Buildings consume major amount of energy as well as natural resources leading to negative environmental impacts like resource depletion and pollution. The current task for the construction sector is to develop an evaluation tool for rating of buildings based on their environmental impacts. There are various assessment tools and models developed by different agencies in different countries to evaluate building's effect on environment. Although these tools have been successfully used and implemented in the respective regions of their origin, the problems of application occur, especially during regional adaptation in other countries due to peculiarities associated with the specific geographic location, climatic conditions, construction methods and materials. India is a rapidly growing economy with exponential increase in housing sector. Impact assessment model for a residential building has been developed based on life cycle assessment (LCA) framework. The life cycle impact assessment score was obtained for a sample house considering fifteen combinations of materials paired with 100% thermal electricity and 70%-30% thermal-solar combination, applying normalization and weighting to the LCA results. The LCA score of portland slag cement with burnt clay red brick and 70%-30% thermal-solar combination (PSC+TS+RB) was found to have the best score and ordinary Portland cement with flyash brick and 100% thermal power (OPC+T+FAB) had the worst score, showing the scope for further improvement in LCA model to include positive scores for substitution of natural resources with industrial waste otherwise polluting the environment.