bibliometric analysis of OROV is still lacking. Therefore, the objective of this study was to provide insight into the research dynamics and current hotspots of OROV. This study used bibliometric analysis to explore the current status of research related to OROV. 148 publications from 1961 to 2024 were retrieved from the Scopus database. Countries, authors, institutions, journals, references, and keywords were visualized using VOSviewer, CiteSpace, R studio, and Bibliometrix. Microsoft Excel was used for statistical analysis. Brazil is the country with the highest number of publications, total cited frequency, and the most extensive international collaboration. The most popular journal in this field is the American Journal of Tropical Medicine and Hygiene. Instituto Evandro Chagas is the institution with the highest number of publications, and Eurico Arruda is involved in the highest number of publications. Keyword co-occurrence analysis showed that Oropouche bunyavirus, virology, bunyavirus, priority journal, and nucleotide sequence are the main research hotspots in this field. Our study provides a comprehensive overview of the research trends and key areas of focus in OROV. The field is currently experiencing rapid growth, as evidenced by the rising number of annual publications, which not only highlights increased research activity but also lays a solid foundation for further in-depth investigations. This trend offers valuable insights for developing effective strategies for outbreak prevention and control in public health. Presently, researchers are concentrating on the detailed study of Bunyavirus infections, employing both virological and genetic approaches to elucidate their complex pathogenic mechanisms.

Empowering Communities to Act for a Change: A Review of the Community Empowerment Programs towards Sustainability and Resilience

At the global level, significant efforts have been made to address societal challenges and improve the lives of people and restore the planet’s ecosystems through sustainability and resilience programs. These programs, however, tend to be driven by governments, private sectors, and financial institutions, and therefore often lack a process of empowerment to ensure that the local communities can participate actively in co-designing and implementing these programs. More knowledge is needed on how to develop such programs and how the process of empowerment can be organized so that it supports in the long run sustainability transformation. Against this background, the paper explores the role of community empowerment programs as a critical tool for sustainability management strategies and practices. A semi-systematic review of 21 community empowerment programs for sustainability and resilience is conducted. The analysis reveals that the programs mostly aimed to address challenges such as the lack of education and capacity, limited access to basic services and resources, and poor governance and management. The programs initiators involve a diverse set of actors, especially through established partnerships and networks. Most of the programs address the specific needs of vulnerable or marginalized groups or communities. The structure of the programs typically follows a phased methodological approach, beginning with awareness-raising and problem identification, followed by capacity building that allows for making decisions collaboratively and for co-creating innovative solutions based on local knowledge and values. Also, monitoring and evaluation of transformative impact are mentioned as important structural elements. Specifically, the analysis highlights four main focus areas of empowerment: (1) capacity building, (2) self-reliance, control, ownership, responsibility, and independence, (3) participation, engagement, and collective action, and (4) integration of local knowledge and values. However, there is no one-size-fits-all approach to such programs. Instead, successful empowerment programs towards sustainability depend on a deep understanding of local contexts and the ability to tailor strategies to meet specific community needs. The review also identified knowledge gaps that require further investigation to enhance the effectiveness of empowerment programs for both people and nature.

Identifying focus areas for science communication training in the context of undergraduate science education

ABSTRACT In this paper, we present recommendations for integrating science communication training into undergraduate science curricula. Science communication training is increasingly acknowledged as an important element of science education. It is essential to introduce this training early in academic development, ideally at the undergraduate level. The current study was aimed at identifying specific focus areas for such training within an undergraduate biomedical sciences program. Therefore, we tasked undergraduate biomedical students with translating general instructions for engaging in science-society interactions into concrete communicative behavior. Following the thematic analysis of 121 written student responses, we identified two primary focus areas, resulting in two recommendations. Firstly, training should concentrate on helping students to operationalize complex communicative concepts, such as respect and listening, into tangible communicative behavior. A special emphasis should be placed on aspects of nonverbal communication. Secondly, science communication training should prioritize fostering informed views of the nature of science, while connecting to building knowledge and understanding of models of science communication. This approach could enhance students’ receptivity to important aspects of the dialogue model, such as accepting diverse forms of knowledge and recognizing scientists and non-scientists as equal participants in dialogue. For both recommendations, we contemplate potential educational interventions and/or pedagogical approaches.

Anesthetic sampling and the tissue regeneration potential of oysters: A study with Crassostrea hongkongensis

The use of an appropriate amount of anesthetic can prevent the sacrifice of oysters during experimental sampling or seedling rearing. In this study, we assessed the effects of air exposure and three concentrations of magnesium chloride (10, 40, and 70 g L–1) on the anesthetic efficiency for Crassostrea hongkongensis. We examined the recuperative capacity of the oysters post-tissue sampling. The results indicated that 36 h of air exposure could significantly enhance the anesthetic efficiency of C. hongkongensis while ensuring the oysters’ survival. A 40 g L–1 solution of magnesium chloride had the optimal anesthetic effect on C. hongkongensis across all oyster sizes. In addition, smaller oysters (119.10 g) had a higher relaxation rate than larger oysters (191.00 g). The oysters anesthetized with 40 g L–1 magnesium chloride also demonstrated the best recovery. No deaths were observed among the non-anesthetized oysters, anesthetized-recovered oysters, or non-recovered oysters during a seven-day post-farming period. In terms of live sampling, the control group (100 %), gonad group (100 %), mantle group (98.67 %), gill group (89.33 %), and adductor muscle group (97.33 %) all showed high survival rates after anesthesia. Observation of tissue growth post-sampling revealed the presence of focal green areas in tissues between days 7 and 14. By day 30, the adductor muscle and mantle tissues had fully healed, and the regrown tissue in the gills had approached its original length. A 40 g L–1 magnesium chloride solution had no significant effects on gametes in terms of fertilization rate, growth rate, and attachment rate. The present findings indicated that C. hongkongensis could be effectively anesthetized using a 40 g L–1 magnesium chloride solution following 36 h of aerial exposure. Post-anesthesia tissue and gamete sampling did not result in significant mortality, and the tissues had fully recovered within 30 days post-sampling. The anesthesia did not have any adverse effects on the progeny.

An Economic Analysis of Coal Pricing in Mongolia

Coal is a critical export for Mongolia, playing a significant role in the nation’s economy by contributing to GDP and export revenues. This paper provides an economic analysis of coal pricing in Mongolia, examining the primary factors that drive price fluctuations in both domestic and international markets. Key areas of focus include global demand, particularly from neighboring China, transportation costs, government policies, currency exchange rates, and environmental regulations. The paper employs a mixed-method approach, analyzing historical price data alongside policy reviews to identify the challenges and opportunities Mongolia faces in stabilizing coal prices. Global coal demand, especially from China, has a profound effect on Mongolian coal prices, while infrastructure limitations and transportation costs further exacerbate price volatility. Additionally, Mongolia’s coal sector is influenced by international competition, particularly from established exporters like Australia and Indonesia, which benefit from more developed supply chains. This research aims to provide valuable insights for policymakers and stakeholders by offering recommendations on how Mongolia can enhance price stability and strengthen its position in the global coal market. By analyzing the economic forces shaping Mongolian coal prices, the study contributes to broader discussions on resource management and economic sustainability in coal-dependent economies. The findings will aid policymakers in developing strategies that address Mongolia's infrastructure challenges and ensure the long-term viability of its coal industry in the face of evolving global energy dynamics.